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1. Full Text QnAs with Bruce M. Spiegelman
by Bruce M. Spiegelman and Prashant Nair
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2011, Volume 108, Issue 48, pp. 19121 - 19121
Obesity | Medical treatment | Brown adipocytes | Brown adipose tissue | Muscle cells | Protein precursors | QnAs | Diabetes | Adipocytes | White adipocytes | Cells | MULTIDISCIPLINARY SCIENCES | Adipose Tissue, Brown - physiology | Cell Biology - trends | Adipose Tissue, Brown - metabolism | Energy Metabolism - physiology | Humans | Cell Lineage - physiology | Index Medicus
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2. Full Text Hormones, Metabolism and the Benefits of Exercise
by Spiegelman, Bruce
03/2018, ISBN 9783319727899, 108
The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in... 
human brown adipose tissue plasticity | type 2 diabetes | Tryptophan-kynurenine metabolites | metabolic diseases | muscle glycogen | AMPK | skeletal muscle microRNAs | FNDC5/irisin | obesity
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3. Cell differentiation
by Spiegelman, Bruce M and Watt, Fiona M and Hunt, Tim and Sherr, Charles J
1994, Volume 6, no. 6., 781-907.
Book
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4. Full Text Activation of the PPAR/PGC-1α Pathway Prevents a Bioenergetic Deficit and Effectively Improves a Mitochondrial Myopathy Phenotype
by Wenz, Tina and Diaz, Francisca and Spiegelman, Bruce M and Moraes, Carlos T
Cell Metabolism, ISSN 1550-4131, 09/2008, Volume 8, Issue 3, pp. 249 - 256
Neuromuscular disorders with defects in the mitochondrial ATP-generating system affect a large number of children and adults worldwide, but remain without... 
HUMDISEASE | CELLS | TRANSCRIPTIONAL COACTIVATOR PGC-1-ALPHA | LACKING | RECEPTOR-GAMMA | BIOGENESIS | ERR-ALPHA | C-OXIDASE DEFICIENCY | DNA | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | MUSCLE | CELL BIOLOGY
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5. Full Text Innervation of thermogenic adipose tissue via a calsyntenin 3β-S100b axis
by Zeng, Xing and Ye, Mengchen and Resch, Jon M and Jedrychowski, Mark P and Hu, Bo and Lowell, Bradford B and Ginty, David D and Spiegelman, Bruce M
Nature, ISSN 0028-0836, 05/2019, Volume 569, Issue 7755, pp. 229 - 235
The sympathetic nervous system drives brown and beige adipocyte thermogenesis through the release of noradrenaline from local axons. However, the molecular... 
Obesity | Adipose tissue | Peptides | Neurons | Secretion | Axonogenesis | Innervation | S100b protein | Amino acids | Nervous system | Adipocytes | Mammals | Sympathetic nervous system | Ablation | High fat diet | Proteins | Axons | Thermogenesis | Sympathetic nerves | Norepinephrine | Localization | Endoplasmic reticulum | Noradrenaline | Growth factors
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6. Full Text Regulation of adipogenesis: toward new therapeutics for metabolic disease
by Spiegelman, Bruce M
Diabetes, ISSN 0012-1797, 06/2013, Volume 62, Issue 6, p. 1774
The Banting Medal for Scientific Achievement Award is the American Diabetes Association's highest scientific award and honors an individual who has made... 
Physiological aspects | Metabolic diseases | Fat cells | Control | Care and treatment | Research
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7. Full Text Irisin Mediates Effects on Bone and Fat via [alpha]V Integrin Receptors
by Kim, Hyeonwoo and Wrann, Christiane D and Jedrychowski, Mark and Vidoni, Sara and Kitase, Yukiko and Nagano, Kenichi and Zhou, Chenhe and Chou, Joshua and Parkman, Virginia-Jeni A and Novick, Scott J and Strutzenberg, Timothy S and Pascal, Bruce D and Le, Phuong T and Brooks, Daniel J and Roche, Alexander M and Gerber, Kaitlyn K and Mattheis, Laura and Chen, Wenjing and Tu, Hua and Bouxsein, Mary L and Griffin, Patrick R and Baron, Roland and Rosen, Clifford J and Bonewald, Lynda F and Spiegelman, Bruce M
Cell, ISSN 0092-8674, 12/2018, Volume 175, Issue 7, p. 1756
Irisin is secreted by muscle, increases with exercise, and mediates certain favorable effects of physical activity. In particular, irisin has been shown to... 
Orthopedic surgery | Integrins | Protein binding
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8. Full Text Banting lecture 2012: Regulation of adipogenesis: Toward new therapeutics for metabolic disease
by Spiegelman, Bruce M
Diabetes, ISSN 0012-1797, 06/2013, Volume 62, Issue 6, pp. 1774 - 1782
The Banting Medal for Scientific Achievement Award is the American Diabetes Association's highest scientific award and honors an individual who has made... 
THERMOGENESIS | COACTIVATOR | ADIPOCYTES | DRIVES | BEIGE | DISTINCT | PRDM16 | ENDOCRINOLOGY & METABOLISM | MUSCLE | FAT | BROWN ADIPOSE-TISSUE | Glucose Tolerance Test | Humans | Adipocytes - cytology | Transcription Factors - genetics | Adipogenesis - physiology | Transcription Factors - metabolism | Adipose Tissue, Brown - cytology | Animals | Metabolic Diseases - metabolism | Adipocytes - metabolism | Metabolic Diseases - genetics | Adipose Tissue, Brown - metabolism | Adipogenesis - genetics | Index Medicus | Abridged Index Medicus | Banting Lecture
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9. Full Text Terminal Differentiation of Human Liposarcoma Cells Induced by Ligands for Peroxisome Proliferator-Activated Receptor γ and the Retinoid X Receptor
by Peter Tontonoz and Samuel Singer and Barry M. Forman and Pasha Sarraf and Jonathan A. Fletcher and Christopher D. M. Fletcher and Regina P. Brun and Elisabetta Mueller and Soner Altiok and Heather Oppenheim and Ronald M. Evans and Bruce M. Spiegelman
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/1997, Volume 94, Issue 1, pp. 237 - 241
Induction of terminal differentiation represents a promising therapeutic approach to certain human malignancies. The peroxisome proliferator-activated receptor... 
Receptors | Liposarcoma | Cell cycle | Ligands | Cultured cells | Adipocytes | Retinoids | Cellular differentiation | Thiazolidinediones | Tumors | BINDING-PROTEIN-ALPHA | SOFT-TISSUE TUMORS | HIGH-AFFINITY LIGAND | ACID | MYXOID LIPOSARCOMA | MULTIDISCIPLINARY SCIENCES | ADIPOCYTE DIFFERENTIATION | PPAR-GAMMA | K RO MULTIDISCIPLINARY SCIENCES | EXPRESSION | ACUTE PROMYELOCYTIC LEUKEMIA | FAMILY | Antigens, Differentiation - analysis | Retinoid X Receptors | Humans | Liposarcoma - pathology | Pioglitazone | Gene Expression Regulation, Neoplastic | Lipid Metabolism | Receptors, Retinoic Acid - metabolism | Liposarcoma - classification | Transcription Factors - metabolism | Liposarcoma - metabolism | Gene Expression Regulation, Developmental | Adipocytes - metabolism | Fibroblasts - drug effects | Cell Differentiation | Thiazoles - pharmacology | Tumor Cells, Cultured | Retinoids - pharmacology | Receptors, Cytoplasmic and Nuclear - metabolism | Pathology | Differentiation therapy | Peroxisomes | Sarcoma | Ligands (Biochemistry) | Research | Biological control systems | Cancer | Medical research | Index Medicus | Biological Sciences
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10. Full Text An Evolutionarily Conserved uORF Regulates PGC1[alpha] and Oxidative Metabolism in Mice, Flies, and Bluefin Tuna
by Dumesic, Phillip A and Egan, Daniel F and Gut, Philipp and Tran, Mei T and Parisi, Alice and Chatterjee, Nirmalya and Jedrychowski, Mark and Paschini, Margherita and Kazak, Lawrence and Wilensky, Sarah E and Dou, Florence and Bogoslavski, Dina and Cartier, Jeffrey A and Perrimon, Norbert and Kajimura, Shingo and Parikh, Samir M and Spiegelman, Bruce M
Cell Metabolism, ISSN 1550-4131, 07/2019, Volume 30, Issue 1, p. 190
Mitochondrial abundance and function are tightly controlled during metabolic adaptation but dysregulated in pathological states such as diabetes,... 
RNA | Resveratrol | Physiological aspects | Kidney diseases | Genetic translation | Cells | Bluefin tuna
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11. Full Text Fat and beyond: The diverse biology of PPARγ
by Tontonoz, Peter and Spiegelman, Bruce M
Annual Review of Biochemistry, ISSN 0066-4154, 2008, Volume 77, Issue 1, pp. 289 - 312
The nuclear receptor PPAR gamma is a ligand-activated transcription factor that plays an important role in the control of gene expression linked to a variety... 
Adipocyte | Nuclear receptor | Insulin sensitivity | Inflammation | Metabolism | Thiazolidindione | Macrophage | HUMAN DENDRITIC CELLS | HEPATIC INSULIN SENSITIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | macrophage | MACROPHAGE-GENE-EXPRESSION | insulin sensitivity | inflammation | thiazolidindione | adipocyte | ACID-BINDING PROTEIN | ACTIVATED-RECEPTOR-GAMMA | nuclear receptor | BODY-MASS INDEX | metabolism | SMOOTH-MUSCLE-CELLS | RETINOID-X-RECEPTOR | TYPE-2 DIABETES-MELLITUS | B SIGNALING PATHWAY
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12. Full Text Retraction Notice to Activation of the PPAR/PGC-1a Pathway Prevents a Bioenergetic Deficit and Effectively Improves a Mitochondrial Myopathy Phenotype (S1550413108002386) (10.1016/j.cmet.2008.07.006)
by Wenz, Tina and Diaz, Francisca and Spiegelman, Bruce M and Moraes, Carlos T
Cell Metabolism, ISSN 1550-4131, 12/2016, Volume 24, Issue 6, p. 889
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13. Full Text Ablation of PM20D1 reveals N-acyl amino acid control of metabolism and nociception
by Long, Jonathan Z and Roche, Alexander M and Berdan, Charles A and Louie, Sharon M and Roberts, Amanda J and Svensson, Katrin J and Dou, Florence Y and Bateman, Leslie A and Mina, Amir I and Deng, Zhaoming and Jedrychowski, Mark P and Lin, Hua and Kamenecka, Theodore M and Asara, John M and Griffin, Patrick R and Banks, Alexander S and Nomura, Daniel K and Spiegelman, Bruce M
Proceedings of the National Academy of Sciences of the United States, ISSN 0027-8424, 07/2018, Volume 115, Issue 29, p. 7466
Physiological aspects | Amino acids | Metabolism | Observations
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14. Full Text PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein
by Ohno, Haruya and Shinoda, Kosaku and Spiegelman, Bruce M and Kajimura, Shingo
Cell Metabolism, ISSN 1550-4131, 03/2012, Volume 15, Issue 3, pp. 395 - 404
Brown adipose tissue dissipates energy through heat and functions as a defense against cold and obesity. PPARγ ligands have been shown to induce the browning... 
OLIGONUCLEOTIDE ARRAYS | GENE | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | ACTIVATED-RECEPTOR-GAMMA | TRANSCRIPTIONAL CONTROL | ADIPOCYTE DIFFERENTIATION | ADULT HUMANS | LIGAND | EXPRESSION | ADIPOSE-TISSUE | CELL BIOLOGY | Mice, Inbred C57BL | Adipose Tissue, White - metabolism | Male | Transcription Factors - genetics | DNA-Binding Proteins - genetics | PPAR gamma - metabolism | Blotting, Western | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Animals | Oxygen Consumption - drug effects | Protein Stability - drug effects | PPAR gamma - agonists | Indoles - pharmacology | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Mice | Thiazolidinediones - pharmacology | Adipose Tissue, White - drug effects | Sulfides - pharmacology | Index Medicus
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15. Full Text Retraction Notice to: Activation of the PPAR/PGC-1[alpha] Pathway Prevents a Bioenergetic Deficit and Effectively Improves a Mitochondrial Myopathy Phenotype
by Wenz, Tina and Diaz, Francisca and Spiegelman, Bruce M and Moraes, Carlos T
Cell Metabolism, ISSN 1550-4131, 12/2016, Volume 24, Issue 6, p. 889
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16. Full Text The role of exercise and PGC1α in inflammation and chronic disease
by Spiegelman, Bruce M and Handschin, Christoph
Nature, ISSN 0028-0836, 07/2008, Volume 454, Issue 7203, pp. 463 - 469
Inadequate physical activity is linked to many chronic diseases. But the mechanisms that tie muscle activity to health are unclear. The transcriptional... 
SKELETAL-MUSCLE | OXIDATIVE-PHOSPHORYLATION | TRANSCRIPTIONAL COACTIVATOR PGC-1-ALPHA | METABOLIC SYNDROME | ANTIOXIDANT DEFENSE | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | NECROSIS-FACTOR-ALPHA | PHYSICAL-ACTIVITY | MUSCLE FIBER-TYPE | PARKINSONS-DISEASE
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17. Full Text ADD1/SREBP1 Activates PPARγ through the Production of Endogenous Ligand
by Jae Bum Kim and Harold M. Wright and Margaret Wright and Bruce M. Spiegelman
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/1998, Volume 95, Issue 8, pp. 4333 - 4337
Adipose differentiation is an important part of the energy homeostasis system of higher organisms. Recent data have suggested that this process is controlled... 
Transcription factors | Transfection | Alleles | Cell lines | Ligands | Lipids | Adipocytes | Lipogenesis | Fatty acids | Cells | Fatty acid metabolism | Nuclear hormone receptor | Adipocyte differentiation | adipocyte differentiation | PROMOTES ADIPOCYTE DIFFERENTIATION | fatty acid metabolism | ENHANCER-BINDING-PROTEIN | MULTIDISCIPLINARY SCIENCES | ALPHA | ADIPOGENESIS | LEUCINE ZIPPER PROTEIN | STEROL REGULATORY ELEMENT | nuclear hormone receptor | GENE-EXPRESSION | ECTOPIC EXPRESSION | TRANSCRIPTION FACTOR | PROGRAM | Biological Sciences
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18. Full Text Erratum: Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity (Cell Metabolism (2017) 26(4) (660–671.e3) (S1550413117304941)(10.1016/j.cmet.2017.08.009))
by Kazak, Lawrence and Chouchani, Edward T and Lu, Gina Z and Jedrychowski, Mark P and Bare, Curtis J and Mina, Amir I and Kumari, Manju and Zhang, Song and Vuckovic, Ivan and Laznik-Bogoslavski, Dina and Dzeja, Petras and Banks, Alexander S and Rosen, Evan D and Spiegelman, Bruce M
Cell Metabolism, ISSN 1550-4131, 10/2017, Volume 26, Issue 4, p. 693
(Cell Metabolism 26, 1–12; October 3, 2017) In the originally published version of this article, in the last sentence of the Introduction subsection, there was... 
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19. Full Text Transcription coactivator TRAP220 is required for PPARδ2-stimulated adipogenesis
by Ge, Kai and Guermah, Mohamed and Yuan, Chao-Xing and Yuan, Chao-Xing and Ito, Mitsuhiro and Wallberg, Annika E and Spiegelman, Bruce M and Spiegelman, Bruce M and Roeder, Robert G and Roeder, Robert G
Nature, ISSN 0028-0836, 2002, Volume 417, Issue 6888, pp. 563 - 567
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20. Full Text Thrap 3 docks on phosphoserine 273 of PPAR γ and controls diabetic gene programming
by Choi, Jang Hyun and Choi, Sun-Sil and Kim, Eun Sun and Jedrychowski, Mark P and Yang, Yong Ryoul and Jang, Hyun-Jun and Suh, Pann-Ghill and Banks, Alexander S and Gygi, Steven P and Spiegelman, Bruce M
Genes and Development, ISSN 0890-9369, 11/2014, Volume 28, Issue 21, pp. 2361 - 2369
Energy homeostasis | Phosphorylation | Thrap3 interaction | Gene reprogramming | PPARγ
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