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Journal of Clinical Investigation, ISSN 0021-9738, 08/2013, Volume 123, Issue 8, pp. 3600 - 3613
Dysfunctional bone morphogenetic protein receptor-2 (BMPR2) signaling is implicated in the pathogenesis of pulmonary arterial hypertension (PAH). We used a... 
MEDICINE, RESEARCH & EXPERIMENTAL | GENE | BONE MORPHOGENETIC PROTEIN | ARTERIAL-HYPERTENSION | HEART-FAILURE | IN-VIVO | APELIN | SMOOTH-MUSCLE-CELLS | TGF-BETA RECEPTOR | EXPRESSION | T-CELLS | Cell Proliferation | Humans | Microvessels - pathology | Male | Cell Hypoxia | Tacrolimus - pharmacology | Hypertension, Pulmonary - drug therapy | Endothelial Cells - physiology | Bone Morphogenetic Protein Receptors, Type II - genetics | Signal Transduction | Bone Morphogenetic Protein 4 - physiology | Endothelium, Vascular - physiopathology | Rats | Hypertension, Pulmonary - metabolism | Inhibitor of Differentiation Protein 1 - metabolism | Neointima - metabolism | Rats, Sprague-Dawley | Bone Morphogenetic Protein Receptors, Type II - metabolism | Mice, Knockout | Animals | High-Throughput Screening Assays | Neointima - drug therapy | Neointima - pathology | Tacrolimus Binding Protein 1A - metabolism | Cell Line, Tumor | Inhibitor of Differentiation Protein 1 - genetics | Endothelium, Vascular - pathology | Mice | Hypertension, Pulmonary - pathology | Smad Proteins - metabolism | Pulmonary Artery - pathology | Apoptosis | Endothelial Cells - drug effects | Hypertension | Cell receptors | Physiological aspects | Cellular signal transduction | Research | Properties | Endothelium | Proteins | Medical research | Scholarships & fellowships | Research & development--R&D | Pulmonary arteries | Rodents | Hypoxia | Ligands | Mutation | Drug dosages | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
American Journal of Cardiology, The, ISSN 0002-9149, 2012, Volume 110, Issue 10, pp. 1546 - 1550
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 06/2015, Volume 191, Issue 11, pp. 1273 - 1286
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 10/2018, Volume 315, Issue 4, pp. L502 - L516
The following review summarizes the pro-con debate about current controversies regarding the pathogenesis of pulmonary arterial hypertension (PAH) that took... 
TO-MESENCHYMAL TRANSITION | PHYSIOLOGY | PULMONARY ARTERIAL-HYPERTENSION | RESPIRATORY SYSTEM | CONGENITAL HEART-DISEASE | II RECEPTOR | ENDOTHELIAL-CELLS | LYMPHORETICULAR DISEASE | SMOOTH-MUSCLE-CELLS | EXTRACELLULAR-MATRIX | BLOOD-FLOW | BMPR-II | Hypertension | Proteins | Pulmonary arteries | Pathogenesis | Thorax | Apoptosis | Immune system
Journal Article
Journal Article
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 08/2015, Volume 192, Issue 3, pp. 356 - 366
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 01/2011, Volume 192, Issue 1, pp. 171 - 188
We present a novel cell-signaling paradigm in which bone morphogenetic protein 2 (BMP-2) consecutively and interdependently activates the wingless... 
CYTOPLASMIC DOMAIN | INTEGRIN-LINKED KINASE | ANKYRIN REPEAT PROTEIN | BONE MORPHOGENETIC PROTEIN-2 | GENE-EXPRESSION | FOCAL ADHESION KINASE | PRIMARY PULMONARY-HYPERTENSION | BETA-CATENIN | GLYCOGEN-SYNTHASE KINASE | APOLIPOPROTEIN-D | CELL BIOLOGY | Bone Morphogenetic Protein 2 - pharmacology | Humans | Glycogen Synthase Kinase 3 beta | rhoA GTP-Binding Protein - metabolism | Phosphoproteins - metabolism | Wnt Proteins - metabolism | Protein Binding - drug effects | Dishevelled Proteins | Myocytes, Smooth Muscle - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Myocytes, Smooth Muscle - cytology | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | Aorta - transplantation | Myocytes, Smooth Muscle - enzymology | Proto-Oncogene Proteins c-sis | Aorta - drug effects | Mutant Proteins - metabolism | Platelet-Derived Growth Factor - pharmacology | Enzyme Activation - drug effects | Glycogen Synthase Kinase 3 - metabolism | beta Catenin - metabolism | Bone Morphogenetic Protein Receptors, Type II - metabolism | Fibronectins - metabolism | Cell Movement - drug effects | Animals | Signal Transduction - drug effects | Models, Biological | Axin Protein | Neointima - pathology | Cell Proliferation - drug effects | Mice | Adaptor Proteins, Signal Transducing - metabolism | rac1 GTP-Binding Protein - metabolism | Proteins | Tomography | Cell growth | Mutation | Cells | Binding sites | Index Medicus | s
Journal Article
Circulation, ISSN 0009-7322, 11/2016, Volume 134, Issue Suppl_1 Suppl 1, pp. A20371 - A20371
IntroductionThe right ventricle (RV) is uniquely at risk in patients with complex congenital heart disease (CHD) involving right-sided obstructive lesions. In... 
Journal Article