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PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, pp. e77243 - e77243
Patients with pancreatic cancer have dismal prognoses, and novel therapies are urgently needed. Mutations of the KRAS oncogene occur frequently in pancreatic... 
PHASE-III TRIAL | BREAST-CANCER | ACTIVATION | RAS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | KINASE | AZD6244 ARRY-142886 | INHIBITOR GDC-0941 | ANTITUMOR-ACTIVITY | PLASMA-MEMBRANE | Pancreatic Neoplasms - metabolism | Apoptosis - drug effects | Humans | Pancreatic Neoplasms - pathology | Pancreas - drug effects | Pancreas - pathology | Antineoplastic Agents - therapeutic use | Phosphatidylinositol 3-Kinases - metabolism | Pancreas - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Pancreatic Neoplasms - drug therapy | Animals | MAP Kinase Signaling System - drug effects | Signal Transduction - drug effects | Mice, Nude | Protein Kinase Inhibitors - therapeutic use | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Health aspects | Analysis | Protein binding | Biotechnology | Phosphorylation | Xenotransplantation | Clinical trials | Oncology | Feedback loops | Kinases | K-Ras protein | Ovarian cancer | Anticancer properties | Proteins | Synergistic effects | Pathways | Surgery | Xenografts | Bioindicators | Inhibition | Cell survival | MEK inhibitors | MAP kinase | Breast cancer | Tumor cell lines | Radiation therapy | 1-Phosphatidylinositol 3-kinase | Medicine | Inhibitors | Protein kinase | Pancreatic cancer | Cell lines | Biomarkers | Antitumor activity | Mutation | Control theory | Viability | Cancer | Apoptosis | Tumors | Index Medicus
Journal Article
PLoS ONE, 10/2013, Volume 8, Issue 10
Patients with pancreatic cancer have dismal prognoses, and novel therapies are urgently needed. Mutations of the KRAS oncogene occur frequently in pancreatic... 
Bioindicators
Journal Article
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