The New England Journal of Medicine, ISSN 0028-4793, 01/2012, Volume 366, Issue 3, pp. 207 - 215
Patients with melanoma who are treated with a BRAF inhibitor have a high incidence of keratoacanthomas. Most of the tumors have oncogenic mutations in HRAS...
MEDICINE, GENERAL & INTERNAL | ACTIVATION | MELANOMA | CARCINOGENESIS | PLX4032 | PATHWAY | KINASE | RESISTANCE | PROLIFERATION | LINES | VEMURAFENIB | Skin Neoplasms - drug therapy | Carcinoma, Squamous Cell - genetics | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Indoles - administration & dosage | Mitogen-Activated Protein Kinase Kinases - metabolism | Aged, 80 and over | Female | Skin Neoplasms - pathology | Gene Expression | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Animals | Carcinoma, Squamous Cell - drug therapy | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Skin Neoplasms - genetics | Indoles - therapeutic use | Aged | Mice | Mutation | Genes, ras | Sulfonamides - administration & dosage | p53 Protein | MEK inhibitors | Extracellular signal-regulated kinase | MAP kinase | Kinases | Patients | Carcinogenesis | Proteins | Protein kinase | Transcription activation | Rodents | Cell lines | Index Medicus | Abridged Index Medicus
MEDICINE, GENERAL & INTERNAL | ACTIVATION | MELANOMA | CARCINOGENESIS | PLX4032 | PATHWAY | KINASE | RESISTANCE | PROLIFERATION | LINES | VEMURAFENIB | Skin Neoplasms - drug therapy | Carcinoma, Squamous Cell - genetics | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Indoles - administration & dosage | Mitogen-Activated Protein Kinase Kinases - metabolism | Aged, 80 and over | Female | Skin Neoplasms - pathology | Gene Expression | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Animals | Carcinoma, Squamous Cell - drug therapy | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Skin Neoplasms - genetics | Indoles - therapeutic use | Aged | Mice | Mutation | Genes, ras | Sulfonamides - administration & dosage | p53 Protein | MEK inhibitors | Extracellular signal-regulated kinase | MAP kinase | Kinases | Patients | Carcinogenesis | Proteins | Protein kinase | Transcription activation | Rodents | Cell lines | Index Medicus | Abridged Index Medicus
Journal Article
New Zealand Journal of Ecology, ISSN 0110-6465, 01/2016, Volume 40, Issue 2, pp. 273 - 273
Vertebrate pest management on Macquarie Island has removed five vertebrate species since 1988; weka (Gallirallus australis scotti), cats (Felis catus), rabbits...
Journal Article
New Zealand Journal of Ecology, ISSN 0110-6465, 2016, Volume 40, Issue 2, pp. 273 - 278
Vertebrate pest management on Macquarie Island has removed five vertebrate species since 1988; weka (Gallirallus australis scotti), cats (Fells catus), rabbits...
Mus musculus | Oryctolagus cuniculus | Rattus rattus | Eradication | Macquarie Island | RABBITS | eradication | FELIS-CATUS | ECOLOGY | FERAL CAT | MACQUARIE-ISLAND | Studies | Animal control | Medical research | Rabbits | Government agencies | Rodents | Vegetation | Population | Planning | Predation | Islands
Mus musculus | Oryctolagus cuniculus | Rattus rattus | Eradication | Macquarie Island | RABBITS | eradication | FELIS-CATUS | ECOLOGY | FERAL CAT | MACQUARIE-ISLAND | Studies | Animal control | Medical research | Rabbits | Government agencies | Rodents | Vegetation | Population | Planning | Predation | Islands
Journal Article
Journal of the American Heart Association, ISSN 2047-9980, 10/2016, Volume 5, Issue 10, p. n/a
Background The extent to which angina is associated with future cardiovascular events in patients with coronary artery disease has long been debated. Methods...
cardiovascular events | coronary artery disease | angina | Cardiovascular events | Coronary artery disease | Angina | CARDIAC & CARDIOVASCULAR SYSTEMS | OUTPATIENTS | MYOCARDIAL-ISCHEMIA | RISK | SYMPTOMS | RATES | HEART-DISEASE | SOUL | PECTORIS | CLARIFY REGISTRY | CLINICAL-OUTCOMES | United States - epidemiology | Myocardial Infarction - epidemiology | Prognosis | Humans | Middle Aged | Proportional Hazards Models | Hospitalization - statistics & numerical data | Male | Case-Control Studies | Myocardial Revascularization - utilization | Angina, Stable - epidemiology | Cardiovascular Diseases - mortality | Female | Registries | Stroke - epidemiology | Aged | Coronary Artery Disease - epidemiology | Odds Ratio | Heart Failure - epidemiology
cardiovascular events | coronary artery disease | angina | Cardiovascular events | Coronary artery disease | Angina | CARDIAC & CARDIOVASCULAR SYSTEMS | OUTPATIENTS | MYOCARDIAL-ISCHEMIA | RISK | SYMPTOMS | RATES | HEART-DISEASE | SOUL | PECTORIS | CLARIFY REGISTRY | CLINICAL-OUTCOMES | United States - epidemiology | Myocardial Infarction - epidemiology | Prognosis | Humans | Middle Aged | Proportional Hazards Models | Hospitalization - statistics & numerical data | Male | Case-Control Studies | Myocardial Revascularization - utilization | Angina, Stable - epidemiology | Cardiovascular Diseases - mortality | Female | Registries | Stroke - epidemiology | Aged | Coronary Artery Disease - epidemiology | Odds Ratio | Heart Failure - epidemiology
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2019, Volume 14, Issue 3, p. e0212128
Invasive alien species are a major threat to native insular species. Eradicating invasive mammals from islands is a feasible and proven approach to prevent...
BIODIVERSITY | RATS | CLIMATE-CHANGE | RESTORATION | CONSERVATION | MULTIDISCIPLINARY SCIENCES | Wildlife conservation | Extinction (Biology) | Biological diversity conservation | Analysis | Introduced species | Endangered species | Ecosystems | Terrestrial environments | Species extinction | Feasibility studies | Birds | Ecology | Mammals | Biodiversity | Ecosystem biology | Biological diversity | Nonnative species | Climate change | Vertebrates | Invasive species | Threatened species | Evolutionary biology | Evolution | Indigenous species | Feasibility | Trends | Islands | Life Sciences | Symbiosis | Ecology, environment | Biodiversity and Ecology | Systematics, Phylogenetics and taxonomy | Environmental Sciences | Global Changes
BIODIVERSITY | RATS | CLIMATE-CHANGE | RESTORATION | CONSERVATION | MULTIDISCIPLINARY SCIENCES | Wildlife conservation | Extinction (Biology) | Biological diversity conservation | Analysis | Introduced species | Endangered species | Ecosystems | Terrestrial environments | Species extinction | Feasibility studies | Birds | Ecology | Mammals | Biodiversity | Ecosystem biology | Biological diversity | Nonnative species | Climate change | Vertebrates | Invasive species | Threatened species | Evolutionary biology | Evolution | Indigenous species | Feasibility | Trends | Islands | Life Sciences | Symbiosis | Ecology, environment | Biodiversity and Ecology | Systematics, Phylogenetics and taxonomy | Environmental Sciences | Global Changes
Journal Article
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Full Text
VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 02/2006, Volume 290, Issue 2, pp. 560 - 576
Unlike during development, blood vessels in the adult are generally thought not to require VEGF for normal function. However, VEGF is a survival factor for...
Immunohistochemistry | Electron microscopy | Endothelial fenestration | Vascular endothelial growth factor inhibitors | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | IMMUNOHISTOCHEMICAL LOCALIZATION | FACTOR RECEPTOR-1 | VASCULAR-PERMEABILITY | FACTOR ANTIBODY | METASTATIC COLORECTAL-CANCER | vascular endothelial growth factor inhibitors | ANGIOGENIC THERAPY | BLOOD-VESSELS | electron microscopy | PERIPHERAL VASCULAR DISEASE | immunohistochemistry | endothelial fenestration | ENDOTHELIAL GROWTH-FACTOR | ESTABLISHED TUMORS | BASEMENT-MEMBRANE | Blood Pressure | Kidney - physiology | Neoplasm Transplantation | Heart - physiology | Pancreatic Neoplasms - blood supply | Reference Values | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Carcinoma, Lewis Lung - blood supply | Capillaries - physiology | Aging | Islets of Langerhans - blood supply | Glucose Tolerance Test | Capillaries - ultrastructure | Mice, Inbred C57BL | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Mice, Transgenic | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Indazoles - pharmacology | Regeneration | Phenotype | Animals | Imidazoles | Signal Transduction - drug effects | Signal Transduction - physiology | Mice | Vascular Endothelial Growth Factor A - physiology
Immunohistochemistry | Electron microscopy | Endothelial fenestration | Vascular endothelial growth factor inhibitors | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | IMMUNOHISTOCHEMICAL LOCALIZATION | FACTOR RECEPTOR-1 | VASCULAR-PERMEABILITY | FACTOR ANTIBODY | METASTATIC COLORECTAL-CANCER | vascular endothelial growth factor inhibitors | ANGIOGENIC THERAPY | BLOOD-VESSELS | electron microscopy | PERIPHERAL VASCULAR DISEASE | immunohistochemistry | endothelial fenestration | ENDOTHELIAL GROWTH-FACTOR | ESTABLISHED TUMORS | BASEMENT-MEMBRANE | Blood Pressure | Kidney - physiology | Neoplasm Transplantation | Heart - physiology | Pancreatic Neoplasms - blood supply | Reference Values | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Carcinoma, Lewis Lung - blood supply | Capillaries - physiology | Aging | Islets of Langerhans - blood supply | Glucose Tolerance Test | Capillaries - ultrastructure | Mice, Inbred C57BL | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Mice, Transgenic | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Indazoles - pharmacology | Regeneration | Phenotype | Animals | Imidazoles | Signal Transduction - drug effects | Signal Transduction - physiology | Mice | Vascular Endothelial Growth Factor A - physiology
Journal Article
Journal of Applied Ecology, ISSN 0021-8901, 06/2016, Volume 53, Issue 3, pp. 733 - 741
Summary Many highly diverse island ecosystems across the globe are threatened by invasive species. Eradications of invasive mammals from islands are being...
decision theory | resource allocation | integer programming | optimization | eradication | threatened species | trophic cascade | island conservation | feral cats | invasive species | MANAGEMENT | OVERSEAS TERRITORIES | CONSERVATION | SEABIRDS | ANTARCTIC MACQUARIE ISLAND | VERTEBRATES | ECOLOGY | COSTING ERADICATIONS | FERAL CAT | IMPACTS | BIODIVERSITY CONSERVATION | EXPERT KNOWLEDGE | Case studies | Wildlife conservation | Endangered species | Ecosystems | Conservation biology | Islands | Biological diversity | Nonnative species
decision theory | resource allocation | integer programming | optimization | eradication | threatened species | trophic cascade | island conservation | feral cats | invasive species | MANAGEMENT | OVERSEAS TERRITORIES | CONSERVATION | SEABIRDS | ANTARCTIC MACQUARIE ISLAND | VERTEBRATES | ECOLOGY | COSTING ERADICATIONS | FERAL CAT | IMPACTS | BIODIVERSITY CONSERVATION | EXPERT KNOWLEDGE | Case studies | Wildlife conservation | Endangered species | Ecosystems | Conservation biology | Islands | Biological diversity | Nonnative species
Journal Article
Medicine & Science in Sports & Exercise, ISSN 0195-9131, 06/2019, Volume 51, Issue Supplement, p. 761
Journal Article
Journal of Arthroplasty, The, ISSN 0883-5403, 2016, Volume 32, Issue 5, pp. 1625 - 1629
Abstract Background Mechanical complications have been underemphasized in reports on TKA in obese patients. Noticing an increased prevalence of varus collapse...
Orthopedics | varus collapse | revision knee arthroplasty | primary total knee arthroplasty | tibial stem | obesity | osteolysis | IMPLANT MIGRATION | BONE STRENGTH | ORTHOPEDICS | FAILURE | MALALIGNMENT | PROXIMAL TIBIA | Reoperation | Arthroplasty, Replacement, Knee - adverse effects | Obesity - complications | Humans | Middle Aged | Stress, Mechanical | Male | Knee Prosthesis - adverse effects | Tibia - surgery | Knee Joint - surgery | Prosthesis Failure | Osteoarthritis, Knee - complications | Female | Registries | Aged | Osteoarthritis, Knee - surgery | Obesity | Bones | Density | Analysis
Orthopedics | varus collapse | revision knee arthroplasty | primary total knee arthroplasty | tibial stem | obesity | osteolysis | IMPLANT MIGRATION | BONE STRENGTH | ORTHOPEDICS | FAILURE | MALALIGNMENT | PROXIMAL TIBIA | Reoperation | Arthroplasty, Replacement, Knee - adverse effects | Obesity - complications | Humans | Middle Aged | Stress, Mechanical | Male | Knee Prosthesis - adverse effects | Tibia - surgery | Knee Joint - surgery | Prosthesis Failure | Osteoarthritis, Knee - complications | Female | Registries | Aged | Osteoarthritis, Knee - surgery | Obesity | Bones | Density | Analysis
Journal Article
Journal of Arthroplasty, ISSN 0883-5403, 2011, Volume 26, Issue 6, pp. 114 - 118
Irrigation and debridement (I&D) is an attractive treatment alternative for periprosthetic joint infection (PJI). Irrigation and debridement failure rates...
Revision arthroplasty | Causative organism | Periprosthetic joint infection | UNITED-STATES | SALVAGE | REVISION | 2-STAGE REIMPLANTATION | SPACER | revision arthroplasty | RETENTION | PROSTHETIC JOINT INFECTION | TOTAL KNEE ARTHROPLASTY | HIP | TREATMENT OPTIONS | periprosthetic joint infection | causative organism | ORTHOPEDICS | Follow-Up Studies | Humans | Middle Aged | Male | Young Adult | Streptococcus - isolation & purification | Treatment Failure | Aged, 80 and over | Adult | Female | Knee Prosthesis - microbiology | Retrospective Studies | Debridement - methods | Streptococcal Infections - therapy | Treatment Outcome | Prosthesis-Related Infections - therapy | Staphylococcal Infections - therapy | Algorithms | Animals | Therapeutic Irrigation - methods | Staphylococcus - isolation & purification | Adolescent | Aged | Hip Prosthesis - microbiology | Cohort Studies
Revision arthroplasty | Causative organism | Periprosthetic joint infection | UNITED-STATES | SALVAGE | REVISION | 2-STAGE REIMPLANTATION | SPACER | revision arthroplasty | RETENTION | PROSTHETIC JOINT INFECTION | TOTAL KNEE ARTHROPLASTY | HIP | TREATMENT OPTIONS | periprosthetic joint infection | causative organism | ORTHOPEDICS | Follow-Up Studies | Humans | Middle Aged | Male | Young Adult | Streptococcus - isolation & purification | Treatment Failure | Aged, 80 and over | Adult | Female | Knee Prosthesis - microbiology | Retrospective Studies | Debridement - methods | Streptococcal Infections - therapy | Treatment Outcome | Prosthesis-Related Infections - therapy | Staphylococcal Infections - therapy | Algorithms | Animals | Therapeutic Irrigation - methods | Staphylococcus - isolation & purification | Adolescent | Aged | Hip Prosthesis - microbiology | Cohort Studies
Journal Article
2002, Water science and application, ISBN 0875903541, Volume 5, vi, 385
Book
Polar Biology, ISSN 0722-4060, 6/2014, Volume 37, Issue 6, pp. 833 - 843
Accurate, long-term population estimates of invasive vertebrate pests are a key element of ecosystem management. Not only can they clarify the role of invasive...
Life Sciences | Rabbits | Biological invasion | Microbiology | Zoology | Macquarie Island | Adaptively smoothed P-spline regression | Ecology | Oceanography | Census techniques | Thermal imaging | Plant Sciences | ET-AL. 2009 | CLIMATE-CHANGE | SIGHT COUNTS | COASTAL SLOPES | RABBITS ORYCTOLAGUS-CUNICULUS | CONSERVATION | REGRESSION SPLINES | ECOLOGY | ERADICATION | MACQUARIE-ISLAND | BIODIVERSITY CONSERVATION | VEGETATION | Ecosystems | Environmental protection | Animal populations | Wildlife management | Islands | Nonnative species
Life Sciences | Rabbits | Biological invasion | Microbiology | Zoology | Macquarie Island | Adaptively smoothed P-spline regression | Ecology | Oceanography | Census techniques | Thermal imaging | Plant Sciences | ET-AL. 2009 | CLIMATE-CHANGE | SIGHT COUNTS | COASTAL SLOPES | RABBITS ORYCTOLAGUS-CUNICULUS | CONSERVATION | REGRESSION SPLINES | ECOLOGY | ERADICATION | MACQUARIE-ISLAND | BIODIVERSITY CONSERVATION | VEGETATION | Ecosystems | Environmental protection | Animal populations | Wildlife management | Islands | Nonnative species
Journal Article
Journal of Geophysical Research: Space Physics, ISSN 2169-9380, 06/2016, Volume 121, Issue 6, pp. 5272 - 5283
We present initial dual spacecraft observations that for the first time both constrain the spatial scale size and provide spectral properties at medium...
precipitation | radiation belts | CubeSat | microbursts | ACCELERATION | LOSSES | GEM STORMS | PRECIPITATION | RELATIVISTIC ELECTRONS | SOURCE REGION | ASTRONOMY & ASTROPHYSICS | STORM-TIME CHORUS | SAMPEX | Geophysics | Electrons | Electron microbursts | Electron precipitation | Radiation | Spacecraft | Microbursts (meteorology) | Earth orbit | Microbursts | Physics | Equator | Earth orbits | Descriptions | Dynamic tests | Dynamics | Spectra | Missions | Cubesat
precipitation | radiation belts | CubeSat | microbursts | ACCELERATION | LOSSES | GEM STORMS | PRECIPITATION | RELATIVISTIC ELECTRONS | SOURCE REGION | ASTRONOMY & ASTROPHYSICS | STORM-TIME CHORUS | SAMPEX | Geophysics | Electrons | Electron microbursts | Electron precipitation | Radiation | Spacecraft | Microbursts (meteorology) | Earth orbit | Microbursts | Physics | Equator | Earth orbits | Descriptions | Dynamic tests | Dynamics | Spectra | Missions | Cubesat
Journal Article
Surgery for Obesity and Related Diseases, ISSN 1550-7289, 2016, Volume 13, Issue 1, pp. 111 - 118
Abstract Obesity accelerates the development of osteoarthritis of the knee and hip by exerting deleterious effects on joints through both biomechanical and...
Gastroenterology and Hepatology | Surgery | Obesity | Lower limb biomechanics | Knee arthroplasty | Bariatric surgery | Hip arthroplasty | Joint arthroplasty | Osteoarthritis | Postoperative complications | MORTALITY | SURGERY | GASTRIC BYPASS | MUSCULOSKELETAL PAIN | RISK-FACTORS | TOTAL JOINT ARTHROPLASTY | GAIT | WEIGHT-LOSS | REPLACEMENT | MORBID-OBESITY | Bariatric Surgery | Postoperative Complications - etiology | Walking - psychology | Obesity, Morbid - surgery | Humans | Osteoarthritis, Hip - surgery | Arthroplasty, Replacement, Hip | Treatment Outcome | Hip Joint - physiology | Biomechanical Phenomena | Knee Joint - physiology | Postoperative Care | Arthroplasty, Replacement, Knee | Osteoarthritis, Knee - surgery | Stair Climbing - physiology | Biomechanics | Orthopedic surgery
Gastroenterology and Hepatology | Surgery | Obesity | Lower limb biomechanics | Knee arthroplasty | Bariatric surgery | Hip arthroplasty | Joint arthroplasty | Osteoarthritis | Postoperative complications | MORTALITY | SURGERY | GASTRIC BYPASS | MUSCULOSKELETAL PAIN | RISK-FACTORS | TOTAL JOINT ARTHROPLASTY | GAIT | WEIGHT-LOSS | REPLACEMENT | MORBID-OBESITY | Bariatric Surgery | Postoperative Complications - etiology | Walking - psychology | Obesity, Morbid - surgery | Humans | Osteoarthritis, Hip - surgery | Arthroplasty, Replacement, Hip | Treatment Outcome | Hip Joint - physiology | Biomechanical Phenomena | Knee Joint - physiology | Postoperative Care | Arthroplasty, Replacement, Knee | Osteoarthritis, Knee - surgery | Stair Climbing - physiology | Biomechanics | Orthopedic surgery
Journal Article
Journal of Solar Energy Engineering, Transactions of the ASME, ISSN 0199-6231, 08/2019, Volume 141, Issue 4
The potential of sky radiation (SR) to serve the latent space cooling loads was evaluated. Using ASHRAE standard 55 comfort limits (room temperature 22 degrees...
SYSTEM | HEATING SEASON PERFORMANCE | ENERGY & FUELS | ENGINEERING, MECHANICAL | WATER
SYSTEM | HEATING SEASON PERFORMANCE | ENERGY & FUELS | ENGINEERING, MECHANICAL | WATER
Journal Article
Marine and Petroleum Geology, ISSN 0264-8172, 03/2016, Volume 71, pp. 134 - 148
The evaporite-cored Hoodoo Dome on southern Ellef Ringnes Island, Sverdrup Basin, was examined to improve the understanding of its structural geological...
Eurekan orogeny | Sverdrup basin | Hoodoo dome | Salt tectonics | Salt diapir | Ellef Ringnes island | (U-TH)/HE THERMOCHRONOMETRY | ARCHIPELAGO | MAGMATISM | APATITE | STRATIGRAPHY | GEOSCIENCES, MULTIDISCIPLINARY | CRUSTAL STRUCTURE | TECTONIC HISTORY | GEOCHEMISTRY | EUREKAN OROGEN | Phosphate minerals | Basins (Geology) | Analysis | Phosphate rock | Diapirs | Domes | Cooling | Geology | Hydrocarbons | Anticlines | Mathematical models | Formations
Eurekan orogeny | Sverdrup basin | Hoodoo dome | Salt tectonics | Salt diapir | Ellef Ringnes island | (U-TH)/HE THERMOCHRONOMETRY | ARCHIPELAGO | MAGMATISM | APATITE | STRATIGRAPHY | GEOSCIENCES, MULTIDISCIPLINARY | CRUSTAL STRUCTURE | TECTONIC HISTORY | GEOCHEMISTRY | EUREKAN OROGEN | Phosphate minerals | Basins (Geology) | Analysis | Phosphate rock | Diapirs | Domes | Cooling | Geology | Hydrocarbons | Anticlines | Mathematical models | Formations
Journal Article