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Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 01/2018, Volume 28, Issue 2, pp. 85 - 93
We disclose the optimization of a high throughput screening hit to yield benzothiazine and tetrahydroquinoline sulfonamides as potent RORγt inverse agonists.... 
POTENT | AUTOIMMUNE | CHEMISTRY, MEDICINAL | INHIBITION | INTERLEUKIN-17 | NUCLEAR RECEPTORS | MODULATORS | DISEASE | GENE-EXPRESSION | CHEMISTRY, ORGANIC | DISCOVERY | PSORIASIS | Rheumatoid factor | Multiple sclerosis | Sulfonamides | Analysis | Gastrointestinal diseases | Liver | Arthritis
Journal Article
Journal of Forensic Sciences, ISSN 0022-1198, 01/2008, Volume 53, Issue 1, pp. 100 - 106
Pigments are rapidly replacing dyes as colorants in pen and printer inks, due to their superior colors and stability. Unfortunately, tools commonly used in... 
forensic science | questioned document examination | laser desorption | mass spectrometry | pigmented ink | colorants | Questioned document examination | Forensic science | Colorants | Mass spectrometry | Laser desorption | Pigmented ink | RED | DYES | MEDICINE, LEGAL | ORGANIC PIGMENTS | Pigments | Analysis
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 09/2016, Volume 26, Issue 17, pp. 4256 - 4260
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 07/2017, Volume 27, Issue 14, pp. 3101 - 3106
Journal Article
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 03/2019, Volume 10, Issue 3, pp. 367 - 373
A new phenyl (3-phenylpyrrolidin-3-yl)sulfone series of ROR gamma t inverse agonists was discovered utilizing the binding conformation of previously reported... 
pyrrolidin-3-ylsulfone | X-ray crystallography | inverse agonist | structure-based design | RORγt | CHEMISTRY, MEDICINAL | ROR gamma t
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 03/2019, Volume 10, Issue 3, pp. 306 - 311
The four members of the Janus family of nonreceptor tyrosine kinases play a significant role in immune function. The JAK family kinase inhibitor, tofacitinib... 
prodrug | mouse CIA model | TYK2 | JAK2 | JAK3 | JAK1 | POTENT | CHEMISTRY, MEDICINAL | COVALENT INHIBITORS | KINASE | TOFACITINIB | IDENTIFICATION
Journal Article
Langmuir, ISSN 0743-7463, 04/2005, Volume 21, Issue 9, pp. 4180 - 4184
Journal Article
Journal of Forensic Sciences, ISSN 0022-1198, 05/2007, Volume 52, Issue 3, pp. 595 - 603
When one looks at an automotive coating, one sees color due to pigments. Modern organic pigments, with high molar absorptivities, may be only minor components... 
forensic science | laser desorption | mass spectrometry | paint | coatings | pigments | Pigments | Paint | Forensic science | Coatings | Mass spectrometry | Laser desorption | MANUSCRIPTS | DYES | MEDICINE, LEGAL | IN-SITU IDENTIFICATION | RED | INFRARED-SPECTRA | METALLIC MONOCOATS | ORIGINAL TOPCOATS 1974-1989 | YELLOW | COLORANTS
Journal Article
Journal of Clinical Pathology, ISSN 0021-9746, 09/2007, Volume 60, Issue 9, pp. 1070 - 1071
  Buccal swabs are most likely contaminated with leucocytes and removal of non-epithelial cells by mouth rinsing was suggested as a precaution in chimerism... 
EPITHELIAL-CELLS | PATHOLOGY | Genetic aspects | Medical examination | Research | Gene mutations | Myeloproliferative disorders | Oral mucosa | Bone marrow | Deoxyribonucleic acid--DNA | Mutation | buccal swabs | Letters to the Editor | chronic myeloproliferative disorders | JAK2 V617F mutation
Journal Article
Leukemia and Lymphoma, ISSN 1042-8194, 11/2006, Volume 47, Issue 11, pp. 2351 - 2358
This study examined the clonality of B- and T-cells by PCR in 83 patients with Philadelphia-negative myeloproliferative disorders (Ph-MPD), to investigate its... 
Chronic myeloproliferative disorders | prognosis | polymerase chain reaction | T-cell clonality of undetermined significance
Journal Article
International Journal of Hematology, ISSN 0925-5710, 8/2007, Volume 86, Issue 2, pp. 130 - 136
We investigated the prevalence of the JAK2 V617F gain-of-function mutation in patients with Philadelphia chromosome-negative chronic myeloproliferative... 
Medicine & Public Health | Hematology | Oncology | Trephine bone marrow biopsy | Mutation | JAK2 | Myeloproliferative disorders
Journal Article
Leukemia & Lymphoma, ISSN 1042-8194, 2006, Volume 47, Issue 11, pp. 2351 - 2358
Journal Article
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