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PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, p. e53851
Journal Article
Journal Article
Nature Biotechnology, ISSN 1087-0156, 01/2010, Volume 28, Issue 1, pp. 63 - 70
Phosphodiesterase 4 (PDE4), the primary cAMP-hydrolyzing enzyme in cells, is a promising drug target for a wide range of conditions. Here we present seven... 
CAMP-SPECIFIC PHOSPHODIESTERASE | PHOSPHORYLATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PROTEIN-KINASE | GENE COMPOSER | SUNCUS-MURINUS | AMP-SPECIFIC PHOSPHODIESTERASE | INHIBITORS | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE | ROLIPRAM BINDING | ANTIDEPRESSANT DRUGS | Phosphodiesterase Inhibitors - therapeutic use | Phosphodiesterase Inhibitors - adverse effects | Humans | Molecular Sequence Data | Crystallography, X-Ray | Structure-Activity Relationship | Benzhydryl Compounds - chemistry | Benzhydryl Compounds - adverse effects | Phenylurea Compounds - adverse effects | Phenylurea Compounds - chemistry | Drug Design | Phosphodiesterase 4 Inhibitors | Behavior, Animal - drug effects | Biological Assay | Phosphodiesterase Inhibitors - chemistry | Benzhydryl Compounds - therapeutic use | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Disease Models, Animal | Allosteric Regulation - drug effects | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Catalytic Domain | Models, Molecular | Phenylurea Compounds - therapeutic use | Phosphodiesterase Inhibitors - pharmacology | Vomiting - drug therapy | Cognition - drug effects | Animals | Benzhydryl Compounds - pharmacology | Mice | Phenylurea Compounds - pharmacology | Kinetics | Care and treatment | Schizophrenia | Physiological aspects | Genetic aspects | Cellular signal transduction | Cyclic adenylic acid | Research | Phosphodiesterases | Enzymes | Biotechnology | Cellular biology | Molecular biology | Cognitive ability | Crystal structure | Index Medicus
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 11/2016, Volume 16, Issue 4, pp. 397 - 414
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 01/2011, Volume 7, Issue 1, pp. 41 - 50
Bruton's tyrosine kinase (Btk) is a therapeutic target for rheumatoid arthritis, but the cellular and molecular mechanisms by which Btk mediates inflammation... 
RHEUMATOID-ARTHRITIS | COLLAGEN-INDUCED ARTHRITIS | BRUTONS TYROSINE KINASE | ACTIVATION | CITRULLINATED PROTEINS | FC-GAMMA RECEPTORS | II COLLAGEN | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTIBODY-INDUCED ARTHRITIS | TEC FAMILY KINASES | Tumor Necrosis Factor-alpha - metabolism | Arthritis, Experimental - drug therapy | Autoantibodies - metabolism | Protein-Tyrosine Kinases - therapeutic use | Arthritis, Experimental - metabolism | Arthritis, Rheumatoid - metabolism | Protein-Tyrosine Kinases - pharmacology | Protein Kinase Inhibitors - chemistry | Benzamides - therapeutic use | Arthritis, Rheumatoid - drug therapy | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Interleukin-1beta - metabolism | Myeloid Cells - immunology | Protein-Tyrosine Kinases - chemistry | Tumor Necrosis Factor-alpha - immunology | Myeloid Cells - drug effects | Benzamides - pharmacology | Phosphorylation - drug effects | Interleukin-6 - metabolism | B-Lymphocytes - metabolism | Benzamides - chemistry | Bridged Bicyclo Compounds, Heterocyclic - chemistry | Interleukin-1beta - immunology | Arthritis, Experimental - immunology | Enzyme Activation - drug effects | B-Lymphocytes - drug effects | Autoantibodies - immunology | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | B-Lymphocytes - immunology | Protein Kinase Inhibitors - therapeutic use | Interleukin-6 - immunology | Myeloid Cells - metabolism | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Arthritis, Rheumatoid - immunology | Arthritis | Biochemistry | Inhibitor drugs | Kinases | Binding sites
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2002, Volume 99, Issue 24, pp. 15387 - 15392
We report the x-ray crystal structure of human topoisomerase I covalently joined to double-stranded DNA and bound to the clinically approved anticancer agent... 
Enzymes | Biological Sciences | Oxygen | Hydrogen bonds | DNA | Drug interactions | Chemical bases | Electron density | Carboxylates | Lactones | Crystal structure | RESISTANT | COMPLEX | INHIBITION | NUCLEIC-ACID | MULTIDISCIPLINARY SCIENCES | MUTATION | CRYSTAL-STRUCTURES | DNA TOPOISOMERASES | CANCER CELL-LINE | BINDING | ANTITUMOR DRUGS | Humans | DNA Topoisomerases, Type I - chemistry | Recombinant Fusion Proteins - physiology | Topoisomerase I Inhibitors | Crystallography, X-Ray | Drug Resistance, Neoplasm | Neoplasm Proteins - antagonists & inhibitors | Structure-Activity Relationship | Neoplasm Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Topotecan - chemistry | Peptide Fragments - physiology | Enzyme Inhibitors - chemistry | Antineoplastic Agents - pharmacology | Molecular Structure | Neoplasm Proteins - genetics | Peptide Fragments - metabolism | Topotecan - pharmacology | DNA Topoisomerases, Type I - metabolism | DNA Topoisomerases, Type I - genetics | Enzyme Inhibitors - pharmacology | Models, Molecular | Neoplasm Proteins - chemistry | Intercalating Agents - pharmacology | DNA - metabolism | Recombinant Fusion Proteins - chemistry | Antineoplastic Agents - chemistry | Intercalating Agents - chemistry | Macromolecular Substances | DNA - chemistry | Peptide Fragments - chemistry | Hydrogen Bonding | Protein Binding | Protein Conformation | Mutation | Physiological aspects | Structure-activity relationship (Pharmacology) | Drug resistance | Drug therapy | Cancer
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 9, pp. 1 - 9
Journal Article
FRONTIERS IN MICROBIOLOGY, ISSN 1664-302X, 04/2019, Volume 10, p. 781
The agglutinin-like sequence (Als) proteins are best-characterized in Candida albicans and known for their role in adhesion of the fungal cell to host and... 
ADHESIVE | ORTHOPSILOSIS | MICROBIOLOGY | ALS family | adhesion | MODEL | Candida species | agglutinin-like sequence genes | PREDICTION | cell-wall proteins | EVOLUTION | ALIGNMENT | fungi | SURFACE | ALBICANS | LONG | Proteins | Genomes | Nucleotide sequencing | Genes | Genomics | DNA sequencing
Journal Article
Sexually Transmitted Infections, ISSN 1368-4973, 07/2019, Volume 95, Issue Suppl 1, p. A169
BackgroundThe UW-STI consortium seeks to develop novel antimicrobials for the treatment of syndromically similar infections caused by Neisseria gonorrhoeae... 
Journal Article