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1. Full Text Response to H. Floris Cohen's essay review on Newtonian scholarship
by Stan, Marius
The British journal for the history of science, ISSN 0007-0874, 06/2019, Volume 52, Issue 2, pp. 359 - 360
Essay Review | Arts & Humanities | History & Philosophy Of Science | Bernoulli, Johann I (1667-1748) | Innovations
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2. Full Text The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial
by Sandhu, Shahneen K, MD and Schelman, William R, MD and Wilding, George, MD and Moreno, Victor, MD and Baird, Richard D, PhD and Miranda, Susana, BSc and Hylands, Lucy, BSc and Riisnaes, Ruth, FIBMS and Forster, Martin, PhD and Omlin, Aurelius, MD and Kreischer, Nathan, MSc and Thway, Khin, MD and Gevensleben, Heidrun, MD and Sun, Linda, PhD and Loughney, John, PhD and Chatterjee, Manash, PhD and Toniatti, Carlo, PhD and Carpenter, Christopher L, MD and Iannone, Robert, MD and Kaye, Stan B, Prof and de Bono, Johann S, Prof and Wenham, Robert M
The lancet oncology, ISSN 1470-2045, 2013, Volume 14, Issue 9, pp. 882 - 892
Hematology, Oncology and Palliative Medicine | Life Sciences & Biomedicine | Oncology | Science & Technology | Prognosis | Follow-Up Studies | Humans | Middle Aged | Ovarian Neoplasms - pathology | Male | Ovarian Neoplasms - genetics | Tissue Distribution | Prostatic Neoplasms - genetics | Neoplasms - genetics | Adult | Female | Piperidines - pharmacokinetics | Ovarian Neoplasms - drug therapy | Prostatic Neoplasms - drug therapy | Prostatic Neoplasms - pathology | Neoplasm Recurrence, Local - diagnosis | Mutation - genetics | Poly(ADP-ribose) Polymerase Inhibitors | Neoplasms - drug therapy | BRCA1 Protein - genetics | Maximum Tolerated Dose | Indazoles - pharmacokinetics | Piperidines - therapeutic use | Heterozygote | Neoplasm Recurrence, Local - genetics | Aged | Neoplasms - pathology | BRCA2 Protein - genetics | Indazoles - therapeutic use | Cohort Studies | Cancer patients | Analysis | Genetic aspects | Genetic transcription | Sugars | Cancer | Monosaccharides | Index Medicus
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3. Full Text Selective Inhibition of CYP17 With Abiraterone Acetate Is Highly Active in the Treatment of Castration-Resistant Prostate Cancer
by Gerhardt Attard and Alison H.M. Reid and Roger A'Hern and Christopher Parker and Nikhil Babu Oommen and Elizabeth Folkerd and Christina Messiou and L. Rhoda Molife and Gal Maier and Emilda Thompson and David Olmos and Rajesh Sinha and Gloria Lee and Mitch Dowsett and Stan B. Kaye and David Dearnaley and Thian Kheoh and Arturo Molina and Johann S. de Bono
Journal of clinical oncology, ISSN 0732-183X, 08/2009, Volume 27, Issue 23, pp. 3742 - 3748
Life Sciences & Biomedicine | Oncology | Science & Technology | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Prospective Studies | Humans | Middle Aged | Drug Resistance, Neoplasm | Male | Neoplasms, Hormone-Dependent - immunology | Androstenols - therapeutic use | Prostatic Neoplasms - immunology | Enzyme Inhibitors - administration & dosage | Antineoplastic Agents, Hormonal - therapeutic use | Aged, 80 and over | Testosterone - blood | Prostatic Neoplasms - drug therapy | Prostatic Neoplasms - pathology | Antineoplastic Agents, Hormonal - pharmacology | Drug Administration Schedule | Androstenols - pharmacology | Antineoplastic Agents, Hormonal - administration & dosage | Enzyme Inhibitors - pharmacology | Kaplan-Meier Estimate | Androgen Antagonists - pharmacology | Androstenes | Enzyme Inhibitors - therapeutic use | Disease Progression | Prostate-Specific Antigen - blood | Neoplasms, Hormone-Dependent - pathology | Androgen Antagonists - therapeutic use | Aged | Androstenols - administration & dosage | Androgen Antagonists - administration & dosage | Neoplasms, Hormone-Dependent - drug therapy | Adrenal Cortex Hormones - administration & dosage | Index Medicus
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4. Full Text Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers
by Fong, Peter C and Boss, David S and Yap, Timothy A and Tutt, Andrew and Wu, Peijun and Mergui-Roelvink, Marja and Mortimer, Peter and Swaisland, Helen and Lau, Alan and O'Connor, Mark J and Ashworth, Alan and Carmichael, James and Kaye, Stan B and Schellens, Jan H.M and de Bono, Johann S
The New England journal of medicine, ISSN 0028-4793, 07/2009, Volume 361, Issue 2, pp. 123 - 134
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | General aspects | Medical sciences | Phthalazines - pharmacokinetics | Humans | Middle Aged | Male | Piperazines - therapeutic use | Piperazines - adverse effects | Poly(ADP-ribose) Polymerase Inhibitors | Neoplasms - drug therapy | Dose-Response Relationship, Drug | Young Adult | Phthalazines - therapeutic use | Neoplasms - genetics | Drug Design | Aged, 80 and over | Genes, BRCA2 | Germ-Line Mutation | Adult | Female | Heterozygote | Aged | Genes, BRCA1 | Piperazines - pharmacokinetics | Phthalazines - adverse effects | Enzyme inhibitors | Gene mutations | Analysis | Genetic aspects | Chemical properties | Research | Drug therapy | Protein kinases | Health aspects | Cancer | Proteins | Genetics | Mutation | DNA repair | Rodents | Index Medicus | Abridged Index Medicus
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5. Full Text RNAi screen reveals synthetic lethality between cyclin G-associated kinase and FBXW7 by inducing aberrant mitoses
by Dolly, Saoirse O and Gurden, Mark D and Drosopoulos, Konstantinos and Clarke, Paul and De Bono, Johann and Kaye, Stan and Workman, Paul and Linardopoulos, Spiros
British journal of cancer, ISSN 0007-0920, 09/2017, Volume 117, Issue 7, pp. 954 - 964
RNAi | screen aberrant mitoses | cyclin G-associated kinase | kinome | FBXW7/FBX7 | Life Sciences & Biomedicine | Oncology | Science & Technology | Cell Cycle - genetics | F-Box-WD Repeat-Containing Protein 7 | Humans | Protein-Serine-Threonine Kinases - genetics | Apoptosis - genetics | Cell Cycle Proteins - deficiency | Synthetic Lethal Mutations | Mitosis - genetics | Sulfonamides - pharmacology | Clathrin - antagonists & inhibitors | Neoplasms - genetics | RNA Interference | Cell Cycle Proteins - genetics | Cell Line, Tumor | Ubiquitin-Protein Ligases - deficiency | RNA, Small Interfering | Thiazolidines - pharmacology | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Index Medicus | Translational Therapeutics | FBXW7 | FBX7
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6. Full Text Poly(ADP)-Ribose Polymerase Inhibition: Frequent Durable Responses in BRCA Carrier Ovarian Cancer Correlating With Platinum-Free Interval
by Peter C. Fong and Timothy A. Yap and David S. Boss and Craig P. Carden and Marja Mergui-Roelvink and Charlie Gourley and Jacques De Greve and Jan Lubinski and Susan Shanley and Christina Messiou and Roger A'Hern and Andrew Tutt and Alan Ashworth and John Stone and James Carmichael and Jan H.M. Schellens and Johann S. de Bono and Stan B. Kaye
Journal of clinical oncology, ISSN 0732-183X, 05/2010, Volume 28, Issue 15, pp. 2512 - 2519
Life Sciences & Biomedicine | Oncology | Science & Technology | Gynecology. Andrology. Obstetrics | Biological and medical sciences | Medical sciences | Tumors | Female genital diseases | Humans | Middle Aged | Ovarian Neoplasms - pathology | Drug Resistance, Neoplasm | Dose-Response Relationship, Drug | Ovarian Neoplasms - genetics | Peritoneal Neoplasms - drug therapy | Fallopian Tube Neoplasms - genetics | Aged, 80 and over | Genes, BRCA2 | Germ-Line Mutation | Adult | Female | Genes, BRCA1 | Ovarian Neoplasms - drug therapy | Fallopian Tube Neoplasms - drug therapy | Peritoneal Neoplasms - pathology | Pharmacogenetics | Fallopian Tube Neoplasms - enzymology | Fallopian Tube Neoplasms - pathology | Piperazines - therapeutic use | Piperazines - adverse effects | Poly(ADP-ribose) Polymerase Inhibitors | Ovarian Neoplasms - enzymology | Peritoneal Neoplasms - enzymology | Phthalazines - therapeutic use | Poly(ADP-ribose) Polymerases - genetics | Peritoneal Neoplasms - genetics | Cell Line, Tumor | Aged | Neoplasm Staging | Phthalazines - adverse effects | Cohort Studies | Index Medicus
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7. Full Text Secondary mutations in BRCA2 associated with clinical resistance to a PARP inhibitor
by Barber, Louise J and Sandhu, Shahneen and Chen, Lina and Campbell, James and Kozarewa, Iwanka and Fenwick, Kerry and Assiotis, Ioannis and Rodrigues, Daniel Nava and Reis-Filho, Jorge S and Moreno, Victor and Mateo, Joaquin and Molife, L Rhoda and De Bono, Johann and Kaye, Stan and Lord, Christopher J and Ashworth, Alan
The Journal of pathology, ISSN 0022-3417, 02/2013, Volume 229, Issue 3, pp. 422 - 429
BRCA | cancer | drug resistance | secondary mutation | massively parallel sequencing | PARP inhibitor | Pathology | Oncology | Life Sciences & Biomedicine | Science & Technology | Breast Neoplasms, Male - genetics | Humans | Middle Aged | Ovarian Neoplasms - pathology | Drug Resistance, Neoplasm | Male | Combined Modality Therapy | Breast Neoplasms, Male - drug therapy | Adenocarcinoma - drug therapy | Piperazines - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors | Sequence Analysis, DNA | Adenocarcinoma - secondary | Ovarian Neoplasms - genetics | Phthalazines - pharmacology | DNA Mutational Analysis | Female | Adenocarcinoma - genetics | Antineoplastic Agents - pharmacology | Breast Neoplasms, Male - pathology | Gene Expression Regulation, Neoplastic - drug effects | Mutation | Ovarian Neoplasms - drug therapy | BRCA2 Protein - genetics | Genetic aspects | Nucleotide sequencing | Drug resistance | Tumors | DNA sequencing | Index Medicus
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8. Full Text Phase I Clinical Trial of a Selective Inhibitor of CYP17, Abiraterone Acetate, Confirms That Castration-Resistant Prostate Cancer Commonly Remains Hormone Driven
by Gerhardt Attard and Alison H.M. Reid and Timothy A. Yap and Florence Raynaud and Mitch Dowsett and Sarah Settatree and Mary Barrett and Christopher Parker and Vanessa Martins and Elizabeth Folkerd and Jeremy Clark and Colin S. Cooper and Stan B. Kaye and David Dearnaley and Gloria Lee and Johann S. de Bono
Journal of clinical oncology, ISSN 0732-183X, 10/2008, Volume 26, Issue 28, pp. 4563 - 4571
Life Sciences & Biomedicine | Oncology | Science & Technology | Tumors of the urinary system | Urinary tract. Prostate gland | Nephrology. Urinary tract diseases | Biological and medical sciences | Medical sciences | Tumors | Prospective Studies | Administration, Oral | Humans | Middle Aged | Androstenes | Male | Treatment Outcome | Adenocarcinoma - drug therapy | Disease Progression | Androstenols - therapeutic use | Androstenols - pharmacokinetics | Castration | Aged, 80 and over | Aged | Androstenols - administration & dosage | Neoplasms, Hormone-Dependent - drug therapy | Prostatic Neoplasms - drug therapy | Index Medicus
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9. Full Text A study of motivations and expectations of patients seen in phase 1 oncology clinics
by Dolly, Saoirse O and Kalaitzaki, Eleftheria and Puglisi, Martina and Stimpson, Sarah and Hanwell, Janet and Fandos, Sonia Serrano and Stapleton, Sarah and Ansari, Thushara and Peckitt, Clare and Kaye, Stan and Lopez, Juanita and Yap, Timothy A and van der Graaf, Winette and de Bono, Johann and Banerji, Udai
Cancer, ISSN 0008-543X, 11/2016, Volume 122, Issue 22, pp. 3501 - 3508
phase 1 trials | cancer | patient motivations | patient expectations | oncology clinical trials | Life Sciences & Biomedicine | Oncology | Science & Technology | Management | Patients | Health aspects | Original
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10. Full Text The role of genomic profiling in adolescents and young adults (AYAs) with advanced cancer participating in phase I clinical trials
by McVeigh, Terri Patricia and Sundar, Raghav and Diamantis, Nikolaos and Kaye, Stan B and Banerji, Udai and Lopez, Juanita S and de Bono, Johann and van der Graaf, Winette T.A and George, Angela J
European journal of cancer (1990), ISSN 0959-8049, 05/2018, Volume 95, pp. 20 - 29
Adolescent and young adult | AYA | Personalised medicine | Genomic profiling | Phase 1 trial | Life Sciences & Biomedicine | Oncology | Science & Technology | Genetic Predisposition to Disease | Prognosis | Clinical Trials, Phase I as Topic - statistics & numerical data | Genetic Testing - statistics & numerical data | Humans | Male | Neoplasms - diagnosis | Genetic Testing - methods | Disease Progression | Young Adult | Gene Expression Profiling - statistics & numerical data | Neoplasms - genetics | Adolescent | Germ-Line Mutation | Monitoring, Physiologic - methods | Adult | Female | Neoplasm Staging | Neoplasms - pathology | Neoplasms - epidemiology | Clinical trials | Genetic aspects | Tumor proteins | Genetic screening | Cancer | Profiling | Genomics | p53 Protein | Drug development | Cancer therapies | Risk factors | Precision medicine | Teenagers | Adolescents | Medical research | Young adults | Sarcoma | Therapeutic applications | Cervix | Risk analysis | Patients | Molecular chains | Adults | Solid tumors | Mutation | Risk management | Tumors | Index Medicus
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11. Full Text Prospective Validation of a Prognostic Score to Improve Patient Selection for Oncology Phase I Trials
by Hendrik-Tobias Arkenau and Jorge Barriuso and David Olmos and Joo Ern Ang and Johann de Bono and Ian Judson and Stan Kaye
Journal of clinical oncology, ISSN 0732-183X, 06/2009, Volume 27, Issue 16, pp. 2692 - 2696
Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Medical sciences | Tumors | Predictive Value of Tests | Prospective Studies | Health Status Indicators | Humans | Middle Aged | Male | Patient Selection | Young Adult | Neoplasm Metastasis | Neoplasms - therapy | Neoplasms - blood | Adult | Female | Reproducibility of Results | Risk Assessment | Kaplan-Meier Estimate | Proportional Hazards Models | Neoplasms - mortality | Treatment Outcome | Biomarkers - blood | Serum Albumin - analysis | Disease-Free Survival | L-Lactate Dehydrogenase - blood | Adolescent | Aged | Neoplasms - pathology | Clinical Trials, Phase I as Topic | Index Medicus
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