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1. Full Text Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models
by Lourenco, Mychael V and Frozza, Rudimar L and de Freitas, Guilherme B and Zhang, Hong and Kincheski, Grasielle C and Ribeiro, Felipe C and Gonçalves, Rafaella A and Clarke, Julia R and Beckman, Danielle and Staniszewski, Agnieszka and Berman, Hanna and Guerra, Lorena A and Forny-Germano, Letícia and Meier, Shelby and Wilcock, Donna M and de Souza, Jorge M and Alves-Leon, Soniza and Prado, Vania F and Prado, Marco A. M and Abisambra, Jose F and Tovar-Moll, Fernanda and Mattos, Paulo and Arancio, Ottavio and Ferreira, Sergio T and De Felice, Fernanda G
Nature Medicine, ISSN 1078-8956, 01/2019, Volume 25, Issue 1, pp. 165 - 175
Defective brain hormonal signaling has been associated with Alzheimer’s disease (AD), a disorder characterized by synapse and memory failure. Irisin is an... 
Potentiation | Physical exercise | Neuroprotection | Brain | Animal models | Long-term potentiation | Memory | Impairment | Cerebrospinal fluid | Pattern recognition | Object recognition | Fibronectin | Membrane proteins | Proteins | Plasticity (synaptic) | Plasticity | Mice | Alzheimer's disease | Hippocampus | FNDC5 | memory | synaptic plasticity | Alzheimer’s disease | irisin | physical exercise
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2. The effects of nano-sized carbon fillers on the physico-chemical, mechanical, and biological properties of polyester nanocomposites
by Zygmunt Staniszewski and Peter Sobolewski and Agnieszka Piegat and Miroslawa El Fray
European Polymer Journal, ISSN 0014-3057, 10/2018, Volume 107, p. 189
Nanocomposites based on poly(ethylene terephthalate-ethylene dilinoleate) (PET-DLA) copolymers of different hard to soft segment ratios (40:60 and 60:40) and... 
Biological properties | Fourier transforms | Nuclear magnetic resonance--NMR | Ethylene | Segments | Impact analysis | Polyesters | Fibroblasts | Biocompatibility | Carbon fiber reinforced plastics | Polymers | Multi wall carbon nanotubes | High aspect ratio | Scanning electron microscopy | Cold crystallization | Carbon black | Fillers | Crystallization | Tensile tests | Mechanical properties | Polyethylene terephthalate | Modulus of elasticity | Carbon | Organic chemistry | Terephthalate | Nanocomposites | Graphene | Viability
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3. Full Text Retromer Deficiency Observed in Alzheimer's Disease Causes Hippocampal Dysfunction, Neurodegeneration, and Aβ Accumulation
by Alim Muhammad and Ingrid Flores and Hong Zhang and Rui Yu and Agnieszka Staniszewski and Emmanuel Planel and Mathieu Herman and Lingling Ho and Robert Kreber and Lawrence S. Honig and Barry Ganetzky and Karen Duff and Ottavio Arancio and Scott A. Small
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2008, Volume 105, Issue 20, pp. 7327 - 7332
Although deficiencies in the retromer sorting pathway have been linked to late-onset Alzheimer's disease, whether these deficiencies underlie the disease... 
Receptors | Animal models | Nervous system diseases | Disease models | Neurodegenerative diseases | Humans | Antibodies | Mice | Amyloids | Alzheimers disease | Pathophysiology | Flies | flies | INHIBITION | TRANSGENIC MODELS | MULTIDISCIPLINARY SCIENCES | pathophysiology | IN-VIVO | PLAQUE-FORMATION | AMYLOID PRECURSOR PROTEIN | mice | EXPRESSION | RECEPTOR LR11 | Biological Sciences
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4. Full Text Picomolar amyloid-β positively modulates synaptic plasticity and memory in hippocampus
by Puzzo, Daniela and Privitera, Lucia and Leznik, Elena and Fà, Mauro and Staniszewski, Agnieszka and Palmeri, Agostino and Arancio, Ottavio
Journal of Neuroscience, ISSN 0270-6474, 12/2008, Volume 28, Issue 53, pp. 14537 - 14545
Amyloid-beta (A beta) peptides are produced in high amounts during Alzheimer's disease, causing synaptic and memory dysfunction. However, they are also... 
Amyloid-β | α-7 nicotinic receptors | Alzheimer's disease | Memory | Hippocampus | Synaptic plasticity | alpha-7 nicotinic receptors | APP | memory | hippocampus | ALZHEIMERS-DISEASE | INTERSTITIAL FLUID | NICOTINIC ACETYLCHOLINE-RECEPTORS | NEUROSCIENCES | amyloid-beta | SECRETED FORMS | IN-VIVO | synaptic plasticity | PRECURSOR PROTEIN | SHORT-TERM | BRAIN | TRANSGENIC MICE | Memory - drug effects | Amyloid beta-Peptides - pharmacology | Humans | 2-Amino-5-phosphonovalerate - pharmacology | Neuronal Plasticity - drug effects | Male | Peptide Fragments - pharmacology | Nicotinic Antagonists - pharmacology | Excitatory Postsynaptic Potentials - drug effects | Dose-Response Relationship, Drug | Neuronal Plasticity - genetics | Mecamylamine - pharmacology | Receptors, Nicotinic - deficiency | Electric Stimulation - methods | Excitatory Postsynaptic Potentials - genetics | Synapses - drug effects | Mice, Inbred C57BL | Excitatory Amino Acid Antagonists - pharmacology | Hippocampus - cytology | Maze Learning - drug effects | Mice, Knockout | Patch-Clamp Techniques | Animals | Analysis of Variance | Mice | In Vitro Techniques | Bungarotoxins - pharmacology | alpha7 Nicotinic Acetylcholine Receptor | amyloid-β
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5. Full Text Preparation of tau oligomers after the protein extraction from bacteria and brain cortices
by Argyrousi, Elentina K and Staniszewski, Agnieszka and Nicholls, Russell E and Arancio, Ottavio
Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1779, pp. 85 - 97
Oligomerization of soluble tau protein is attracting the attention of an increasingly larger number of scientists involved in research on Alzheimer's disease... 
Tau extraction | Tau oligomerization | Affinity tag purification | Alzheimer’s disease | Fast protein liquid chromatography | Recombinant tau | Tauopathy | Bacteria - metabolism | Oxidation-Reduction | Humans | Protein Multimerization | Recombinant Proteins - chemistry | Chromatography, High Pressure Liquid | Cysteine - chemistry | tau Proteins - isolation & purification | Bacteria - genetics | tau Proteins - chemistry | Brain - metabolism | Recombinant Proteins - isolation & purification | Animals | Chromatography, Affinity | tau Proteins - genetics | Autopsy | Alzheimer Disease - metabolism | Mice
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6. Full Text Quality control procedure based on partitioning of nmr time series
by Staniszewski, Michał and Skorupa, Agnieszka and Boguszewicz, Łukasz and Sokół, Maria and Polański, Andrzej
Sensors (Switzerland), ISSN 1424-8220, 03/2018, Volume 18, Issue 3, p. 792
The quality of the magnetic resonance spectroscopy (MRS) depends on the stability of magnetic resonance (MR) system performance and optimal hardware... 
Magnetic resonance spectroscopy | Reproducibility | Change points detection | Quality control | Biomedical signal processing | ELECTROCHEMISTRY | CHEMISTRY, ANALYTICAL | quality control | PHANTOM | reproducibility | magnetic resonance spectroscopy | INSTRUMENTS & INSTRUMENTATION | SEQUENCE | biomedical signal processing | ASSURANCE | change points detection | MR SPECTROSCOPY | SPECTRA | BRAIN | Data points | Nuclear magnetic resonance--NMR | Computer simulation | Change detection | Time series | Spectra | Artifacts | Algorithms | Spectral resolution | Partitioning | Mathematical analysis | White noise | Software | Dynamic programming
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7. Full Text Dynamin 1 is required for memory formation
by Fa, Mauro and Staniszewski, Agnieszka and Saeed, Faisal and Francis, Yitshak I and Arancio, Ottavio
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, p. e91954
Dynamin 1-3 isoforms are known to be involved in endocytotic processes occurring during synaptic transmission. No data has directly linked dynamins yet with... 
TRANSMITTER RELEASE | RELEASE PROBABILITY | ISOFORMS | INHIBITION | AMYLOID-BETA | CALMODULIN | MULTIDISCIPLINARY SCIENCES | LONG-TERM POTENTIATION | ENDOCYTOSIS | SYNAPTIC PLASTICITY | MODULATION | Memory - drug effects | Memory Disorders - physiopathology | RNA, Small Interfering - genetics | Electric Stimulation | Refractory Period, Electrophysiological - physiology | Synaptic Transmission - physiology | Memory Disorders - metabolism | Neuronal Plasticity - drug effects | Male | Hippocampus - drug effects | Dynamin I - genetics | Excitatory Postsynaptic Potentials - drug effects | Excitatory Postsynaptic Potentials - physiology | Neuronal Plasticity - physiology | Long-Term Potentiation - drug effects | Long-Term Potentiation - physiology | Synaptic Transmission - drug effects | Refractory Period, Electrophysiological - drug effects | Synapses - drug effects | Gene Expression | Synapses - physiology | Mice, Inbred C57BL | Hydrazones - pharmacology | Animals | Dynamin I - metabolism | Mice | Hippocampus - physiology | Dynamin I - antagonists & inhibitors | Memory - physiology | Memory Disorders - chemically induced | RNA, Small Interfering - metabolism | Animal behavior | Hostages | Memory | Potentiation | Long-term potentiation | Fatigue | Stimulation | Pharmacology | siRNA | Proteins | Associative memory | Brain research | Plasticity (synaptic) | Synaptic transmission | Isoforms | Dynamin | Aging | Inhibition | Laboratory animals | Alzheimers disease | Hippocampus
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8. Full Text Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer’s disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid
by Asam, Kesava and Staniszewski, Agnieszka and Zhang, Hong and Melideo, Scott L and Mazzeo, Adolfo and Voronkov, Michael and Huber, Kristen L and Pérez, Eduardo and Stock, Maxwell and Stock, Jeffry B and Arancio, Ottavio and Nicholls, Russell E
PLoS ONE, ISSN 1932-6203, 12/2017, Volume 12, Issue 12, p. e0189413
Soluble forms of oligomeric beta-amyloid (Aβ) are thought to play a central role in Alzheimer’s disease (AD). Transgenic manipulation of methylation of the... 
Potentiation | Animal models | Traumatic brain injury | Peptides | Pathogenesis | Serine | Cognitive ability | Transgenic | Coffee | Phosphatase | Proteins | Rodents | Aging | Protected animals | Alzheimer's disease | Enzymes | Sensitivity analysis | Threonine | Neurodegenerative diseases | Pathological effects | Long-term potentiation | Pharmacology | Exposure | Apolipoproteins | Fear conditioning | Pathology | Sensitivity | Beans | Brain research | Animals | β-Amyloid | Mice | Protein phosphatase | Methylation | Molecular biology | Animal cognition
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9. Full Text Application of reiteration of Hankel singular value decomposition in quality control
by Staniszewski, Michał and Skorupa, Agnieszka and Boguszewicz, Łukasz and Michalczuk, Agnieszka and Wereszczyński, Kamil and Wicher, Magdalena and Konopka, Marek and Sokół, Maria and Polański, Andrzej
AIP Conference Proceedings, ISSN 0094-243X, 07/2017, Volume 1863, Issue 1
Medical centres are obliged to store past medical records, including the results of quality assurance (QA) tests of the medical equipment, which is especially... 
magnetic resonance spectroscopy | time series | change point detection | quality control | reproducibility | Medical equipment | Medical centres | Medical devices | Quality assurance | Nuclear magnetic resonance--NMR | Reproducibility | Quality control | Medical electronics | Singular value decomposition
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10. Full Text SUMO1 affects synaptic function, spine density and memory
by Matsuzaki, Shinsuke and Lee, Linda and Knock, Erin and Srikumar, Tharan and Sakurai, Mikako and Hazrati, Lili-Naz and Katayama, Taiichi and Staniszewski, Agnieszka and Raught, Brian and Arancio, Ottavio and Fraser, Paul E
Scientific Reports, ISSN 2045-2322, 05/2015, Volume 5, Issue 1, p. 10730
Small ubiquitin-like modifier-1 (SUMO1) plays a number of roles in cellular events and recent evidence has given momentum for its contributions to neuronal... 
RAT HIPPOCAMPAL-NEURONS | MORPHOGENESIS | PROTEIN SUMOYLATION | ROLES | PHOSPHORYLATION | AMYLOID-BETA | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | NEURODEGENERATION | MICE | PLASTICITY | Sumoylation - genetics | Synaptic Transmission - genetics | Cells, Cultured | Mice, Transgenic | Brain - growth & development | Brain - metabolism | Animals | SUMO-1 Protein - genetics | Synaptotagmin I - metabolism | Proteomics | Mice | Neurons - metabolism | SUMO-1 Protein - metabolism | Ubiquitin | Immunoprecipitation | Spine | Memory | Transgenic mice | Synaptic density | Molecular weight | SUMO protein | Proteins | Learning | Synaptic transmission | Neurodegeneration | Rodents | Cytoskeleton | Synaptotagmin | Age
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11. Full Text PP2A methylation controls sensitivity and resistance to β-amyloid–induced cognitive and electrophysiological impairments
by Russell E. Nicholls and Jean-Marie Sontag and Hong Zhang and Agnieszka Staniszewski and Shijun Yan and Carla Y. Kim and Michael Yim and Caitlin M. Woodruff and Erland Arning and Brandi Wasek and Deqi Yin and Teodoro Bottiglieri and Estelle Sontag and Eric R. Kandel and Ottavio Arancio
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2016, Volume 113, Issue 12, pp. 3347 - 3352
Elevated levels of the β-amyloid peptide (Aβ) are thought to contribute to cognitive and behavioral impairments observed in Alzheimer’s disease (AD). Protein... 
Methylation | Alzheimer's disease | Cognitive impairment | Protein phosphatase 2A | β-amyloid | TAU-PROTEIN | CATALYTIC SUBUNIT | METHYLTRANSFERASE | PHOSPHOPROTEIN PHOSPHATASE 2A | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | DOWN-REGULATION | SYNAPTIC PLASTICITY | beta-amyloid | IN-VITRO | protein phosphatase 2A | methylation | cognitive impairment | PRECURSOR PROTEIN | CARBOXYL METHYLATION | Behavior, Animal | Amyloid beta-Peptides - physiology | Cognition Disorders - physiopathology | Animals | Protein Phosphatase 2 - metabolism | Mice, Transgenic | Mice | Biological Sciences
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12. Full Text Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction
by Watterson, D. Martin and Grum-Tokars, Valerie L and Roy, Saktimayee M and Schavocky, James P and de Bradaric, Brindasai and Bachstetter, Adam D and Xing, Bin and Dimayuga, Edgardo and Saeed, Faisal and Zhang, Hong and Staniszewski, Agnieszka and Pelletier, Jeffrey C and Minasov, George and Anderson, Wayne F and Arancio, Ottavio and van Eldik, Linda J
PLoS ONE, ISSN 1932-6203, 06/2013, Volume 8, Issue 6, p. e66226
Serine-threonine protein kinases are critical to CNS function, yet there is a dearth of highly selective, CNS-active kinase inhibitors for in vivo... 
POTENT | ACTIVATION | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | BEHAVIORAL DEFICITS | MOUSE MODEL | P38-ALPHA MAPK | CYTOKINE UP-REGULATION | INHIBITORS | BINDING | DISCOVERY | Mitogen-Activated Protein Kinase 14 - antagonists & inhibitors | Peptide Fragments - toxicity | Pyridines - chemistry | Humans | Brain - enzymology | Male | Pyridazines - pharmacology | Pyridazines - chemical synthesis | Brain - metabolism | Protein Kinase Inhibitors - chemistry | Long-Term Potentiation - drug effects | Drug Design | Mitogen-Activated Protein Kinase 14 - chemistry | Cell Line | Protein Kinase Inhibitors - chemical synthesis | Catalytic Domain | Amyloid beta-Peptides - toxicity | Mice, Inbred C57BL | Pyridines - chemical synthesis | Models, Molecular | Pyridazines - chemistry | Brain - drug effects | Animals | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Development and progression | Nervous system diseases | Cognition disorders | Protein kinases | Analysis | G protein-coupled receptors | Target recognition | Disease | Serine | Central nervous system | Cognitive ability | Activation | Biology | Selectivity | Catalytic activity | Kinases | Crystallography | Neuronal-glial interactions | Proteins | Cascades | Modulation | Aging | Catalysis | Probes | Alzheimer's disease | Cytokines | Threonine | Neurodegenerative diseases | Pharmacology | Mammals | Screens | Studies | Pathology | Signaling | Chemistry | Inhibitors | Protein kinase | β-Amyloid | In vivo methods and tests
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13. Full Text Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer's disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid
by Asam, K and Staniszewski, A and Zhang, H and Melideo, SL and Mazzeo, A and Voronkov, M and Huber, KL and Perez, E and Stock, M and Stock, JB and Arancio, O and Nicholls, RE
PLOS ONE, ISSN 1932-6203, 12/2017, Volume 12, Issue 12, p. e0189413
Soluble forms of oligomeric beta-amyloid (A beta) are thought to play a central role in Alzheimer's disease (AD). Transgenic manipulation of methylation of the... 
TAU HYPERPHOSPHORYLATION | METHYLATION | MEMORY | MULTIDISCIPLINARY SCIENCES | A-BETA | INJURY | SODIUM SELENATE | E-BASED PEPTIDE | PROTEIN PHOSPHATASE 2A | SYNAPTIC PLASTICITY | APOLIPOPROTEIN-E | Phosphorylation | Electrophysiology | Male | Coffee | Serotonin - pharmacology | Alzheimer Disease - pathology | Cognition Disorders - prevention & control | Female | Disease Models, Animal | Nervous System Diseases - pathology | Mice, Inbred C57BL | Nervous System Diseases - drug therapy | Solubility | Alzheimer Disease - drug therapy | Cognition - drug effects | Fear | Animals | Maze Learning | Conditioning (Psychology) | Neuronal Plasticity | Long-Term Potentiation | Serotonin - analogs & derivatives | Mice | Amyloid beta-Peptides - chemistry | Methylation | Prevention | Usage | Dietary supplements | Amyloid beta-protein | Cognition disorders | Research | Alzheimer's disease
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14. Full Text The effects of nano-sized carbon fillers on the physico-chemical, mechanical, and biological properties of polyester nanocomposites
by Staniszewski, Zygmunt and Sobolewski, Peter and Piegat, Agnieszka and El Fray, Miroslawa
European Polymer Journal, ISSN 0014-3057, 10/2018, Volume 107, pp. 189 - 201
Nanocomposites based on poly(ethylene terephthalate-ethylene dilinoleate) (PET-DLA) copolymers of different hard to soft segment ratios (40:60 and 60:40) and... 
Carbon nanotubes | Thermoplastic elastomers | Carbon black | Heart assist device | Nanocomposites | Graphene | POLYMER SCIENCE | POLY(ETHYLENE-TEREPHTHALATE) | Biological products | Analysis | Graphite | Elastomers | Nanotubes | Mechanical properties | Polymerization | Nuclear magnetic resonance spectroscopy
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15. Full Text Endogenous amyloid‐β is necessary for hippocampal synaptic plasticity and memory
by Puzzo, Daniela and Privitera, Lucia and Fa', Mauro and Staniszewski, Agnieszka and Hashimoto, Gakuji and Aziz, Fahad and Sakurai, Mikako and Ribe, Elena M and Troy, Carol M and Mercken, Marc and Jung, Sonia S and Palmeri, Agostino and Arancio, Ottavio
Annals of Neurology, ISSN 0364-5134, 05/2011, Volume 69, Issue 5, pp. 819 - 830
Objective: The goal of this study was to investigate the role of endogenous amyloid‐β peptide (Aβ) in healthy brain. Methods: Long‐term potentiation (LTP), a... 
CA1 REGION | ALZHEIMERS-DISEASE | IN-VIVO | NICOTINIC ACETYLCHOLINE-RECEPTOR | PRECURSOR-PROTEIN | PROTEIN-DEFICIENT MICE | RAT HIPPOCAMPUS | SPATIAL MEMORY | LONG-TERM POTENTIATION | NEUROSCIENCES | CLINICAL NEUROLOGY | COGNITIVE DEFICITS | Enzyme-Linked Immunosorbent Assay - methods | Memory - drug effects | Humans | Male | Hippocampus - drug effects | Long-Term Potentiation - drug effects | Amyloid beta-Peptides - genetics | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Long-Term Potentiation - physiology | Behavior, Animal - drug effects | Electric Stimulation - methods | Peptide Fragments - metabolism | Mice, Inbred C57BL | RNA, Small Interfering - pharmacology | Gene Expression Regulation - physiology | Maze Learning - drug effects | Antibodies - pharmacology | Amyloid beta-Protein Precursor - genetics | Animals | Amyloid beta-Peptides - immunology | Mice | Biophysics - methods | Hippocampus - physiology | Memory - physiology
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16. Full Text Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-β load in an Alzheimer's disease mouse model
by Puzzo, Daniela and Staniszewski, Agnieszka and XianDeng, Shi and Privitera, Lucia and Leznik, Elena and Liu, Shumin and Zhang, Hong and Feng, Yan and Palmeri, Agostino and Landry, Donald W and Arancio, Ottavio
Journal of Neuroscience, ISSN 0270-6474, 06/2009, Volume 29, Issue 25, pp. 8075 - 8086
Memory loss, synaptic dysfunction, and accumulation of amyloid beta-peptides (A beta) are major hallmarks of Alzheimer's disease (AD). Downregulation of the... 
NEURONAL GENES | SILDENAFIL | AVOIDANCE | SELECTIVE PDE5 INHIBITOR | NITRIC-OXIDE | CGMP | RAT HIPPOCAMPUS | MICE | MECHANISMS | DYSFUNCTION | NEUROSCIENCES | Immunohistochemistry | Memory - drug effects | Piperazines - administration & dosage | Phosphodiesterase 5 Inhibitors | Purines - administration & dosage | Sulfones - pharmacology | Sildenafil Citrate | Time Factors | Amyloid beta-Peptides - metabolism | Polymerase Chain Reaction | Spatial Behavior - drug effects | Synaptic Transmission - drug effects | Phosphorylation - drug effects | Piperazines - pharmacokinetics | Alzheimer Disease - psychology | Disease Models, Animal | Psychomotor Performance | Conditioning, Classical - drug effects | Phosphodiesterase Inhibitors - pharmacokinetics | Purines - pharmacology | Purines - pharmacokinetics | Injections, Intraperitoneal | Alzheimer Disease - drug therapy | Phosphodiesterase Inhibitors - pharmacology | Mice, Transgenic | Treatment Outcome | Sulfones - pharmacokinetics | Piperazines - pharmacology | Neuropsychological Tests | Phosphodiesterase Inhibitors - administration & dosage | Amyloid beta-Protein Precursor - genetics | Animals | Analysis of Variance | Cyclic GMP - metabolism | Alzheimer Disease - metabolism | Cyclic AMP Response Element-Binding Protein - metabolism | Mice | Mutation | Sulfones - administration & dosage
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