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1. Full Text Age of islet autoantibody appearance and mean levels of insulin, but not GAD or IA-2 autoantibodies, predict age of diagnosis of type 1 diabetes: Diabetes autoimmunity study in the young
by Steck, Andrea K and Johnson, Kelly and Barriga, Katherine J and Miao, Dongmei and Yu, Liping and Hutton, John C and Eisenbarth, George S and Rewers, Marian J
Diabetes Care, ISSN 0149-5992, 06/2011, Volume 34, Issue 6, pp. 1397 - 1399
We evaluated predictors of progression to diabetes in children with high-risk HLA genotypes and persistent islet autoantibodies. The Diabetes Autoimmunity... 
Prospective Studies | Humans | Child, Preschool | Diabetes Mellitus, Type 1 - genetics | Islets of Langerhans - immunology | Infant | Insulin | Disease Progression | Diabetes Mellitus, Type 1 - diagnosis | Insulin Antibodies | Autoantibodies - immunology | Age of Onset | Diabetes Mellitus, Type 1 - immunology | Glutamate Decarboxylase - immunology | Child | Autoimmunity | Autoantibodies | Type 1 diabetes | Development and progression | Genetic aspects | Research | Diagnosis | Diabetes | Studies | Survival analysis | Medical research | Age | Index Medicus | Original Research
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2. Full Text GAD65 autoantibodies detected by electrochemiluminescence assay identify high risk for type 1 diabetes
by Miao, Dongmei and Guyer, K. Michelle and Dong, Fran and Jiang, Ling and Steck, Andrea K and Rewers, Marian and Eisenbarth, George S and Yu, Liping
Diabetes, ISSN 0012-1797, 12/2013, Volume 62, Issue 12, pp. 4174 - 4178
The identification of diabetes-relevant islet autoantibodies is essential for predicting and preventing type 1 diabetes (T1D). The aim of the current study was... 
INSULIN | RELATIVES | AFFINITY | ENDOCRINOLOGY & METABOLISM | PROGRESSION | PREDICTION | CHILDREN | Humans | Luminescence | Child, Preschool | Infant | Male | Risk | Prediabetic State - diagnosis | Diabetes Mellitus, Type 1 - diagnosis | Sensitivity and Specificity | Adolescent | Prediabetic State - immunology | Autoantibodies - analysis | Female | Diabetes Mellitus, Type 1 - immunology | Glutamate Decarboxylase - immunology | Child | Measurement | Immunoassay | Usage | Autoantibodies | Type 1 diabetes | Physiological aspects | Research | Diagnosis | Risk factors | Disease prevention | Diabetes | Medical diagnosis | Risk assessment | Children & youth | Index Medicus | Abridged Index Medicus | Original Research
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3. Full Text Predictors of progression from the appearance of islet autoantibodies to early childhood diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY)
by Steck, Andrea K and Vehik, Kendra and Bonifacio, Ezio and Lernmark, Ake and Ziegler, Anette-G and Hagopian, William A and She, Jinxiong and Simell, Olli and Akolkar, Beena and Krischer, Jeffrey and Schatz, Desmond and Rewers, Marian J and TEDDY Study Grp and TEDDY Study Group and the TEDDY Study Group and Lund University and Diabetes och celiaki and Diabetes and Celiac Unit and Lunds universitet and EXODIAB: Excellence in Diabetes Research in Sweden
Diabetes Care, ISSN 0149-5992, 05/2015, Volume 38, Issue 5, pp. 808 - 813
OBJECTIVEWhile it is known that there is progression to diabetes in <10 years in 70% of children with two or more islet autoantibodies, predictors of the... 
INSULIN | POPULATION | GLUTAMIC-ACID DECARBOXYLASE | RELATIVES | ENDOCRINOLOGY & METABOLISM | AUTOANTIGEN | ASSAYS | RISK SCORE | TYPE-1 | ASSOCIATION | CHILDREN | Autoantibodies - metabolism | Insulin Antibodies - metabolism | Receptor-Like Protein Tyrosine Phosphatases, Class 8 - immunology | Humans | Risk Factors | Child, Preschool | Islets of Langerhans - immunology | Genotype | Infant | Male | Disease Progression | HLA-DQ Antigens - immunology | Female | HLA-DR Antigens - immunology | Diabetes Mellitus, Type 1 - immunology | Glutamate Decarboxylase - immunology | Child | Usage | Autoantibodies | Mortality | Diabetes in children | Research | Health aspects | Portrayals | Health risk assessment | Diabetes | Children & youth | Index Medicus | Epidemiology | Health Services Research | Clinical Medicine | Endokrinologi och diabetes | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Endocrinology and Diabetes
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4. Full Text Prevalence, Characteristics and Clinical Diagnosis of Maturity Onset Diabetes of the Young Due to Mutations in HNF1A, HNF4A, and Glucokinase: Results From the SEARCH for Diabetes in Youth
by Pihoker, Catherine and Gilliam, Lisa K and Ellard, Sian and Dabelea, Dana and Davis, Cralen and Dolan, Lawrence M and Greenbaum, Carla J and Imperatore, Giuseppina and Lawrence, Jean M and Marcovina, Santica M and Mayer-Davis, Elizabeth and Rodriguez, Beatriz L and Steck, Andrea K and Williams, Desmond E and Hattersley, Andrew T and for the SEARCH for Diabetes in Youth Study Group and SEARCH Diabet Youth Study Grp and SEARCH for Diabetes in Youth Study Group and for the SEARCH for Diabetes in Youth Study Group
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 10/2013, Volume 98, Issue 10, pp. 4055 - 4062
Aims: Our study aims were to determine the frequency of MODY mutations (HNF1A, HNF4A, glucokinase) in a diverse population of youth with diabetes and to assess... 
NUCLEAR FACTOR-1-ALPHA GENE | MULTICENTER | MODY | HYPERGLYCEMIA | ADOLESCENTS | ENDOCRINOLOGY & METABOLISM | CLASSIFICATION | MELLITUS | IDENTIFICATION | ALPHA-GENE | CHILDREN | Prevalence | Hepatocyte Nuclear Factor 1-alpha - genetics | Diabetes Mellitus, Type 2 - genetics | Humans | Child, Preschool | Glucokinase - genetics | Male | Hepatocyte Nuclear Factor 4 - genetics | Diabetes Mellitus, Type 2 - epidemiology | Young Adult | Diabetes Mellitus, Type 2 - diagnosis | DNA Mutational Analysis | Adolescent | Age of Onset | Female | Mutation | Child | Index Medicus | Abridged Index Medicus | 11 | 4 | Endocrine Care
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5. Full Text Increased DNA methylation variability in type 1 diabetes across three immune effector cell types
by Paul, Dirk S and Teschendorff, Andrew E and Dang, Mary A.N and Lowe, Robert and Hawa, Mohammed I and Ecker, Simone and Beyan, Huriya and Cunningham, Stephanie and Fouts, Alexandra R and Ramelius, Anita and Burden, Frances and Farrow, Samantha and Rowlston, Sophia and Rehnstrom, Karola and Frontini, Mattia and Downes, Kate and Busche, Stephan and Cheung, Warren A and Ge, Bing and Simon, Marie-Michelle and Bujold, David and Kwan, Tony and Bourque, Guillaume and Datta, Avik and Lowy, Ernesto and Clarke, Laura and Flicek, Paul and Libertini, Emanuele and Heath, Simon and Gut, Marta and Gut, Ivo G and Ouwehand, Willem H and Pastinen, Tomi and Soranzo, Nicole and Hofer, Sabine E and Karges, Beate and Meissner, Thomas and Boehm, Bernhard O and Cilio, Corrado and Larsson, Helena Elding and Lernmark, Åke and Steck, Andrea K and Rakyan, Vardhman K and Beck, Stephan and Leslie, R. David and Paediatric Endocrinology and Lund University and Diabetes and Celiac Unit and Diabetes - Cellular Autoimmunity and Pediatrisk endokrinologi and Diabetes och celiaki and Diabetes - cellulär autoimmunitet and Lunds universitet and EXODIAB: Excellence in Diabetes Research in Sweden
Nature Communications, ISSN 2041-1723, 11/2016, Volume 7, Issue 1, pp. 13555 - 13555
The incidence of type 1 diabetes (T1D) has substantially increased over the past decade, suggesting a role for non-genetic factors such as epigenetic... 
METABOLISM | PACKAGE | MULTIDISCIPLINARY SCIENCES | RISK | DIFFERENTIAL VARIABILITY | FIELD DEFECTS | CANCER | EPIGENOME-WIDE ASSOCIATION | T-CELLS | MONOZYGOTIC TWINS | FOXP1 | Index Medicus | Type 1 diabetes | Disease genetics | Epigenomics | Clinical Medicine | Endokrinologi och diabetes | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Endocrinology and Diabetes
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6. Full Text Increased inflammation is associated with islet autoimmunity and type 1 diabetes in the Diabetes Autoimmunity Study in the Young (DAISY)
by Waugh, Kathleen and Snell-Bergeon, Janet and Michels, Aaron and Dong, Fran and Steck, Andrea K and Frohnert, Brigitte I and Norris, Jill M and Rewers, Marian
PLoS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, pp. e0174840 - e0174840
Background Type 1 diabetes (TID) is characterized by a loss of pancreatic islet beta cell function resulting in loss of insulin production. Genetic and... 
AUTOANTIBODIES | INSULIN | CYTOKINES | T-CELL RESPONSES | ASSAY | HIGH-RISK | IDDM | MULTIDISCIPLINARY SCIENCES | MELLITUS | PROGRESSION | CHILDREN | Humans | Child, Preschool | Islets of Langerhans - immunology | Infant | Male | Inflammation - immunology | Case-Control Studies | Inflammation - blood | Autoimmunity - immunology | Diabetes Mellitus, Type 1 - blood | Female | Diabetes Mellitus, Type 1 - immunology | Child | Cytokines - blood | Autoimmunity | Complications and side effects | Cytokines | Type 1 diabetes | Analysis | Inflammation | Health aspects | Risk factors | Health care | Immune response | Control methods | Identification methods | Pathogenesis | Diabetes mellitus | Antibodies | Families & family life | Environmental factors | Family medical history | IL-1β | Medical screening | Insulin | Immune systems | Beta cells | Immunology | Damage detection | Diabetes | Children | Chemokines | Age | Immune system | Index Medicus
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7. Full Text TCF7L2 genetic variants contribute to phenotypic heterogeneity of type 1 diabetes
by Redondo, Maria J and Geyer, Susan and Steck, Andrea K and Sosenko, Jay and Anderson, Mark and Antinozzi, Peter and Michels, Aaron and Wentworth, John and Xu, Ping and Pugliese, Alberto and Type 1 Diabet TrialNet Study Grp and Type 1 Diabetes TrialNet Study Group and the Type 1 Diabetes TrialNet Study Group
Diabetes Care, ISSN 0149-5992, 02/2018, Volume 41, Issue 2, pp. 311 - 317
OBJECTIVE The phenotypic diversity of type 1 diabetes suggests heterogeneous etiopathogenesis. We investigated the relationship of type 2 diabetes-associated... 
COMMON VARIANTS | AUTOIMMUNE | DISEASE | ENDOCRINOLOGY & METABOLISM | ADULT-ONSET | RISK | C-PEPTIDE | LOCI | ASSOCIATION | BETA-CELL FUNCTION | CHILDREN | Genetic Predisposition to Disease | Transcription Factor 7-Like 2 Protein - genetics | Humans | Middle Aged | Child, Preschool | Diabetes Mellitus, Type 1 - genetics | Male | Genetic Heterogeneity | Young Adult | Phenotype | Adolescent | Alleles | Adult | Female | Polymorphism, Single Nucleotide | Child | Cohort Studies | Care and treatment | Genetic aspects | Research | Genetic variation | Type 1 diabetes | Autoantibodies | Diabetes mellitus | Diabetes mellitus (insulin dependent) | Single-nucleotide polymorphism | Glucose | Medical diagnosis | Immunological tolerance | Glucose tolerance | Genotype & phenotype | Genetic variance | Genetics | Research design | Diabetes | Diagnosis | Islets of Langerhans | Pancreas | Diabetes mellitus (non-insulin dependent) | Index Medicus | Pathophysiology | Complications | 0408
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8. Full Text The Influence of Type 2 Diabetes-Associated Factors on Type 1 Diabetes
by Redondo, MJ and Evans-Molina, C and Steck, AK and Atkinson, MA and Sosenko, J
DIABETES CARE, ISSN 0149-5992, 08/2019, Volume 42, Issue 8, pp. 1357 - 1364
Current efforts to prevent progression from islet autoimmunity to type 1 diabetes largely focus on immunomodulatory approaches. However, emerging data suggest... 
HETEROGENEITY | TCF7L2 | RISK-FACTOR | AUTOIMMUNITY | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | ACCELERATOR HYPOTHESIS | WEIGHT-GAIN | ENDOPLASMIC-RETICULUM STRESS | PROGRESSION | AGE | Prevention | Genetic variation | Type 1 diabetes | Development and progression | Genetic aspects | B cells | Research | Obesity | Autoantibodies | Immunomodulation | Pathogenesis | Medical treatment | Diabetes mellitus | Clinical trials | Diabetes mellitus (insulin dependent) | Insulin | Disease control | Genetic variance | Heterogeneity | Algorithms | Predictions | Diagnostic systems | Diabetes | Genetic factors | Diagnosis | Diabetes mellitus (non-insulin dependent) | Immune system
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9. Full Text Stepwise or linear decrease in penetrance of type 1 diabetes with lower-risk HLA genotypes over the past 40 years
by Steck, Andrea K and Armstrong, Taylor K and Babu, Sunanda R and Eisenbarth, George S and Type 1 Diabet Genetics Consortitun and Type 1 Diabetes Genetics Consortium and the Type 1 Diabetes Genetics Consortium
Diabetes, ISSN 0012-1797, 03/2011, Volume 60, Issue 3, pp. 1045 - 1049
OBJECTIVE-The objective of this study was to test if the proportion of new-onset diabetic subjects with the HLA-DR3/4-DQB1*0302 genotype is decreasing over... 
AUTOIMMUNE | FAMILIES | RISING INCIDENCE | HYPOTHESIS | ENDOCRINOLOGY & METABOLISM | COLORADO YOUTH | HAPLOTYPES | GENETICS CONSORTIUM | MISSING LINK | MELLITUS | CHILDREN | Diabetes Mellitus, Type 1 - epidemiology | Gene Frequency | Humans | Risk Factors | Diabetes Mellitus, Type 1 - genetics | Genotype | Male | Penetrance | Incidence | HLA-DR3 Antigen - genetics | Adolescent | Age of Onset | Female | Diabetes Mellitus, Type 1 - immunology | HLA-DR3 Antigen - immunology | Child | Histocompatibility antigens | Type 1 diabetes | HLA histocompatibility antigens | Physiological aspects | Development and progression | Genetic aspects | Research | Risk factors | Index Medicus | Abridged Index Medicus | Genetics
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10. Full Text Age of Islet Autoantibody Appearance and Mean Levels of Insulin, but Not GAD or IA-2 Autoantibodies, Predict Age of Diagnosis of Type 1 Diabetes
by Steck, AK and Johnson, K and Barriga, KJ and Miao, DM and Yu, LP and Hutton, JC and Eisenbarth, GS and Rewers, MJ
DIABETES CARE, ISSN 0149-5992, 06/2011, Volume 34, Issue 6, pp. 1397 - 1399
OBJECTIVE-We evaluated predictors of progression to diabetes in children with high-risk HLA genotypes and persistent islet autoantiboclies. RESEARCH DESIGN AND... 
GENERAL-POPULATION | AUTOIMMUNITY | ENDOCRINOLOGY & METABOLISM | AFFECTED CHILDREN | PREVENTION | SIBLINGS | RISK
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11. Full Text Continuous Glucose Monitoring Predicts Progression to Diabetes in Autoantibody Positive Children
by Steck, Andrea K and Dong, Fran and Taki, Iman and Hoffman, Michelle and Simmons, Kimber and Frohnert, Brigitte I and Rewers, Marian J
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 03/2019, Volume 104, Issue 8, pp. 3337 - 3344
Accurate measures are needed for the prediction and diagnosis of type 1 diabetes (T1D) in at risk subjects. The purpose of this study was to explore the value... 
HBA(1C) | ENDOCRINE-SOCIETY | A1C | AUTOIMMUNITY | PERFORMANCE | ENDOCRINOLOGY & METABOLISM | MARKERS | RISK SCORE | TIME | TYPE-1 | ACCURACY | Index Medicus | Abridged Index Medicus
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12. Full Text Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children
by Bonifacio, Ezio and Beyerlein, Andreas and Hippich, Markus and Winkler, Christiane and Vehik, Kendra and Weedon, Michael N and Laimighofer, Michael and Hattersley, Andrew T and Krumsiek, Jan and Frohnert, Brigitte I and Steck, Andrea K and Hagopian, William A and Krischer, Jeffrey P and Lernmark, Åke and Rewers, Marian J and She, Jin-Xiong and Toppari, Jorma and Akolkar, Beena and Oram, Richard A and Rich, Stephen S and Ziegler, Anette-G and TEDDY Study Grp and TEDDY Study Group and for the TEDDY Study Group and Lund University and Diabetes och celiaki and Diabetes and Celiac Unit and Lunds universitet
PLoS Medicine, ISSN 1549-1277, 04/2018, Volume 15, Issue 4, pp. e1002548 - e1002548
Background Around 0.3% of newborns will develop autoimmunity to pancreatic beta cells in childhood and subsequently develop type 1 diabetes before adulthood.... 
MEDICINE, GENERAL & INTERNAL | RANDOMIZED CLINICAL-TRIAL | TEDDY | BETA-CELL AUTOIMMUNITY | HLA | POSITIVITY | INTERVENTION | SUSCEPTIBILITY GENES | GENOME-WIDE ASSOCIATION | CELIAC-DISEASE | PREDICTION | Autoantibodies - metabolism | Genetic Predisposition to Disease | Genetic Testing | Risk Assessment | Humans | Risk Factors | Child, Preschool | Diabetes Mellitus, Type 1 - genetics | Islets of Langerhans - immunology | Infant | Male | Case-Control Studies | Family | Female | Diabetes Mellitus, Type 1 - immunology | Child | Infant, Newborn | Pancreatic beta cells | Autoantibodies | Type 1 diabetes | Genotype | Genetic aspects | Health aspects | Identification and classification | Risk factors | Neonates | Risk groups | Diabetes mellitus | Health risks | Clinical trials | Risk | Sex differences | Infants | Diabetes mellitus (insulin dependent) | Single-nucleotide polymorphism | Males | Beta cells | Prevention | Sensitivity | Predictions | Genetics | Histocompatibility antigen HLA | Children | Islets of Langerhans | Pancreas | Females | Age | Genotypes | Index Medicus | Medicinsk genetik | Basic Medicine | Medical Genetics | Clinical Medicine | Medical and Health Sciences | Endokrinologi och diabetes | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Klinisk medicin | Endocrinology and Diabetes
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13. Full Text Role of type 1 diabetes- Associated snps on risk of autoantibody positivity in the TEDDY study
by Törn, Carina and Hadley, David and Lee, Hye-Seung and Hagopian, William and Lernmark, Åke and Simell, Olli and Rewers, Marian and Ziegler, Anette and Schatz, Desmond and Akolkar, Beena and Onengut-Gumuscu, Suna and Chen, Wei-Min and Toppari, Jorma and Mykkänen, Juha and Ilonen, Jorma and Rich, Stephen S and She, Jin-Xiong and Steck, Andrea K and Krischer, Jeffrey and TEDDY Study Grp and TEDDY Study Group and the TEDDY Study Group and Lund University and Diabetes och celiaki and Diabetes and Celiac Unit and Lunds universitet and EXODIAB: Excellence in Diabetes Research in Sweden
Diabetes, ISSN 0012-1797, 05/2015, Volume 64, Issue 5, pp. 1818 - 1829
The Environmental Determinants of Diabetes in the Young (TEDDY) study prospectively follows 8,677 children enrolled from birth who carry HLA-susceptibility... 
POPULATION | GLUTAMIC-ACID DECARBOXYLASE | GENE | ENDOCRINOLOGY & METABOLISM | ISLET AUTOIMMUNITY | ASSAYS | POLYMORPHISM | TYROSINE-PHOSPHATASE PTPN22 | CONCORDANCE | LINKAGE | ANTIBODY STANDARDIZATION PROGRAM | Autoantibodies - metabolism | Genetic Predisposition to Disease | United States | Autoantibodies - blood | Europe | Humans | Risk Factors | Autoimmunity - genetics | Diabetes Mellitus, Type 1 - genetics | HLA Antigens - immunology | Islets of Langerhans - immunology | Genotype | HLA Antigens - genetics | Polymorphism, Single Nucleotide - genetics | Genome | Infant, Newborn | Genetics | Adjustments | Diabetes | Pathogenesis | Risk factors | Meta-analysis | Index Medicus | Abridged Index Medicus | Metabolomics | Genomes | Proteomics | Clinical Medicine | Endokrinologi och diabetes | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Endocrinology and Diabetes
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