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Current Biology, ISSN 0960-9822, 02/2007, Volume 17, Issue 4, pp. 316 - 322
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 05/2009, Volume 15, Issue 9, pp. 3094 - 3102
Purpose: Antimitotic chemotherapy remains a cornerstone of multimodality treatment for locally advanced and metastatic cancers. To identify novel... 
Polo-arrest | monopolar spindle | BI 6727 | Plk | Polo-like kinase inhibitor | CYTOKINESIS | CHEMICAL GENETICS | ONCOLOGY | POLO-LIKE-KINASE-1 | PLK1 | SPINDLE | MAMMALIAN-CELLS | DRUG TARGETS | CANCER-THERAPY | SMALL-MOLECULE INHIBITOR | REVEALS | Lung Neoplasms - drug therapy | Rats, Wistar | Apoptosis - drug effects | Pteridines - chemistry | Colonic Neoplasms - drug therapy | Humans | Crystallography, X-Ray | Lung Neoplasms - pathology | Forkhead Transcription Factors - physiology | Immunoenzyme Techniques | Cell Cycle Proteins - antagonists & inhibitors | Tissue Distribution | Enzyme Inhibitors - pharmacokinetics | Enzyme Inhibitors - chemistry | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Pteridines - pharmacology | Lung Neoplasms - enzymology | Cell Cycle Proteins - metabolism | Enzyme Inhibitors - pharmacology | Rats | Pteridines - pharmacokinetics | Antineoplastic Agents - chemistry | Blotting, Western | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Colonic Neoplasms - pathology | Fluorescent Antibody Technique | Cell Line, Tumor | Protein Conformation | Cell Proliferation - drug effects | Colonic Neoplasms - enzymology | Mice | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | Cell Cycle - drug effects
Journal Article
Journal Article
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2007, Volume 401, Issue 1, pp. 29 - 38
Hormones and growth factors induce the activation of a number of protein kinases that belong to the AGC subfamily, including isoforms of PKA, protein kinase B... 
Kinase-specific inhibitor | Phosphorylation | p90 ribosomal S6 kinase (RSK) | BI-D1870 | Mitogen-activated protein kinase (MAPK) | ACTIVATED PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK) | MSK1 | INDUCTION | IDENTIFICATION | INACTIVATION | CREB | GROWTH | BI-DI870 | SUPPRESSES | phosphorylation | kinase-specific inhibitor | Cell Line | Pteridines - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Rats | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Kinetics | Chromones - pharmacology | Isoenzymes - antagonists & inhibitors | MES, mouse embryonic stem | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | PKA, cAMP-dependent protein kinase A | FKHR, forkhead in rhabdosarcoma transcription factor | RSK, p90 ribosomal S6 kinase | JNK, c-Jun N-terminal kinase | CREB, cAMP-response-element-binding protein | SGK1, serum- and glucocorticoid-induced kinase-1 | PDK1, phosphoinositide-dependent kinase 1 | PKB, protein kinase B | Lck, lymphocyte kinase | ROCK, Rho-dependent protein kinase | MKK1, MAPK kinase-1 | protein kinase G | AGC, cAMP-dependent protein kinase | protein kinase C | HEK-293, human embryonic kidney 293 | ERK1, extracellular-signal-regulated kinase 1 | GST, glutathione S-transferase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | PH, pleckstrin homology | PLK1, polo-like kinase 1 | CK1, casein kinase-1 | FBS, foetal bovine serum | MSK, mitogen- and stress-activated protein kinase | CDK2–A, cyclin-dependent kinase 2 complexed with cyclin A | DYRK1a, dual-specificity tyrosine-phosphorylated and -regulated kinase 1a | GSK3α, glycogen synthase kinase 3α | MAPK, mitogen-activated protein kinase
Journal Article
Nature, ISSN 0028-0836, 02/1995, Volume 373, Issue 6515, pp. 615 - 620
E-SELECTIN is an inducible cell-adhesion molecule on endothelial cells, which mediates the binding of neutrophils and functions as a Ca2+-dependent... 
LEUKOCYTE ADHESION MOLECULE-1 | CELLS | SPECIFICITIES | MULTIDISCIPLINARY SCIENCES | GLYCOPROTEIN LIGAND | DISTINCT | P-SELECTIN | SURFACE | IDENTIFICATION | EXPRESSION | ANTIGEN | Membrane Glycoproteins - metabolism | Fucose - metabolism | Humans | Glycoproteins - metabolism | Molecular Sequence Data | Recombinant Fusion Proteins - metabolism | Sialoglycoproteins | Transfection | Base Sequence | Cloning, Molecular | Glycoproteins - isolation & purification | Receptors, Fibroblast Growth Factor - genetics | Receptors, Fibroblast Growth Factor - isolation & purification | Glycoproteins - chemistry | Neutrophils - metabolism | CHO Cells | Glycoproteins - genetics | Amino Acid Sequence | Cricetinae | Membrane Glycoproteins - isolation & purification | Receptors, Fibroblast Growth Factor - chemistry | Cell Adhesion Molecules - metabolism | Precipitin Tests | Membrane Glycoproteins - genetics | Sequence Homology, Amino Acid | Animals | Immunoglobulin G - genetics | Chickens | Receptors, Fibroblast Growth Factor - metabolism | Protein Binding | Recombinant Fusion Proteins - genetics | Ligands | E-Selectin | Mice | Receptors, Immunologic - genetics | Receptors, Immunologic - isolation & purification | Receptors, Immunologic - metabolism | DNA, Complementary | Immunoglobulin G - metabolism | Fibroblast growth factors | Research | Cell adhesion molecules | Molecules | Amino acids | Rodents | Deoxyribonucleic acid | DNA
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 2/1997, Volume 136, Issue 3, pp. 707 - 716
L-Selectin on neutrophils as well as inducible E- and P-selectin on endothelium are involved in the recruitment of neutrophils into inflamed tissue. Based on... 
Humans | Neutrophils | Antibodies | Tin | Selectins | Ligands | Glycoproteins | Leukocytes | Butchering | Blood | AMINO-TERMINUS | MOLECULE | INVITRO | GLYCOPROTEIN LIGAND | ENDOTHELIAL-CELLS | HOMING RECEPTOR | P-SELECTIN | K DR CELL BIOLOGY | DEFICIENT MICE | LEUKOCYTE ADHESION | MYELOID CELLS | CELL BIOLOGY | Physiological aspects | Research | Cell adhesion molecules | Protein binding
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/1999, Volume 274, Issue 9, pp. 5649 - 5653
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 02/1997, Volume 185, Issue 3, pp. 573 - 578
We have shown recently that mouse Th1 cells but not Th2 cells are selectively recruited into inflamed sites of a delayed-type hypersensitivity (DTH) reaction... 
AMINO-TERMINUS | MEDICINE, RESEARCH & EXPERIMENTAL | HUMAN NEUTROPHILS | ADHESION MOLECULE | TYROSINE SULFATION | MEDIATE | IMMUNOLOGY | MYELOID CELLS | IDENTIFICATION | EXPRESSION | FLOW | LYMPHOCYTES
Journal Article