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1. Full Text C-Reactive Protein, Fibrinogen, and Cardiovascular Disease Prediction
by Kaptoge, Stephen and Angelantonio, Emanuele and Pennells, Lisa and Wood, Angela and White, Ian and Gao, Pei and Walker, Mark and Thompson, Alexander and Sarwar, Sheryar and Caslake, Muriel and Butterworth, Adam and Amouyel, Philippe and Assmann, Gerd and Bakker, Stephan and Barr, E.L.M and Barrett-Connor, Elizabeth and Benjamin, Emelia and Björkelund, Cecilia and Brenner, Hermann and Brunner, Eric and Clarke, Robert and Cooper, Jackie and Cremer, P and Cushman, Mary Ann and Dagenais, Gilles R and D'Agostino, Ralph and Dankner, Rachel and Davey-Smith, George and Deeg, Dorly and Dekker, Jacqueline and Engström, G and Folsom, Aaron and Fowkes, F. Gerald R and Gallacher, John and Gaziano, J. Michael and Giampaoli, Simona and Gillum, Richard and Hofman, Albert and Howard, Barbara and Ingelsson, Erik and Iso, Hiroyasu and Jorgensen, Torben and Kiechl, Stefan and Kitamura, A and Kiyohara, Yutaka and Koenig, Wolfgang and Kromhout, Daan and Kuller, Lewis and Lawlor, Debbie and Meade, Tom and Nissinen, Aulikki and Nordestgaard, Børge and Onat, Altan and Panagiotakos, Demosthenes and Psaty, Bruce and Roiguez, Beatriz and Rosengren, Annika and Salomaa, Veikko and Kauhanen, Jussi and Salonen, J.T and Shaffer, Jonathan and Shea, Steven and Ford, Ian and Stehouwer, Coen and Strandberg, Timo and Tipping, Alex and Tosetto, Alberto and Wassertheil-Smoller, Sylvia and Wennberg, Patrik and Westendorp, Rudi and Whincup, Peter and Wilhelmsen, Lars and Woodward, Mark and Lowe, Gordon and Wareham, Nick and Khaw, Kay-Tee and Sattar, Naveed and Packard, Chris and Gudnason, Vilmundur and Ridker, Paul and Pepys, Mark and Thompson, Simon and Danesh, John and The Emerging Risk Factors Collaboration and Emerging Risk Factors and Emerging Risk Factors Collaboration and Medicinska fakulteten and Institutionen för folkhälsa och klinisk medicin and Allmänmedicin and Umeå universitet
The New England Journal of Medicine, ISSN 0028-4793, 10/2012, Volume 367, Issue 14, pp. 1310 - 1320
In a pooled analysis of data from nearly 250,000 people from 52 studies, the authors estimated the incremental value of C-reactive protein or fibrinogen level... 
RISK PROFILE | MEDICINE, GENERAL & INTERNAL | COST-EFFECTIVENESS | INFLAMMATION | GUIDELINES | CORONARY-HEART-DISEASE | ASSOCIATION | PRIMARY PREVENTION | CARE | Prognosis | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Risk Factors | Proportional Hazards Models | Male | Biomarkers - blood | C-Reactive Protein - metabolism | Mass Screening | Lipids - blood | Fibrinogen - metabolism | Cardiovascular Diseases - blood | Adult | Female | Cohort Studies | Practice Guidelines as Topic | Care and treatment | C-reactive protein | Fibrinogen | Diagnosis | Cardiovascular diseases | Health aspects | Risk factors | Heart attacks | Diabetes mellitus | Data processing | Cardiovascular disease | Reclassification | Cholesterol | Biomarkers | Blood pressure | Smoking | Index Medicus | Abridged Index Medicus | Kardiologi | Clinical Medicine | Cardiac and Cardiovascular Systems | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | cost-effectiveness | metaanalysis | practice guidelines | inflammation | nonvascular mortality | primary prevention | coronary-heart-disease | association | risk profile | statin therapy
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2. Full Text C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis
by Kaptoge, Stephen and Di Angelantonio, Emanuele and Lowe, Gordon and Pepys, Mark B and Thompson, Simon G and Collins, Rory and Danesh, John and Tipping, Robert W and Ford, C. E and Pressel, S. L and Walldius, G and Jungner, I and Folsom, Aaron R and Chambless, L.E and Ballantyne, C. M and Panagiotakos, Demosthenes B and Pitsavos, C and Chrysohoou, C and Stefanadis, Christodoulos and Knuiman, Matthew W and Goldbourt, Uri and Benderly, M and Tanne, David and Whincup, P.H and Wannamethee, S.G and Morris, Richard W and Kiechl, S and Willeit, J and Mayr, A and Schett, G and Wald, N and Ebrahim, S and Lawlor, D.A and Yarnell, J.W and Gallacher, J and Casiglia, Edoardo and Tikhonoff, Valerie and Nietert, Paul J and Sutherland, Susan E and Bachman, D. L and Keil, J. E and Cushman, M and Psaty, Bruce M and Tracy, R and Tybjaerg-Hansen, A and Nordestgaard, B. G and Zacho, J and Frikke-Schmidt, R and Giampaoli, S and Palmieri, L and Panico, S and Vanuzzo, D and Pilotto, L and de la Camara, A. Gomez and Gerique, J. A. Gomez and Simons, Laura and McCallum, J and Friedlander, Yechiel and Fowkes, F. Gerry R and Lee, A and Taylor, Clare J and Guralnik, Jack M and Phillips, Caroline L and Wallace, Robert B and Blazer, Dan G and Khaw, Kay-Tee and Brenner, H and Raum, E and Mueller, Heiko and Rothenbacher, Dietrich and Jansson, J-H and Wennberg, Patrik and Nissinen, A and Donfrancesco, C and Salomaa, Veikko and Harald, K and Jousilahti, P and Vartiainen, E and Woodward, M and D'Agostino, Ralph B., Sr and Wolf, P. A and Vasan, Ramachanan S and Benjamin, Emelia J and Bladbjerg, E.M and Jorgensen, T and Moller, L and Jespersen, J and Dankner, Rachel and Chetrit, A and Lubin, F and Rosengren, Annika and Wilhelmsen, Lars and Lappas, G and Eriksson, HG and Bjorkelund, Cecilia and Lissner, L and Bengtsson, C and Cremer, Peter and Nagel, Dorothea and Tilvis, Reijo S and ... and Emerging Risk Factors Collaboration
Lancet, The, ISSN 0140-6736, 2010, Volume 375, Issue 9709, pp. 132 - 140
Summary Background Associations of C-reactive protein (CRP) concentration with risk of major diseases can best be assessed by long-term prospective follow-up... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | INDEPENDENT PREDICTOR | PLASMA-FIBRINOGEN | REGRESSION DILUTION | INFLAMMATION | CARDIOVASCULAR-DISEASE | PROSPECTIVE COHORTS | LOW-DENSITY LIPOPROTEIN | NONVASCULAR MORTALITY | MENDELIAN RANDOMIZATION | VASCULAR-DISEASE | Blood Pressure | Diabetes Mellitus - blood | Cholesterol - blood | Humans | Middle Aged | Lung Diseases - mortality | Male | Motor Activity | Coronary Disease - mortality | Neoplasms - blood | Lung Diseases - blood | Interleukin-6 - blood | Female | Leukocyte Count | Stroke - mortality | C-Reactive Protein - analysis | Databases, Factual | Body Mass Index | Coronary Disease - blood | Stroke - prevention & control | Risk Assessment | Smoking - blood | Risk Factors | Neoplasms - mortality | Biomarkers - blood | Stroke - blood | Regression Analysis | Coronary Disease - prevention & control | Serum Albumin | Alcohol Drinking - blood | Alcohol Drinking - epidemiology | Smoking - epidemiology | Diabetes Mellitus - epidemiology | Fibrinogen - analysis | Sex Factors | Triglycerides - blood | Proteins | Mortality | Cardiovascular disease | Statistical methods | Blood pressure | Risk factors | Statins | Inflammatory diseases | Meta-analysis | Index Medicus | Abridged Index Medicus | Clinical Medicine | Kirurgisk forskning | Medical and Health Sciences | Medicin och hälsovetenskap | MEDICIN | Surgery | Surgical research | Klinisk medicin | MEDICINE | Kirurgi | Ortopedi | Orthopaedics
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3. Full Text MTHFR 677 C>T polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis
by Antoniades, Charalambos and Shirodaria, Cheerag and Leeson, Paul and Baarholm, Otto A and Van-Assche, Tim and Cunnington, Colin and Pillai, Ravi and Ratnatunga, Chandi and Tousoulis, Dimitris and Stefanadis, Christodoulos and Refsum, Helga and Channon, Keith M
Circulation, ISSN 0009-7322, 05/2009, Volume 119, Issue 18, pp. 2507 - 2515
Background-The role of circulating homocysteine as an atherosclerosis risk factor has recently been questioned. However, 5-methyl-tetrahydrofolate (5-MTHF),... 
Antioxidants | Nitric oxide synthase | Superoxide | Homocysteine | Nitric oxide | Atherosclerosis | atherosclerosis | homocysteine | nitric oxide | CARDIAC & CARDIOVASCULAR SYSTEMS | antioxidants | NITRIC-OXIDE SYNTHASE | FOLIC-ACID | CARDIOVASCULAR-DISEASE | IMPROVEMENT | PERIPHERAL VASCULAR DISEASE | nitric oxide synthase | DYSFUNCTION | superoxide | HEMATOLOGY | PLASMA HOMOCYSTEINE | CORONARY-ARTERY-DISEASE | UREMIC PATIENTS | FOLATE | Mammary Arteries - metabolism | Oxidation-Reduction | Coronary Artery Disease - metabolism | Humans | Middle Aged | Genotype | Male | Homocysteine - metabolism | Methylenetetrahydrofolate Reductase (NADPH2) - metabolism | Phenols - metabolism | Polymorphism, Genetic | Saphenous Vein - metabolism | Tetrahydrofolates - metabolism | Plant Extracts - metabolism | Methylenetetrahydrofolate Reductase (NADPH2) - genetics | Endothelium, Vascular - metabolism | Coronary Artery Disease - genetics | Superoxides - metabolism | Female | Aged | Nitric Oxide - metabolism | Physiological aspects | Development and progression | Vascular endothelium | Genetic aspects | Research | Dihydrofolate reductase | Genetic polymorphisms | Index Medicus | Abridged Index Medicus
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4. Full Text ADMA, C-Reactive Protein, and Albuminuria in Untreated Essential Hypertension: A Cross-sectional Study
by Tsioufis, Costas, MD, PhD and Dimitriadis, Kyriakos, MD and Andrikou, Eirini, MD and Thomopoulos, Costas, MD and Tsiachris, Dimitris, MD and Stefanadi, Elli, MD and Mihas, Costas, MD and Miliou, Antigoni, PhD and Papademetriou, Vassilios, MD, PhD and Stefanadis, Christodoulos, MD, PhD
American Journal of Kidney Diseases, ISSN 0272-6386, 2010, Volume 55, Issue 6, pp. 1050 - 1059
Background Asymmetric dimethylarginine (ADMA) and subclinical inflammation are associated with atherosclerosis progression, whereas microalbuminuria is an... 
Nephrology | atherosclerosis | kidney | inflammation | hypertension | Endothelium | ENDOTHELIAL DYSFUNCTION | CAROTID-ARTERY | ASYMMETRIC DIMETHYLARGININE ADMA | BLOOD-PRESSURE | MICROALBUMINURIA | L-ARGININE | UROLOGY & NEPHROLOGY | STAGE RENAL-DISEASE | CARDIOVASCULAR RISK | PLASMA-CONCENTRATION | Cross-Sectional Studies | Humans | Middle Aged | Endothelium, Vascular - physiopathology | Male | Arginine - analogs & derivatives | Hypertension - physiopathology | Hypertension - metabolism | Albuminuria - physiopathology | Creatinine - metabolism | Regression Analysis | C-Reactive Protein - metabolism | Adult | Female | Albuminuria - metabolism | Blood Pressure - physiology | Arginine - metabolism | Inflammation - physiopathology | Serum Albumin - metabolism | Index Medicus
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5. Full Text The association of the 174G > C polymorphism of interleukin 6 gene with diabetic nephropathy in patients with type 2 diabetes mellitus
by Papaoikonomou, Stavroula and Tentolouris, Nicholas and Tousoulis, Dimitris and Papadodiannis, Dimitris and Miliou, Antigoni and Papageorgiou, Nikolaos and Hatzis, George and Stefanadis, Christodoulos
Journal of Diabetes and Its Complications, ISSN 1056-8727, 2013, Volume 27, Issue 6, pp. 576 - 579
Abstract Aims To evaluate the association of 174G > C polymorphism on interleukin-6 (IL-6) gene with diabetic nephropathy in patients with type 2 diabetes.... 
Endocrinology & Metabolism | Diabetic nephropathy | Gene polymorphism association study | Interleukin-6 174G > C polymorphism | RENAL-FUNCTION | PROMOTER POLYMORPHISM | CYTOKINE | IL-6 | REGION | INFLAMMATION | ENDOCRINOLOGY & METABOLISM | MESANGIAL CELLS | COMPLICATIONS | GROWTH-FACTOR | Genetic Predisposition to Disease | Genetic Association Studies | Interleukin-6 - genetics | Diabetes Mellitus, Type 2 - genetics | Gene Frequency | Humans | Middle Aged | Diabetic Nephropathies - genetics | Genotype | Male | Diabetes Mellitus, Type 2 - epidemiology | Female | Aged | Diabetic Nephropathies - epidemiology | Polymorphism, Single Nucleotide | Diabetes Mellitus, Type 2 - complications | Index Medicus
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6. Full Text Cystatin-C serum levels and vascular function in heart failure
by Tousoulis, Dimitris and Michalea, Stavroula and Siasos, Gerasimos and Oikonomou, Evangelos and Athanasiou, Dimitris and Tourikis, Panagiotis and Kokkou, Eleni and Mazaris, Savvas and Konsola, Theodosia and Papageorgiou, Nikolaos and Stefanadis, Christodoulos
International Journal of Cardiology, ISSN 0167-5273, 2014, Volume 173, Issue 3, pp. 542 - 544
Cardiovascular | Cystatin-C | Heart failure | Vascular function | PRESSURE | CARDIAC & CARDIOVASCULAR SYSTEMS | PROGNOSIS | DYSFUNCTION | OUTCOMES | KIDNEY | Cystatin C - blood | Humans | Middle Aged | Vascular Stiffness - physiology | Heart Failure - physiopathology | Female | Male | Aged | Heart Failure - diagnosis | Biomarkers - blood | Heart Failure - blood | Index Medicus
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7. Full Text Relation of Microalbuminuria to Adiponectin and Augmented C-Reactive Protein Levels in Men With Essential Hypertension
by Tsioufis, Costas and Dimitriadis, Kyriakos and Chatzis, Dimitris and Vasiliadou, Carmen and Tousoulis, Dimitrios and Papademetriou, Vasilios and Toutouzas, Pavlos and Stefanadis, Christodoulos and Kallikazaros, Ioannis
The American Journal of Cardiology, ISSN 0002-9149, 2005, Volume 96, Issue 7, pp. 946 - 951
Microalbuminuria, and recently, hypoadiponectinemia, have been associated with progression of atherosclerotic disease and increased cardiovascular risk. We... 
URINARY ALBUMIN EXCRETION | CARDIAC & CARDIOVASCULAR SYSTEMS | CARDIOVASCULAR-DISEASE | ATHEROSCLEROSIS | PREVENTION | RISK | HYPOADIPONECTINEMIA | ASSOCIATION | BLOOD-PRESSURE | INFLAMMATORY MARKERS | Cardiovascular Diseases - etiology | Cardiovascular Diseases - metabolism | Humans | Middle Aged | Risk Factors | Male | Adiponectin | Intercellular Signaling Peptides and Proteins - blood | Hypertension - blood | Adult | Aged | Albuminuria - urine | C-Reactive Protein - analysis | Hypertension | Development and progression | C-reactive protein | Peptide hormones | Proteins | Cardiovascular disease | Cardiology | Men | Index Medicus | Abridged Index Medicus
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8. Full Text C-reactive protein and endothelial dysfunction: Gazing at the coronaries
by Tousoulis, Dimitris and Papageorgiou, Nikolaos and Latsios, George and Siasos, Gerasimos and Antoniades, Charalambos and Stefanadis, Christodoulos
International Journal of Cardiology, ISSN 0167-5273, 2011, Volume 152, Issue 1, pp. 1 - 3
Cardiovascular | C-reactive protein | Acute coronary syndromes | Atherosclerosis | Endothelium | ATHEROSCLEROTIC LESIONS | MICROVASCULAR DYSFUNCTION | CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | SERUM-AMYLOID-A | PLAQUE | SYSTEMIC INFLAMMATION | PLASMA-LEVELS | CARDIOVASCULAR-DISEASE | EXPRESSION | ARTERY-DISEASE | C-Reactive Protein - metabolism | Coronary Circulation - physiology | Acute Coronary Syndrome - metabolism | Humans | Endothelium, Vascular - physiopathology | Acute Coronary Syndrome - physiopathology | Female | Male | C-Reactive Protein - genetics | Index Medicus
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9. Full Text Genetic Predisposition to Left Ventricular Hypertrophy and the Potential Involvement of Cystatin-C in Untreated Hypertension
by Tousoulis, Dimitris and Androulakis, Emmanuel and Papageorgiou, Nikolaos and Miliou, Antigoni and Chatzistamatiou, Evaggelos and Oikonomou, Evaggelos and Moustakas, George and Kallikazaros, Ioannis and Stefanadis, Christodoulos
American Journal of Hypertension, ISSN 0895-7061, 5/2013, Volume 26, Issue 5, pp. 683 - 690
BACKGROUND The angiotensinogen M235T and aldosterone synthase C-344T gene polymorphisms have been associated with cardiac and structure function. However,... 
blood pressure | aldosterone synthase | hypertrophy | cystatin-C | polymorphism | angiotensinogen | hypertension | SYSTEM | POPULATION | HEART-FAILURE | BLOOD-PRESSURE | ANGIOTENSINOGEN GENE | POLYMORPHISMS | CYP11B2 | ALDOSTERONE SYNTHASE GENE | MASS | PERIPHERAL VASCULAR DISEASE | ASSOCIATION | Cystatin C - physiology | Genetic Predisposition to Disease - genetics | Echocardiography | Prevalence | Cystatin C - blood | Humans | Middle Aged | Male | Biomarkers - blood | Case-Control Studies | Hypertension - physiopathology | Vascular Cell Adhesion Molecule-1 - blood | Hypertension - blood | Angiotensinogen - genetics | C-Reactive Protein - metabolism | Hypertrophy, Left Ventricular - genetics | Alleles | Hypertension - complications | Adult | Female | Intercellular Adhesion Molecule-1 - blood | Aged | Cytochrome P-450 CYP11B2 - genetics | Hypertrophy, Left Ventricular - diagnostic imaging | Hypertension | Medical research | Cell adhesion & migration | Index Medicus
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10. Full Text Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies
by Sarwar, Nadeem and Butterworth, Adam S and Freitag, Daniel F and Gregson, John and Willeit, Peter and Gorman, Donal N and Gao, Pei and Saleheen, Danish and Rendon, Augusto and Nelson, Christopher P and Braund, Peter S and Hall, Alistair S and Chasman, Daniel I and Tybjærg-Hansen, Anne and Chambers, John C and Benjamin, Emelia J and Franks, Paul W and Clarke, Robert and Wilde, Arthur A. M and Trip, Mieke D and Steri, Maristella and Witteman, Jacqueline C. M and Qi, Lu and van der Schoot, C. Ellen and de Faire, Ulf and Erdmann, Jeanette and Stringham, Heather M and Koenig, Wolfgang and Rader, Daniel J and Melzer, David and Reich, David and Psaty, Bruce M and Kleber, Marcus E and Panagiotakos, Demosthenes B and Willeit, Johann and Wennberg, Patrik and Woodward, Mark and Adamovic, Svetlana and Rimm, Eric B and Meade, Tom W and Gillum, Richard F and Shaffer, Jonathan A and Hofman, Albert and Onat, Altan and Sundström, Johan and Wassertheil-Smoller, Sylvia and Mellström, Dan and Gallacher, John and Cushman, Mary and Tracy, Russell P and Kauhanen, Jussi and Karlsson, Magnus and Salonen, Jukka T and Wilhelmsen, Lars and Amouyel, Philippe and Cantin, Bernard and Best, Lyle G and Ben-Shlomo, Yoav and Manson, JoAnn E and Davey-Smith, George and de Bakker, Paul I. W and O'Donnell, Christopher J and Wilson, James F and Wilson, Anthony G and Assimes, Themistocles L and Jansson, John-Olov and Ohlsson, Claes and Tivesten, Åsa and Ljunggren, Östen and Reilly, Muredach P and Hamsten, Anders and Ingelsson, Erik and Cambien, Francois and Hung, Joseph and Thomas, G. Neil and Boehnke, Michael and Schunkert, Heribert and Asselbergs, Folkert W and Kastelein, John J. P and Gudnason, Vilmundur and Salomaa, Veikko and Harris, Tamara B and Kooner, Jaspal S and Allin, Kristine H and Nordestgaard, Børge G and Hopewell, Jemma C and Goodall, Alison H and Ridker, Paul M and Hólm, Hilma and Watkins, Hugh and Ouwehand, Willem H and Samani, Nilesh J and Kaptoge, Stephen and Di Angelantonio, Emanuele and Harari, Olivier and Danesh, John and Quertermous, Thomas and Go, Alan S and Hlatky, Mark A and Knowles, Joshua W and ... and IL6R Genetics Consortium Emerging and IL6R Genetics Consortium Emerging Risk Factors Collaboration and Medicinska fakulteten and Institutionen för folkhälsa och klinisk medicin and Umeå universitet and Medicin
Lancet, The, ISSN 0140-6736, 2012, Volume 379, Issue 9822, pp. 1205 - 1213
Summary Background Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6... 
Internal Medicine | C-REACTIVE PROTEIN | RHEUMATOID-ARTHRITIS | INDIVIDUAL PARTICIPANT METAANALYSIS | MEDICINE, GENERAL & INTERNAL | WOMENS GENOME HEALTH | GENE-EXPRESSION | ATHEROSCLEROSIS | RISK | LOCI | MENDELIAN RANDOMIZATION | ARTERY-DISEASE | Coronary Disease - immunology | Coronary Disease - genetics | Receptors, Interleukin-6 - genetics | Gene Frequency | Humans | Risk Factors | Inflammation Mediators - blood | Genetic Variation - genetics | Signal Transduction - genetics | Causality | Care and treatment | Interleukins | Physiological aspects | Genetic aspects | Cellular signal transduction | Research | Cardiovascular diseases | Genetic variation | Cytokine receptors | Development and progression | Risk factors | Interleukin-6 | Studies | Medical research | Cardiovascular disease | Inventors | Womens health | Index Medicus | Abridged Index Medicus | Clinical Medicine | Allmänmedicin | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | General Practice
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