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2011, 1st ed., ISBN 9780470414118, xii, 302
"Few scientists have the knowledge to perform the studies that are necessary to discover and characterize enzyme inhibitors, despite the vested interest the... 
Enzymes | Enzyme inhibitors | Enzyme Activation | Pharmacokinetics | Drug Discovery | SCIENCE / Life Sciences / Molecular Biology | Enzyme activation
Book
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 1471 - 1471
Abstract Acute Myeloid Leukemia (AML) is a biologically diverse disease with subtypes that can be identified through integrated cytogenetic, mutational, and... 
Journal Article
by D Stein and L Ross
Value in Health : The Journal of the International Society for Pharmacoeconomics and Outcomes Research, ISSN 1098-3015, 05/2017, Volume 20, Issue 5, p. A342
OBJECTIVES: The growing importance of real-world evidence (RWE) has resulted in the need to generate and evaluate more data under tighter timelines. We aim to... 
Health care | Medical research | Accessibility | Data protection | Innovations | Clinical trials | Data processing | Oncology | Patients | Electronic medical records | Clinical outcomes | Clinical assessment | Chart reviews | Privacy | Execution | Confidentiality | Technology | Consent | Respiratory diseases | Barriers | Data collection | Evidence | Robustness | Ethics committees
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 4053 - 4053
Abstract Background: The prognosis for acute myeloid leukemia (AML) patients age >60 years is poor. Rapid pre-treatment identification of molecular disease... 
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 287 - 287
Abstract The majority of patients with acute myeloid leukemia (AML), including nearly all patients older than age 60, present with multiple, sequentially... 
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 1489 - 1489
Abstract Introduction: In contrast to younger pts with AML, those ages 60 years (y) and above often have multiple, sequentially acquired, somatic mutations... 
Journal Article
JAMA Ophthalmology, ISSN 2168-6165, 08/2016, Volume 134, Issue 8, p. 888
  Anti-vascular endothelial growth factor (VEGF) medicines have revolutionized diabetic macular edema (DME) treatment. A recent randomized clinical trial... 
Prescription drugs | Edema | Medical treatment | Cost analysis | Comparative analysis | Eyes & eyesight
Journal Article
Blood, ISSN 0006-4971, 11/2013, Volume 122, Issue 21, pp. 109 - 109
Abstract We recently reported that the induction of polyploidization of malignant megakaryocytes shows great promise as a new therapy for acute leukemia.... 
Journal Article
2011, ISBN 9780470414118
"Few scientists have the knowledge to perform the studies that are necessary to discover and characterize enzyme inhibitors, despite the vested interest the... 
Enzymes | Enzyme inhibitors | Enzyme Activation | Pharmacokinetics | Drug Discovery
Web Resource
by Do, Ron and Stitziel, Nathan O and Won, Hong-Hee and Jørgensen, Anders Berg and Duga, Stefano and Angelica Merlini, Pier and Kiezun, Adam and Farrall, Martin and Goel, Anuj and Zuk, Or and Guella, Illaria and Asselta, Rosanna and Lange, Leslie A and Peloso, Gina M and Auer, Paul L and Girelli, Domenico and Martinelli, Nicola and Farlow, Deborah N and DePristo, Mark A and Roberts, Robert and Stewart, Alexander F. R and Saleheen, Danish and Danesh, John and Epstein, Stephen E and Sivapalaratnam, Suthesh and Hovingh, G. Kees and Kastelein, John J and Samani, Nilesh J and Schunkert, Heribert and Erdmann, Jeanette and Shah, Svati H and Kraus, William E and Davies, Robert and Nikpay, Majid and Johansen, Christopher T and Wang, Jian and Hegele, Robert A and Hechter, Eliana and Marz, Winfried and Kleber, Marcus E and Huang, Jie and Johnson, Anew D and Li, Mingyao and Burke, Greg L and Gross, Myron and Liu, Yongmei and Assimes, Themistocles L and Heiss, Gerardo and Lange, Ethan M and Folsom, Aaron R and Taylor, Herman A and Olivieri, Oliviero and Hamsten, Anders and Clarke, Robert and Reilly, Dermot F and Yin, Wu and Rivas, Manuel A and Donnelly, Peter and Rossouw, Jacques E and Psaty, Bruce M and Herrington, David M and Wilson, James G and Rich, Stephen S and Bamshad, Michael J and Tracy, Russell P and Cupples, L. Aienne and Rader, Daniel J and Reilly, Muredach P and Spertus, John A and Cresci, Sharon and Hartiala, Jaana and Tang, W. H. Wilson and Hazen, Stanley L and Allayee, Hooman and Reiner, Alex P and Carlson, Christopher S and Kooperberg, Charles and Jackson, Rebecca D and Boerwinkle, Eric and Lander, Eric S and Schwartz, Stephen M and Siscovick, David S and McPherson, Ruth and Tybjaerg-Hansen, Anne and Abecasis, Goncalo R and Watkins, Hugh and Nickerson, Deborah A and Ardissino, Diego and Sunyaev, Shamil R and O'Donnell, Christopher J and Altshuler, David and Gabriel, Stacey and Kathiresan, Sekar and Gabriel, Stacey B and Altshuler, David M and Abecasis, Gonçalo R and Daly, Mark J and de Bakker, Paul I. W and Fennell, Tim and Garimella, Kiran and ... and NHLBI Exome Sequencing Project
Nature, ISSN 0028-0836, 2015, Volume 518, Issue 7537, pp. 102 - +
Journal Article
Blood, ISSN 0006-4971, 11/2013, Volume 122, Issue 21, pp. 1328 - 1328
Abstract Xenotransplantation of primary AML samples into immunodeficient mice (PDX models) represents a unique opportunity for pre-clinical testing on a group... 
Journal Article
Clinical Lymphoma, Myeloma & Leukemia, ISSN 2152-2650, 2014, Volume 14, Issue 6, pp. e229 - e229
Journal Article
Blood, ISSN 0006-4971, 12/2014, Volume 124, Issue 21, pp. 2984 - 2984
Abstract High throughput genomic studies have identified novel recurrent somatic alterations with prognostic or therapeutic relevance in hematological... 
Journal Article
Blood, ISSN 0006-4971, 12/2014, Volume 124, Issue 21, pp. 1039 - 1039
Abstract Genome and exome sequencing have provided important insights into the biology of hematologic malignancies, and have led to the identification of... 
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 06/2007, Volume 356, Issue 25, pp. 2591 - 2602
Journal Article