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Cancer Letters, ISSN 0304-3835, 2016, Volume 385, pp. 160 - 167
Abstract Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is overexpressed in malignant tumors and involved in DNA damage response upon ionizing radiation... 
Hematology, Oncology and Palliative Medicine | hnRNPK | Ionizing radiation | KRAS | Colorectal carcinoma | MEK inhibition | MESSENGER-RNA TRANSLATION | PROTEIN | PHOSPHORYLATION | DNA-DAMAGE | P53 | RECTAL-CANCER | NASOPHARYNGEAL CARCINOMA | INHIBITION | ONCOLOGY | POOR-PROGNOSIS | PROMOTES | Up-Regulation | Apoptosis - radiation effects | Proto-Oncogene Proteins p21(ras) - genetics | Colorectal Neoplasms - genetics | Heterogeneous-Nuclear Ribonucleoprotein K | Humans | Middle Aged | Colorectal Neoplasms - radiotherapy | Gene Expression Regulation, Neoplastic | Male | Transfection | RNA Interference | Time Factors | Aged, 80 and over | Female | Ribonucleoproteins - genetics | Signal Transduction - radiation effects | MAP Kinase Kinase Kinases - antagonists & inhibitors | Chorioallantoic Membrane - blood supply | Colorectal Neoplasms - enzymology | Genetic Predisposition to Disease | Cell Cycle - radiation effects | Radiation Tolerance - genetics | MAP Kinase Kinase Kinases - metabolism | Ribonucleoproteins - metabolism | Chick Embryo | Radiation Tolerance - drug effects | Phenotype | Animals | Signal Transduction - drug effects | Cell Line, Tumor | Aged | Biomarkers, Tumor - genetics | Protein Kinase Inhibitors - pharmacology | Mutation | Colorectal Neoplasms - pathology | Dose-Response Relationship, Radiation | Carcinoma | DNA repair | Colorectal cancer | Cancer | Cell growth | Immunoglobulins | DNA damage | Colleges & universities | Melanoma | Software | Kinases | Experiments | Skin cancer | Tumors
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2011, Volume 6, Issue 11, p. e27045
Background: Abelson-interacting protein 1 (Abi-1) plays an important role for dendritic branching and synapse formation in the central nervous system. It is... 
NERVOUS-SYSTEM | XENOPUS-LAEVIS | MESSENGER-RNA TRANSLATION | DOMAIN PROTEINS | STEM-CELLS | MULTIDISCIPLINARY SCIENCES | SYNAPSE FORMATION | CELL-PROLIFERATION | N-WASP | BINDING | HNRNP-K | NIH 3T3 Cells | RNA, Small Interfering - genetics | Immunoprecipitation | Actins - metabolism | Cercopithecus aethiops | Neurons - cytology | Immunoenzyme Techniques | Heterogeneous-Nuclear Ribonucleoprotein K - antagonists & inhibitors | Cell Nucleus - metabolism | In Situ Hybridization | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Neurons - metabolism | Synapses - physiology | Cells, Cultured | Dendritic Spines - physiology | Rats | Hippocampus - cytology | Heterogeneous-Nuclear Ribonucleoprotein K - genetics | Blotting, Western | Hippocampus - metabolism | Two-Hybrid System Techniques | Heterogeneous-Nuclear Ribonucleoprotein K - metabolism | Phenotype | Animals | Pseudopodia - metabolism | Adaptor Proteins, Signal Transducing - genetics | Mice | Adaptor Proteins, Signal Transducing - metabolism | COS Cells | RNA | Muscle proteins | Actin | Neurons | Protein binding | Cerebellum | Brain | Neurosciences | Phosphorylation | Synaptogenesis | Spine | Central nervous system | Intracellular signalling | Nervous system | Biology | mRNA | Kinases | Proteins | Morphogenesis | Dendritic spines | Cell growth | Cascades | Binding | Neurochemistry | RNA-mediated interference | Granule cells | Polymerization | Pseudopodia | Gene expression | Ribonucleic acid--RNA | Ribonucleoprotein K | Morphology | Stem cells | Cytoskeleton | Ligands | Nuclei (cytology) | Postsynaptic density | Dendritic branching | Synapses | Hippocampus | Ribonucleic acid
Journal Article
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, ISSN 1107-3756, 12/2018, Volume 42, Issue 6, pp. 3269 - 3277
Ionizing radiation (IR) is frequently applied in the treatment of rectal adenocarcinoma, however, there is marked variance in the response to radiochemotherapy... 
CARCINOMA-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | PHOSPHORYLATION | DNA-DAMAGE | DOWN-REGULATION | p21 | NUCLEAR RIBONUCLEOPROTEIN-K | p53 | KRAS MUTATIONS | rectal adenocarcinoma | PREOPERATIVE RADIOCHEMOTHERAPY | COLORECTAL-CANCER | RADIORESISTANCE | radiotherapy | hnRNP K | IONIZING-RADIATION
Journal Article
PATHOLOGE, ISSN 0172-8113, 12/2018, Volume 39, Issue Suppl 2, pp. 225 - 230
BackgroundThe ability of tumor cells to leave the primary tumor is prerequisite for metastatic spread. In previous studies, we identified regulator proteins of... 
NUCLEAR RIBONUCLEOPROTEIN K | COMPLEX | INHIBITION | Synaptogenesis | Radioresistance | N-WASP | Metastasis | CANCER-CELL MIGRATION | PATHOLOGY | Cell migration | Invasion | HNRNP-K | Phosphorylation | Animals | Signal Transduction | Actins | Cell Line, Tumor | Colorectal Neoplasms | Antineoplastic Agents - therapeutic use | Cell Movement
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, p. e40671
Background: Abelson interactor 1 (Abi1) is an important regulator of actin dynamics during cytoskeletal reorganization. In this study, our aim was to... 
MIGRATION | COMPLEX | INVASION | PROTEIN | SERRATED POLYPS | PATHWAY | COLORECTAL-CANCER | MULTIDISCIPLINARY SCIENCES | RECEPTOR | CELL-ADHESION | CARCINOMA | Immunohistochemistry | Inflammation - pathology | ras Proteins - genetics | Colonic Neoplasms - genetics | Proto-Oncogene Proteins p21(ras) | Adenoma - genetics | Humans | Middle Aged | Male | Intestinal Mucosa - drug effects | Neoplasm Metastasis | Transfection | Cell Transformation, Neoplastic - genetics | Cytoskeletal Proteins - metabolism | Female | Proto-Oncogene Proteins - genetics | Mutation - genetics | Tumor Necrosis Factor-alpha - pharmacology | Models, Biological | Proto-Oncogene Proteins B-raf - genetics | Colonic Neoplasms - pathology | Adenoma - pathology | Cell Line, Tumor | Aged | Cell Transformation, Neoplastic - drug effects | Adaptor Proteins, Signal Transducing - metabolism | Cell Transformation, Neoplastic - pathology | Intestinal Mucosa - pathology | Colon cancer | Gene mutations | Actin | Tumor necrosis factor | Development and progression | Genetic aspects | Inflammation | Metastasis | Muscle proteins | Biotechnology | Downstream effects | Mucosa | Colorectal carcinoma | Colorectal cancer | Immunoblotting | Inflammatory response | Kinases | Carcinogenesis | K-Ras protein | Metastases | Proteins | Carcinogens | Abi1 protein | Tumorigenesis | Localization | Microsatellites | Invasiveness | Aerospace medicine | Breast cancer | Tumor cell lines | Gene expression | Accident investigations | 1-Phosphatidylinositol 3-kinase | Pathology | Signaling | Chemotherapy | Wortmannin | Cell lines | Epigenetics | Cytoskeleton | Mutation | Polyps | Tumors
Journal Article
Der Pathologe, ISSN 0172-8113, 12/2018, Volume 39, Issue S2, pp. 225 - 230
Die metastatische Ausbreitung maligner Neoplasien setzt voraus, dass Tumorzellen die Fähigkeit entwickeln, den Primärtumor zu verlassen. In Vorarbeiten wurden... 
Zellmigration | Pathology | Medicine & Public Health | Synaptogenese | Synaptogenesis | Radioresistance | Metastasis | Invasion | Metastasierung | Strahlenresistenz | Cell migration
Journal Article
Der Pathologe, ISSN 0172-8113, 12/2018, Volume 39, Issue 2, p. 225
Hintergrund Zum Einsatz kamen immunhistochemische Expressionsanalysen an Gewebeschnitten sowie in-vitro-Arbeiten (Zellkultur, Fluoreszenzmikroskopie,... 
Journal Article
Pathologe, ISSN 0172-8113, 12/2018, Volume 39, pp. 225 - 230
Journal Article
Molecular Cancer, ISSN 1476-4598, 06/2014, Volume 13, Issue 1, p. 145
Journal Article
Journal Article
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 11/2018, Volume 128, Issue 11, pp. 5056 - 5072
Journal Article
PLOS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e65189
Journal Article
ONCOTARGET, 07/2015, Volume 6, Issue 19, pp. 17178 - 17191
Background: Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is an important cofactor in the p53-mediated DNA damage response pathway upon ionizing... 
CYTOPLASMIC ACCUMULATION | MESSENGER-RNA TRANSLATION | PROTEIN | DNA-DAMAGE | melanoma | BRAF | nRNP K | CELL BIOLOGY | NRAS | GAMMA-H2AX FOCI | COLORECTAL-CANCER | CUTANEOUS MELANOMA | radiotherapy | IONIZING-RADIATION | CARCINOMA | MEK inhibition
Journal Article