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by Waddell, Nicola and Pajic, Marina and Patch, Ann-Marie and Chang, David K and Kassahn, Karin S and Bailey, Peter and Johns, Amber L and Miller, David and Nones, Katia and Quek, Kelly and Quinn, Michael C. J and Robertson, Alan J and Fadlullah, Muhammad Z. H and Bruxner, Tim J. C and Christ, Angelika N and Harliwong, Ivon and Idrisoglu, Senel and Manning, Suzanne and Nourse, Craig and Nourbakhsh, Ehsan and Wani, Shivangi and Wilson, Peter J and Markham, Emma and Cloonan, Nicole and Anderson, Matthew J and Fink, J. Lynn and Holmes, Oliver and Kazakoff, Stephen H and Leonard, Conrad and Newell, Felicity and Poudel, Barsha and Song, Sarah and Taylor, Darrin and Waddell, Nick and Wood, Scott and Xu, Qinying and Wu, Jianmin and Pinese, Mark and Cowley, Mark J and Lee, Hong C and Jones, Marc D and Nagrial, Adnan M and Humphris, Jeremy and Chantrill, Lorraine A and Chin, Venessa and Steinmann, Angela M and Mawson, Amanda and Humphrey, Emily S and Colvin, Emily K and Chou, Angela and Scarlett, Christopher J and Pinho, Andreia V and Giry-Laterriere, Marc and Rooman, Ilse and Samra, Jaswinder S and Kench, James G and Pettitt, Jessica A and Merrett, Neil D and Toon, Christopher and Epari, Krishna and Nguyen, Nam Q and Barbour, Andrew and Zeps, Nikolajs and Jamieson, Nigel B and Graham, Janet S and Niclou, Simone P and Bjerkvig, Rolf and Grützmann, Robert and Aust, Daniela and Hruban, Ralph H and Maitra, Anirban and Iacobuzio-Donahue, Christine A and Wolfgang, Christopher L and Morgan, Richard A and Lawlor, Rita T and Corbo, Vincenzo and Bassi, Claudio and Falconi, Massimo and Zamboni, Giuseppe and Tortora, Giampaolo and Tempero, Margaret A and Gill, Anthony J and Eshleman, James R and Pilarsky, Christian and Scarpa, Aldo and Musgrove, Elizabeth A and Pearson, John V and Biankin, Andrew V and Grimmond, Sean M and Australian Pancreatic Canc Genome and Australian Pancreatic Cancer Genome Initiative
Nature, ISSN 0028-0836, 02/2015, Volume 518, Issue 7540, pp. 495 - 501
Journal Article
Gut, ISSN 0017-5749, 12/2018, Volume 67, Issue 12, pp. 2142 - 2155
ObjectiveExtensive molecular heterogeneity of pancreatic ductal adenocarcinoma (PDA), few effective therapies and high mortality make this disease a prime... 
molecular mechanisms | pancreatic cancer | cell cycle | extracellular matrix | KINASE 4/6 INHIBITOR | BREAST-CANCER | SURVIVAL | PALBOCICLIB | THERAPY | DUCTAL ADENOCARCINOMA | NAB-PACLITAXEL | FULVESTRANT | CELL-CYCLE | GASTROENTEROLOGY & HEPATOLOGY | GEMCITABINE | Phosphorylation | Pancreatic Neoplasms - metabolism | Prognosis | Humans | Pancreatic Neoplasms - pathology | Retinoblastoma Protein - metabolism | Carcinoma, Pancreatic Ductal - metabolism | Antineoplastic Agents - therapeutic use | Piperazines - therapeutic use | Carcinoma, Pancreatic Ductal - pathology | Pancreatic Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice, Nude | Biomarkers, Tumor - metabolism | Mice, Inbred BALB C | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Molecular Targeted Therapy - methods | Disease Models, Animal | Pyridines - therapeutic use | Cell proliferation | Adenocarcinoma | Animal models | Genomes | Shear stresses | Metastasis | Kinases | Cancer therapies | Phase transitions | Cyclin-dependent kinase 4 | Metastases | Proteins | Cyclin-dependent kinase | Signal transduction | Cell cycle | Extracellular matrix | Cyclin D | Cyclin-dependent kinases | Retinoblastoma protein | Breast cancer | Patients | Chemotherapy | Molecular modelling | Pancreatic cancer | Biomarkers | Genetic engineering | Clinical medicine | Mutation | Retinoblastoma | Apoptosis | Tumors | 2312 | Pancreas | 1506
Journal Article
by Vennin, C and Melenec, P and Rouet, R and Nobis, M and Cazet, AS and Murphy, KJ and Herrmann, D and Reed, DA and Lucas, MC and Warren, SC and Elgundi, Z and Pinese, M and Kalna, G and Roden, D and Samuel, M and Zaratzian, A and Grey, ST and Da Silva, A and Leung, W and Mathivanan, S and Wang, YX and Braithwaite, AW and Christ, D and Benda, A and Parkin, A and Phillips, PA and Whitelock, JM and Gill, AJ and Sansom, OJ and Croucher, DR and Parker, BL and Pajic, M and Morton, JP and Cox, TR and Timpson, P and Johns, AL and Chantrill, LA and Chou, A and Steinmann, A and Arshi, M and Dwarte, T and Froio, D and Pereira, B and Ritchie, S and Chambers, CR and Metcalf, X and Waddell, N and Pearson, JV and Patch, AM and Nones, K and Newell, F and Mukhopadhyay, P and Addala, V and Kazakoff, S and Holmes, O and Leonard, C and Wood, S and Grimmond, SM and Hofmann, O and Christ, A and Bruxner, T and Samra, JS and Pavlakis, N and High, HA and Asghari, R and Merrett, ND and Pavey, D and Das, A and Cosman, PH and Ismail, K and O'Connnor, C and Stoita, A and Williams, D and Spigellman, A and Lam, VW and McLeod, D and Kirk, J and Kench, JG and Grimison, P and Cooper, CL and Sandroussi, C and Goodwin, A and Mead, RS and Tucker, K and Andrews, L and Texler, M and Forest, C and Epari, KP and Ballal, M and Fletcher, DR and Mukhedkar, S and Zeps, N and Beilin, M and Feeney, K and Nguyen, NQ and Ruszkiewicz, AR and Worthley, C and Chen, J and Brooke-Smith, ME and Papangelis, V and ... and APGI and Australian Pancreatic Genome Initiative (APGI)
NATURE COMMUNICATIONS, ISSN 2041-1723, 08/2019, Volume 10, Issue 1, pp. 3637 - 22
Heterogeneous subtypes of cancer-associated fibroblasts (CAFs) coexist within pancreatic cancer tissues and can both promote and restrain disease progression.... 
Journal Article
by Zappi, Daniela C and Ranzato Filardi, Fabiana L and Leitman, Paula and Souza, Vinícius C and Walter, Bruno M.T and Pirani, José R and Morim, Marli P and Queiroz, Luciano P and Cavalcanti, Taciana B and Mansano, Vidal F and Forzza, Rafaela C and Abreu, Maria C and Acevedo-Rodríguez, Pedro and Agra, Maria F and Almeida, Eduardo B and Almeida, Gracineide S.S and Almeida, Rafael F and Alves, Flávio M and Alves, Marccus and Alves-Araujo, Anderson and Amaral, Maria C.E and Amorim, André M and Amorim, Bruno and Andrade, Ivanilza M and Andreata, Regina H.P and Andrino, Caroline O and Anunciação, Elisete A and Aona, Lidyanne Y.S and Aranguren, Yani and Aranha Filho, João L.M and Araújo, Andrea O and Araújo, Ariclenes A.M and Araújo, Diogo and Arbo, María M and Assis, Leandro and Assis, Marta C and Assunção, Vivian A and Athiê-Souza, Sarah M and Azevedo, Cecilia O and Baitello, João B and Baitello, João B and Barberena, Felipe F.V.A and Barbosa, Maria R.V and Barros, Fábio and Barros, Lucas A.V and Barros, Michel J.F and Baumgratz, José F.A and Bernacci, Luis C and Berry, Paul E and Bigio, Narcísio C and Biral, Leonardo and Bittrich, Volker and Borges, Rafael A.X and Bortoluzzi, Roseli L.C and Bove, Cláudia P and Bovini, Massimo G and Braga, João M.A and Braz, Denise M and Bringel, João B.A and Bruniera, Carla P and Buturi, Camila V and Cabral, Elza and Cabral, Fernanda N and Caddah, Mayara K and Caires, Claudenir S and Calazans, Luana S.B and Calió, Maria F and Camargo, Rodrigo A and Campbell, Lisa and Canto-Dorow, Thais S and Carauta, Jorge P.P and Cardiel, José M and Cardoso, Domingos B.O.S and Cardoso, Leandro J.T and Carneiro, Camila R and Carneiro, Cláudia E and Carneiro-Torres, Daniela S and Carrijo, Tatiana T and Caruzo, Maria B.R and Carvalho, Maria L.S and Carvalho-Silva, Micheline and Castello, Ana C.D and Cavalheiro, Larissa and Cervi, Armando C and Chacon, Roberta G and Chautems, Alain and Chiavegatto, Berenice and Chukr, Nádia S and Coelho, Alexa A.O.P and Coelho, Marcus A.N and Coelho, Rubens L.G and Cordeiro, Inês and Cordula, Elizabeth and Cornejo, Xavier and Côrtes, Ana L.A and Costa, Andrea F and Costa, Fabiane N and Costa, Jorge A.S and Costa, Leila C and Costa-e-Silva, Maria B and ...
Rodriguesia, ISSN 0370-6583, 10/2015, Volume 66, Issue 4, pp. 1085 - 1113
Abstract An updated inventory of Brazilian seed plants is presented and offers important insights into the country's biodiversity. This work started in 2010,... 
Biomes | Life-forms | Endemism | Angiosperms | Gymnosperms | life-forms | endemism | biomes
Journal Article
by Balachandran, Vinod P and Luksza, Marta and Zhao, Julia N and Makarov, Vladimir and Moral, John Alec and Remark, Romain and Herbst, Brian and Askan, Gokce and Bhanot, Umesh and Senbabaoglu, Yasin and Wells, Daniel K and Cary, Charles Ian Ormsby and Grbovic-Huezo, Olivera and Attiyeh, Marc and Medina, Benjamin and Zhang, Jennifer and Loo, Jennifer and Saglimbeni, Joseph and Abu-Akeel, Mohsen and Zappasodi, Roberta and Riaz, Nadeem and Smoragiewicz, Martin and Kelley, Z. Larkin and Basturk, Olca and Gönen, Mithat and Levine, Arnold J and Allen, Peter J and Fearon, Douglas T and Merad, Miriam and Gnjatic, Sacha and Iacobuzio-Donahue, Christine A and Wolchok, Jedd D and DeMatteo, Ronald P and Chan, Timothy A and Greenbaum, Benjamin D and Merghoub, Taha and Leach, Steven D and Australian Pancreatic Canc Genom and Garvan Institute of Medical Research and Bankstown Hospital and St Vincent’s Hospital and Royal Adelaide Hospital and Royal North Shore Hospital and Envoi Pathology and QIMR Berghofer Medical Research Institute and Prince of Wales Hospital and University of Melbourne, Centre for Cancer Research and University of Queensland, Institute for Molecular Bioscience and Royal Prince Alfred Hospital, Chris O’Brien Lifehouse and Princess Alexandria Hospital and Fremantle Hospital and Liverpool Hospital and Austin Hospital and University of Glasgow and Johns Hopkins Medical Institutes and Flinders Medical Centre and Westmead Hospital and St John of God Healthcare and ARC-Net Centre for Applied Research on Cancer and Australian Pancreatic Cancer Genome Initiative
Nature, ISSN 0028-0836, 11/2017, Volume 551, Issue 7681, pp. S12 - S16
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2015, Volume 10, Issue 12, p. e0144203
Journal Article
Science Translational Medicine, ISSN 1946-6234, 04/2017, Volume 9, Issue 384, pp. eaai8504 - eaai8504
The emerging standard of care for patients with inoperable pancreatic cancer is a combination of cytotoxic drugs gemcitabine and Abraxane, but patient response... 
MIGRATION | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | DUCTAL ADENOCARCINOMA | CELL INVASION | RHO-KINASE/ROCK | TUMOR | TENSION | EXTRACELLULAR-MATRIX | CLEAVAGE FURROW | REVEALS | CELL BIOLOGY | Liver - pathology | Humans | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Extracellular Matrix - metabolism | Deoxycytidine - pharmacology | Antineoplastic Agents - therapeutic use | rho-Associated Kinases - antagonists & inhibitors | CDC2 Protein Kinase - metabolism | Pancreatic Neoplasms - drug therapy | Deoxycytidine - therapeutic use | Neoplasm Metastasis | rho-Associated Kinases - metabolism | Actin Cytoskeleton - drug effects | src-Family Kinases - metabolism | Albumin-Bound Paclitaxel - therapeutic use | Antineoplastic Agents - pharmacology | Actin Cytoskeleton - metabolism | Neoplasm Invasiveness | Pancreatic Neoplasms - pathology | Albumin-Bound Paclitaxel - pharmacology | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - therapeutic use | Treatment Outcome | Disease Progression | Collagen - metabolism | Animals | Signal Transduction - drug effects | Protein Kinase Inhibitors - therapeutic use | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Biosensing Techniques | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Deoxycytidine - analogs & derivatives
Journal Article