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Trends in Cell Biology, ISSN 0962-8924, 10/2018, Volume 28, Issue 10, p. 776
Microtubule-targeting agents (MTAs) such as paclitaxel and the vinca alkaloids are among the most important medical weapons available to combat cancer. MTAs... 
Cell proliferation | Dynamic structural analysis | Kinases | Cancer therapies | Antimitotic agents | Alkaloids | Cell growth | Molecular modelling | Tubulin | Cell death | Microtubules | Paclitaxel | Cytoskeleton | Apoptosis | Cancer | Structural analysis
Journal Article
Journal of cell science, ISSN 0021-9533, 06/2019, Volume 132, Issue 11, p. jcs227850
Microtubules are cytoskeletal filaments essential for numerous aspects of cell physiology. They are polarized polymeric tubes with a fast growing plus end and... 
Spindle pole | Gamma-tubulin ring complex | Microtubule | Centrosome | Dynein | CAMSAP | CYTOPLASMIC DYNEIN | COMPLEX | SPINDLE POLES | STRUCTURAL MODEL | DYNAMIC INSTABILITY | CELL BIOLOGY | ORGANIZATION | PROTEIN ASP | NUCLEATION | TUBULIN
Journal Article
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 04/2008, Volume 9, Issue 4, pp. 309 - 322
Journal Article
Structure, ISSN 0969-2126, 04/2018, Volume 26, Issue 4, pp. 607 - 618.e4
In budding yeast, the microtubule plus-end tracking proteins Bik1 (CLIP-170) and Bim1 (EB1) form a complex that interacts with partners involved in spindle... 
X-ray crystallography | microtubule plus-end tracking proteins | structure-function relationship | CAP-Gly domains | protein-protein interactions | MICROTUBULE PLUS END | BIOCHEMISTRY & MOLECULAR BIOLOGY | SPINDLE | SACCHAROMYCES-CEREVISIAE | CAP-GLY DOMAINS | CELL BIOLOGY | YEAST | TIP LOCALIZATION SIGNAL | BIOPHYSICS | STRUCTURE VALIDATION | DYNAMICS | CLIP-170 | END-TRACKING PROTEINS | Microtubule-Associated Proteins - chemistry | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Spindle Apparatus - chemistry | Crystallography, X-Ray | Saccharomyces cerevisiae - ultrastructure | Structure-Activity Relationship | Cell Cycle Proteins - chemistry | Saccharomyces cerevisiae - metabolism | Microtubule Proteins - chemistry | Cell Division | Cloning, Molecular | Escherichia coli - metabolism | Microtubules - ultrastructure | Cell Cycle Proteins - genetics | Microtubules - chemistry | Microtubule Proteins - genetics | Protein Interaction Domains and Motifs | Nuclear Proteins - genetics | Spindle Apparatus - ultrastructure | Binding Sites | Recombinant Proteins - metabolism | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | Genetic Vectors - chemistry | Cell Cycle Proteins - metabolism | Genetic Vectors - metabolism | Microtubule Proteins - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Nuclear Proteins - metabolism | Recombinant Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Nuclear Proteins - chemistry | Saccharomyces cerevisiae - chemistry | Sequence Homology, Amino Acid | Sequence Alignment | Protein Conformation, beta-Strand | Escherichia coli - genetics | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Evolution, Molecular | Saccharomyces cerevisiae Proteins - chemistry | Proteins | Phenylalanine | Analysis | Crystals | Glycine | Structure | Protein-protein interactions
Journal Article
eLife, ISSN 2050-084X, 09/2019, Volume 8
In eukaryotes, the organization and function of the microtubule cytoskeleton depend on the allocation of different roles to individual microtubules. For... 
Proteins | Phosphorylation | Spindle pole bodies | Yeast | Microtubules | Centrosomes | Dynein | Polymerization | Cytoskeleton | Behavior | Kinesin | Remote control
Journal Article
Bioscience Reports, ISSN 0144-8463, 09/2018, Volume 38, Issue 5, pp. 1 - 11
Coiled-coils are ubiquitous protein-protein interaction motifs found in many eukaryotic proteins. The elongated, flexible and often irregular nature of... 
DOMAIN | MOLECULAR-REPLACEMENT | ANOMALOUS DIFFRACTION | WAVELENGTH | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CRYSTAL-STRUCTURES | PREDICTION | CELL BIOLOGY | Index Medicus
Journal Article
ISSN 2041-1723, 2018
Microtubule-targeting agents (MTAs) like taxol and vinblastine are amongst the most successful chemotherapeutic drugs against cancer. Here, we describe a... 
Journal Article
Bioscience Reports, ISSN 0144-8463, 10/2018, Volume 38, Issue 5
Coiled-coils are ubiquitous protein–protein interaction motifs found in many eukaryotic proteins. The elongated, flexible and often irregular nature of... 
Proteins | X-ray crystallography | Coils | Domains | Mutagenesis | Coiling | Crystals | Sulfur | Crystallography | Combinatorial analysis | Phasing
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 1364 - 1364
Journal Article
Trends in Cell Biology, ISSN 0962-8924, 10/2018, Volume 28, Issue 10, pp. 776 - 792
Microtubule-targeting agents (MTAs) such as paclitaxel and the vinca alkaloids are among the most important medical weapons available to combat cancer. MTAs... 
microtubule-targeting agents | tubulin-ligand binding modes | molecular mechanisms of action | COLCHICINE BINDING-SITE | DOMAIN | COMPLEX | ALPHA-BETA-TUBULIN | MECHANISM | STRUCTURAL BASIS | INHIBITORS | ANTITUMOR-ACTIVITY | ANTITUBULIN ACTIVITY | PIRONETIN | CELL BIOLOGY
Journal Article
International Journal of Biomedicine, ISSN 2158-0510, 06/2019, Volume 9, Issue Suppl_1, pp. S9 - S9
Background: Microtubules are dynamic protein filaments that are crucial for cell division and constitute key elements of the cytoskeleton. They are assembled... 
microtubule | microtubule-stabilizing agents | cryo-EM
Journal Article
Science, ISSN 0036-8075, 2/2013, Volume 339, Issue 6119, pp. 587 - 590
Journal Article