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01/2014, ISBN 9814630160
Book Chapter
Journal Article
Science, ISSN 0036-8075, 8/2000, Volume 289, Issue 5481, pp. 920 - 930
Using the atomic structures of the large ribosomal subunit from Haloarcula marismortui and its complexes with two substrate analogs, we establish that the... 
Phosphates | Molecules | RNA | Active sites | Hydrogen bonds | Ribosomes | Chemical bases | Atoms | Research Articles | Transfer RNA | Tunnels | LOCATION | RIBOZYME | PROTEIN | RECOGNITION | MULTIDISCIPLINARY SCIENCES | COLI RIBOSOME | A-SITE | TRANSFER-RNA | TRANSLATION | MICROSCOPY | SUBUNIT | Ribosomal Proteins - chemistry | Haloarcula marismortui - metabolism | Haloarcula marismortui - ultrastructure | RNA, Archaeal - chemistry | RNA, Catalytic - metabolism | Archaeal Proteins - chemistry | Phosphates - chemistry | Molecular Sequence Data | Ribosomes - metabolism | Ribosomal Proteins - metabolism | Haloarcula marismortui - chemistry | Peptide Biosynthesis | Peptides - metabolism | Base Sequence | RNA, Transfer, Amino Acyl - metabolism | Catalysis | Nucleic Acid Conformation | RNA, Catalytic - chemistry | Binding Sites | Peptidyl Transferases - antagonists & inhibitors | Archaeal Proteins - metabolism | Peptidyl Transferases - metabolism | RNA, Transfer - metabolism | Peptidyl Transferases - chemistry | Puromycin - metabolism | Crystallization | Ribosomes - chemistry | Models, Molecular | RNA, Ribosomal, 23S - chemistry | Oligonucleotides - metabolism | Phosphates - metabolism | Base Pairing | Hydrogen Bonding | RNA, Archaeal - metabolism | Protein Conformation | RNA, Ribosomal, 23S - metabolism | Evolution, Molecular | Hydrogen-Ion Concentration | Proteins | Synthesis | Peptides | Biochemistry | Research | Structure | Bacteria | Chemistry | Ribonucleic acid--RNA | Ribonucleic acid | L4 protein | L22 protein | L39e protein
Journal Article
Journal Article
Science, ISSN 0036-8075, 12/1999, Volume 286, Issue 5448, pp. 2305 - 2309
The structure of a T7 RNA polymerase (T7 RNAP) initiation complex captured transcribing a trinucleotide of RNA from a 17-base pair promoter DNA containing a... 
Enzymes | Ribonucleotides | Active sites | RNA | Hydrogen bonds | DNA | Thumb | Crystals | Nucleotides | Binding sites | Research Article | T7-RNA POLYMERASE | ANGSTROM RESOLUTION | BACTERIOPHAGE-T7 | REPLICATION | MITOCHONDRIAL | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | REVERSE-TRANSCRIPTASE | DNA-POLYMERASE | BINDING-SITES | PROMOTER | Substrate Specificity | Templates, Genetic | Crystallography, X-Ray | Viral Proteins | DNA-Directed DNA Polymerase - chemistry | Nucleic Acid Heteroduplexes - metabolism | DNA, Single-Stranded - genetics | RNA, Messenger - biosynthesis | Bacteriophage T7 - enzymology | Oligoribonucleotides - metabolism | Conserved Sequence | Transcription, Genetic | DNA-Directed RNA Polymerases - chemistry | Oligoribonucleotides - chemistry | Nucleic Acid Conformation | Protein Structure, Tertiary | Promoter Regions, Genetic | Catalytic Domain | DNA, Single-Stranded - metabolism | RNA, Messenger - genetics | Models, Molecular | DNA, Single-Stranded - chemistry | Amino Acid Motifs | Nucleic Acid Heteroduplexes - chemistry | N-Acetylmuramoyl-L-alanine Amidase - metabolism | Hydrogen Bonding | Protein Conformation | RNA, Messenger - chemistry | DNA-Directed DNA Polymerase - metabolism | DNA-Directed RNA Polymerases - metabolism | Polymerase chain reaction | Research | Polymers | Ribonucleic acid--RNA | Ribonucleic acid | Deoxyribonucleic acid | Deoxyribonucleic acid--DNA
Journal Article
2009, RSC biomolecular sciences, ISBN 9780854041343, xix, 331
The cell can be viewed as a 'collection of protein machines' and understanding these molecular machines requires sophisticated cooperation between cell... 
Life Sciences | Science | Chemistry | Biochemistry | Physical & Theoretical | Molecules | RNA polymerases
Book
Molecular Cell, ISSN 1097-2765, 05/2015, Volume 58, Issue 3, pp. 534 - 540
During transcription initiation, RNA polymerase binds to promoter DNA to form an initiation complex containing a DNA bubble and enters into abortive cycles of... 
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 2019, Volume 62, Issue 3, pp. 1484 - 1501
To address drug resistance to HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs), a series of novel diarylpyrimidine (DAPY) derivatives targeting... 
DESIGN | CHEMISTRY, MEDICINAL | LIPOPHILIC EFFICIENCY | POTENCY | OPTIMIZATION | DRUG-RESISTANCE | NEVIRAPINE
Journal Article