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Cancer Discovery, ISSN 2159-8274, 06/2011, Volume 1, Issue 2, pp. 170 - 185
Journal Article
Nature Medicine, ISSN 1078-8956, 07/2012, Volume 18, Issue 7, pp. 1052 - 1059
Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in similar to 30% of patients with breast cancer. However, many patients have... 
MEDICINE, RESEARCH & EXPERIMENTAL | STEM-CELLS | METASTASIS | PREDICTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | MEK | INHIBITION | GENE-EXPRESSION | RECURRENCE | KI67 | Tissue Banks | Humans | Gene Expression Regulation, Neoplastic | ras Proteins - metabolism | Ki-67 Antigen - metabolism | Gene Expression Profiling | Extracellular Signal-Regulated MAP Kinases - metabolism | RNA, Messenger - metabolism | Gene Knockdown Techniques | Neoplasm, Residual | Paraffin Embedding | Mitogen-Activated Protein Kinase Kinases - metabolism | Breast Neoplasms - enzymology | MAP Kinase Signaling System - genetics | Dual-Specificity Phosphatases - genetics | Female | Neoadjuvant Therapy | Tissue Fixation | Genes, Neoplasm - genetics | Breast Neoplasms - classification | Cell Survival | Dual-Specificity Phosphatases - metabolism | RNA, Messenger - genetics | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinase Phosphatases - deficiency | Treatment Outcome | Breast Neoplasms - drug therapy | Mitogen-Activated Protein Kinase Phosphatases - genetics | Dual-Specificity Phosphatases - deficiency | Drug Resistance, Neoplasm - genetics | Animals | Breast Neoplasms - genetics | Mice | Enzyme Activation | Apoptosis | Mitogen-Activated Protein Kinase Phosphatases - metabolism | Adjuvant treatment | Breast cancer | Research | Drug resistance | Drug therapy | Health aspects | Cancer | Chemotherapy | Index Medicus
Journal Article
International Journal of Cancer, ISSN 0020-7136, 11/2012, Volume 131, Issue 10, pp. 2456 - 2464
Journal Article
Nature Genetics, ISSN 1061-4036, 11/2011, Volume 43, Issue 11, pp. 1119 - 1126
G protein-coupled receptors (GPCRs), the largest human gene family, are important regulators of signaling pathways. However, knowledge of their genetic... 
CELLS | INHIBITION | GLUTAMATE | METALLOPROTEINASE | GENETICS & HEREDITY | PHASE-II | BRAF | CANCER | REVEALS | Receptors, G-Protein-Coupled - genetics | Mutation | Exons | Melanoma - genetics | Humans | Proteins | Studies | Signal transduction | Phosphorylation | Cell growth | Cloning | Genetic testing | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 12/2009, Volume 15, Issue 24, pp. 7538 - 7546
Purpose: Activation of the phosphoinositide 3-kinase (PI3K)-AKT pathway has been implicated in melanoma based primarily on the prevalence of mutations in PTEN... 
melanoma | NRAS | AKT | BRAF | signal transduction | PIK3CA | ONCOLOGY | BRAF MUTATIONS | PRIMARY CUTANEOUS MELANOMA | HIGH-FREQUENCY | PTEN | MALIGNANT-MELANOMA | CELL-LINES | EXPRESSION | HUMAN CANCER | PTEN/MMAC1 ALTERATIONS
Journal Article
Journal Article
Cell, ISSN 0092-8674, 07/2012, Volume 150, Issue 2, pp. 251 - 263
Journal Article
Cancer Cell, ISSN 1535-6108, 10/2007, Volume 12, Issue 4, pp. 395 - 402
A large-scale RNA interference screen to discover genes involved in trastuzumab resistance in breast cancer identified only as a modulator of drug sensitivity.... 
CELLCYCLE | CELLS | OVEREXPRESSION | PIK3CA MUTATIONS | INHIBITION | EFFICACY | ONCOLOGY | HERCEPTIN | MONOCLONAL-ANTIBODY | RECEPTORS | CHEMOTHERAPY | P53 | Oligonucleotide Array Sequence Analysis | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | Antibodies, Monoclonal - therapeutic use | Antineoplastic Agents - therapeutic use | Phosphatidylinositol 3-Kinases - metabolism | Breast Neoplasms - metabolism | Patient Selection | Antibodies, Monoclonal, Humanized | Breast Neoplasms - enzymology | RNA Interference | Biomarkers, Tumor - metabolism | Adult | Female | Antineoplastic Agents - pharmacology | Receptor, ErbB-2 - antagonists & inhibitors | PTEN Phosphohydrolase - genetics | Transduction, Genetic | Antibodies, Monoclonal - pharmacology | Kaplan-Meier Estimate | PTEN Phosphohydrolase - metabolism | Gene Expression Profiling - methods | Treatment Outcome | Signal Transduction - genetics | Breast Neoplasms - drug therapy | Disease Progression | Phosphatidylinositol 3-Kinases - genetics | Drug Resistance, Neoplasm - genetics | Breast Neoplasms - genetics | Class I Phosphatidylinositol 3-Kinases | Signal Transduction - drug effects | Cell Line, Tumor | Breast Neoplasms - mortality | Aged | Biomarkers, Tumor - genetics | Mutation | Trastuzumab | Cohort Studies | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Integrative Biology, ISSN 1757-9694, 08/2011, Volume 3, Issue 8, pp. 850 - 862
Journal Article