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Psychopharmacology, ISSN 0033-3158, 11/2015, Volume 232, Issue 21, pp. 3849 - 3851
  The Innovative Medicines Initiative is Europe's largest public-private initiative aiming to speed up the development of better and safer medicines for... 
Neurosciences | Biomedicine | Pharmacology/Toxicology | Psychiatry | PSYCHIATRY | PHARMACOLOGY & PHARMACY | NEUROSCIENCES | Medicine, Experimental | Medical research | Psychotropic drugs | Psychopharmacology
Journal Article
European Neuropsychopharmacology, ISSN 0924-977X, 2016
Abstract The 15q13.3 microdeletion copy number variation is strongly associated with schizophrenia and epilepsy. The CHRNA 7 gene, encoding nicotinic... 
Internal Medicine | Psychiatry
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2012, Volume 676, Issue 1, pp. 6 - 11
The serotonin6 (5-HT ) receptor has received attention for its proposed role in cognitive impairments associated with schizophrenia and Alzheimer's disease.... 
Striatum | Brain | In vivo binding | Radioligand | 5-HT 6 receptor | Occupancy | receptor | 5-HT
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2011, Volume 54, Issue 9, pp. 3206 - 3221
The synthesis and structure−activity relationship of a novel series of compounds with combined effects on 5-HT3A and 5-HT1A receptors and on the serotonin... 
FREELY MOVING RATS | ARYL BROMIDES | SEROTONIN REUPTAKE INHIBITORS | IN-VIVO MICRODIALYSIS | CHEMISTRY, MEDICINAL | PALLADIUM-CATALYZED SYNTHESIS | 5-HT1A RECEPTORS | MOOD DISORDERS | DRUG DISCOVERY | FRONTAL-CORTEX | ANTIDEPRESSANT-LIKE BEHAVIOR | Xenopus | Humans | Microsomes, Liver - metabolism | Receptor, Serotonin, 5-HT2C - metabolism | Sulfides - chemistry | Serotonin 5-HT1 Receptor Agonists - pharmacology | Sulfides - chemical synthesis | Piperazines - chemistry | Structure-Activity Relationship | Hippocampus - drug effects | Serotonin Uptake Inhibitors - chemical synthesis | Receptors, Serotonin, 5-HT1 - metabolism | Serotonin 5-HT1 Receptor Agonists - chemistry | Antidepressive Agents - chemistry | Oocytes - drug effects | Antidepressive Agents - pharmacology | Radioligand Assay | Serotonin 5-HT3 Receptor Antagonists - chemistry | Receptor, Serotonin, 5-HT1A - metabolism | Depressive Disorder, Major - drug therapy | Sulfides - pharmacology | Cell Line | Recombinant Proteins - antagonists & inhibitors | Drug Partial Agonism | Drug Stability | Rats | Serotonin Uptake Inhibitors - chemistry | Serotonin 5-HT1 Receptor Agonists - chemical synthesis | Recombinant Proteins - agonists | Piperazines - pharmacology | Receptors, Serotonin - metabolism | Serotonin 5-HT3 Receptor Antagonists - chemical synthesis | Serotonin Plasma Membrane Transport Proteins - metabolism | Hippocampus - metabolism | Animals | Oocytes - physiology | Receptors, Serotonin, 5-HT3 - metabolism | Serotonin - metabolism | Antidepressive Agents - chemical synthesis | Piperazines - chemical synthesis | Serotonin 5-HT3 Receptor Antagonists - pharmacology | In Vitro Techniques | Serotonin Uptake Inhibitors - pharmacology
Journal Article
Journal Article
PLoS Medicine, ISSN 1549-1277, 10/2012, Volume 9, Issue 10, p. e1001326
Journal Article
PLoS Medicine, ISSN 1549-1277, 10/2012, Volume 9, Issue 10
  Background It has been suggested that outcomes of antidepressant treatment for major depressive disorder could be significantly improved if treatment choice... 
Studies | Medical research | Antidepressants | Genetics
Journal Article
European Neuropsychopharmacology, ISSN 0924-977X, 07/2016, Volume 26, Issue 7, pp. 1150 - 1160
The 15q13.3 microdeletion copy number variation is strongly associated with schizophrenia and epilepsy. The 7 gene, encoding nicotinic acetylcholine alpha 7... 
Schizophrenia | Resting-state fMRI | Mouse model | 15q13.3 Microdeletion | PSYCHIATRY | RESTING-STATE | HIPPOCAMPAL | DBA/2 MICE | NICOTINIC RECEPTOR | COGNITION | NEUROSCIENCES | CLINICAL NEUROLOGY | GENE | PHARMACOLOGY & PHARMACY | EPILEPSY | SENSORY INHIBITION | EXPRESSION | Brain - diagnostic imaging | Schizophrenia - metabolism | Neural Pathways - drug effects | Seizures - genetics | Endophenotypes | Phenylethyl Alcohol - analogs & derivatives | Cholinergic Agents - pharmacology | Seizures - drug therapy | Male | Seizures - metabolism | Intellectual Disability - genetics | Intellectual Disability - metabolism | Brain - metabolism | Rest | Cyclopropanes - pharmacology | Disease Models, Animal | Chromosome Deletion | Chromosomes, Human, Pair 15 - metabolism | Chromosome Disorders - metabolism | alpha7 Nicotinic Acetylcholine Receptor - genetics | Mice, Transgenic | Chromosomes, Human, Pair 15 - genetics | Brain - drug effects | Chromosome Disorders - drug therapy | Intellectual Disability - drug therapy | Magnetic Resonance Imaging | Phenylethyl Alcohol - pharmacology | Animals | Neural Pathways - diagnostic imaging | Brain Mapping | Neural Pathways - metabolism | alpha7 Nicotinic Acetylcholine Receptor - metabolism | Schizophrenia - drug therapy | Chromosome Disorders - genetics | Psychotherapy | Neurosciences | Acetylcholine | Epilepsy
Journal Article
European journal of pharmacology, ISSN 0014-2999, 02/2012, Volume 676, Issue 1-3, pp. 6 - 11
The serotonin6 (5-HT(6)) receptor has received attention for its proposed role in cognitive impairments associated with schizophrenia and Alzheimer's disease.... 
Reproducibility of Results | Humans | Rats | Substrate Specificity | Sulfones - metabolism | Male | Receptors, Serotonin - metabolism | Brain - metabolism | Quinolines - metabolism | Autoradiography | Animals | Protein Binding | Ligands | Serotonin Antagonists - metabolism | Mice
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 09/2009, Volume 110, Issue 5, pp. 1377 - 1387
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 09/2009, Volume 110, Issue 5, p. 1377
Alzheimer's disease (AD) is hypothesized to result from elevated brain levels of [beta]-amyloid peptide (A[beta]) which is the main component of plaques found... 
Brain | Enzymes | Mice | Universities and colleges | Peptides | Analysis | Neurology | Biochemistry | Glycoproteins | Alzheimers disease | Rodents
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2000, Volume 43, Issue 26, pp. 4930 - 4933
Journal Article