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Journal of the American Chemical Society, ISSN 0002-7863, 2009, Volume 131, Issue 44, pp. 16313 - 16318
Here we report a proof-of-principle study demonstrating the efficient folding, with concomitant formation of the correct disulfides, of an isolated polypeptide... 
ANALOG | A-CHAIN | CONVERSION | COMBINATION | PROTEINS | PRECURSORS | CHEMISTRY, MULTIDISCIPLINARY | PEPTIDE | Oximes - chemistry | Insulin - chemical synthesis | Disulfides | Hypoglycemic Agents - chemical synthesis | Proinsulin - chemical synthesis | Insulin - analogs & derivatives | Insulin Lispro
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2017, Volume 114, Issue 10, p. E1857
  Voltage-gated sodium channels (Navs) play crucial roles in excitable cells. Although vertebrate Nav function has been extensively studied, the detailed... 
Frogs | Sodium | Rodents | Toxins | Cells | Binding sites
Journal Article
Protein Science, ISSN 0961-8368, 02/2019, Volume 28, Issue 2, pp. 313 - 328
Journal Article
TETRAHEDRON LETTERS, ISSN 0040-4039, 03/2007, Volume 48, Issue 10, pp. 1795 - 1799
Modification of a peptide-(alpha)thioester with a sequence of six arginines on the thioester leaving group can render soluble all peptides derived from a... 
COLI DIACYLGLYCEROL KINASE | thioester | TERMINAL DOMAIN | ESCHERICHIA-COLI | TRANSMEMBRANE PEPTIDES | LIGATION | CHEMISTRY, ORGANIC | diacylglycerol kinase | LIQUID-CHROMATOGRAPHIC PURIFICATION | integral membrane proteins | CHANNELS | VPU | native chemical ligation | chemical protein synthesis
Journal Article
Chemical Society Reviews, ISSN 0306-0012, 2009, Volume 38, Issue 2, pp. 338 - 351
This tutorial review outlines the modern ligation methods that enable the efficient total chemical synthesis of enzymes and other protein molecules. Key to... 
ENZYME | CRYSTAL-STRUCTURE | ENANTIOMERS | X-RAY-STRUCTURE | LIGATION | HIV-1 PROTEASE | RESIDUES | CHEMISTRY, MULTIDISCIPLINARY | PEPTIDE
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2017, Volume 114, Issue 9, p. 2241
  The burial of hydrophobic side chains in a protein core generally is thought to be the major ingredient for stable, cooperative folding. Here, we show that,... 
Temperature | Protein folding | Arthropods | Entropy | Hydrophobic surfaces
Journal Article
Angewandte Chemie, ISSN 1433-7851, 04/2014, Volume 53, Issue 18, p. 4662
  The enzyme sortaseA is a ligase which catalyzes transpeptidation reactions.1,2 Surface proteins, including virulence factors, that have a C terminal... 
Enzymes | Medical research | Polypeptides | Gram-positive bacteria
Journal Article
Chemical Society reviews, ISSN 0306-0012, 02/2009, Volume 38, Issue 2, pp. 338 - 351
This tutorial review outlines the modern ligation methods that enable the efficient total chemical synthesis of enzymes and other protein molecules. Key to... 
Magnetic Resonance Spectroscopy | Humans | Mass Spectrometry | Crystallography, X-Ray | Protein Conformation | Proteins - classification | Cysteine - chemistry | Proteins - chemistry | Proteins - chemical synthesis | Proteins - isolation & purification
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2015, Volume 112, Issue 14, p. 4310
  Protein 3D structure can be a powerful predictor of function, but it often faces a critical roadblock at the crystallization step. Rv1738, a protein from... 
Pathogens | Diffraction | Hibernation | Crystallization | Bacteria | Chemical synthesis
Journal Article
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 05/2014, Volume 53, Issue 20, pp. 5194 - 5198
Journal Article