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1. Full Text Ruth Nussenzweig (1928–2018)
by Hoffman, Stephen L
Immunity, ISSN 1074-7613, 06/2018, Volume 48, Issue 6, pp. 1061 - 1062
Sporozoites are the malaria parasite life-cycle stage that is transmitted to humans, mice, and other hosts by mosquitoes. [...]publication of the 1967 paper,... 
Medicine | Proteins | Leadership | Parasitology | Malaria | Clinical trials | Aquatic insects | Tropical diseases
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2. Full Text Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine
by Robert A. Seder and Lee-Jah Chang and Mary E. Enama and Kathryn L. Zephir and Uzma N. Sarwar and Ingelise J. Gordon and LaSonji A. Holman and Eric R. James and Peter F. Billingsley and Anusha Gunasekera and Adam Richman and Sumana Chakravarty and Anita Manoj and Soundarapandian Velmurugan and MingLin Li and Adam J. Ruben and Tao Li and Abraham G. Eappen and Richard E. Stafford and Sarah H. Plummer and Cynthia S. Hendel and Laura Novik and Pamela J. M. Costner and Floreliz H. Mendoza and Jamie G. Saunders and Martha C. Nason and Jason H. Richardson and Jittawadee Murphy and Silas A. Davidson and Thomas L. Richie and Martha Sedegah and Awalludin Sutamihardja and Gary A. Fahle and Kirsten E. Lyke and Matthew B. Laurens and Mario Roederer and Kavita Tewari and Judith E. Epstein and B. Kim Lee Sim and Julie E. Ledgerwood and Barney S. Graham and Stephen L. Hoffman and VRC 312 Study Team and the VRC 312 Study Team
Science, ISSN 0036-8075, 9/2013, Volume 341, Issue 6152, pp. 1359 - 1365
Consistent high-level, vaccine-induced protection against human malaria has only been achieved by inoculation of Plasmodium falciparum (Pf) sporozoites (SPZ)... 
T lymphocytes | Antigens | Patents | Immunization | RESEARCH ARTICLE | Malaria | Intravenous injections | Vaccination | Sporozoites | Antibodies | Dosage | ANTIBODIES | TRIAL | IMMUNITY | CD8+ T-CELLS | EFFICACY | LIVER STAGES | MULTIDISCIPLINARY SCIENCES | MICE | PLASMODIUM-FALCIPARUM MALARIA | CIRCUMSPOROZOITE PROTEIN VACCINE | Malaria, Falciparum - prevention & control | Humans | Male | Plasmodium falciparum - immunology | Vaccination - adverse effects | Sporozoites - immunology | Administration, Intravenous | Animals | Malaria Vaccines - administration & dosage | Vaccination - methods | Malaria Vaccines - adverse effects | Malaria Vaccines - immunology | Adult | Female | T-Lymphocytes - immunology | Mice | Immunity, Cellular | Cytokines - immunology | Prevention | Intravenous therapy | Sporozoa | Health aspects | Risk factors | Methods | Monoclonal antibodies | Vaccines | Immune system | Medical research | Cellular | Correlation | Attenuation | Parasites
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3. Malaria vaccine development
: a multi-immune response approach
by Hoffman, Stephen L
1996, ISBN 9781555811112, x, 310
Malaria | Malaria Vaccines | immunology
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4. Full Text Efficacy of Tafamidis in Transthyretin Amyloid Cardiomyopathy in the ATTR-ACT Trial: Sensitivity Analyses Further Support the Primary Results
by Maurer, Mathew S and Schwartz, Jeffrey H and Gundapaneni, Balarama and Elliott, Perry and Merlini, Giampaolo and Cruz, Márcia Waddington and Kristen, Arnt V and Grogan, Martha and Witteles, Ronald and Damy, Thibaud and Drachman, Brian M and Shah, Sanjiv J and Hanna, Mazen and Judge, Daniel P and Gottlieb, Stephen S and Berk, John L and Lenihan, Daniel J and Hoffman, James E and Hummel, Scott L and Velazquez, Eric J and Patterson, Terrell A and Sultan, Marla B and Rapezzi, Claudio
Journal of Cardiac Failure, ISSN 1071-9164, 11/2018, Volume 24, Issue 11, pp. 813 - 813
Transthyretin cardiomyopathy (ATTR-CM) is an underdiagnosed, fatal disease caused by the deposition of transthyretin amyloid fibrils in the heart leading to... 
Cardiomyopathy | Heart diseases | Analysis
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5. Full Text The march toward malaria vaccines
by Hoffman, Stephen L and Vekemans, Johan and Richie, Thomas L and Duffy, Patrick E
Vaccine, ISSN 0264-410X, 2015, Volume 33, Issue Suppl 4, pp. D13 - D23
Abstract In 2013 there were an estimated 584,000 deaths and 198 million clinical illnesses due to malaria, the majority in sub-Saharan Africa. Vaccines would... 
Allergy and Immunology | Plasmodium falciparum | Malaria vaccines | Malaria elimination | Malaria | Vaccine | Plasmodium falciparum vaccines | Malaria prevention | DIRECT VENOUS INOCULATION | LISTERIA-MONOCYTOGENES | MEDICINE, RESEARCH & EXPERIMENTAL | T-CELL IMMUNITY | PLASMODIUM-FALCIPARUM SPOROZOITES | INTRADERMAL INJECTION | IMMUNOLOGY | TRANSMISSION-BLOCKING VACCINE | SEQUENTIAL IMMUNIZATION | ANTIBODY-RESPONSES | MONOCLONAL-ANTIBODIES | CIRCUMSPOROZOITE PROTEIN VACCINE | Plasmodium vivax - growth & development | Disease Eradication | Malaria, Falciparum - prevention & control | Malaria, Vivax - parasitology | Humans | Plasmodium vivax - genetics | Plasmodium falciparum - immunology | Recombinant Proteins | Plasmodium vivax - immunology | Sporozoites - immunology | Life Cycle Stages | Malaria, Falciparum - parasitology | Clinical Trials, Phase III as Topic | Animals | Plasmodium falciparum - genetics | Malaria Vaccines - immunology | Malaria, Falciparum - immunology | Malaria, Vivax - immunology | Malaria, Vivax - prevention & control | Plasmodium falciparum - growth & development | Immunity, Cellular | Prevention | Malaria vaccine | Bacteria | Vaccines | Health aspects | Recombinant proteins | Antigens | Anopheles | Parasitic diseases | Mosquitoes | Parasites | Mortality
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6. Full Text Adaptive clinical trials of three PfSPZ products for development of a whole sporozoite vaccine that prevents Plasmodium falciparum infection, disease and transmission
by Hoffman, Stephen L
Malaria Journal, ISSN 1475-2875, 10/2012, Volume 11, Issue S1, pp. O48 - O48
  Doc number: O48 
Immunization | Infections | Malaria | Disease
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7. Full Text Sterile protection against human malaria by chemoattenuated PfSPZ vaccine
by Mordmüller, Benjamin and Surat, Güzin and Lagler, Heimo and Chakravarty, Sumana and Ishizuka, Andrew S and Lalremruata, Albert and Gmeiner, Markus and Campo, Joseph J and Esen, Meral and Ruben, Adam J and Held, Jana and Calle, Carlos Lamsfus and Mengue, Juliana B and Gebru, Tamirat and Ibáñez, Javier and Sulyok, Mihály and James, Eric R and Billingsley, Peter F and Natasha, Kc and Manoj, Anita and Murshedkar, Tooba and Gunasekera, Anusha and Eappen, Abraham G and Li, Tao and Stafford, Richard E and Li, Minglin and Felgner, Phil L and Seder, Robert A and Richie, Thomas L and Sim, B. Kim Lee and Hoffman, Stephen L and Kremsner, Peter G
Nature, ISSN 0028-0836, 02/2017, Volume 542, Issue 7642, pp. 445 - 449
A highly protective malaria vaccine would greatly facilitate the prevention and elimination of malaria and containment of drug-resistant parasites(1). A high... 
DIRECT VENOUS INOCULATION | ANTIBODIES | LIVER-STAGE | IMMUNIZATION | IMMUNITY | CD8+ T-CELLS | MULTIDISCIPLINARY SCIENCES | PLASMODIUM-FALCIPARUM SPOROZOITES | CHLOROQUINE PROPHYLAXIS | INFECTION | HUMAN VOLUNTEERS | Malaria, Falciparum - prevention & control | Double-Blind Method | Antibodies, Protozoan - immunology | Humans | Middle Aged | Chloroquine - therapeutic use | Plasmodium falciparum - immunology | Healthy Volunteers | Sporozoites - immunology | Young Adult | Malaria, Falciparum - blood | Malaria, Falciparum - parasitology | Antibodies, Protozoan - blood | Vaccines, Attenuated - immunology | Malaria Vaccines - administration & dosage | Plasmodium falciparum - classification | Time Factors | Vaccines, Attenuated - administration & dosage | Adolescent | Malaria Vaccines - immunology | Malaria, Falciparum - immunology | Adult | T-Lymphocytes - immunology | Immunologic Memory - immunology | Prevention | Dosage and administration | Malaria | Malaria vaccine | Proteins | Automation | Immunoglobulins | Mosquitoes | Lymphocytes | Liver | Infections | Parasites | Vaccines | Drug dosages
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8. Full Text Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue
by Sophie H. Adjalley and Geoffrey L. Johnston and Tao Li and Richard T. Eastman and Eric H. Ekland and Abraham G. Eappen and Adam Richman and B. Kim Lee Sim and Marcus C. S. Lee and Stephen L. Hoffman and David A. Fidock
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 11/2011, Volume 108, Issue 47, pp. E1214 - E1223
Clinical studies and mathematical models predict that, to achieve malaria elimination, combination therapies will need to incorporate drugs that block the... 
CONTROLLED-TRIAL | MOSQUITOS | VIVAX | MULTIDISCIPLINARY SCIENCES | transfection | COMBINATION | GAMETOCYTES | PHARMACOKINETICS | artemisinin-based combination therapies | MALARIA | EXPRESSION | PRIMAQUINE | ARTESUNATE | Quinolines | Blotting, Southern | Germ Cells, Plant - drug effects | Green Fluorescent Proteins | Naphthyridines | Fluorenes | Plasmodium falciparum - drug effects | Ethanolamines | Methylene Blue - pharmacology | Antimalarials - pharmacology | Dose-Response Relationship, Drug | Amodiaquine - analogs & derivatives | Animals | Artemisinins | Luciferases | Sexual Development - physiology | Anopheles - microbiology | Malaria - transmission | Plasmodium falciparum - physiology | Genetic Vectors | Biological Sciences | PNAS Plus
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9. Full Text Malaria A protective paradox
by Hoffman, Stephen L
Nature, ISSN 0028-0836, 12/2006, Volume 444, Issue 7121, pp. 824 - 827
The infectious form of the malaria parasite has thousands of proteins, making it tough to develop a vaccine for it. Narrowing down which proteins cause... 
IMMUNIZATION | GENOMICS | EFFICACY | SAFETY | MULTIDISCIPLINARY SCIENCES | PLASMODIUM-FALCIPARUM SPOROZOITES | VACCINE | Immunodominant Epitopes - immunology | Antigens, Protozoan - immunology | Humans | Malaria - immunology | Sporozoites - immunology | Malaria Vaccines - chemistry | Malaria - prevention & control | Sporozoites - chemistry | Immunodominant Epitopes - administration & dosage | Animals | Malaria Vaccines - administration & dosage | Antigens, Protozoan - administration & dosage | Malaria - parasitology | Malaria Vaccines - immunology | Mice | Protozoan Proteins - administration & dosage | Protozoan Proteins - immunology | Proteins | Pharmacology | Immunology | Vaccines | Malaria
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10. Full Text Safety and efficacy of PfSPZ Vaccine against Plasmodium falciparum via direct venous inoculation in healthy malaria-exposed adults in Mali: a randomised, double-blind phase 1 trial
by Sissoko, Mahamadou S, MD and Healy, Sara A, MD and Katile, Abdoulaye, MD and Omaswa, Freda, MD and Zaidi, Irfan, PhD and Gabriel, Erin E, PhD and Kamate, Bourama, MD and Samake, Yacouba, MD and Guindo, Merepen A, PharmD and Dolo, Amagana, PharmD and Niangaly, Amadou, PharmD and Niaré, Karamoko, PharmD and Zeguime, Amatigue, PharmD and Sissoko, Kourane, MD and Diallo, Hama, MD and Thera, Ismaila, MSc and Ding, Kelly, PhD and Fay, Michael P, PhD and O'Connell, Elise M, MD and Nutman, Thomas B, MD and Wong-Madden, Sharon, BA and Murshedkar, Tooba, MS and Ruben, Adam J, PhD and Li, Minglin, PhD and Abebe, Yonas, MS and Manoj, Anita, PhD and Gunasekera, Anusha, PhD and Chakravarty, Sumana, PhD and Sim, B Kim Lee, PhD and Billingsley, Peter F, PhD and James, Eric R, PhD and Walther, Michael, PhD and Richie, Thomas L, MD and Hoffman, Stephen L, MD and Doumbo, Ogobara, Prof and Duffy, Patrick E, Dr
Lancet Infectious Diseases, The, ISSN 1473-3099, 2017, Volume 17, Issue 5, pp. 498 - 509
Summary Background Plasmodium falciparum sporozite (PfSPZ) Vaccine is a metabolically active, non-replicating, whole malaria sporozoite vaccine that has been... 
Infectious Disease | IMMUNIZATION | IMMUNITY | INFECTIOUS DISEASES | PROTECTION | MEMORY | NONREPLICATING SPOROZOITE VACCINE | GAMBIA | MEN | HUMANS | Malaria, Falciparum - prevention & control | Double-Blind Method | Humans | Fluorenes - therapeutic use | Artemisinins - administration & dosage | Male | Antimalarials - therapeutic use | Plasmodium falciparum - immunology | Ethanolamines - administration & dosage | Artemisinins - therapeutic use | Vaccination - methods | Antimalarials - administration & dosage | Mali | Adolescent | Adult | Ethanolamines - therapeutic use | Female | Fluorenes - administration & dosage | Immunization Schedule | Plasmodium falciparum | Medical research | Malaria | Parasitic diseases | Clinical trials | Medicine, Experimental | Product development | Adults | Vaccines | Analysis | Vaccination | Biometrics | Asymptotic properties | Toxicity | Antibodies | Bites | Homology | Infections | Parasites | Developing countries--LDCs | Antibody response | Incidence | Hepatitis | Towns | Alignment | Cryopreservation | Syphilis | Human immunodeficiency virus--HIV | Attenuation | Libraries | Masking | Safety | Drug dosages | Age | Circumsporozoite protein | EKG | Antigens | Hum | Immunological memory | Effectiveness | Review boards | Abnormalities | Hypersensitivity | BCG | Contraception | Exposure | Vectors | Appendix | Pregnancy | Disease transmission | Infectious diseases | Immunogenicity | Artemether | Added value | Differentiation
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11. Full Text Protection against malaria at 1 year and immune correlates following PfSPZ vaccination
by Ishizuka, Andrew S and Lyke, Kirsten E and DeZure, Adam and Berry, Andrea A and Richie, Thomas L and Mendoza, Floreliz H and Enama, Mary E and Gordon, Ingelise J and Chang, Lee-Jah and Sarwar, Uzma N and Zephir, Kathryn L and Holman, Lasonji A and James, Eric R and Billingsley, Peter F and Gunasekera, Anusha and Chakravarty, Sumana and Manoj, Anita and Li, Minglin and Ruben, Adam J and Li, Tao and Eappen, Abraham G and Stafford, Richard E and Natasha, K.C and Murshedkar, Tooba and DeCederfelt, Hope and Plummer, Sarah H and Hendel, Cynthia S and Novik, Laura and Costner, Pamela J.M and Saunders, Jamie G and Laurens, Matthew B and Plowe, Christopher V and Flynn, Barbara and Whalen, William R and Todd, J.P and Noor, Jay and Rao, Srinivas and Sierra-Davidson, Kailan and Lynn, Geoffrey M and Epstein, Judith E and Kemp, Margaret A and Fahle, Gary A and Mikolajczak, Sebastian A and Fishbaugher, Matthew and Sack, Brandon K and Kappe, Stefan H. I and Davidson, Silas A and Garver, Lindsey S and Björkström, Niklas K and Nason, Martha C and Graham, Barney S and Roederer, Mario and Kim Lee Sim, B and Hoffman, Stephen L and Ledgerwood, Julie E and Seder, Robert A and VRC 312& VRC Study Teams
Nature Medicine, ISSN 1078-8956, 06/2016, Volume 22, Issue 6, pp. 614 - 623
An attenuated Plasmodium falciparum (Pf) sporozoite (SPZ) vaccine, PfSPZ Vaccine, is highly protective against controlled human malaria infection (CHMI) 3... 
MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | DELTA T-CELLS | ELIMINATION | PLASMODIUM-YOELII | CELL BIOLOGY | SPOROZOITE VACCINE | IMMUNIZATION | INTERFERON | MEMORY | ENHANCEMENT | MICE | MONOCLONAL-ANTIBODIES | Malaria, Falciparum - prevention & control | Humans | Middle Aged | Male | Macaca mulatta | Plasmodium falciparum - immunology | Healthy Volunteers | Sporozoites - immunology | Young Adult | Liver - immunology | Immunoglobulin G - immunology | Malaria Vaccines - immunology | Adult | Female | Malaria Vaccines - therapeutic use | Immunogenicity, Vaccine - immunology | Enzyme-Linked Immunosorbent Assay | Antibodies, Protozoan - immunology | Parasitemia - immunology | Administration, Intravenous | Animals | Interferon-gamma - immunology | Adolescent | Parasitemia - prevention & control | T-Lymphocytes - immunology | Liver - cytology | CD8-Positive T-Lymphocytes - immunology | Prevention | Malaria | Malaria vaccine | Physiological aspects | Causes of | Research | T cells | Vaccines | Immune system
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