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1. Full Text Secretory Phospholipase A2 -IIA and Cardiovascular Disease
by Holmes, Michael V., MSc and Simon, Tabassome, MD, PhD and Exeter, Holly J., PhD and Folkersen, Lasse, PhD and Asselbergs, Folkert W., MD, PhD and Guardiola, Montse, PhD and Cooper, Jackie A., MSc and Palmen, Jutta, MSc and Hubacek, Jaroslav A., DSc, PhD and Carruthers, Kathryn F., MPhil and Horne, Benjamin D., PhD, MPH and Brunisholz, Kimberly D., MST and Mega, Jessica L., MD, MPH and van Iperen, Erik P.A., MSc and Li, Mingyao, PhD and Leusink, Maarten, MSc and Trompet, Stella, PhD and Verschuren, Jeffrey J.W., MD, MSc and Hovingh, G. Kees, MD, PhD and Dehghan, Abbas, MD, PhD and Nelson, Christopher P., PhD and Kotti, Salma, PharmD, PhD and Danchin, Nicolas, MD, PhD and Scholz, Markus, PhD and Haase, Christiane L., PhD and Rothenbacher, Dietrich, MD and Swerdlow, Daniel I., MBBS, PhD and Kuchenbaecker, Karoline B., Dipl Psych, MSc and Staines-Urias, Eleonora, MD, MSc and Goel, Anuj, MSc and van 't Hooft, Ferdinand, MD, PhD and Gertow, Karl, PhD and de Faire, Ulf, MD, PhD and Panayiotou, Andrie G., PhD and Tremoli, Elena, PhD and Baldassarre, Damiano, PhD and Veglia, Fabrizio, PhD and Holdt, Lesca M., MD, PhD and Beutner, Frank, MD, PhD and Gansevoort, Ron T., MD, PhD and Navis, Gerjan J., MD, PhD and Mateo Leach, Irene, PhD and Breitling, Lutz P., MD and Brenner, Hermann, MD, MPH and Thiery, Joachim, MD, MBA and Dallmeier, Dhayana, MD and Franco-Cereceda, Anders, MD, PhD and Boer, Jolanda M.A., PhD and Stephens, Jeffrey W., PhD and Hofker, Marten H., PhD and Tedgui, Alain, PhD and Hofman, Albert, MD, PhD and Uitterlinden, André G., PhD and Adamkova, Vera, MD, PhD and Pitha, Jan, MD, PhD and Onland-Moret, N. Charlotte, PhD and Cramer, Maarten J., MD, PhD and Nathoe, Hendrik M., MD, PhD and Spiering, Wilko, MD, PhD and Klungel, Olaf H., PharmD, PhD and Kumari, Meena, PhD and Whincup, Peter H and Morrow, David A., MD and Braund, Peter S., MSc and Hall, Alistair S., PhD and Olsson, Anders G., MD, PhD and Doevendans, Pieter A., MD, PhD and Trip, Mieke D., MD, PhD and Tobin, Martin D., PhD and Hamsten, Anders, PhD and Watkins, Hugh, PhD and Koenig, Wolfgang, MD and Nicolaides, Andrew N., PhD and Teupser, Daniel, MD, PhD and Day, Ian N.M and Carlquist, John F., PhD and Gaunt, Tom R., PhD and Ford, Ian, PhD and Sattar, Naveed and Tsimikas, Sotirios, MD and Schwartz, Gregory G., MD PhD and Lawlor, Debbie A., PhD and Morris, Richard W., PhD and Sandhu, Manjinder S., PhD and Poledne, Rudolf, PhD and Maitland-van der Zee, Anke H., PhD and Khaw, Kay-Tee, MBBChir and Keating, Brendan J., PhD and van der Harst, Pim, MD, PhD and Price, Jackie F., MD and Mehta, Shamir R., MD, MSc and Yusuf, Salim, MBBS, DPhil and Witteman, Jaqueline C.M., PhD and Franco, Oscar H., MD, PhD and Jukema, J. Wouter, MD, PhD and de Knijff, Peter, PhD and Tybjaerg-Hansen, Anne, MD, DMSc and Rader, Daniel J., MD and Farrall, Martin, MD, PhD and Samani, Nilesh J., MD and ...
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2013, Volume 62, Issue 21, pp. 1966 - 1976
Objectives This study sought to investigate the role of secretory phospholipase A2 (sPLA2 )-IIA in cardiovascular disease. Background Higher circulating levels... 
Cardiovascular | Internal Medicine | drug development | epidemiology | genetics | cardiovascular diseases | Mendelian randomization | Studies | Cardiovascular disease | Heart attacks | Drug therapy | Mortality | Cholesterol
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2. Full Text Is surgical intervention frequently required for medically managed macroprolactinomas? A study of spontaneous cerebrospinal fluid rhinorrhea
by de Lacy, Patricia, MBChB and Benjamin, Silas, MB, MRCP and Dixon, Rebecca, MBChB and Stephens, Jeffrey W., MB, PhD, FRCP and Redfern, Robert, MBChB, FRCS and Price, David E., MD, FRCP
Surgical Neurology, ISSN 0090-3019, 2009, Volume 72, Issue 5, pp. 461 - 463
Abstract Background The frequency of spontaneous CSF rhinorrhea in macroprolactinoma patients is poorly documented and was previously thought to be a very rare... 
Neurology | Surgery | Cabergoline | CSF rhinorrhea | Macroprolactinoma | SURGERY | PROLACTINOMA | BROMOCRIPTINE | CLINICAL NEUROLOGY | INVASIVE MACROPROLACTINOMA | Cavernous Sinus - diagnostic imaging | Pituitary Neoplasms - surgery | Sphenoid Bone - surgery | Sphenoid Sinus - pathology | Humans | Middle Aged | Clinical Protocols | Male | Tomography, X-Ray Computed | Neurosurgical Procedures - standards | Sphenoid Sinus - diagnostic imaging | Nasal Cavity - pathology | Neoplasm Invasiveness - pathology | Sphenoid Bone - pathology | Adult | Cerebrospinal Fluid Rhinorrhea - pathology | Female | Retrospective Studies | Prolactinoma - drug therapy | Sphenoid Sinus - surgery | Prolactinoma - pathology | Prolactinoma - surgery | Cerebrospinal Fluid Rhinorrhea - etiology | Prolactin - secretion | Cavernous Sinus - pathology | Risk Assessment | Pituitary Gland - pathology | Pituitary Gland - surgery | Biomarkers - analysis | Pituitary Gland - diagnostic imaging | Pituitary Neoplasms - pathology | Biomarkers - blood | Sphenoid Bone - diagnostic imaging | Disease Progression | Nasal Cavity - surgery | Neoplasm Invasiveness - physiopathology | Prolactin - blood | Magnetic Resonance Imaging | Pituitary Neoplasms - drug therapy | Craniotomy - methods | Craniotomy - standards | Cerebrospinal Fluid Rhinorrhea - surgery | Prolactin - analysis
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3. Full Text Role of cardiorespiratory fitness in lifetime cardiovascular risk prediction models: a cross-sectional analysis
by Gray, Benjamin J and Stephens, Jeffrey W and Thomas, Michael and Williams, Sally P and Davies, Christine A and Bracken, Richard M
The Lancet, ISSN 0140-6736, 11/2017, Volume 390, pp. S40 - S40
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1016/S0140-6736(17)32975-6... 
Medicine, Experimental | Medical research | Models | Algorithms | Cardiovascular diseases | Risk factors | Prediction models | Health risks | Fitness
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4. Full Text Older Blood Is Associated With Increased Mortality and Adverse Events in Massively Transfused Trauma Patients: Secondary Analysis of the PROPPR Trial
by Jones, Allison R and Patel, Rakesh P and Marques, Marisa B and Donnelly, John P and Griffin, Russell L and Pittet, Jean-Francois and Kerby, Jeffrey D and Stephens, Shannon W and DeSantis, Stacia M and Hess, John R and Wang, Yao-Wei W and Wang, Henry E and Holcomb, John B and Wade, Christine and Wade, Sarah E and Wade, Charles E and del Junco, Deborah J and Fox, Erin E and Matijevic, Nena and Podbielski, Jeanette and Beeler, Angela M and Tilley, Barbara C and Baraniuk, Sarah and Zhu, Jay G and Zhu, Hongjian and Nixon, Joshua and Seay, Roann and Appana, Savitri N and Yang, Hui and Gonzalez, Michael O and Baer, Lisa and Hula, Brittany S and Espino, Elena and Nguyen, An and Pawelczyk, Nicholas and Arora-Nutall, Kisha D and Sharma, Rishika and Cardenas, Jessica C and Rahbar, Elaheh and Burnett, Tyrone and Clark, David and van Belle, Gerald and May, Susanne and Leroux, Brian and Hoyt, David and Powell, Judy and Sheehan, Kellie and Hubbard, Alan and Arkin, Adam P and Callum, Jeanne and Cotton, Bryan A and Vincent, Laura and Welch, Timothy and Poole, Tiffany and Pivalizza, Evan G and Gumbert, Sam D and Bai, Yu and McCarthy, James J and Noland, Amy and Hobbs, Rhonda and Bulger, Eileen M and Klotz, Patricia and Cattin, Lindsay and Warner, Keir J and Wilson, Angela and Wilson, Suzanne and Boman, David and White, Nathan and Grabinsky, Andreas and Daniel-Johnson, Jennifer A and Cohen, Mitchell J and Callcut, Rachael A and Nelson, Janice M and Nelson, Allia and Nelson, Mary and Redick, Brittney and Conroy, Amanda and Steurer, Marc P and Maxim, Preston C and Fiebig, Eberhard and Moore, Joanne and Mallari, Eireen and Muskat, Peter and Johannigman, Jay A and Robinson, Bryce R.H and Branson, Richard D and Gomaa, Dina and Barczak, Christopher and Bennett, Suzanne and Carey, Patricia M and Miller, Beth and Miller, Christopher N and Hancock, Helen and Rodriguez, Carolina and Inaba, Kenji and Wong, Monica D and Menchine, Michael and Katzberg, Kelly and Henderson, Sean O and McKeever, Rodney and ...
Annals of Emergency Medicine, ISSN 0196-0644, 06/2019, Volume 73, Issue 6, pp. 650 - 661
The transfusion of older packed RBCs may be harmful in critically ill patients. We seek to determine the association between packed RBC age and mortality among... 
Mortality | Analysis
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5. Full Text Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study
by Kugathasan, Subra, Dr and Denson, Lee A, MD and Walters, Thomas D, MD and Kim, Mi-Ok, PhD and Marigorta, Urko M, PhD and Schirmer, Melanie, PhD and Mondal, Kajari, PhD and Liu, Chunyan, MS and Griffiths, Anne, MD and Noe, Joshua D, MD and Crandall, Wallace V, MD and Snapper, Scott, MD and Rabizadeh, Shervin, MD and Rosh, Joel R, MD and Shapiro, Jason M, MD and Guthery, Stephen, MD and Mack, David R, MD and Kellermayer, Richard, MD and Kappelman, Michael D, MD and Steiner, Steven, MD and Moulton, Dedrick E, MD and Keljo, David, MD and Cohen, Stanley, MD and Oliva-Hemker, Maria, MD and Heyman, Melvin B, MD and Otley, Anthony R, MD and Baker, Susan S, MD and Evans, Jonathan S, MD and Kirschner, Barbara S, MD and Patel, Ashish S, MD and Ziring, David, MD and Trapnell, Bruce C, MD and Sylvester, Francisco A, MD and Stephens, Michael C, MD and Baldassano, Robert N, MD and Markowitz, James F, MD and Cho, Judy, MD and Xavier, Ramnik J, MD and Huttenhower, Curtis, PhD and Aronow, Bruce J, PhD and Gibson, Greg, PhD and Hyams, Jeffrey S, MD and Dubinsky, Marla C, MD
Lancet, The, ISSN 0140-6736, 2017, Volume 389, Issue 10080, pp. 1710 - 1718
Summary Background Stricturing and penetrating complications account for substantial morbidity and health-care costs in paediatric and adult onset Crohn's... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | THERAPY | INFLIXIMAB | RESECTION | ILEAL | Medicine, Experimental | Medical research | Children | Analysis | Diseases | Pediatrics | Therapy | Pathogenesis | Antiinfectives and antibacterials | Gastroenterology | Classification | Gangrene | Extracellular matrix | Mathematical models | Diagnosis | Genotypes | Chronic illnesses | Complications | Health risks | Inflammation | Crohn's disease | Gene expression | Patients | Morbidity | Crohns disease | Inflammatory bowel disease | Tumor necrosis factor | Medical prognosis | Rectum | Predictions | Colitis | Tumors
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6. Full Text Safety and efficacy of ceftriaxone for amyotrophic lateral sclerosis: a multi-stage, randomised, double-blind, placebo-controlled trial
by Cudkowicz, Merit E, Prof and Titus, Sarah, MPH and Kearney, Marianne, BA and Yu, Hong, MS and Sherman, Alexander, MSc and Schoenfeld, David, Prof and Hayden, Douglas, PhD and Shui, Amy, MA and Brooks, Benjamin, Prof and Conwit, Robin, MD and Felsenstein, Donna, MD and Greenblatt, David J, Prof and Keroack, Myles, MD and Kissel, John T, Prof and Miller, Robert, Prof and Rosenfeld, Jeffrey, Prof and Rothstein, Jeffrey D, Prof and Simpson, Ericka, MD and Tolkoff-Rubin, Nina, Prof and Zinman, Lorne, MD and Shefner, Jeremy M, Prof and Ceftriaxone Study Investigators
Lancet Neurology, The, ISSN 1474-4422, 2014, Volume 13, Issue 11, pp. 1083 - 1091
Summary Background Glutamate excitotoxicity might contribute to the pathophysiology of amyotrophic lateral sclerosis. In animal models, decreased excitatory... 
Neurology | SURVIVAL | STROKE | NERVOUS-SYSTEM | RILUZOLE | INFECTIONS | MODELS | GLUTAMATE | ALS | CEREBROSPINAL-FLUID | EXPRESSION | CLINICAL NEUROLOGY | Dyspnea - chemically induced | Double-Blind Method | Dyspnea - diagnosis | Humans | Middle Aged | Amyotrophic Lateral Sclerosis - diagnosis | Male | Treatment Outcome | Amyotrophic Lateral Sclerosis - drug therapy | Ceftriaxone - therapeutic use | Ceftriaxone - adverse effects | Adult | Female | Aged | Clinical trials | Medical colleges | Amyotrophic lateral sclerosis | Nervous system diseases | Glutamate | Analysis | Disease | Laboratories | Hispanic Americans | Family medical history | Quality of life | Studies | Hospitals | Antibiotics | Neurodegeneration | Pharmacy | Drug dosages | Drug stores | Inventory
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7. Full Text Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial: Design and Methods
by Buse, John B., MD, PhD and ACCORD Study Grp and ACCORD Study Group
American Journal of Cardiology, The, ISSN 0002-9149, 2007, Volume 99, Issue 12, pp. S21 - S33
Most patients with type 2 diabetes mellitus develop cardiovascular disease (CVD), with substantial loss of life expectancy. Nonfatal CVD contributes greatly to... 
Cardiovascular | CARDIAC & CARDIOVASCULAR SYSTEMS | RATIONALE | DISEASE | ADULTS | PREVENTION | MELLITUS | HEALTH | INTERVENTION | STRATEGIES | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Humans | Coronary Artery Disease - prevention & control | Fenofibrate - administration & dosage | Diabetic Angiopathies - blood | Coronary Artery Disease - blood | Fenofibrate - therapeutic use | Patient Selection | Randomized Controlled Trials as Topic | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Glycated Hemoglobin A | Hypolipidemic Agents - administration & dosage | Diabetes Mellitus, Type 2 | Hypolipidemic Agents - therapeutic use | Diabetic Angiopathies - prevention & control | Research Design | Obesity | Diabetics | Anticholesteremic agents | Clinical trials | Diabetes | Cardiovascular diseases | Blood lipoproteins | Health aspects | Risk factors | Methods | Diabetes therapy
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8. Full Text Onset of Coagulation Function Recovery Is Delayed in Severely Injured Trauma Patients with Venous Thromboembolism
by McCully, Belinda H., PhD and Connelly, Christopher R., MD and Fair, Kelly A., MD and Holcomb, John B., MD, FACS and Fox, Erin E., PhD and Wade, Charles E., PhD and Bulger, Eileen M., MD, FACS and Schreiber, Martin A., MD, FACS and PROPPR Study Grp and PROPPR Study Group
Journal of the American College of Surgeons, ISSN 1072-7515, 2017, Volume 225, Issue 1, pp. 42 - 51
Abstract Background Altered coagulation function after trauma may contribute to venous thromboembolism (VTE) development. Severe trauma impairs coagulation... 
Surgery | CLOT FORMATION | HYPERCOAGULABILITY | SURGERY | THROMBOSIS | PULMONARY-EMBOLISM | PLATELET-FUNCTION | RISK | COAGULOPATHY | THROMBOPROPHYLAXIS | FIBRINOGEN | PATHOPHYSIOLOGY | Thrombelastography | Humans | Middle Aged | Wounds and Injuries - complications | Trauma Centers | Anticoagulants - therapeutic use | Male | Recovery of Function | Venous Thromboembolism - drug therapy | Injury Severity Score | Venous Thromboembolism - etiology | Blood Coagulation Tests | Adult | Female | Venous Thromboembolism - diagnostic imaging | Blood Coagulation Disorders - complications | Thromboembolism | Thrombin | Analysis | trauma | coagulopathy | platelet function | venous thromboembolism
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9. Full Text Switching from tenofovir disoproxil fumarate to tenofovir alafenamide in antiretroviral regimens for virologically suppressed adults with HIV-1 infection: a randomised, active-controlled, multicentre, open-label, phase 3, non-inferiority study
by Mills, Anthony, MD and Arribas, Jose R, MD and Andrade-Villanueva, Jaime, Prof and DiPerri, Giovanni, MD and Van Lunzen, Jan, Prof and Koenig, Ellen, MD and Elion, Richard, MD and Cavassini, Matthias, MD and Madruga, Jose Valdez, MD and Brunetta, Jason, MD and Shamblaw, David, MD and DeJesus, Edwin, MD and Orkin, Chloe, MBBch and Wohl, David A, MD and Brar, Indira, MD and Stephens, Jeffrey L, MD and Girard, Pierre-Marie, Prof and Huhn, Gregory, MD and Plummer, Andrew, BS and Liu, Ya-Pei, PhD and Cheng, Andrew K, MD and McCallister, Scott, Dr and GS-US-292-0109 Team and GS-US-292-0109 team
Lancet Infectious Diseases, The, ISSN 1473-3099, 2016, Volume 16, Issue 1, pp. 43 - 52
Summary Background Antiretroviral regimens containing tenofovir disoproxil fumarate have been associated with renal toxicity and reduced bone mineral density.... 
Infectious Disease | LONG-TERM | GLOMERULAR-FILTRATION-RATE | INFECTIOUS DISEASES | ABACAVIR-LAMIVUDINE | BONE-MINERAL DENSITY | DOUBLE-BLIND | INITIAL TREATMENT | SINGLE-TABLET REGIMEN | CHRONIC KIDNEY-DISEASE | ELVITEGRAVIR/COBICISTAT/EMTRICITABINE/TENOFOVIR DF | CKD-EPI | HIV-1 | Adenine - analogs & derivatives | Tenofovir - therapeutic use | Humans | Middle Aged | Male | CD4 Lymphocyte Count | Viral Load | Adenine - administration & dosage | Adenine - therapeutic use | RNA, Viral | Adult | Anti-HIV Agents - therapeutic use | Female | HIV Infections - drug therapy | Drug Combinations | Tenofovir | Highly active antiretroviral therapy | Bones | Cross infection | Nosocomial infections | HIV (Viruses) | Density | HIV infection | Osteoporosis | Laboratories | Human immunodeficiency virus--HIV | Collaboration | Infections | Bone density | Kidney diseases | Drug dosages | Epidemiology
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10. Full Text Long-Term Effect of Endothelin Receptor Antagonism With Bosentan on the Morbidity and Mortality of Patients With Severe Chronic Heart Failure
by Packer, Milton, MD and McMurray, John J.V., MD and Krum, Henry, MD, PhD and Kiowski, Wolfgang, MD and Massie, Barry M., MD and Caspi, Avi, MD and Pratt, Craig M., MD and Petrie, Mark C., MD and DeMets, David, PhD and Kobrin, Isaac, MD and Roux, Sebastien, MD and Swedberg, Karl, MD
JACC: Heart Failure, ISSN 2213-1779, 2017, Volume 5, Issue 5, pp. 317 - 326
Abstract Objectives The objective of this clinical trial was to evaluate the long-term effect of endothelin receptor antagonism with bosentan on the morbidity... 
Cardiovascular | clinical trial | endothelin | heart failure | bosentan | placebo
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11. Full Text Secretory Phospholipase A(2)-IIA and Cardiovascular Disease
by Holmes, Michael V and Simon, Tabassome and Exeter, Holly J and Folkersen, Lasse and Asselbergs, Folkert W and Guardiola, Montse and Cooper, Jackie A and Palmen, Jutta and Hubacek, Jaroslav A and Carruthers, Kathryn F and Horne, Benjamin D and Brunisholz, Kimberly D and Mega, Jessica L and Van Iperen, Erik P. A and Li, Mingyao and Leusink, Maarten and Trompet, Stella and Verschuren, Jeffrey J. W and Hovingh, G. Kees and Dehghan, Abbas and Nelson, Christopher P and Kotti, Salma and Danchin, Nicolas and Scholz, Markus and Haase, Christiane L and Rothenbacher, Dietrich and Swerdlow, Daniel I and Kuchenbaecker, Karoline B and Staines-Urias, Eleonora and Goel, Anuj and van 't Hooft, Ferdinand and Gertow, Karl and de Faire, Ulf and Panayiotou, Anie G and Tremoli, Elena and Baldassarre, Damiano and Veglia, Fabrizio and Holdt, Lesca M and Beutner, Frank and Gansevoort, Ron T and Navis, Gerjan J and Mateo Leach, Irene and Breitling, Lutz P and Brenner, Hermann and Thiery, Joachim and Dallmeier, Dhayana and Franco-Cereceda, Anders and Boer, Jolanda M. A and Stephens, Jeffrey W and Hofker, Marten H and Tedgui, Alain and Hofman, Albert and Uitterlinden, Ane G and Adamkova, Vera and Pitha, Jan and Onland-Moret, N. Charlotte and Cramer, Maarten J and Nathoe, Henik M and Spiering, Wilko and Klungel, Olaf H and Kumari, Meena and Whincup, Peter H and Morrow, David A and Braund, Peter S and Hall, Alistair S and Olsson, Anders G and Doevendans, Pieter A and Trip, Mieke D and Tobin, Martin D and Hamsten, Anders and Watkins, Hugh and Koenig, Wolfgang and Nicolaides, Anew N and Teupser, Daniel and Day, Ian N. M and Carlquist, John F and Gaunt, Tom R and Ford, Ian and Sattar, Naveed and Tsimikas, Sotirios and Schwartz, Gregory G and Lawlor, Debbie A and Morris, Richard W and Sandhu, Manjinder S and Poledne, Rudolf and Maitland-van der Zee, Anke H and Khaw, Kay-Tee and Keating, Brendan J and van der Harst, Pim and Price, Jackie F and Mehta, Shamir R and Yusuf, Salim and Witteman, Jaqueline C. M and Franco, Oscar H and Jukema, J. Wouter and de Knijff, Peter and Tybjaerg-Hansen, Anne and Rader, Daniel J and Farrall, Martin and Samani, Nilesh J and ... and Avdelningen för kardiovaskulär medicin and Endokrinmedicinska kliniken and Linköpings universitet and Institutionen för medicin och hälsa and Hjärt- och Medicincentrum and Östergötlands Läns Landsting and Hälsouniversitetet
Journal of the American College of Cardiology, ISSN 0735-1097, 11/2013, Volume 62, Issue 21, pp. 1966 - 1976
Objectives This study sought to investigate the role of secretory phospholipase A(2) (sPLA(2))-IIA in cardiovascular disease. Background Higher circulating... 
EVENTS | drug development | RISK | ACUTE CORONARY SYNDROMES | cardiovascular diseases | Mendelian randomization | TRIAL | epidemiology | genetics | EPIC-NORFOLK | SERUM-LEVELS | INHIBITOR | HEALTHY-MEN | ARTERY-DISEASE | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | ACUTE CORONARY SYNDROME | ENZYMES | ASSOCIATION | TEKNIKVETENSKAP | Engineering and Technology | Teknik och teknologier | TECHNOLOGY
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12. Full Text Resuscitation Outcomes Consortium–Amiodarone, Lidocaine or Placebo Study (ROC-ALPS): Rationale and methodology behind an out-of-hospital cardiac arrest antiarrhythmic drug trial
by Kudenchuk, Peter J., MD and Brown, Siobhan P., PhD and Daya, Mohamud, MD and Morrison, Laurie J., MSc, MD and Grunau, Brian E., MD and Rea, Tom, MD and Aufderheide, Tom, MD and Powell, Judy, BSN and Leroux, Brian, PhD and Vaillancourt, Christian, MD and Larsen, Jonathan and Wittwer, Lynn, MD and Colella, M. Riccardo, DO, MPH and Stephens, Shannon W., EMT-P and Gamber, Mark, DO and Egan, Debra, MSc, MPH and Dorian, Paul, MD and Resuscitation Outcomes Consortium Investigators
American Heart Journal, ISSN 0002-8703, 2014, Volume 167, Issue 5, pp. 653 - 659.e4
Background Despite their wide use, whether antiarrhythmic drugs improve survival after out-of-hospital cardiac arrest (OHCA) is not known. The ROC-ALPS is... 
Cardiovascular | INTERNATIONAL LIAISON COMMITTEE | CARDIAC & CARDIOVASCULAR SYSTEMS | INTRAVENOUS AMIODARONE | VENTRICULAR-FIBRILLATION | CONSENSUS STATEMENT | AMERICAN-HEART-ASSOCIATION | EMERGENCY CARDIOVASCULAR CARE | CARDIOPULMONARY-RESUSCITATION | STROKE FOUNDATION | SOUTHERN AFRICA | DEFIBRILLATION ENERGY-REQUIREMENTS | Cardiopulmonary Resuscitation - methods | Prospective Studies | Follow-Up Studies | Ventricular Fibrillation - drug therapy | Humans | Out-of-Hospital Cardiac Arrest - etiology | Male | Out-of-Hospital Cardiac Arrest - mortality | Amiodarone - administration & dosage | Dose-Response Relationship, Drug | Young Adult | Heart Rate - drug effects | Out-of-Hospital Cardiac Arrest - therapy | Ventricular Fibrillation - complications | Adult | Female | Drug Therapy, Combination | Double-Blind Method | Ventricular Fibrillation - mortality | Treatment Outcome | Lidocaine - administration & dosage | Anti-Arrhythmia Agents - administration & dosage | Adolescent | North America - epidemiology | Emergency Medical Services | Amiodarone | Lidocaine | Analysis | Methods | Cardiac arrest | Heart | Medical research | Substance abuse treatment | Heart attacks | Hospitals | Research & development--R&D | Ventilation | Licensed products | FDA approval | Cardiopulmonary resuscitation--CPR | Pharmaceuticals
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