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Current Topics in Microbiology and Immunology, ISSN 0070-217X, 2010, Volume 346, Issue 1, pp. 183 - 202
PI3Ks play important roles in the signaling pathways used by a wide variety of cell surface receptors on neutrophils. Class IB PI3K plays a major role in the... 
Animals | Humans | Neutrophils - physiology | Phosphatidylinositol 3-Kinases - physiology | Signal Transduction - physiology | rho GTP-Binding Proteins - physiology | NADPH Oxidases - physiology
Journal Article
Science, ISSN 0036-8075, 10/2007, Volume 318, Issue 5847, pp. 64 - 66
Class I phosphoinositide 3-kinase (PI3K) signaling pathways regulate several important cellular functions, including cellular growth, division, survival, and... 
T lymphocytes | Receptors | Disease models | Neutrophils | Lipids | Ligands | Mast cells | Perspectives | Physiological regulation | Cells | Endothelial cells | PHOSPHOINOSITIDE 3-KINASE P110-GAMMA | INHIBITION | MULTIDISCIPLINARY SCIENCES | KINASE | SUBUNIT
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 09/2016, Volume 113, Issue 38, p. 10571
  Phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are enigmatic lipid kinases with physiological functions that are incompletely understood, not the least... 
Phosphorylation | Lymphocytes | Genomics | Lipids | Biosynthesis | Kinases
Journal Article
Annals of the New York Academy of Sciences, ISSN 0077-8923, 12/2012, Volume 1273, Issue 1, pp. 68 - 73
Journal Article
Biochemical Society Transactions, ISSN 0300-5127, 02/2016, Volume 44, Issue 1, pp. 307 - 314
There are eight members of the phosphoinositide family of phospholipids in eukaryotes; PI, PI3P, PI4P, PI5P, PI(4,5)P2, PI(3,4)P2, PI(3,5)P2 and PI(3,4,5)P3.... 
PI(3,4)P2 | Class I PI3K | INPP4 | FEME | PTEN | CME | SHIP | Class II PI3K | Endocytosis | Animals | Pseudopodia - metabolism | Signal Transduction | Models, Biological | Humans | Phosphatidylinositols - metabolism | Phosphatidylinositol 3-Kinases - metabolism
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2014, Volume 111, Issue 1, p. 155
  Insulin activation of phosphoinositide 3-kinase (PI3K) signaling regulates glucose homeostasis through the production of phosphatidylinositol... 
Proteins | Phosphorylation | Homeostasis | Glucose | Kinases | Gene expression | Insulin | Density
Journal Article
Nature Methods, ISSN 1548-7091, 03/2011, Volume 8, Issue 3, pp. 267 - 272
Class I phosphoinositide-3-kinase (PI3K) isoforms generate the intracellular signaling lipid, phosphatidylinositol(3,4,5)trisphosphate (PtdIns(3,4,5)P(3)).... 
Fats - chemistry | Neutrophils - chemistry | Animals | Humans | Cell Line, Tumor | Cells - chemistry | Mice | Phosphatidylinositol Phosphates - analysis | Chromatography, Liquid - methods | Mass Spectrometry - methods | Liver - chemistry | Lipids | Scientific method | Cellular biology | Kinases | Molecular biology | Mass spectrometry
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, p. e58425
We disrupted the gene encoding lysophosphatidylinositol-acyltransferase-1 (LPIAT1) in the mouse with the aim of understanding its role in determining cellular... 
Brain | Enzymes | Phosphoinositides | Laboratories | Liver | Lipids | Esters | Phospholipids | Metabolism | Acyltransferase | Mammals | Fatty acids | Defects | Brain research | Rodents | Animal tissues | Deacylation | Physiology | Species
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2017, Volume 68, Issue 3, pp. 566 - 580.e10
The PI3K signaling pathway regulates cell growth and movement and is heavily mutated in cancer. Class I PI3Ks synthesize the lipid messenger PI(3,4,5)P .... 
INPP4B | PI(3,4)P2 | invadopodia | PI3K | SHIP2 | PTEN | prostate | cancer | PI(3,4,5)P3 | PI(3,4,5)P | PI(3,4)P
Journal Article
Journal of Immunology, ISSN 0022-1767, 02/2017, Volume 198, Issue 3, pp. 1285 - 1296
Journal Article