Journal of Neuroscience, ISSN 0270-6474, 08/2018, Volume 38, Issue 34, pp. 7365 - 7374
Animals successfully thrive in noisy environments with finite resources. The necessity to function with resource constraints has led evolution to design animal...
MUSHROOM BODIES | CIRCUITS | ORGANIZATION | NEURAL-NETWORKS | MEMORY | REPRESENTATIONS | INFORMATION | NEURONS | SYNAPTIC PLASTICITY | NEUROSCIENCES | BRAIN | Viewpoints
MUSHROOM BODIES | CIRCUITS | ORGANIZATION | NEURAL-NETWORKS | MEMORY | REPRESENTATIONS | INFORMATION | NEURONS | SYNAPTIC PLASTICITY | NEUROSCIENCES | BRAIN | Viewpoints
Journal Article
The Journal of Neuroscience, ISSN 0270-6474, 08/2018, Volume 38, Issue 34, p. 7365
Animals successfully thrive in noisy environments with finite resources. The necessity to function with resource constraints has led evolution to design animal...
Brain | Circuit design | Computational neuroscience | Artificial neural networks | Olfactory discrimination learning | Background noise | Design optimization | Learning | Design | Animals | Computation | Neural networks | Computer applications | Machine learning | Fruit flies | Case depth
Brain | Circuit design | Computational neuroscience | Artificial neural networks | Olfactory discrimination learning | Background noise | Design optimization | Learning | Design | Animals | Computation | Neural networks | Computer applications | Machine learning | Fruit flies | Case depth
Journal Article
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Full Text
Genome-wide association studies identify four ER negative-specific breast cancer risk loci
Nature genetics, ISSN 1061-4036, 2013, Volume 45, Issue 4, pp. 392 - 398
Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African...
ESTROGEN | GENE | COMMON VARIANT | EXPRESSION | SUSCEPTIBILITY | GENETICS & HEREDITY | Genetic Predisposition to Disease | Genome-Wide Association Study | Meta-Analysis as Topic | Receptors, Estrogen - metabolism | Receptors, Estrogen - genetics | Oligonucleotide Array Sequence Analysis | Humans | Risk Factors | Breast Neoplasms - etiology | Genetic Loci - genetics | Cooperative Behavior | Genotype | Case-Control Studies | Breast Neoplasms - metabolism | Breast Neoplasms - pathology | Polymorphism, Single Nucleotide - genetics | Female | Quantitative trait loci | Receptors | Estrogen | Physiological aspects | Breast cancer | Genetic aspects | Research | Identification and classification | Health aspects | Risk factors | Confidence intervals | Genealogy | Womens health | Cell cycle | African Americans | Genetics | Genomes | Family medical history | Tumors
ESTROGEN | GENE | COMMON VARIANT | EXPRESSION | SUSCEPTIBILITY | GENETICS & HEREDITY | Genetic Predisposition to Disease | Genome-Wide Association Study | Meta-Analysis as Topic | Receptors, Estrogen - metabolism | Receptors, Estrogen - genetics | Oligonucleotide Array Sequence Analysis | Humans | Risk Factors | Breast Neoplasms - etiology | Genetic Loci - genetics | Cooperative Behavior | Genotype | Case-Control Studies | Breast Neoplasms - metabolism | Breast Neoplasms - pathology | Polymorphism, Single Nucleotide - genetics | Female | Quantitative trait loci | Receptors | Estrogen | Physiological aspects | Breast cancer | Genetic aspects | Research | Identification and classification | Health aspects | Risk factors | Confidence intervals | Genealogy | Womens health | Cell cycle | African Americans | Genetics | Genomes | Family medical history | Tumors
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 11/2013, Volume 1833, Issue 11, pp. 2410 - 2424
The endoplasmic reticulum is a major compartment of protein biogenesis in the cell, dedicated to production of secretory, membrane and organelle proteins. The...
Secretome | Chaperones | Protein folding | Endoplasmic reticulum | DISULFIDE BOND FORMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEWLY SYNTHESIZED PROTEINS | PHOSPHATIDYLSERINE-CONTAINING MEMBRANES | NEMATODE CAENORHABDITIS-ELEGANS | HUMAN CHORIONIC-GONADOTROPIN | VIRUS-G PROTEIN | ENDOPLASMIC-RETICULUM CHAPERONES | MARINESCO-SJOGREN-SYNDROME | CELL BIOLOGY | MHC CLASS-I | NUCLEOTIDE EXCHANGE FACTOR | Molecular Chaperones | Protein Biosynthesis | Animals | Proteins - secretion | Humans | Endoplasmic Reticulum - metabolism | Protein Processing, Post-Translational | Protein Folding | Protein Transport | Enzymes
Secretome | Chaperones | Protein folding | Endoplasmic reticulum | DISULFIDE BOND FORMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEWLY SYNTHESIZED PROTEINS | PHOSPHATIDYLSERINE-CONTAINING MEMBRANES | NEMATODE CAENORHABDITIS-ELEGANS | HUMAN CHORIONIC-GONADOTROPIN | VIRUS-G PROTEIN | ENDOPLASMIC-RETICULUM CHAPERONES | MARINESCO-SJOGREN-SYNDROME | CELL BIOLOGY | MHC CLASS-I | NUCLEOTIDE EXCHANGE FACTOR | Molecular Chaperones | Protein Biosynthesis | Animals | Proteins - secretion | Humans | Endoplasmic Reticulum - metabolism | Protein Processing, Post-Translational | Protein Folding | Protein Transport | Enzymes
Journal Article
Breast Cancer Research and Treatment, ISSN 0167-6806, 1/2014, Volume 143, Issue 2, pp. 325 - 332
Fulvestrant, which degrades ER, is used after AI failure in metastatic breast cancer but resistance develops quickly. We hypothesized that using everolimus to...
Estrogen receptor | Endocrine resistance | Medicine & Public Health | Oncology | Breast cancer | Everolimus | MTOR | Fulvestrant | TAMOXIFEN | ENDOCRINE THERAPY | RANDOMIZED-TRIAL | ANTIESTROGEN | EXEMESTANE | ONCOLOGY | GROWTH | DOUBLE-BLIND | RESISTANCE | COMBINATION ANASTROZOLE | POSTMENOPAUSAL WOMEN | Estradiol - analogs & derivatives | Receptors, Estrogen - metabolism | Sirolimus - analogs & derivatives | Sirolimus - therapeutic use | Estradiol - therapeutic use | Humans | Immunosuppressive Agents - therapeutic use | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Neoplasm Recurrence, Local - drug therapy | Breast Neoplasms - drug therapy | TOR Serine-Threonine Kinases - antagonists & inhibitors | Antineoplastic Agents, Hormonal - adverse effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Antineoplastic Agents, Hormonal - therapeutic use | Treatment Failure | Aged, 80 and over | Estradiol - adverse effects | Female | Immunosuppressive Agents - adverse effects | Aged | Aromatase Inhibitors - therapeutic use | Sirolimus - adverse effects | Medical research | Care and treatment | Estrogen | Clinical trials | Postmenopausal women | Metastasis | Tamoxifen | Chemotherapy | Phenols | Medicine, Experimental | Product development | Cancer | Index Medicus
Estrogen receptor | Endocrine resistance | Medicine & Public Health | Oncology | Breast cancer | Everolimus | MTOR | Fulvestrant | TAMOXIFEN | ENDOCRINE THERAPY | RANDOMIZED-TRIAL | ANTIESTROGEN | EXEMESTANE | ONCOLOGY | GROWTH | DOUBLE-BLIND | RESISTANCE | COMBINATION ANASTROZOLE | POSTMENOPAUSAL WOMEN | Estradiol - analogs & derivatives | Receptors, Estrogen - metabolism | Sirolimus - analogs & derivatives | Sirolimus - therapeutic use | Estradiol - therapeutic use | Humans | Immunosuppressive Agents - therapeutic use | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Neoplasm Recurrence, Local - drug therapy | Breast Neoplasms - drug therapy | TOR Serine-Threonine Kinases - antagonists & inhibitors | Antineoplastic Agents, Hormonal - adverse effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Antineoplastic Agents, Hormonal - therapeutic use | Treatment Failure | Aged, 80 and over | Estradiol - adverse effects | Female | Immunosuppressive Agents - adverse effects | Aged | Aromatase Inhibitors - therapeutic use | Sirolimus - adverse effects | Medical research | Care and treatment | Estrogen | Clinical trials | Postmenopausal women | Metastasis | Tamoxifen | Chemotherapy | Phenols | Medicine, Experimental | Product development | Cancer | Index Medicus
Journal Article
British Journal of Cancer, ISSN 0007-0920, 03/2015, Volume 112, Issue 5, pp. 912 - 917
Background: Several prognostic models have been proposed and demonstrated to be predictive of survival outcomes in breast cancer. In the present article, we...
risk assessment | ADJUVANT ONLINE | survival | VALIDATION | breast cancer | RISK | DEATH | PROGNOSTIC MODEL | WOMEN | THERAPY | predictive models | ONCOLOGY | RECURRENCE | adjuvant treatment | PROGRAM | Receptors, Estrogen - metabolism | SEER Program | Breast Neoplasms - pathology | Models, Biological | Humans | Middle Aged | Receptor, ErbB-2 - metabolism | Survival Analysis | Adult | Breast Neoplasms - mortality | Female | Web Browser | Epidemiology
risk assessment | ADJUVANT ONLINE | survival | VALIDATION | breast cancer | RISK | DEATH | PROGNOSTIC MODEL | WOMEN | THERAPY | predictive models | ONCOLOGY | RECURRENCE | adjuvant treatment | PROGRAM | Receptors, Estrogen - metabolism | SEER Program | Breast Neoplasms - pathology | Models, Biological | Humans | Middle Aged | Receptor, ErbB-2 - metabolism | Survival Analysis | Adult | Breast Neoplasms - mortality | Female | Web Browser | Epidemiology
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2017, Volume 114, Issue 47, pp. 12489 - 12494
BiP (Kar2 in yeast) is an essential Hsp70 chaperone and master regulator of endoplasmic reticulum (ER) function. BSP's activity is regulated by its intrinsic...
ERAD | Redox | Sil1 | N-glycosylation | Ost3 | ALPHA-FACTOR | ATPASE ACTIVITY | YEAST ENDOPLASMIC-RETICULUM | UBIQUITIN LIGASE | RETICULUM-ASSOCIATED DEGRADATION | PROTEIN TRANSLOCATION | MOLECULAR CHAPERONES | MULTIDISCIPLINARY SCIENCES | FUNCTIONAL-CHARACTERIZATION | SACCHAROMYCES-CEREVISIAE | redox | SECRETORY PATHWAY | Homeostasis | Research | Nucleotides | Gene expression | Endoplasmic reticulum | Risk factors | Biological Sciences
ERAD | Redox | Sil1 | N-glycosylation | Ost3 | ALPHA-FACTOR | ATPASE ACTIVITY | YEAST ENDOPLASMIC-RETICULUM | UBIQUITIN LIGASE | RETICULUM-ASSOCIATED DEGRADATION | PROTEIN TRANSLOCATION | MOLECULAR CHAPERONES | MULTIDISCIPLINARY SCIENCES | FUNCTIONAL-CHARACTERIZATION | SACCHAROMYCES-CEREVISIAE | redox | SECRETORY PATHWAY | Homeostasis | Research | Nucleotides | Gene expression | Endoplasmic reticulum | Risk factors | Biological Sciences
Journal Article
Breast Cancer Research and Treatment, ISSN 0167-6806, 1/2015, Volume 149, Issue 2, pp. 565 - 565
Journal Article
META, ISSN 2033-639X, 06/2018, Volume 94, Issue 5, p. 21
Journal Article
PLOS ONE, ISSN 1932-6203, 02/2017, Volume 12, Issue 2, p. e0169962
Background Avoiding axillary lymph node dissection (ALND) for invasive breast cancers with isolated tumor cells or micrometastatic sentinel node biopsy (SNB)...
DISSECTION | MULTIDISCIPLINARY SCIENCES | METASTASES | INVOLVEMENT | BIOPSY | MICROMETASTASES | RECURRENCE | PROGNOSTIC-SIGNIFICANCE | OUTCOMES | CARCINOMA | AXILLARY LYMPH-NODES | Lymph Node Excision | Breast Neoplasms - economics | Humans | Middle Aged | Receptor, ErbB-2 - metabolism | Models, Economic | Breast Neoplasms - metabolism | Sentinel Lymph Node - pathology | Neoplasm Metastasis | Breast Neoplasms - pathology | Computer Simulation | Cost-Benefit Analysis | Lymphatic Metastasis - pathology | Nomograms | Aged, 80 and over | Axilla | Adult | Estrogen Receptor alpha - metabolism | Female | Aged | Breast Neoplasms - diagnosis | Retrospective Studies | Sentinel Lymph Node Biopsy | Neoplasm Micrometastasis - pathology | Treatment outcome | Care and treatment | Usage | Breast cancer | Analysis | Sentinel lymph node biopsy | Surgical outcomes | Oncology | Metastasis | Lymph nodes | Metastases | Impact analysis | Surgery | Mastectomy | Dissection | Economics | Medical research | Lymphatic system | Review boards | Tumor cells | Invasiveness | Calibration | Patients | ErbB-2 protein | Morbidity | Simulation | Biopsy | Minimum inhibitory concentration | Predictions | Surgeons | Breast | Economic impact | Cancer
DISSECTION | MULTIDISCIPLINARY SCIENCES | METASTASES | INVOLVEMENT | BIOPSY | MICROMETASTASES | RECURRENCE | PROGNOSTIC-SIGNIFICANCE | OUTCOMES | CARCINOMA | AXILLARY LYMPH-NODES | Lymph Node Excision | Breast Neoplasms - economics | Humans | Middle Aged | Receptor, ErbB-2 - metabolism | Models, Economic | Breast Neoplasms - metabolism | Sentinel Lymph Node - pathology | Neoplasm Metastasis | Breast Neoplasms - pathology | Computer Simulation | Cost-Benefit Analysis | Lymphatic Metastasis - pathology | Nomograms | Aged, 80 and over | Axilla | Adult | Estrogen Receptor alpha - metabolism | Female | Aged | Breast Neoplasms - diagnosis | Retrospective Studies | Sentinel Lymph Node Biopsy | Neoplasm Micrometastasis - pathology | Treatment outcome | Care and treatment | Usage | Breast cancer | Analysis | Sentinel lymph node biopsy | Surgical outcomes | Oncology | Metastasis | Lymph nodes | Metastases | Impact analysis | Surgery | Mastectomy | Dissection | Economics | Medical research | Lymphatic system | Review boards | Tumor cells | Invasiveness | Calibration | Patients | ErbB-2 protein | Morbidity | Simulation | Biopsy | Minimum inhibitory concentration | Predictions | Surgeons | Breast | Economic impact | Cancer
Journal Article
Seminars in Cell and Developmental Biology, ISSN 1084-9521, 10/1999, Volume 10, Issue 5, pp. 443 - 454
The endoplasmic reticulum (ER) is a major protein folding compartment for secreted, plasma membrane and organelle proteins. Each of these newly-synthesized...
chaperones, ER quality control, cooperativity, thermodynamics | Thermodynamics | Chaperones | Cooperativity | ER quality control | DISULFIDE BOND FORMATION | cooperativity | MOLTEN GLOBULE STATE | ESCHERICHIA-COLI | thermodynamics | ENDOPLASMIC-RETICULUM PROTEINS | DEVELOPMENTAL BIOLOGY | FK506-BINDING PROTEIN | VIRUS-G PROTEIN | MOLECULAR CHAPERONE BIP | CELL BIOLOGY | GLUCOSE-REGULATED PROTEINS | MALTOSE-BINDING PROTEIN | INFLUENZA-VIRUS | chaperones | Translocation, Genetic | Endoplasmic Reticulum - chemistry | Oxidation-Reduction | Protein Sorting Signals - genetics | Calcium - metabolism | Humans | Molecular Chaperones - genetics | Models, Molecular | Glycosylation | Molecular Chaperones - chemistry | Protein Folding | Proteins | Protein folding | MODIFICATIONS | ENDOPLASMIC RETICULUM | PLASMA | BASIC BIOLOGICAL SCIENCES | AMINO ACID SEQUENCE | MEMBRANES | AGGLOMERATION | PROTEINS | CELL CONSTITUENTS | POLYPEPTIDES
chaperones, ER quality control, cooperativity, thermodynamics | Thermodynamics | Chaperones | Cooperativity | ER quality control | DISULFIDE BOND FORMATION | cooperativity | MOLTEN GLOBULE STATE | ESCHERICHIA-COLI | thermodynamics | ENDOPLASMIC-RETICULUM PROTEINS | DEVELOPMENTAL BIOLOGY | FK506-BINDING PROTEIN | VIRUS-G PROTEIN | MOLECULAR CHAPERONE BIP | CELL BIOLOGY | GLUCOSE-REGULATED PROTEINS | MALTOSE-BINDING PROTEIN | INFLUENZA-VIRUS | chaperones | Translocation, Genetic | Endoplasmic Reticulum - chemistry | Oxidation-Reduction | Protein Sorting Signals - genetics | Calcium - metabolism | Humans | Molecular Chaperones - genetics | Models, Molecular | Glycosylation | Molecular Chaperones - chemistry | Protein Folding | Proteins | Protein folding | MODIFICATIONS | ENDOPLASMIC RETICULUM | PLASMA | BASIC BIOLOGICAL SCIENCES | AMINO ACID SEQUENCE | MEMBRANES | AGGLOMERATION | PROTEINS | CELL CONSTITUENTS | POLYPEPTIDES
Journal Article