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New England Journal of Medicine, ISSN 0028-4793, 04/2015, Volume 372, Issue 18, pp. 1774 - 1775
Journal Article
Science, ISSN 0036-8075, 2014, Volume 343, Issue 6168, pp. 256 - 257
The surprising ability of thalidomide and its analogs to treat various hematologic malignancies is through the loss of two transcription factors. 
MULTIPLE-MYELOMA | IRF4 | IKAROS | MULTIDISCIPLINARY SCIENCES | LENALIDOMIDE | CEREBLON EXPRESSION | POMALIDOMIDE | AIOLOS | Care and treatment | Dosage and administration | Research | Thalidomide | Oncology, Experimental | Cancer | Medicine | Drug therapy | Multiple myeloma
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 01/2015, Volume 372, Issue 2, pp. 142 - 152
Journal Article
PLoS Genetics, ISSN 1553-7390, 02/2014, Volume 10, Issue 2, pp. e1004135 - e1004135
Author Summary Cholangiocarcinoma is a cancer that affects the bile ducts. Unfortunately, many patients diagnosed with cholangiocarcinoma have disease that... 
C-VIRUS-INFECTION | GROWTH-FACTOR RECEPTOR | BILIARY-TRACT CANCER | K-RAS MUTATIONS | RISK-FACTORS | GENETICS & HEREDITY | TUMOR-SUPPRESSOR GENE | HEPATITIS-C | PRIMARY SCLEROSING CHOLANGITIS | FLUKE-ASSOCIATED CHOLANGIOCARCINOMA | NEGATIVE BREAST-CANCER | Erlotinib Hydrochloride | Receptor, Epidermal Growth Factor - genetics | Prognosis | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | Transcriptome | Imidazoles - administration & dosage | Molecular Targeted Therapy | Receptor, Epidermal Growth Factor - metabolism | Pyridazines - administration & dosage | Quinazolines - administration & dosage | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Bile Duct Neoplasms - genetics | Bile Duct Neoplasms - drug therapy | Bile Ducts, Intrahepatic - pathology | Pyrimidines - administration & dosage | Signal Transduction - genetics | Cholangiocarcinoma - pathology | Protein Kinase Inhibitors | Cholangiocarcinoma - drug therapy | Cell Line, Tumor | Cholangiocarcinoma - genetics | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Bile Duct Neoplasms - pathology | Mutation | Genome, Human | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Sulfonamides - administration & dosage | Antimitotic agents | Analysis | Genomics | Research | Antineoplastic agents | Health aspects | Tumors | Index Medicus | Studies | Hepatitis | Substance abuse treatment | Genetic engineering | Genomes | Kinases | Gene expression | Patients | Cancer
Journal Article
Cancer Cell, ISSN 1535-6108, 09/2013, Volume 24, Issue 3, pp. 289 - 304
Proteasome inhibitor (PI) resistance mechanisms in multiple myeloma (MM) remain controversial. We report the existence of a progenitor organization in primary... 
BORTEZOMIB RESISTANCE | OVEREXPRESSION | DEXAMETHASONE | BLIMP-1 | UNFOLDED PROTEIN RESPONSE | ONCOLOGY | FACTOR XBP-1 | MECHANISMS | DIFFERENTIATION | CANCER | GENOME | CELL BIOLOGY | eIF-2 Kinase - metabolism | Humans | Precursor Cells, B-Lymphoid - metabolism | Transcription Factors - deficiency | Pyrazines - therapeutic use | Boronic Acids - therapeutic use | DNA-Binding Proteins - deficiency | X-Box Binding Protein 1 | Plasma Cells - pathology | DNA-Binding Proteins - metabolism | Multiple Myeloma - drug therapy | Precursor Cells, B-Lymphoid - pathology | Plasma Cells - metabolism | Membrane Proteins - metabolism | Protein-Serine-Threonine Kinases - metabolism | Cell Survival - drug effects | Bortezomib | Endoribonucleases - metabolism | Proteasome Inhibitors - pharmacology | Signal Transduction | Immunophenotyping | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Multiple Myeloma - metabolism | Regulatory Factor X Transcription Factors | Proteasome Inhibitors - therapeutic use | Transcription Factors - metabolism | Activating Transcription Factor 6 - metabolism | Drug Resistance, Neoplasm - genetics | Endoplasmic Reticulum Stress | Mutation | Pyrazines - pharmacology | Multiple Myeloma - genetics | Boronic Acids - pharmacology | Immunoglobulins | Care and treatment | Multiple myeloma | Genetic research | Health aspects | Tumors | Cancer | Index Medicus
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 10/2017, Volume 377, Issue 14, pp. 1319 - 1330
Journal Article