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Journal of Visualized Experiments, ISSN 1940-087X, 03/2018, Volume 2018, Issue 133
Covalent DNA adducts formed by chemicals or drugs with carcinogenic potency are judged as one of the most important factors in the initiation phase of... 
Drug | Carcinogen | Reductases | DNA Adducts | Bioactivation | Cytochrome P450 | Issue 133 | P-postlabeling | Biochemistry
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 07/2017, Volume 18, Issue 7, p. 1414
Carcinogenesis cannot be explained only by genetic alterations, but also involves epigenetic processes. Modification of histones by acetylation plays a key... 
Histone deacetylase inhibitors | Anti-angiogenic effect | Cell cycle arrest | Drug combinations | Histone deacetylases | Autophagy | Apoptosis | Cancer | HDAC INHIBITORS | autophagy | SUBEROYLANILIDE HYDROXAMIC ACID | HUMAN LEUKEMIA-CELLS | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR GENES | apoptosis | VALPROIC ACID | cell cycle arrest | anti-angiogenic effect | CHEMISTRY, MULTIDISCIPLINARY | drug combinations | CELL LUNG-CANCER | EPITHELIAL-MESENCHYMAL TRANSITION | PHASE-II TRIAL | LONG NONCODING RNA | histone deacetylases | cancer | histone deacetylase inhibitors | Immunomodulation - drug effects | Apoptosis - drug effects | Humans | Angiogenesis Inhibitors - pharmacology | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Antineoplastic Agents - therapeutic use | Clinical Trials as Topic | Autophagy - drug effects | Acetylation - drug effects | Animals | Signal Transduction - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Cell Cycle Checkpoints - drug effects | Angiogenesis Inhibitors - therapeutic use | Histone Deacetylase Inhibitors - pharmacology | Antineoplastic Agents - pharmacology | Epigenesis, Genetic - drug effects | Histone Deacetylase Inhibitors - therapeutic use | Gene Expression Regulation, Neoplastic - drug effects | Drug Evaluation, Preclinical
Journal Article
Archives of Toxicology, ISSN 0340-5761, 11/2016, Volume 90, Issue 11, pp. 2595 - 2615
Balkan endemic nephropathy (BEN) is a unique, chronic renal disease frequently associated with upper urothelial cancer (UUC). It only affects residents of... 
Biomedicine, general | Biomedicine | Environmental Health | Disease aetiology | Occupational Medicine/Industrial Medicine | Upper urothelial cancer | Aristolochic acid | Pharmacology/Toxicology | Balkan endemic nephropathy | Aristolochic acid nephropathy | Environmental and genetic factors | UROTHELIAL CANCER | MYCOTOXIN OCHRATOXIN-A | ARISTOLOCHIC-ACID-I | METABOLIC-ACTIVATION | CYTOCHROMES P450 1A1 | P-32 POSTLABELING ANALYSIS | DNA ADDUCT FORMATION | CHINESE HERBS NEPHROPATHY | RISK-FACTOR | REDUCTIVE ACTIVATION | TOXICOLOGY | Balkan Nephropathy - epidemiology | Europe, Eastern - epidemiology | Plant Weeds - growth & development | Urologic Neoplasms - epidemiology | Flour - adverse effects | Prevalence | Diet - adverse effects | Humans | Crops, Agricultural - growth & development | Balkan Nephropathy - chemically induced | Carcinogens, Environmental - analysis | Triticum - growth & development | Plant Weeds - chemistry | Risk | Aristolochia - toxicity | Carcinogens, Environmental - toxicity | Plant Weeds - toxicity | Endemic Diseases | Food Contamination - prevention & control | Seeds - growth & development | Urologic Neoplasms - prevention & control | Aristolochic Acids - toxicity | Drug Resistance | Kidney - physiopathology | Kidney - drug effects | Balkan Nephropathy - physiopathology | Urologic Neoplasms - chemically induced | Balkan Nephropathy - prevention & control | Aristolochia - growth & development | Evidence-Based Medicine | Aristolochia - chemistry | Flour - analysis | Animals | Confounding Factors (Epidemiology) | Aristolochic Acids - analysis | Urologic Neoplasms - physiopathology | Oncology, Experimental | Disease susceptibility | Kidney diseases | Research | Health aspects | Epidemiology | Cancer | Genetics | Environment | Review
Journal Article
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 10/2017, Volume 18, Issue 10, p. 2144
Journal Article
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 02/2014, Volume 21, Issue 5, pp. 575 - 591
The anti-tumor therapeutic ellipticine and its derivatives act as potent anticancer agents via a combined mechanism involving cell cycle arrest and induction... 
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 11/2015, Volume 16, Issue 11, pp. 27561 - 27575
Aristolochic acid I (AAI) is a plant alkaloid causing aristolochic acid nephropathy, Balkan endemic nephropathy and their associated urothelial malignancies.... 
Plant nephrotoxin and carcinogen aristolochic acid I | Cytochrome P450-mediated detoxification of aristolochic acid I | Molecular modeling | Contribution of cytochromes P450 in detoxification of aristolochic acid I in human and rat livers | cytochrome P450-mediated detoxification of aristolochic acid I | ANTICANCER DRUG ELLIPTICINE | UROTHELIAL CANCER | SUDAN-I | BIOCHEMISTRY & MOLECULAR BIOLOGY | NAD(P)H/QUINONE OXIDOREDUCTASE | METABOLIC-ACTIVATION | P-32 POSTLABELING ANALYSIS | DNA ADDUCT FORMATION | CHEMISTRY, MULTIDISCIPLINARY | RENAL TISSUE | RISK-FACTOR | molecular modeling | contribution of cytochromes P450 in detoxification of aristolochic acid I in human and rat livers | REDUCTIVE ACTIVATION | plant nephrotoxin and carcinogen aristolochic acid I | Activation, Metabolic | Inactivation, Metabolic | Humans | Microsomes, Liver - metabolism | Molecular Conformation | Cytochrome P-450 Enzyme System - metabolism | Male | Liver - drug effects | Microsomes, Liver - drug effects | Oxidation-Reduction - drug effects | Catalysis | Kidney Diseases - metabolism | Catalytic Domain | Liver - metabolism | Models, Molecular | Rats | Aristolochic Acids - adverse effects | Cytochrome P-450 Enzyme Inhibitors - pharmacology | Cytochrome P-450 Enzyme System - chemistry | Animals | Aristolochic Acids - metabolism | Methylation - drug effects | Protein Binding | Aristolochic Acids - chemistry | Kidney Diseases - etiology | Cytochrome | Chemical reactions | Acids | Rodents | Liver
Journal Article
Journal Article