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Biochimie, ISSN 0300-9084, 2017, Volume 136, pp. 75 - 84
The peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor that is abundantly expressed in liver. PPARα is activated... 
Target genes | Human liver | Lipid metabolism | Non-alcoholic fatty liver disease | PPARα
Journal Article
Diabetologia, ISSN 0012-186X, 2016, pp. 879 - 894
Inflammation originating from the adipose tissue is considered to be one of the main driving forces for the development of insulin resistance and type 2... 
Obesity | Adipose tissue | Fat | Insulin resistance | Inflammation | Review | Immune cells | Macrophages | Metabolism
Journal Article
Trends in Endocrinology & Metabolism, ISSN 1043-2760, 2018, Volume 29, Issue 12, pp. 813 - 814
In addition to the impact of Bacillus Calmette–Guerin (BCG) vaccination on antimicrobial host defence, a novel study reveals beneficial effects on glycaemic... 
Nutrition, Metabolism and Genomics | Chair Nutrition Metabolism and Genomics | HNE Voeding, Metabolisme en Genomics | Voeding, Metabolisme en Genomica | HNE Nutrition, Metabolism and Genomics
Journal Article
Diabetologia, ISSN 0012-186X, 2018, Volume 61, Issue 4, pp. 942 - 953
Recent studies have identified intracellular metabolism as a fundamental determinant of macrophage function. In obesity, proinflammatory macrophages accumulate... 
Immunometabolism | Adipose tissue | Medicine & Public Health | Human Physiology | Oxidative phosphorylation | Metabolic Diseases | Internal Medicine | Inflammation | Glycolysis obesity | Macrophages | CELLS | LOCALIZATION | ADIPOCYTES | NECROSIS-FACTOR-ALPHA | Immuno metabolism | CIRCULATING LEVELS | INSULIN-RESISTANCE | FUNCTIONAL POLARIZATION | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | CHEMOKINE | HIF-1-ALPHA | Myeloid Cells - cytology | Activation, Metabolic | Cytokines - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Mice, Inbred C57BL | Gene Expression Regulation | Insulin Resistance | Adipose Tissue - cytology | Male | Gene Expression Profiling | Mice, Knockout | Obesity - metabolism | Macrophages - metabolism | Phenotype | Animals | Adipocytes - metabolism | Oxygen - chemistry | Glycolysis | Mice | Adipose tissues | Lactates | Obesity | Glucose metabolism | Analysis | Leptin | Insulin resistance | Metabolic rate | Energy metabolism | CD14 antigen | Cell activation | Bone marrow | Oxidation | Enzyme-linked immunosorbent assay | Hypoxia-inducible factors | Explants | Cytokines | Diabetes mellitus | Metabolism | Gene expression | Insulin | DNA microarrays | Metabolic activation | Hypoxia | Lactic acid | Intracellular | Peritoneum | Nutrition, Metabolism and Genomics | Chair Nutrition Metabolism and Genomics | HNE Voeding, Metabolisme en Genomics | VLAG | Voeding, Metabolisme en Genomica | HNE Nutrition, Metabolism and Genomics
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2011, Volume 108, Issue 37, pp. 15324 - 15329
Inflammation plays a key role in the pathogenesis of obesity. Chronic overfeeding leads to macrophage infiltration in the adipose tissue, resulting in... 
Adipose tissues | Obesity | Cytokines | Insulin resistance | Mice | Gene expression regulation | Triglycerides | Inflammation | Adipocytes | Macrophages | APOPTOSIS | ACTIVATION | INTERLEUKIN-18 | MICE DEFICIENT | CASPASE-1 | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | CRYSTALS | IL-1-BETA | EXPRESSION | ADIPOSE-TISSUE | Inflammasomes - metabolism | Fatty Liver - pathology | NLR Family, Pyrin Domain-Containing 3 Protein | Cholesterol - blood | Humans | Fatty Liver - complications | Caspase 1 - metabolism | Male | Adipocytes - drug effects | Obesity - blood | Cytoskeletal Proteins - deficiency | Dietary Fats - pharmacology | Dietary Fats - administration & dosage | Cytoskeletal Proteins - metabolism | Hyperinsulinism - complications | Macrophages - pathology | Obesity - complications | Adipose Tissue - pathology | Fatty Liver - prevention & control | Insulin Resistance | Adipocytes - pathology | Obesity - metabolism | Cell Movement - drug effects | Hyperinsulinism - pathology | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Adipocytes - metabolism | CARD Signaling Adaptor Proteins | Triglycerides - blood | Macrophages - drug effects | Glucose Clamp Technique | Energy Metabolism - drug effects | Hypertrophy | Physiological aspects | Research | Gene expression | Leptin | Biological Sciences | crystals | expression | interleukin-18 | mice deficient | il-1-beta | apoptosis | sensitivity | adipose-tissue | activation | caspase-1
Journal Article
Clinical science, ISSN 0143-5221, 2019, Volume 133, Issue 2, pp. 195 - 203
Trained immunity is a recently described phenomenon whereby innate immune cells undergo functional reprogramming in response to microbial products, vaccines,... 
Immunometabolism | Monocyte | Cardiovascular disease | Diabetes | Trained immunity | Macrophage
Journal Article
Nature Communications, ISSN 2041-1723, 2014, Volume 5, Issue 1, p. 4711
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 4/2011, Volume 52, Issue 4, pp. 591 - 592
Journal Article
Journal of clinical investigation, ISSN 0021-9738, 2012, Volume 122, Issue 9, pp. 3343 - 3354
Lipid overload and adipocyte dysfunction are key to the development of insulin resistance and can be induced by a high-fat diet. CD1d-restricted invariant... 
OBESE MICE | MEDICINE, RESEARCH & EXPERIMENTAL | ALTERNATIVELY ACTIVATED MACROPHAGES | METABOLIC SYNDROME | NONOBESE DIABETIC MICE | INFLAMMATION | DISEASE | INVARIANT NKT CELLS | FAT | HEPATIC STEATOSIS | INNATE IMMUNITY | Intra-Abdominal Fat - physiopathology | Liver - pathology | Oligonucleotide Array Sequence Analysis | Coculture Techniques | Humans | Transcriptome | Lymphocyte Depletion | T-Lymphocytes, Regulatory - pathology | Natural Killer T-Cells - physiology | Subcutaneous Fat - immunology | Natural Killer T-Cells - metabolism | Diet, High-Fat | Antigens, CD1d - genetics | Cytokines - genetics | Intra-Abdominal Fat - immunology | Cell Line | Gene Expression | Cytokines - metabolism | Down-Regulation | Liver - metabolism | Mice, Inbred C57BL | Cytokines - secretion | Subcutaneous Fat - pathology | Antigens, CD1d - metabolism | Triglycerides - metabolism | Receptors, CCR2 - metabolism | Animals | Adipocytes - metabolism | Subcutaneous Fat - physiopathology | Insulin Resistance - immunology | Mice | Intra-Abdominal Fat - pathology | Adipose tissues | Prevention | Killer cells | Physiological aspects | Insulin resistance | T cells | Risk factors | metabolic syndrome | disease | innate immunity | alternatively activated macrophages | inflammation | invariant nkt cells | obese mice | fat | nonobese diabetic mice | hepatic steatosis
Journal Article
Diabetologia, ISSN 0012-186X, 2017, Volume 60, Issue 7, pp. 1304 - 1313
Journal Article
BMC Physiology, ISSN 1472-6793, 2012, Volume 12, Issue 1, pp. 13 - 13
Journal Article