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PLoS One, ISSN 1932-6203, 10/2014, Volume 9, Issue 10, pp. e111115 - e111115
Background and objective: The long term effects of fingolimod, an oral treatment for relapsing-remitting (RR) multiple sclerosis (MS), on blood circulating B... 
ORAL FINGOLIMOD | IMMUNE CELLS | MEMORY | MARGINAL ZONE | FTY720 | MULTIDISCIPLINARY SCIENCES | SUBSETS | PHASE-II | FOXP3 | SYSTEMIC AUTOIMMUNITY | SPHINGOSINE 1-PHOSPHATE | T-Lymphocyte Subsets - immunology | T-Lymphocytes, Regulatory - metabolism | Follow-Up Studies | Humans | Immunosuppressive Agents - therapeutic use | Middle Aged | Male | T-Lymphocytes, Regulatory - pathology | T-Lymphocytes, Regulatory - immunology | Young Adult | Propylene Glycols - therapeutic use | Adult | B-Lymphocyte Subsets - immunology | Female | Multiple Sclerosis, Relapsing-Remitting - immunology | B-Lymphocyte Subsets - pathology | Multiple Sclerosis, Relapsing-Remitting - blood | Multiple Sclerosis, Relapsing-Remitting - drug therapy | Fingolimod Hydrochloride | B7-1 Antigen - metabolism | B7-2 Antigen - metabolism | Sphingosine - analogs & derivatives | T-Lymphocyte Subsets - pathology | B-Lymphocyte Subsets - metabolism | T-Lymphocyte Subsets - metabolism | Adolescent | Sphingosine - therapeutic use | Aged | Medical research | Multiple sclerosis | Automobile driving | Medicine, Experimental | B cells | Biological response modifiers | T cells | Motor vehicle driving | Flow cytometry | Neurosciences | Nuclear magnetic resonance--NMR | Biomedical research | CD86 antigen | Leukocyte migration | Pathogenesis | Memory | Homeostasis | Lymphocytes T | Blood | Immunology | Lymphocytes | Peripheral blood | Life sciences | Antigen presentation | Antigens | Data analysis | Immunological memory | Memory cells | Immune response | Immunoregulation | CD80 antigen | Long term effects | Patients | Neurology | Cytometry | Blood circulation | Lymphocytes B | Interferon | Rehabilitation | Cell migration | Apoptosis | Index Medicus | Nuclear magnetic resonance | NMR
Journal Article
Journal of Autoimmunity, ISSN 0896-8411, 02/2012, Volume 38, Issue 1, pp. 10 - 19
Immunosenescence, or ageing of the immune system, contributes to the increased morbidity and mortality seen in the elderly population. Premature... 
CX3CR1 | Immunosenescence | Multiple sclerosis | Fractalkine | T cells | CR1 | CX
Journal Article
Immunology, ISSN 0019-2805, 2008, Volume 123, Issue 1, pp. 79 - 89
CD4 + CD25 high regulatory T cells (Tregs) of patients with relapsing-remitting (RR) multiple sclerosis (MS), in contrast to those of patients with secondary... 
Autoimmunity | Tolerance | Multiple sclerosis | Regulatory T cells | FOXP3 | regulatory T cells | autoimmunity | Original | multiple sclerosis | tolerance
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 663 - 11
Cytomegalovirus (CMV) is a latent virus which causes chronic activation of the immune system. Here, we demonstrate that cytotoxic and pro-inflammatory CD4(+)... 
ENCEPHALOMYELITIS | CD4(+)CD28(-) T-CELLS | MULTIPLE-SCLEROSIS | CD28 EXPRESSION | FUNCTIONAL SUBSETS | MULTIDISCIPLINARY SCIENCES | PEPTIDE 981-1003 | COSTIMULATION | PATHOGENIC FEATURES | CORONARY-ARTERY-DISEASE | IMMUNOSENESCENCE | Autoimmunity | T-Lymphocyte Subsets - immunology | Humans | Middle Aged | Encephalomyelitis, Autoimmune, Experimental - immunology | Male | Cytomegalovirus Infections - complications | Cytomegalovirus Infections - immunology | CD4-Positive T-Lymphocytes - immunology | Young Adult | Cytomegalovirus Infections - virology | Adult | Female | Demyelinating Diseases | Disease Models, Animal | Severity of Illness Index | Encephalomyelitis, Autoimmune, Experimental - pathology | CD4-Positive T-Lymphocytes - metabolism | Disease Progression | Multiple Sclerosis - complications | Cytomegalovirus - immunology | Animals | T-Lymphocyte Subsets - metabolism | Encephalomyelitis, Autoimmune, Experimental - complications | Multiple Sclerosis - immunology | Multiple Sclerosis - pathology | Antigens - immunology | Mice | Multiple Sclerosis - drug therapy | Cytomegalovirus | Spinal cord | Immunoglobulins | Animal models | Multiple sclerosis | Oligodendrocyte-myelin glycoprotein | Encephalomyelitis | Central nervous system | Cytotoxicity | Leukocytes (mononuclear) | Lymphocytes T | Inflammation | CD28 antigen | Experimental allergic encephalomyelitis | Sclerosis | CD4 antigen | Cell activation | Demyelination | Lymphocytes | Peripheral blood mononuclear cells | Cell migration | Immune system | Index Medicus
Journal Article
Clinical Immunology, ISSN 1521-6616, 2007, Volume 123, Issue 2, pp. 209 - 218
Abstract The objective of this study was to evaluate the degree of immunosenescence in patients with autoimmune disease. T cell receptor excision circles... 
Allergy and Immunology | Autoimmunity | Thymic involution | Immunosenescence | CD4 +CD28 null T cells | CD28 | CD4 | T cells | RHEUMATOID-ARTHRITIS | POPULATION | SYSTEMIC-LUPUS-ERYTHEMATOSUS | thymic involution | T-CELL HOMEOSTASIS | CLASSIFICATION | MECHANISMS | IMMUNOLOGY | PATHOGENESIS | CD4(+)CD28(null) T cells | immunosenescence | REMITTING MULTIPLE-SCLEROSIS | autoimmunity | REVISED CRITERIA | SENESCENCE | Complementarity Determining Regions - genetics | Humans | Middle Aged | Male | CD4-Positive T-Lymphocytes - pathology | Aging - immunology | CD28 Antigens - analysis | Lupus Erythematosus, Systemic - immunology | Aged, 80 and over | Adult | Female | Granzymes - immunology | Autoimmune Diseases - pathology | CD4-Positive T-Lymphocytes - chemistry | Granzymes - analysis | Gene Expression | Autoimmune Diseases - immunology | Biomarkers - analysis | CD4-Positive T-Lymphocytes - metabolism | Genes, T-Cell Receptor beta - genetics | Arthritis, Rheumatoid - pathology | Interferon-gamma - analysis | Gene Rearrangement | HLA-DRB1 Chains | Interferon-gamma - immunology | Adolescent | Genes, T-Cell Receptor - genetics | HLA-DR Antigens - analysis | Multiple Sclerosis - immunology | Multiple Sclerosis - pathology | Aged | HLA-DR Antigens - immunology | Arthritis, Rheumatoid - immunology | Lupus Erythematosus, Systemic - pathology | Index Medicus
Journal Article
Trends in Molecular Medicine, ISSN 1471-4914, 2014, Volume 21, Issue 1, pp. 16 - 23
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 09/2017, Volume 8, pp. 1160 - 1160
Journal Article