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Journal of Experimental Medicine, ISSN 0022-1007, 04/2010, Volume 207, Issue 4, pp. 881 - 896
Endothelial cell-cell junctions regulate vascular permeability, vasculogenesis, and angiogenesis. Familial cerebral cavernous malformations (CCMs) in humans... 
CELL PERMEABILITY | PATHOGENESIS | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNE-RESPONSE | P38 MAPK ACTIVATION | ACUTE LUNG INJURY | VE-CADHERIN | CCM2 | IMMUNOLOGY | 2-HIT MECHANISM | BRAIN | ENDOTHELIAL BARRIER FUNCTION | RNA, Small Interfering - genetics | Humans | Capillary Permeability - drug effects | Endothelium, Vascular - drug effects | rhoA GTP-Binding Protein - metabolism | Animal Structures - blood supply | Mutation - physiology | Phosphorylation - genetics | rho-Associated Kinases - metabolism | Edema, Cardiac - pathology | Phosphorylation - drug effects | Endothelial Cells - metabolism | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - therapeutic use | Hemangioma, Cavernous, Central Nervous System - drug therapy | Edema, Cardiac - genetics | Hemangioma, Cavernous, Central Nervous System - pathology | Signal Transduction - drug effects | Endothelium, Vascular - metabolism | Endothelium, Vascular - pathology | Mice | Myosin Light Chains - metabolism | Animal Structures - metabolism | Protein Binding - physiology | Capillary Permeability - physiology | KRIT1 Protein | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Hemangioma, Cavernous, Central Nervous System - metabolism | rho-Associated Kinases - antagonists & inhibitors | Brain Edema - genetics | Edema, Cardiac - drug therapy | Mice, Mutant Strains | Pulmonary Edema - pathology | Microfilament Proteins - metabolism | Microfilament Proteins - genetics | Proto-Oncogene Proteins - metabolism | Pulmonary Edema - genetics | Brain Edema - pathology | Mice, Inbred C57BL | Proto-Oncogene Proteins - genetics | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Protein Kinase Inhibitors - therapeutic use | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Signal Transduction - physiology | Brain Edema - drug therapy | Protein Kinase Inhibitors - pharmacology | Endothelial Cells - drug effects
Journal Article
Nature Medicine, ISSN 1078-8956, 04/2008, Volume 14, Issue 4, pp. 448 - 453
Journal Article
Journal Article
Genetics in Medicine, ISSN 1098-3600, 03/2015, Volume 17, Issue 3, pp. 188 - 196
Purpose: The phenotypic manifestations of cerebral cavernous malformation disease caused by rare PDCD10 mutations have not been systematically examined, and a... 
cerebral cavernous malformation | vascular malformations | CCM3 | Rho kinase | PDCD10 | MANAGEMENT | MECHANISM | GCKIII PROTEINS | RHO-KINASE | MODEL | NATURAL-HISTORY | LESION | STRATEGIES | VASCULAR INTEGRITY | GENETICS & HEREDITY | Human Umbilical Vein Endothelial Cells | Prospective Studies | Stress Fibers - drug effects | Humans | Middle Aged | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Child, Preschool | Infant | Intracellular Signaling Peptides and Proteins - metabolism | Hemangioma, Cavernous, Central Nervous System - genetics | rho-Associated Kinases - antagonists & inhibitors | Young Adult | rho-Associated Kinases - metabolism | Apoptosis Regulatory Proteins - genetics | Adult | Membrane Proteins - metabolism | Child | Intracellular Signaling Peptides and Proteins - genetics | Disease Models, Animal | Proto-Oncogene Proteins - metabolism | Keratin-1 - genetics | Membrane Proteins - genetics | Central Nervous System Neoplasms - genetics | Cells, Cultured | Proto-Oncogene Proteins - genetics | Apoptosis Regulatory Proteins - metabolism | Carrier Proteins - genetics | Central Nervous System Neoplasms - pathology | Stress Fibers - metabolism | Animals | Hemangioma, Cavernous, Central Nervous System - enzymology | Hemangioma, Cavernous, Central Nervous System - pathology | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Adolescent | Central Nervous System Neoplasms - enzymology | Mice | Mutation | Cerebral cavernous malformations
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 04/2010, Volume 189, Issue 1, pp. i2 - i2
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 07/2011, Volume 22, Issue 14, pp. 2509 - 2519
Activation of Rap1 small GTPases stabilizes cell-cell junctions, and this activity requires Krev Interaction Trapped gene 1 (KRIT1). Loss of KRIT1 disrupts... 
ENCODING KRIT1 | PATHOGENESIS | CEREBRAL CAVERNOUS MALFORMATIONS | AUTOMATED PROTEIN-STRUCTURE | RAP1 | BARRIER FUNCTION | BINDING-PROTEIN | CCM1 | I-TASSER | STRUCTURE PREDICTION | CELL BIOLOGY | Microtubule-Associated Proteins - chemistry | KRIT1 Protein | Microtubule-Associated Proteins - genetics | rap1 GTP-Binding Proteins - chemistry | Microtubule-Associated Proteins - metabolism | Humans | Proto-Oncogene Proteins - chemistry | Structure-Activity Relationship | Microtubules - metabolism | HEK293 Cells | Muscle Proteins - metabolism | Muscle Proteins - physiology | Umbilical Veins - cytology | Endothelial Cells - physiology | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | rap1 GTP-Binding Proteins - metabolism | Gene Expression | Signal Transduction | Zebrafish Proteins - chemistry | Cardiovascular System - growth & development | Endothelial Cells - metabolism | Zebrafish Proteins - metabolism | Intercellular Junctions - metabolism | Proto-Oncogene Proteins - genetics | Monomeric GTP-Binding Proteins - genetics | Intercellular Junctions - genetics | Zebrafish - growth & development | Zebrafish - genetics | Zebrafish Proteins - physiology | Muscle Proteins - genetics | Animals | Cardiovascular System - metabolism | Monomeric GTP-Binding Proteins - metabolism | Microtubules - genetics | Monomeric GTP-Binding Proteins - chemistry | Zebrafish - metabolism | Protein Conformation | RNA, Small Interfering | Zebrafish Proteins - genetics | Genetic Vectors | rap1 GTP-Binding Proteins - genetics
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 01/2011, Volume 20, Issue 2, pp. 211 - 222
Cerebral cavernous malformations (CCMs) are vascular lesions of the central nervous system appearing as multicavernous, blood-filled capillaries, leading to... 
Journal Article
Annales medico-psychologiques, ISSN 0003-4487, 05/2014, Volume 172, Issue 3, p. 212
Les recommandations francaises concernant la prescription de lithium ont ete publiees, mais a ce jour, il n'existe pas de synthese exhaustive recente en langue... 
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 10/2007, Volume 179, Issue 2, p. 247
  Cerebral cavernous malformation (CCM), a disease associated with defective endothelial junctions, result from autosomal dominant CCM1 mutations that cause... 
Proteins | Cell culture | RNA-protein interactions | Mutation | Ribonucleic acid--RNA | Cells
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 07/2011, Volume 22, Issue 14, pp. 2509 - 2519
Activation of Rap1 small GTPases stabilizes cell–cell junctions, and this activity requires Krev Interaction Trapped gene 1 (KRIT1). Loss of KRIT1 disrupts... 
Journal Article
Annales médico-psychologiques, ISSN 0003-4487, 05/2014, Volume 172, Issue 3, pp. 212 - 218
Les recommandations françaises concernant la prescription de lithium ont été publiées, mais à ce jour, il n’existe pas de synthèse exhaustive récente en langue... 
Effet secondaire | Lithium citrate | Teratogenicity | Sel de lithium | Tératogenèse | Revue de la littérature | Review of the writing | Side effect
Journal Article
Annales Medico-Psychologiques, ISSN 0003-4487, 2014, Volume 172, Issue 3, pp. 212 - 218
Objectives: Lithium is a widely used and effective treatment for mood disorders. There has been concern about the safety of lithium but no adequate recent... 
Lithium citrate | Teratogenicity | Review of the writing | Side effect
Journal Article
Physical & Health Education Journal, ISSN 1498-0940, 09/2012, Volume 78, Issue 3, p. 28
  Planning, implementing, and sustaining a HSC requires strategic effort targeting all four of the key components. A recent review supports the notion that HSC... 
Access control | Usage | School management and organization | Health promotion | Laws, regulations and rules | Natural foods | Health aspects | Community | Methods | Initiatives | Health education | Schools
Journal Article
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