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Journal of Clinical Investigation, ISSN 0021-9738, 06/2017, Volume 127, Issue 6, pp. 2392 - 2406
Quiescent and proliferating leukemia cells accumulate highly lethal DNA double-strand breaks that are repaired by 2 major mechanisms: BRCA-dependent homologous... 
GENOMIC INSTABILITY | MEDICINE, RESEARCH & EXPERIMENTAL | POLY(ADP-RIBOSE) POLYMERASE | NHEJ PATHWAYS | HEMATOPOIETIC STEM-CELLS | DOUBLE-STRAND BREAKS | PARP | HOMOLOGOUS RECOMBINATION | DNA-REPAIR | CANCER | CHRONIC MYELOID-LEUKEMIA | Cell Proliferation | Mouse Embryonic Stem Cells - physiology | Humans | Transcriptome | DNA Breaks, Double-Stranded | Genes, Lethal | DNA End-Joining Repair | Genes, BRCA2 | Antineoplastic Agents - pharmacology | Genes, BRCA1 | Leukemia - genetics | Cricetinae | Leukemia - drug therapy | Mice, SCID | Piperazines - pharmacology | Mice, Knockout | Xenograft Model Antitumor Assays | Phthalazines - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Animals | Cell Transformation, Neoplastic | Genes, abl | Cell Line, Tumor | Mice, Inbred NOD | Mice | Biotechnology | Pharmacogenetics | Leukemia | Analysis | Genes | Genetic aspects | Genetic transcription | Protein kinases | Sugars | Monosaccharides | Cancer | Cell proliferation | Gene mutations | Cancer cells | Development and progression | Gene expression | Health aspects | BCR protein | Flow cytometry | DNA damage | Homologous recombination | Reverse transcription | Genomes | Lethality | Breast cancer | Drug delivery | Kinases | DNA repair | Polymerase chain reaction | Poly(ADP-ribose) Polymerase 1 | DNA-dependent protein kinase | DNA microarrays | Ribose | Stem cells | DNA methylation | Mutation | Solid tumors
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2017, Volume 12, Issue 1, p. e0169007
Journal Article
Blood, ISSN 0006-4971, 11/2019, Volume 134, Issue Supplement_1, pp. 4148 - 4148
Clinical resistance to tyrosine kinase inhibitors (TKI) remains a significant problem in the therapy of patients with chronic myeloid leukemia (CML). Although... 
Journal Article
BMC Medical Genetics, ISSN 1471-2350, 04/2015, Volume 16, Issue 1, pp. 1 - 9
Journal Article
Organic Letters, ISSN 1523-7060, 06/2012, Volume 14, Issue 11, pp. 2670 - 2673
A synthetic approach to the structurally diverse family of π-expanded diketopyrrolopyrroles is described. A three-step strategy appears to be very general and... 
Fluorescent Dyes - chemical synthesis | Fluorescent Dyes - chemistry | Combinatorial Chemistry Techniques | Pyrroles - chemical synthesis | Humans | Color | Models, Molecular | Pyrroles - chemistry | Spectrometry, Fluorescence | Molecular Structure | HeLa Cells | Microscopy, Fluorescence
Journal Article
Blood and Lymphatic Cancer: Targets and Therapy, ISSN 1179-9889, 01/2015, Volume 5, Issue default, pp. 101 - 108
Imatinib was the first tyrosine kinase inhibitor (TKI), successfully used in a clinical setting. It inhibits activity of BCR-ABL1 oncogenic tyrosine kinase... 
Antimitotic agents | Care and treatment | Analysis | Dosage and administration | Chronic myeloid leukemia | Drug therapy | Antineoplastic agents | Cancer | Signal transduction | Medical prognosis | Leukemia | Cell cycle | Clinical trials | Kinases | Binding sites | Cell adhesion & migration
Journal Article
Journal Article
Blood, ISSN 0006-4971, 05/2013, Volume 121, Issue 20, pp. 4175 - 4183
Journal Article
Blood, ISSN 0006-4971, 05/2012, Volume 119, Issue 18, pp. 4253 - 4263
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 5426 - 5426
Abstract The introduction of tyrosine kinase inhibitors (TKI) revolutionized therapy of chronic myeloid leukemia (CML) and gives long-lasting remission in... 
Journal Article
Cell Cycle, ISSN 1538-4101, 05/2006, Volume 5, Issue 9, pp. 994 - 1000
Journal Article
Entropy, ISSN 1099-4300, 07/2016, Volume 18, Issue 7, pp. 253 - 253
The paper presents a method for processing acoustic signals which allows the extraction, from a very noisy signal, of components which contain diagnostically... 
Condition monitoring | Entropy | Acoustic signal | Denoising | denoising | COMBUSTION NOISE | entropy | PHYSICS, MULTIDISCIPLINARY | DECOMPOSITION | condition monitoring | AIR | acoustic signal | WAVELET SHRINKAGE | DIESEL-ENGINE | VIBRATION SIGNAL | INDEPENDENT COMPONENT ANALYSIS | Acoustic noise | Signal processing | Valves | Extraction | Clearances | Combustion | Engines
Journal Article