X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (179) 179
Patent (54) 54
Publication (24) 24
Book Review (22) 22
Conference Proceeding (16) 16
Book / eBook (9) 9
Book Chapter (8) 8
Newspaper Article (8) 8
Magazine Article (1) 1
Trade Publication Article (1) 1
Web Resource (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (99) 99
humans (92) 92
animals (38) 38
basic electric elements (33) 33
current collectors (33) 33
electricity (33) 33
line connectors (33) 33
phosphorylation (32) 32
oncology (31) 31
biochemistry & molecular biology (28) 28
cell biology (28) 28
cell line, tumor (27) 27
cancer (23) 23
mice (22) 22
female (21) 21
research (21) 21
proto-oncogene proteins - metabolism (20) 20
signal transduction (20) 20
mutation (19) 19
proto-oncogene proteins c-akt (19) 19
biochemistry (18) 18
phosphatidylinositol 3-kinases - metabolism (18) 18
proteins (18) 18
activation (16) 16
beer (16) 16
cell line (16) 16
chemistry (16) 16
enzymology (16) 16
metallurgy (16) 16
microbiology (16) 16
mutation or genetic engineering (16) 16
spirits (16) 16
vinegar (16) 16
wine (16) 16
enzyme activation (15) 15
human necessities (15) 15
hygiene (15) 15
male (15) 15
medical or veterinary science (15) 15
molecular sequence data (15) 15
preparations for medical, dental, or toilet purposes (15) 15
protein kinases - metabolism (14) 14
protein-serine-threonine kinases - metabolism (14) 14
pten phosphohydrolase (14) 14
aged (13) 13
amino acid sequence (13) 13
cells (13) 13
gene expression regulation, neoplastic (13) 13
middle aged (13) 13
pten (13) 13
compositions thereof (12) 12
culture media (12) 12
microorganisms or enzymes (12) 12
propagating, preserving or maintaining microorganisms (12) 12
tor serine-threonine kinases (12) 12
akt (11) 11
apoptosis (11) 11
casings or constructional details of electric apparatus (11) 11
electric techniques not otherwise provided for (11) 11
expression (11) 11
manufacture of assemblages of electrical components (11) 11
organic chemistry (11) 11
printed circuits (11) 11
sign language (11) 11
adult (10) 10
cell cycle (10) 10
enzyme inhibitors - pharmacology (10) 10
language (10) 10
phosphatidylinositol 3-kinases - antagonists & inhibitors (10) 10
phosphoric monoester hydrolases - genetics (10) 10
physiological aspects (10) 10
american sign language (9) 9
article (9) 9
compositions or test papers therefor (9) 9
condition-responsive control in microbiological orenzymological processes (9) 9
gene (9) 9
general tagging of cross-sectional technologies spanning over several sections of the ipc (9) 9
general tagging of new technological developments (9) 9
measuring or testing processes involving enzymes, nucleicacids or microorganisms (9) 9
multidisciplinary sciences (9) 9
pathway (9) 9
processes of preparing such compositions (9) 9
protein (9) 9
protein kinases (9) 9
protein-serine-threonine kinases (9) 9
pten phosphohydrolase - genetics (9) 9
ras proteins - metabolism (9) 9
specific therapeutic activity of chemical compounds ormedicinal preparations (9) 9
technical subjects covered by former us classification (9) 9
technical subjects covered by former uspc (9) 9
technical subjects covered by former uspc cross-reference art collections [xracs] and digests (9) 9
transfection (9) 9
base sequence (8) 8
binding (8) 8
biology (8) 8
breast-cancer (8) 8
cell lung-cancer (8) 8
genetic aspects (8) 8
identification (8) 8
inhibition (8) 8
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Robarts - Stacks (4) 4
UofT at Scarborough - Stacks (3) 3
OISE - Stacks (2) 2
UTL at Downsview - May be requested (2) 2
Collection Dvlpm't (Acquisitions) - Vendor file (1) 1
New College (Ivey) - Stacks (1) 1
Online Resources - Online (1) 1
Royal Ontario Museum - Rare Book (1) 1
UofT at Mississauga - Stacks (1) 1
Victoria University E.J. Pratt - Stacks (1) 1
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature, ISSN 0028-0836, 08/2010, Volume 466, Issue 7308, pp. 869 - 873
Journal Article
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 06/2005, Volume 97, Issue 12, pp. 880 - 887
Background. The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib (also known as Tarceva or OSI-774) has shown promising response... 
CELL LUNG-CANCER | BREAST-CANCER | AMPLIFICATION | ONCOLOGY | CYCLIN D1 | TYROSINE KINASE | PHOSPHATIDYLINOSITOL 3-KINASE | AKT | INHIBITORS | EXPRESSION | BRAIN-TUMORS | Erlotinib Hydrochloride | Immunohistochemistry | Receptor, Epidermal Growth Factor - genetics | Phosphorylation | Area Under Curve | Humans | Middle Aged | Receptor, Epidermal Growth Factor - drug effects | Drug Resistance, Neoplasm | Male | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Glioma - metabolism | Supratentorial Neoplasms - drug therapy | PTEN Phosphohydrolase | Glioma - pathology | Tumor Suppressor Proteins - genetics | Dacarbazine - analogs & derivatives | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Phosphoric Monoester Hydrolases - drug effects | Adult | Female | Quinazolines - administration & dosage | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Dacarbazine - administration & dosage | Phosphoric Monoester Hydrolases - genetics | Drug Administration Schedule | Supratentorial Neoplasms - pathology | Supratentorial Neoplasms - metabolism | In Situ Hybridization, Fluorescence | Proto-Oncogene Proteins c-akt | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Quinazolines - therapeutic use | Aged | Tumor Suppressor Proteins - drug effects | Mutation | Glioma - drug therapy | Care and treatment | Diagnosis | Research | Gliomas | Protein kinases | Risk factors | Proteins | Oncology | Gene expression | Tumors | Index Medicus
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 04/2014, Volume 53, Issue 15, pp. 3777 - 3779
One of the first oncogenes to be discovered and one of the most prevalently mutated tumor genes is Ras. Shokat et al. and Gray et al. have succeeded in... 
inhibitors | cancer | drug design | Ras mutations | CHEMISTRY, MULTIDISCIPLINARY | ras Proteins - metabolism | Mutant Proteins - metabolism | Signal Transduction | Binding Sites | Humans | Protein binding | Index Medicus | Proteins | Binding | Covalence | Inhibitors | Genes | Strategy | Nucleotides | Tumors
Journal Article
Nature Biotechnology, ISSN 1087-0156, 01/2015, Volume 33, Issue 3, pp. 306 - 312
Journal Article
Nature, ISSN 0028-0836, 03/2010, Volume 464, Issue 7287, pp. 431 - 435
Activating mutations in KRAS and BRAF are found in more than 30% of all human tumours and 40% of melanoma, respectively, thus targeting this pathway could have... 
SELECTIVE INHIBITOR | POTENT | EFFICACY | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | C-RAF | HETERODIMERIZATION | B-RAF | PROTEIN-KINASE KINASE | CANCER | Neoplasms - metabolism | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Diphenylamine - pharmacology | raf Kinases - antagonists & inhibitors | Humans | Protein Multimerization | ras Proteins - metabolism | Protein Transport - drug effects | Extracellular Signal-Regulated MAP Kinases - metabolism | raf Kinases - metabolism | Diphenylamine - analogs & derivatives | Mitogen-Activated Protein Kinase Kinases - metabolism | Adenosine Triphosphate - metabolism | Indoles - pharmacology | Benzamides - pharmacology | Cell Membrane - metabolism | raf Kinases - genetics | Cell Membrane - drug effects | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Pyrazoles - pharmacology | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Line | Indenes - pharmacology | raf Kinases - chemistry | Proto-Oncogene Proteins c-raf - genetics | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Neoplasms - enzymology | Proto-Oncogene Proteins - genetics | Enzyme Activation - drug effects | Sulfonamides - pharmacology | Proto-Oncogene Proteins c-raf - metabolism | Neoplasms - drug therapy | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Proto-Oncogene Proteins c-raf - deficiency | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Neoplasms - pathology | Ras genes | Growth | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Mitogen-activated protein kinases | Competition | Clinical trials | Enzymes | Kinases | Index Medicus | Proteins | Cellular | Inhibitors | Pathways | Tumours | Signalling | Dimerization
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2012, Volume 109, Issue 14, pp. 5299 - 5304
Journal Article
Cancer Research, ISSN 0008-5472, 12/2005, Volume 65, Issue 23, pp. 10669 - 10673
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2007, Volume 13, Issue 1, pp. 84 - 88
Journal Article
Cell, ISSN 0092-8674, 2006, Volume 125, Issue 4, pp. 733 - 747
Phosphoinositide 3-kinases (PI3-Ks) are an important emerging class of drug targets, but the unique roles of PI3-K isoforms remain poorly defined. We describe... 
CATALYTIC SUBUNIT | ACTIVATION | P85 REGULATORY SUBUNIT | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEPENDENT PROTEIN-KINASE | EMBRYONIC LETHALITY | MICE | ATM | PHOSPHOINOSITIDE 3-KINASE INHIBITORS | INSIGHTS | CELL BIOLOGY
Journal Article