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The New England journal of medicine, ISSN 1533-4406, 08/2016, Volume 375, Issue 6, pp. 534 - 544
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 03/2011, Volume 108, Issue 12, pp. 4834 - 4839
A specific small-molecule inhibitor of p97 would provide an important tool to investigate diverse functions of this essential ATPase associated with diverse... 
Proteins | HEK293 cells | Cell death | Ubiquitins | Adenosine triphosphatases | Cell lines | HeLa cells | Small interfering RNA | Inhibitory concentration 50 | Apoptosis | Autophagy | Unfolded protein response | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Caspase 7 - metabolism | Quinazolines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Caspase 3 - metabolism | Ubiquitin - metabolism | Enzyme Inhibitors - chemical synthesis | Autophagy - drug effects | Enzyme Inhibitors - chemistry | Caspase 3 - genetics | Antineoplastic Agents - pharmacology | Nuclear Proteins - genetics | Quinazolines - chemistry | Endoplasmic Reticulum - enzymology | Cell Line | Endoplasmic Reticulum - genetics | Caspase 7 - genetics | Enzyme Inhibitors - pharmacology | Adenosine Triphosphatases - metabolism | Neoplasms - enzymology | Nuclear Proteins - metabolism | Ubiquitin - genetics | Antineoplastic Agents - chemistry | Neoplasms - drug therapy | Proteasome Endopeptidase Complex - genetics | Adenosine Triphosphatases - antagonists & inhibitors | Animals | Nuclear Proteins - antagonists & inhibitors | Adenosine Triphosphatases - genetics | Mice | Proteasome Endopeptidase Complex - metabolism | Quinazolines - pharmacology | Ubiquitin | Autophagy (Cytology) | Enzyme inhibitors | Proteolysis | Genetic aspects | Research | Properties | Molecules | Cell growth | Ribonucleic acid--RNA | Cancer therapies | Adenosine triphosphatase | Substrates | Cancer | Index Medicus | Biological Sciences | unfolded protein response | apoptosis | Physical Sciences | autophagy
Journal Article
The New England journal of medicine, ISSN 1533-4406, 01/2019, Volume 380, Issue 4, pp. 347 - 357
In a randomized trial of patients with type 2 diabetes, treatment with dapagliflozin, an SGLT2 inhibitor that promotes glucosuria, did not result in a higher... 
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Cardiovascular Diseases - etiology | Sodium-Glucose Transporter 2 Inhibitors - therapeutic use | Sodium-Glucose Transporter 2 Inhibitors - adverse effects | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Hospitalization - statistics & numerical data | Male | Benzhydryl Compounds - adverse effects | Cardiovascular Diseases - mortality | Female | Glucosides - therapeutic use | Aged | Diabetes Mellitus, Type 2 - drug therapy | Benzhydryl Compounds - therapeutic use | Heart Failure - epidemiology | Diabetes Mellitus, Type 2 - complications | Glucosides - adverse effects | Type 2 diabetes | Safety and security measures | Dapagliflozin | Dosage and administration | Drug therapy | Cardiovascular diseases | Risk factors | Heart failure | Myocardial infarction | Cerebral infarction | End-stage renal disease | Heart attacks | Mortality | Diabetes mellitus | Cardiovascular disease | FDA approval | Patients | Glomerular filtration rate | Heart rate | Ischemia | Sodium | Arteriosclerosis | Ketoacidosis | Death | Diabetes | Kidney diseases | Safety | Diabetes mellitus (non-insulin dependent) | Heart diseases | Index Medicus | Abridged Index Medicus | Life Sciences | Food and Nutrition | Animal biology | Cellular Biology | Pharmaceutical sciences | Cardiovascular Diseases | drug therapy | Benzhydryl Compounds | complications | Sodium-Glucose Transporter 2 Inhibitors | Hospitalization | prevention & control | Klinisk medicin | Diabetes Mellitus | etiology | Clinical Medicine | epidemiology | statistics & numerical data | adverse effects | mortality | Type 2 | Heart Failure | therapeutic use | Glucosides
Journal Article
Nature (London), ISSN 0028-0836, 06/2006, Volume 441, Issue 7094, pp. 731 - 734
The amide functional group is one of the most fundamental motifs found in chemistry and biology, and it has been studied extensively for the past century.... 
Proteins | Chemistry | Biochemistry | Molecular structure | Chemical synthesis
Journal Article
by Chen, W and Stambolian, D and Edwards, A. O and Branham, K. E and Othman, M and Jakobsdottir, J and Tosakulwong, N and Pericak-Vance, M. A and Campochiaro, P. A and Klein, M. L and Tan, P. L and Conley, Y. P and Kanda, A and Kopplin, L and Li, Y and Augustaitis, K. J and Karoukis, A. J and Scott, W. K and Agarwal, A and Kovach, J. L and Schwartz, S. G and Postel, E. A and Brooks, M and Baratz, K. H and Brown, W. L and Brucker, A. J and Orlin, A and Brown, G and Ho, A and Regillo, C and Donoso, L and Tian, L and Kaderli, B and Hadley, D and Hagstrom, S. A and Peachey, N. S and Klein, R and Klein, B. E. K and Gotoh, N and Yamashiro, K and Ferris, F and Fagerness, J. A and Reynolds, R and Farrer, L. A and Kim, I. K and Miller, J. W and Corton, M and Carracedo, A and Sanchez-Salorio, M and Pugh, E. W and Doheny, K. F and Brion, M and DeAngelis, M. M and Weeks, D. E and Zack, D. J and Chew, E. Y and Heckenlively, J. R and Yoshimura, N and Iyengar, S. K and Francis, P. J and Katsanis, N and Seddon, J. M and Haines, J. L and Gorin, M. B and Abecasis, G. R and Swaroop, A and Johnson, R. N and Ai, E and McDonald, H. R and Stolarczuk, M and Pavan, P. R and Billiris, K. K and Iyer, M and Menosky, M. M and Pautler, S. E and Millard, S. M and Hubbard, B and Aaberg, T and DuBois, L and Lyon, A and Anderson-Nelson, S and Jampol, L. M and Weinberg, D. V and Munana, A and Rozenbajgier, Z and Orth, D and Cohen, J and MacCumber, M and Figliulo, C and Porcz, L and Folk, J and Boldt, H. C and Russell, S. R and Ivins, R and Hinz, C. J and Barr, C. C and Bloom, S and Jaegers, K and Kritchman, B and Whittington, G and ... and Complications of Age-Related Macular Degeneration Prevention Trial (CAPT) Research Group and Complications Age-Related Macular and Complications of Age-Related Macular Degeneration Prevention Trial Research Group
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 04/2010, Volume 107, Issue 16, pp. 7401 - 7406
Journal Article
Chemical reviews, ISSN 0009-2665, 06/2012, Volume 112, Issue 6, pp. 3550 - 3577
Journal Article