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1. Full Text A Multicenter Trial of Remote Ischemic Preconditioning for Heart Surgery
by Meybohm, Patrick and Bein, Berthold and Brosteanu, Oana and Cremer, Jochen and Gruenewald, Matthias and Stoppe, Christian and Coburn, Mark and Schaelte, Gereon and Böning, Andreas and Niemann, Bernd and Roesner, Jan and Kletzin, Frank and Strouhal, Ulrich and Reyher, Christian and Laufenberg-Feldmann, Rita and Ferner, Marion and Brandes, Ivo F and Bauer, Martin and Stehr, Sebastian N and Kortgen, Andreas and Wittmann, Maria and Baumgarten, Georg and Meyer-Treschan, Tanja and Kienbaum, Peter and Heringlake, Matthias and Schön, Julika and Sander, Michael and Treskatsch, Sascha and Smul, Thorsten and Wolwender, Ewa and Schilling, Thomas and Fuernau, Georg and Hasenclever, Dirk and Zacharowski, Kai and RIPHeart Study Collaborators
The New England Journal of Medicine, ISSN 0028-4793, 10/2015, Volume 373, Issue 15, pp. 1397 - 1407
This multicenter, randomized, controlled trial involving adults undergoing elective cardiac surgery with cardiopulmonary bypass while under propofol anesthesia... 
ACUTE KIDNEY INJURY | MEDICINE, GENERAL & INTERNAL | METAANALYSIS | THERAPY | MYOCARDIAL-INFARCTION | CARDIAC-SURGERY | DOUBLE-BLIND | COMPLICATIONS | RANDOMIZED CONTROLLED-TRIAL | BYPASS GRAFT-SURGERY | CARDIOPROTECTION | Length of Stay | Prospective Studies | Double-Blind Method | Humans | Middle Aged | Kaplan-Meier Estimate | Postoperative Complications - prevention & control | Male | Anesthesia, Intravenous | Cardiopulmonary Bypass | Upper Extremity - blood supply | Ischemic Preconditioning - methods | Cardiac Surgical Procedures | Ischemia | Treatment Failure | Troponin - blood | Female | Aged | Propofol | Elective Surgical Procedures | Cardiopulmonary bypass | Heart | Treatment outcome | Vasomotor conditioning | Usage | Analysis | Surgery | Clinical trials | Health aspects | Myocardial infarction | Cerebral infarction | Intravenous administration | Heart surgery | Patients | Clinical outcomes | Troponin | Reperfusion | Fibrillation | Calcium-binding protein | Renal failure | Ventilation | Anesthesia | Cardiology
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2. Full Text Retrospective Analysis of Air Handling by Contemporary Oxygenators in the Setting of Cardiac Surgery
by Benstoem, Carina and Christian, Bleilevens and Ralf, Borchardt and Christian, Stoppe and Andreas, Goetzenich and Ruedriger, Autschbach and Thomas, Breuer
Annals of Thoracic and Cardiovascular Surgery, ISSN 1341-1098, 2018, Volume 24, Issue 5, pp. 230 - 237
Purpose: Cardiac surgery with the use of extracorporeal circulation is associated with a significant risk for gaseous microemboli (GME) despite excellent... 
gaseous microemboli | perioperative outcome | extracorporeal circulation | thoracic surgery | oxygenator | Perioperative outcome | Thoracic surgery | Gaseous microemboli | Oxygenator | Extracorporeal circulation | SURGERY | EMBOLISM | CARDIAC & CARDIOVASCULAR SYSTEMS | INTEGRATED ARTERIAL FILTER | CLINICAL-EVALUATION | CORONARY-BYPASS SURGERY | CARDIOPULMONARY BYPASS | QUADROX | STROKE | Embolism, Air - prevention & control | Delirium - etiology | Extracorporeal Circulation - adverse effects | Humans | Middle Aged | Risk Factors | Male | Treatment Outcome | Cardiac Surgical Procedures - adverse effects | Equipment Design | Stroke - etiology | Oxygenators | Time Factors | Extracorporeal Circulation - instrumentation | Ultrasonography | Female | Aged | Retrospective Studies | Myocardial Infarction - etiology | Acute Kidney Injury - etiology | Embolism, Air - etiology | Embolism, Air - diagnostic imaging | Original
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3. Full Text Genetic predisposition in anti‐LGI1 and anti‐NMDA receptor encephalitis
by Mueller, Stefanie H and Färber, Anna and Prüss, Harald and Melzer, Nico and Golombeck, Kristin S and Kümpfel, Tania and Thaler, Franziska and Elisak, Martin and Lewerenz, Jan and Kaufmann, Max and Sühs, Kurt‐Wolfram and Ringelstein, Marius and Kellinghaus, Christoph and Bien, Christian G and Kraft, Andrea and Zettl, Uwe K and Ehrlich, Sven and Handreka, Robert and Rostásy, Kevin and Then Bergh, Florian and Faiss, Jürgen H and Lieb, Wolfgang and Franke, Andre and Kuhlenbäumer, Gregor and Wandinger, Klaus‐Peter and Leypoldt, Frank and Krämer, Markus and Lyss, Birgit and Schreiber, Stephan and Faiss, J and Wallenfelsova, Eva and Othman, Jalal and Sinnecker, Tim and Riedlinger, Arne and Fonseca, Patricia and Kern, Peter and Bogarin, Yuri and Hoffmann, Anna and Schwabe, Julia and Seidel, Gunter and Herwig, Antje and Handreka, Robert and Rostasy, Kevin and Stolze, Henning and Körber, Rüdiger and Wiese, Lars and Schulze‐Amberger, Jörg and Heide, Wolfgang and Geis, Tobias and Blaes, Franz and Köhler, Wolfgang and Ehrlich, Sven and Dogan, Muejgan and Bien, Christian and Kramme, Corinna and Grofß, Martin and Thomsen, Jens and Pulkowski, Ulrich and Hoepner, Robert and Schindler, Kaspar and Lippert, Julian and Marziniak, Martin and Ewering, Carina and Reimann, Gemot and Juranek, Aleksandra and Kanitz, Rolf‐Dieter and Obrocki, Jost and Pfefferkorn, Thomas and Schimrigk, Sebastian and Urbanek, Christian and Schön, Frauke and Schabet, Martin and Melville, Jutta and Finke, Alexander and Henningsen, Henning and Hansen, Hans‐Christian and Küpper, Philipp and Berning, Sascha and Kellinghaus, Christoph and Nagel, Michael and Hofstadt, Ulrich and Trendelenburg, George and Heider, Steffen and Linsa, Andreas and Thaler, Franziska and Muth, Carolin and Borggräfe, Ingo and Blaschek, Astrid and Laurent, Sarah and Kümpfel, Tania and Havla, Joachim and Menge, Til and Bieniek, Rolf and Kraft, Andrea and Hoffmann, Frank and Philipsen, Alexandra and Gorsler, Anna and Pomschlegel, Sebastian and Tesch, Manfred and Lempert, Thomas and ... and German Network Res Autoimmune Ence and German Network for Research on Autoimmune Encephalitis (GENERATE)
Annals of Neurology, ISSN 0364-5134, 04/2018, Volume 83, Issue 4, pp. 863 - 869
We performed a genome‐wide association study in 1,194 controls and 150 patients with anti‐N‐methyl‐D‐aspartate receptor (anti‐NMDAR, n = 96) or... 
DOUBLECORTIN | MICE | VARIANTS | GENOTYPE IMPUTATION | NEUROSCIENCES | CLINICAL NEUROLOGY | Haplotypes | Encephalitis | Glutamic acid receptors (ionotropic) | DQA1 protein | N-Methyl-D-aspartic acid receptors | LGI1 protein | Genomes | Single-nucleotide polymorphism | Glutamic acid receptors | Leucine | Risk analysis | Zinc | Risk factors | Glioma | Alleles | Drb1 protein | Doublecortin protein | Histocompatibility antigen HLA
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4. Full Text Limb remote ischemic conditioning of the recipient protects the liver in a rat model of arterialized orthotopic liver transplantation
by Czigany, Zoltan and Bleilevens, Christian and Beckers, Christian and Stoppe, Christian and Moehring, Michaela and Fueloep, Anas and Szijarto, Attila and Lurje, Georg and Neumann, Ulf P and Tolba, Rene H
PLOS ONE, ISSN 1932-6203, 04/2018, Volume 13, Issue 4, p. e0195507
Background Ischemic-reperfusion (IR) injury still represents a major concern in clinical transplantation, especially in the era of extreme organ shortage and... 
PRESERVATION | APOPTOSIS | ISCHEMIA/REPERFUSION INJURY | PRETREATMENT | PROTOCOLS | GRAFTS | REPERFUSION INJURY | MICROCIRCULATION | MECHANISMS | CARDIOPROTECTION | MULTIDISCIPLINARY SCIENCES | Prevention | Complications and side effects | Transplantation | Liver | Reperfusion injury | Risk factors | Intensive care | Heart attacks | Transplants & implants | Zoology | Grafting | Western blotting | Reperfusion | Allografts | Ischemia | Rodents | Surgery | Aorta | Conditioning | Liver diseases | Cytokines | Animal sciences | Feasibility studies | Organs | Implantation | Gene expression | Malondialdehyde | Medicine | Serum levels | Polymerase chain reaction | Injury prevention | MicroRNAs | Transaminases | Interleukin 10 | Laboratory animals | ATP | Liver transplantation | Apoptosis
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5. Full Text Argon induces protective effects in cardiomyocytes during the second window of preconditioning
by Mayer, Britta and Soppert, Josefin and Kraemer, Sandra and Schemmel, Sabrina and Beckers, Christian and Bleilevens, Christian and Rossaint, Rolf and Coburn, Mark and Goetzenich, Andreas and Stoppe, Christian
International Journal of Molecular Sciences, ISSN 1661-6596, 07/2016, Volume 17, Issue 7, pp. 1159 - 1159
Increasing evidence indicates that argon has organoprotective properties. So far, the underlying mechanisms remain poorly understood. Therefore, we... 
Cardiomyocytes | Cardioprotection | Late phase of preconditioning | Argon | RAT CARDIOMYOCYTES | NOBLE-GAS ARGON | LATE-PHASE | NITRIC-OXIDE SYNTHASE | MOLECULAR CHAPERONES | BIOCHEMISTRY & MOLECULAR BIOLOGY | REPERFUSION INJURY | CARDIAC MYOCYTES | CHEMISTRY, MULTIDISCIPLINARY | cardiomyocytes | MITOCHONDRIAL PERMEABILITY TRANSITION | IN-VIVO | SIMULATED ISCHEMIA | late phase of preconditioning | cardioprotection | argon | Cell Survival - drug effects | Superoxide Dismutase - genetics | Rats, Wistar | Heat-Shock Proteins - metabolism | Rats | Heart Diseases - prevention & control | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Argon - pharmacology | Blotting, Western | Heat-Shock Proteins - genetics | Animals | Myocytes, Cardiac - drug effects | Nitric Oxide Synthase Type II - genetics | Ischemic Preconditioning, Myocardial | Cytoprotection - drug effects | Cell Proliferation - drug effects | Real-Time Polymerase Chain Reaction | Superoxide Dismutase - metabolism | Nitric Oxide Synthase Type II - metabolism | Heat shock proteins | Chemical elements | Ribonucleic acid--RNA
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6. Full Text Neuromyelitis optica: Evaluation of 871 attacks and 1,153 treatment courses
by Kleiter, Ingo and Gahlen, Anna and Borisow, Nadja and Fischer, Katrin and Wernecke, Klaus‐Dieter and Wegner, Brigitte and Hellwig, Kerstin and Pache, Florence and Ruprecht, Klemens and Havla, Joachim and Krumbholz, Markus and Kümpfel, Tania and Aktas, Orhan and Hartung, Hans‐Peter and Ringelstein, Marius and Geis, Christian and Kleinschnitz, Christoph and Berthele, Achim and Hemmer, Bernhard and Angstwurm, Klemens and Stellmann, Jan‐Patrick and Schuster, Simon and Stangel, Martin and Lauda, Florian and Tumani, Hayrettin and Mayer, Christoph and Zeltner, Lena and Ziemann, Ulf and Linker, Ralf and Schwab, Matthias and Marziniak, Martin and Then Bergh, Florian and Hofstadt‐van Oy, Ulrich and Neuhaus, Oliver and Winkelmann, Alexander and Marouf, Wael and Faiss, Jürgen and Wildemann, Brigitte and Paul, Friedemann and Jarius, Sven and Trebst, Corinna and Albrecht, Philipp and Ayzenberg, Ilya and Bischof, Felix and Böttcher, Tobias and Brettschneider, Johannes and Buttmann, Mathias and Ettrich, Barbara and Gass, Achim and Guthke, Kersten and Hoffmann, Frank and Kaste, Matthias and Kermer, Pawel and Kern, Peter and Köhler, Wolfgang and Kolesilova, Ekaterina and Langel, Stefan and Liebetrau, Martin and Melms, Arthur and Metz, Imke and Münch, Christoph and Niehaus, Sabine and Pellkofer, Hannah and Riedlinger, Arne and Röpke, Luise and Rommer, Paulus and Ruschil, Christoph and Schippling, Sven and Stoppe, Muriel and Tünnerhoff, Johannes and Veauthier, Christian and Walter, Annette and Wandinger, Klaus‐Peter and Weber, Martin S and Weissert, Robert and Wilke, Christian and Young, Kim and Zentner, Christian and Zettl, Uwe and Neuromyelitis Optica Study Grp and Neuromyelitis Optica Study Group
Annals of Neurology, ISSN 0364-5134, 02/2016, Volume 79, Issue 2, pp. 206 - 216
Objective Neuromyelitis optica (NMO) attacks often are severe, are difficult to treat, and leave residual deficits. Here, we analyzed the frequency, sequence,... 
PLASMA-EXCHANGE | NEURITIS | MULTIPLE-SCLEROSIS | EFFICACY | PREDICTORS | IMMUNOADSORPTION THERAPY | CNS DEMYELINATION | SPECTRUM | NEUROSCIENCES | CLINICAL NEUROLOGY | Neuromyelitis Optica - drug therapy | Neuromyelitis Optica - therapy | Outcome Assessment (Health Care) - statistics & numerical data | Registries - statistics & numerical data | Humans | Middle Aged | Adult | Female | Male | Retrospective Studies | Remission Induction | Germany | Aquaporin 4 | Exchanging | Myelitis | Therapy | Evaluation | Intravenous administration | Effectiveness | Optic neuritis | Estimation | Criteria | Statistics | Patients | Recovery | Demographics | Neuromyelitis | Mathematical analysis | Neuritis | Remission | Diagnostic systems | Mathematical models | Steroid hormones | Age | Steroids
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7. Full Text The role of macrophage migration inhibitory factor in anesthetic-induced myocardial preconditioning
by Goetzenich, Andreas and Kraemer, Sandra and Rossaint, Rolf and Bleilevens, Christian and Dollo, Florian and Siry, Laura and Rajabi-Alampour, Setareh and Beckers, Christian and Soppert, Josefin and Lue, Hongqi and Rex, Steffen and Bernhagen, Jürgen and Stoppe, Christian
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, p. e92827
Introduction: Anesthetic-induced preconditioning (AIP) is known to elicit cardioprotective effects that are mediated at least in part by activation of the... 
ACTIVATED PROTEIN-KINASE | PROTECTION | PATHWAY | MULTIDISCIPLINARY SCIENCES | MITOCHONDRIAL-PERMEABILITY | ISCHEMIA | MECHANISMS | MIF | SECRETION | CARDIOPROTECTION | EPSILON | Protein Kinases - metabolism | Anesthetics, Inhalation - pharmacology | Isoflurane - pharmacology | Myocytes, Cardiac - cytology | Rats, Wistar | Cells, Cultured | Myocytes, Cardiac - secretion | Rats | Cardiotonic Agents - pharmacology | Macrophage Migration-Inhibitory Factors - secretion | Enzyme Activation - drug effects | Myocardium - cytology | Gene Expression Regulation - drug effects | Intramolecular Oxidoreductases - secretion | Myocardium - secretion | Animals | Muscle Proteins - metabolism | Cytokines | Macrophages | Protein kinases | Central nervous system agents | Protein kinase C | Leukocyte migration | Migration | Activation | Biochemistry | Biology | Kinases | Western blotting | Antioxidants | Proteins | Lysates | Signal transduction | Cell activation | Ischemia | Rodents | Inhibition | Enzyme-linked immunosorbent assay | Adenosine | Vascular surgery | Secretion | Cardiomyocytes | JNK protein | Permeability | Gene expression | Isoflurane | Macrophage migration inhibitory factor | Polymerase chain reaction | Migration inhibitory factor | Hypoxia | Anesthesiology | Preconditioning
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8. Full Text Evaluation of the cardioprotective potential of extracellular vesicles – a systematic review and meta-analysis
by Wendt, Sebastian and Goetzenich, Andreas and Goettsch, Claudia and Stoppe, Christian and Bleilevens, Christian and Kraemer, Sandra and Benstoem, Carina
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 15702 - 14
Cardiovascular diseases are the main cause of death worldwide, demanding new treatments and interventions. Recently, extracellular vesicles (EVs) came in focus... 
CARDIAC-FUNCTION | HEART | MYOCARDIUM | IMPROVE | THERAPY | CARDIOMYOCYTE APOPTOSIS | EXOSOMES PROTECT | ANGIOGENESIS | MULTIDISCIPLINARY SCIENCES | CARDIOSPHERE-DERIVED CELLS | Myocardial infarction | Body fluids | Systematic review | Vesicles | Reviews | Cardiovascular diseases
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9. Full Text Xenon anaesthesia for laparoscopic cholecystectomy in a patient with multiple chemical sensitivity
by Stoppe, Christian
BJA: British Journal of Anaesthesia, ISSN 0007-0912, 08/2011, Volume 107, Issue eLetters
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10. Full Text Nausea and vomiting following balanced xenon anesthesia compared to sevoflurane: A Post-Hoc explorative analysis of a randomized controlled trial
by Fahlenkamp, Astrid V and Stoppe, Christian and Cremer, Jan and Biener, Ingeborg A and Peters, Dirk and Leuchter, Ricarda and Eisert, Albrecht and Apfel, Christian C and Rossaint, Rolf and Coburn, Mark
PLoS ONE, ISSN 1932-6203, 04/2016, Volume 11, Issue 4, p. e0153807
Like other inhalational anesthetics xenon seems to be associated with post-operative nausea and vomiting (PONV). We assessed nausea incidence following... 
Nausea - chemically induced | Humans | Middle Aged | Male | Xenon - adverse effects | Anesthetics, Inhalation - adverse effects | Young Adult | Vomiting - chemically induced | Methyl Ethers - adverse effects | Adolescent | Adult | Female | Aged | Sevoflurane | Complications and side effects | Vomiting | Complications | Surgery | Dosage and administration | Nausea | Risk factors | Prophylaxis | Clinical trials | Risk | Systematic review | Incidence | Randomization | Anesthesia | Nitrous oxide | Age | Abdominal surgery | Medical research | Statistical analysis | Dexamethasone | Xenon | Group size | Laparoscopy | Regression analysis | Anesthetics | Pharmacy | Informed consent | Anesthesiology
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11. Full Text Kommentar zu: Tageszeitliche Variation der perioperativen Myokardschädigung in der Kardiochirurgie
by Schälte, Gereon and Schälte, Gereon and Stoppe, Christian and Stoppe, Christian
Der Anaesthesist, ISSN 0003-2417, 2/2018, Volume 67, Issue 2, pp. 144 - 146
Intensive / Critical Care Medicine | Pain Medicine | Emergency Medicine | Anesthesiology | Medicine & Public Health
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12. Full Text Comments on: Daytime variation of perioperative myocardial injury in cardiac surgery/Kommentar zu: Tageszeitliche Variation der perioperativen Myokardschadigung in der Kardiochirurgie
by Schalte, Gereon and Stoppe, Christian
Der Anaesthesist, ISSN 0003-2417, 02/2018, Volume 67, Issue 2, p. 144
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s00101-017-0395-0 
Heart | Surgery | Patient outcomes
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13. Full Text Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - a sub-analysis of the RIPHeart-Study
by Westphal, Sabine and Westphal, Sabine and Stoppe, Christian and Stoppe, Christian and Gruenewald, Matthias and Gruenewald, Matthias and Bein, Berthold and Bein, Berthold and Renner, Jochen and Renner, Jochen and Cremer, Jochen and Cremer, Jochen and Coburn, Mark and Coburn, Mark and Schaelte, Gereon and Schaelte, Gereon and Boening, Andreas and Boening, Andreas and Niemann, Bernd and Niemann, Bernd and Kletzin, Frank and Kletzin, Frank and Roesner, Jan and Roesner, Jan and Strouhal, Ulrich and Strouhal, Ulrich and Reyher, Christian and Reyher, Christian and Laufenberg-Feldmann, Rita and Laufenberg-Feldmann, Rita and Ferner, Marion and Ferner, Marion and Brandes, Ivo F and Brandes, Ivo F and Bauer, Martin and Bauer, Martin and Kortgen, Andreas and Kortgen, Andreas and Stehr, Sebastian N and Stehr, Sebastian N and Wittmann, Maria and Wittmann, Maria and Baumgarten, Georg and Baumgarten, Georg and Struck, Rafael and Struck, Rafael and Meyer-Treschan, Tanja and Meyer-Treschan, Tanja and Kienbaum, Peter and Kienbaum, Peter and Heringlake, Matthias and Heringlake, Matthias and Schoen, Julika and Schoen, Julika and Sander, Michael and Sander, Michael and Treskatsch, Sascha and Treskatsch, Sascha and Smul, Thorsten and Smul, Thorsten and Wolwender, Ewa and Wolwender, Ewa and Schilling, Thomas and Schilling, Thomas and Degenhardt, Frauke and Degenhardt, Frauke and Franke, Andre and Franke, Andre and Mucha, Soeren and Mucha, Soeren and Tittmann, Lukas and Tittmann, Lukas and Kohlhaas, Madeline and Kohlhaas, Madeline and Fuernau, Georg and Fuernau, Georg and Brosteanu, Oana and Brosteanu, Oana and Hasenclever, Dirk and Hasenclever, Dirk and Zacharowski, Kai and Zacharowski, Kai and Meybohm, Patrick and Stevanovic, Ana and Rossaint, Rolf and Felzen, Marc and Goetzenich, Andreas and Moormann, Tobias and Chalk, Katharina and Knuefermann, Pascal and Boehm, Olaf and Hoeft, Andreas and Winterhalter, Michael and Iken, Sonja and Weber, Christian and Wiedenbeck, Carolin and Schwarzmann, Gerhard and Pense, Karin and Fichtlscherer, Andreas Zierer Stephan and Goerlach, Gerold and ... and RIPHeart-Study Collaborators
BMC cardiovascular disorders, ISSN 1471-2261, 01/2019, Volume 19, Issue 1, pp. 26 - 12
BackgroundThe aim of our study was the identification of genetic variants associated with postoperative complications after cardiac surgery.MethodsWe conducted... 
Delirium | Myocardial infarction | Stroke | Genome-wide association study | Acute kidney injury | Atrial fibrillation | Cardiac surgery | DEFINITION | PHLPP2 | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | KINASE | MECHANISMS | CA2 | DYSFUNCTION | INFLAMMATORY RESPONSE | CEREBRAL ISCHEMIA/REPERFUSION INJURY | Heart | Medical research | Genome-wide association studies | Usage | Complications | Surgery | Medicine, Experimental | Genetic aspects | Research | Heart attack | Risk factors | Oxidative stress | Cardiac arrhythmia | Heart attacks | Heart surgery | Clinical trials | Ryanodine receptors | Cardiovascular disease | Genomes | Single-nucleotide polymorphism | Fibrillation | Ischemia | Rodents | Chromosomes | Cerebral infarction | Kidneys | Mortality | Studies | Genetic variance | Coronary vessels | Quality control | Renal failure
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