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Journal Article
Clinical Cancer Research, ISSN 1078-0432, 07/2006, Volume 12, Issue 13, pp. 4080 - 4089
Purpose: Aurora kinases play critical roles during mitosis in chromosome segregation and cell division. The aim of this study was to determine the preclinical... 
mitosis | kinase inhibitor | Aurora kinase | OVEREXPRESSION | ONCOLOGY | HISTONE H3 | PROTEIN-KINASE | ANTICANCER AGENTS | B KINASE | CHROMOSOME CONDENSATION | SPINDLE | A KINASE | MITOTIC PHOSPHORYLATION | CANCER | Pyrazoles - therapeutic use | Humans | Antineoplastic Agents - therapeutic use | Dose-Response Relationship, Drug | Aurora Kinase B | Enzyme Inhibitors - chemistry | Reverse Transcriptase Polymerase Chain Reaction - methods | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Biomarkers, Tumor - metabolism | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacology | Molecular Structure | Phosphorylation - drug effects | Biomarkers, Tumor - antagonists & inhibitors | Pyrroles - therapeutic use | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Mammary Neoplasms, Experimental - drug therapy | Pyrazoles - pharmacology | Recombinant Proteins - metabolism | Recombinant Proteins - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Mice, Transgenic | Recombinant Proteins - genetics | Aurora Kinases | Antineoplastic Agents - chemistry | Enzyme Inhibitors - therapeutic use | Phenotype | Pyrroles - pharmacology | Animals | Cell Line, Tumor | HL-60 Cells | Cell Proliferation - drug effects | Mice | HeLa Cells | Cell Cycle - drug effects | Drug Screening Assays, Antitumor
Journal Article
Biochemistry, ISSN 0006-2960, 05/2018, Volume 57, Issue 19, pp. 2876 - 2888
Selected members of the large rolipram-related GEBR family of type 4 phosphodiesterase (PDE4) inhibitors have been shown to facilitate long-term potentiation... 
APREMILAST | CONTROLLED-TRIAL | STRUCTURAL BASIS | PHARMACOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHASE-III | DYNAMICS | MUTATIONS | PHOSPHODIESTERASE 4D | ROFLUMILAST | CAMP | Molecular simulation | Usage | Research | Phosphodiesterases | Ligands (Biochemistry) | Analysis | Index Medicus
Journal Article
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 03/2017, Volume 24, Issue 3, pp. 270 - 278
Journal Article
Nature Communications, ISSN 2041-1723, 06/2017, Volume 8, Issue 1, p. 15772
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 10/2019, Volume 20, Issue 20, p. 5219
The formation of multienzymatic complexes allows for the fine tuning of many aspects of enzymatic functions, such as efficiency, localization, stability, and... 
protein painting | SITE | serine acetyltransferase | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | CHEMISTRY, MULTIDISCIPLINARY | SAXS | SALMONELLA-TYPHIMURIUM | FUNCTIONAL-ANALYSIS | PLANTS | INTERACTION NETWORKS | INHIBITORS | cysteine biosynthesis | cysteine synthase complex | O-acetylserine sulfhydrylase | CARBOXYLIC-ACIDS | saxs | o-acetylserine sulfhydrylase
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2010, Volume 18, Issue 19, pp. 7113 - 7120
Journal Article
CHEMICAL COMMUNICATIONS, ISSN 1359-7345, 12/2019, Volume 55, Issue 93, pp. 14043 - 14046
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2005, Volume 48, Issue 8, pp. 3080 - 3084
Journal Article
Protein Expression and Purification, ISSN 1046-5928, 02/2020, Volume 166, p. 105505
Recombinant antibodies can be expressed as fusion constructs in combination with tags which simplify their engineering into reliable and homogeneous... 
Antibody functionalization | Fusion tags | Recombinant antibodies | Nanobodies | Sortase | BIOMARKERS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | SCFV | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | SINGLE-DOMAIN ANTIBODIES | PROTEINS
Journal Article
BBA - Proteins and Proteomics, ISSN 1570-9639, 12/2018, Volume 1866, Issue 12, p. 1260
Methionine deprivation of cancer cells, which are deficient in methionine biosynthesis, has been envisioned as a therapeutic strategy to reduce cancer cell... 
Phosphates | Enzymes | Care and treatment | Analysis | Physiological aspects | Amino acids | Catalysis | Cancer
Journal Article
Nature structural & molecular biology, ISSN 1545-9993, 3/2017, Volume 24, Issue 3, pp. 270 - 278
Protein modification by ubiquitin and ubiquitin-like modifiers (Ubls) is counteracted by ubiquitin- and Ubl-proteases collectively called DUBs. In contrast to... 
Journal Article
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 12/2015, Volume 14, Issue 12 Supplement 2, pp. B61 - B61
Journal Article
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