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Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 02/2014, Volume 54, Issue 2, pp. 168 - 178
Romosozumab (formerly AMG 785/CDP7851) is a monoclonal antibody that blocks sclerostin from inhibiting osteoblast maturation and function. This double‐blind,... 
CDP7851 | romosozumab | bone mineral density | pharmacodynamics | pharmacokinetics | AMG 785 | sclerostin | Pharmacodynamics | Sclerostin | Bone mineral density | Romosozumab | Pharmacokinetics | PROTEIN | STRENGTH | OSTEOPOROSIS | DENSITY | GENE | PHARMACOLOGY & PHARMACY | SOST | Collagen Type I - blood | Peptides - blood | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Osteoporosis, Postmenopausal - metabolism | Male | Antibodies, Monoclonal, Humanized - administration & dosage | Antibodies, Monoclonal, Humanized - pharmacokinetics | Antibodies, Monoclonal, Humanized - pharmacology | Peptide Fragments - blood | Aged, 80 and over | Female | Bone Density Conservation Agents - pharmacokinetics | Antibodies, Monoclonal, Humanized - adverse effects | Bone Density Conservation Agents - adverse effects | Double-Blind Method | Drug Administration Schedule | Antibodies, Monoclonal - pharmacology | Antibodies, Monoclonal - pharmacokinetics | Lumbar Vertebrae - drug effects | Procollagen - blood | Bone Density Conservation Agents - administration & dosage | Osteoporosis, Postmenopausal - drug therapy | Bone Density Conservation Agents - pharmacology | Bone Density - drug effects | Osteoporosis, Postmenopausal - blood | Antibodies, Monoclonal - administration & dosage | Aged | Viral antibodies | Antibodies | Care and treatment | Dosage and administration | Postmenopausal women | Research | Osteoporosis | Men
Journal Article
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 01/2015, Volume 6, Issue 1, pp. 84 - 88
The structure of LX7101, a dual LIM-kinase and ROCK inhibitor for the treatment of ocular hypertension and associated glaucoma, is disclosed. Previously... 
kinase | ROCK inhibitor | LIM-kinase | LX7101 | glaucoma | CHEMISTRY, MEDICINAL | IDENTIFICATION | FAMILY
Journal Article
Bioanalysis, ISSN 1757-6180, 08/2012, Volume 4, Issue 16, pp. 2037 - 2047
Background: Dried blood spot (DBS) sampling in combination with LC-MS/MS has been used increasingly in drug discovery for quantitative analysis to support... 
STORAGE | DIAGNOSIS | CHEMISTRY, ANALYTICAL | ASSAY | HIV | SPOTS | QUANTIFICATION | PERFORMANCE | TRANSFERABILITY | BIOCHEMICAL RESEARCH METHODS | VALIDATION | TANDEM MASS-SPECTROMETRY
Journal Article
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