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by Gad, Helge and Gad, Helge and Koolmeister, Tobias and Koolmeister, Tobias and Jemth, Ann-Sofie and Jemth, Ann-Sofie and Eshtad, Saeed and Eshtad, Saeed and Jacques, Sylvain A and Jacques, Sylvain A and Ström, Cecilia E and Ström, Cecilia E and Svensson, Linda M and Svensson, Linda M and Schultz, Niklas and Schultz, Niklas and Lundbäck, Thomas and Lundbäck, Thomas and Einarsdottir, Berglind Osk and Einarsdottir, Berglind Osk and Saleh, Aljona and Saleh, Aljona and Göktürk, Camilla and Göktürk, Camilla and Baranczewski, Pawel and Baranczewski, Pawel and Svensson, Richard and Svensson, Richard and Berntsson, Ronnie P-A and Berntsson, Ronnie P.-A and Gustafsson, Robert and Gustafsson, Robert and Strömberg, Kia and Strömberg, Kia and Sanjiv, Kumar and Sanjiv, Kumar and Jacques-Cordonnier, Marie-Caroline and Jacques-Cordonnier, Marie-Caroline and Desroses, Matthieu and Desroses, Matthieu and Gustavsson, Anna-Lena and Gustavsson, Anna-Lena and Olofsson, Roger and Olofsson, Roger and Johansson, Fredrik and Johansson, Fredrik and Homan, Evert J and Homan, Evert J and Loseva, Olga and Loseva, Olga and Bräutigam, Lars and Bräutigam, Lars and Johansson, Lars and Johansson, Lars and Höglund, Andreas and Höglund, Andreas and Hagenkort, Anna and Hagenkort, Anna and Pham, Therese and Pham, Therese and Altun, Mikael and Altun, Mikael and Gaugaz, Fabienne Z and Gaugaz, Fabienne Z and Vikingsson, Svante and Vikingsson, Svante and Evers, Bastiaan and Evers, Bastiaan and Henriksson, Martin and Henriksson, Martin and Vallin, Karl S A and Vallin, Karl S.A and Wallner, Olov A and Wallner, Olov A and Hammarström, Lars G.J and Hammarström, Lars G J and Wiita, Elisee and Wiita, Elisee and Almlöf, Ingrid and Almlöf, Ingrid and Kalderén, Christina and Kalderén, Christina and Axelsson, Hanna and Axelsson, Hanna and Djureinovic, Tatjana and Djureinovic, Tatjana and Puigvert, Jordi Carreras and Puigvert, Jordi Carreras and Häggblad, Maria and Häggblad, Maria and Jeppsson, Fredrik and Jeppsson, Fredrik and Martens, Ulf and Martens, Ulf and Lundin, Cecilia and Lundin, Cecilia and Lundgren, B and Lundgren, Bo and Granelli, Ingrid and Granelli, Ingrid and ... and Institutionen för medicin och hälsa and Avdelningen för läkemedelsforskning and Linköpings universitet and Hälsouniversitetet
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, pp. 215 - 221
Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes... 
TARGET | CELLS | OXIDATIVE STRESS | REPAIR | HMTH1 | PROTEIN | MULTIDISCIPLINARY SCIENCES | DNA-SYNTHESIS | MUTAGENIC SUBSTRATE | CELLULAR SENESCENCE | 8-OXOGUANINE | Neoplasms - metabolism | Humans | Molecular Conformation | Male | Molecular Targeted Therapy | Pyrimidines - chemistry | Pyrophosphatases - antagonists & inhibitors | Enzyme Inhibitors - pharmacokinetics | Enzyme Inhibitors - chemistry | DNA Repair Enzymes - metabolism | Oxidation-Reduction - drug effects | Female | Deoxyguanine Nucleotides - metabolism | Cell Death - drug effects | DNA Repair Enzymes - antagonists & inhibitors | DNA Repair Enzymes - chemistry | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Cell Survival - drug effects | Catalytic Domain | Reproducibility of Results | Crystallization | Enzyme Inhibitors - pharmacology | Models, Molecular | Pyrimidines - pharmacology | Nucleotides - metabolism | Enzyme Inhibitors - therapeutic use | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Pyrimidines - therapeutic use | Pyrimidines - pharmacokinetics | Mice | DNA Damage | Neoplasms - pathology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Prevention | Deoxyribonucleotides | DNA damage | Cancer cells | Physiological aspects | Research | Binding proteins | Cancer | Cytotoxicity | Kinases | Cancer therapies | Defects | Proteins | Genotype & phenotype | Mutagenesis | Rodents | Cell cycle | Mutation | Deoxyribonucleic acid--DNA | Tumors | Apoptosis | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
PLoS Genetics, ISSN 1553-7390, 2015, Volume 11, Issue 12, p. e1005710
Degeneration of nigrostriatal dopaminergic system is the principal lesion in Parkinson's disease. Because glial cell line-derived neurotrophic factor (GDNF)... 
DELTA-TK | TYROSINE-HYDROXYLASE | PROTEASOME INHIBITION | NEUROTROPHIC FACTOR | IN-VIVO | GENETICS & HEREDITY | DOWN-REGULATION | MICE | GENE-TRANSFER | EXPRESSION | PARKINSONS-DISEASE | Central Nervous System - metabolism | Substantia Nigra - pathology | Dopaminergic Neurons - pathology | Humans | Central Nervous System - pathology | Dopamine - genetics | Substantia Nigra - metabolism | Neuroprotective Agents - metabolism | Parkinson Disease, Secondary - pathology | Kidney - metabolism | Acetylcysteine - analogs & derivatives | Gene Expression Regulation, Developmental | Dopaminergic Neurons - metabolism | Neostriatum - metabolism | Parkinson Disease, Secondary - chemically induced | Dopamine - metabolism | Disease Models, Animal | Neostriatum - pathology | Glial Cell Line-Derived Neurotrophic Factor - biosynthesis | Glial Cell Line-Derived Neurotrophic Factor - genetics | Kidney - growth & development | Animals | Parkinson Disease, Secondary - genetics | Mice | Acetylcysteine - toxicity | Transcription factors | MicroRNA | Gene expression | Observations | Health aspects | Medical Biotechnology | Medical and Health Sciences | Medicin och hälsovetenskap | Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) | Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci) | Medicinsk bioteknologi | Dopamine | Kidneys | Funding | Neurons | Parkinsons disease | Colleges & universities | Kinases | Experiments | Proteins | Rodents | MicroRNAs | Graduate studies | Growth hormones | Physiology
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 07/2011, Volume 118, Issue 1, pp. 12 - 23
J. Neurochem. (2011) 10.1111/j.1471‐4159.2011.07292.x l‐DOPA is the most commonly used treatment for symptomatic control in patients with Parkinson’s disease.... 
chronoamperometry | l‐DOPA‐induced dyskinesia | SERT | 5‐HT | 5-HT | l- DOPA-induced dyskinesia | IN-VIVO MICRODIALYSIS | EXTRACELLULAR DOPAMINE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MODEL | 5-HT1A RECEPTOR STIMULATION | SUBSTANTIA-NIGRA | NEUROSCIENCES | EXOGENOUS L-DOPA | LEVODOPA-INDUCED DYSKINESIA | L-DOPA-induced dyskinesia | 6-HYDROXYDOPAMINE LESIONED RATS | STRIATUM | PARKINSONS-DISEASE | Severity of Illness Index | Tyrosine 3-Monooxygenase - metabolism | Dyskinesia, Drug-Induced - physiopathology | Presynaptic Terminals - drug effects | Stereotyped Behavior - drug effects | Rats | Levodopa - toxicity | Dyskinesia, Drug-Induced - pathology | Rats, Sprague-Dawley | Adrenergic Agents - toxicity | Dopa Decarboxylase - metabolism | Serotonin Plasma Membrane Transport Proteins - metabolism | Oxidopamine - toxicity | Animals | Apomorphine - pharmacology | Potassium Chloride - pharmacology | Serotonin - metabolism | Functional Laterality - drug effects | Presynaptic Terminals - metabolism | Female | Electrochemistry - methods | Corpus Striatum - pathology | Dopamine - metabolism | Disease Models, Animal | Phenols | Neurosciences | Dopamine | Parkinson's disease | Serotonin | Neurochemistry | Neurotransmitters | Side effects | Pharmacology | Parkinsons disease | Neurodegenerative diseases | Innervation | Neostriatum | Nerves | Levodopa | Movement disorders | Dyskinesia | Fibers | Chronoamperometry | L-DOPA induced dyskinesia | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Cell and Molecular Biology | Cell- och molekylärbiologi
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2014, Volume 9, Issue 11, pp. e112941 - e112941
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, p. e55706
L-DOPA-induced dyskinesia is a common side effect developed after chronic treatment with 3,4-dihydroxyphenyl-L-alanine (L-DOPA) in Parkinson's disease. The... 
DOUBLE-LABELING IMMUNOFLUORESCENCE | AMINO-ACID DECARBOXYLASE | LEVODOPA-INDUCED DYSKINESIA | INDUCED MOTOR COMPLICATIONS | BASAL GANGLIA | MULTIDISCIPLINARY SCIENCES | MULTISITE MICROELECTRODES | 5-HT1A RECEPTOR STIMULATION | SEROTONERGIC FIBERS | RAT MODEL | PARKINSONS-DISEASE | Dyskinesia, Drug-Induced - etiology | Potassium - metabolism | Benserazide - adverse effects | Injections, Intraventricular | Rats | 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology | Dyskinesia, Drug-Induced - pathology | Antiparkinson Agents - adverse effects | Corpus Striatum - metabolism | Rats, Sprague-Dawley | Serotonin Receptor Agonists - pharmacology | Animals | Signal Transduction - drug effects | Levodopa - adverse effects | Corpus Striatum - drug effects | Female | Glutamic Acid - metabolism | Dyskinesia, Drug-Induced - metabolism | Corpus Striatum - pathology | Dopamine - metabolism | Drug Combinations | Receptor, Serotonin, 5-HT1A - metabolism | Complications and side effects | Physiological aspects | Development and progression | Genetic aspects | Dosage and administration | Research | Glutamate | Dopa | Movement disorders | Risk factors | Tetralin | Neurosciences | Parkinson's disease | Parkinsons disease | Serotonin S1 receptors | Biological effects | Rodents | Neostriatum | L-Alanine | Amperometry | Levodopa | Lesions | Dyskinesia | Dopamine receptors | Dihydroxyphenylalanine | Alanine | Dopamine | Neurodegenerative diseases | Neurons | Medical treatment | 6-Hydroxydopamine | Urethane | Monkeys & apes | Electrical measurement | Side effects | Depletion | 8-Hydroxy-2-(di-n-propylamino)tetralin | Psychopharmacology | In vivo methods and tests | Glutamatergic transmission | Potassium | Cell and Molecular Biology | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Cell- och molekylärbiologi | Medicinska och farmaceutiska grundvetenskaper
Journal Article
Journal Article
Ergonomics, ISSN 0014-0139, 10/2009, Volume 52, Issue 10, pp. 1226 - 1239
Journal Article
Immunology, ISSN 0019-2805, 07/2011, Volume 133, Issue 3, pp. 296 - 306
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2014, Volume 9, Issue 11, p. e112941
Journal Article
Molecular and cellular neurosciences, ISSN 1044-7431, 11/2014, Volume 63, pp. 83 - 95
Several studies have shown that elevated plasma cholesterol levels (i.e. hypercholesterolemia) serve as a risk factor for late-onset Alzheimer’s disease (AD).... 
Learning | Hypercholesterolemia | Alzheimer’s disease | MRI | Memory | Vascular pathology | β-Amyloid | Tau | Neuroinflammation | Cholesterol
Journal Article