PLoS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, p. e0126041
Journal Article
Radiation Protection Dosimetry, ISSN 0144-8420, 2017, Volume 173, Issue 1, pp. 32 - 35
There has been a long process of growth and development of statistical approaches to the analysis of cancer incidence and mortality data obtained from the...
ENVIRONMENTAL SCIENCES | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | RANDOM ERRORS | MODELS | EPILATION | NUCLEAR SCIENCE & TECHNOLOGY | DISEASE | UNCERTAINTY | POWER | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | ATOMIC-BOMB SURVIVOR | DOSE ESTIMATION | Biostatistics | Risk Assessment | Humans | Dose-Response Relationship, Radiation | Forecasting | Neoplasms, Radiation-Induced | Incidence | Radiation Protection
ENVIRONMENTAL SCIENCES | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | RANDOM ERRORS | MODELS | EPILATION | NUCLEAR SCIENCE & TECHNOLOGY | DISEASE | UNCERTAINTY | POWER | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | ATOMIC-BOMB SURVIVOR | DOSE ESTIMATION | Biostatistics | Risk Assessment | Humans | Dose-Response Relationship, Radiation | Forecasting | Neoplasms, Radiation-Induced | Incidence | Radiation Protection
Journal Article
Nature Genetics, ISSN 1061-4036, 2010, Volume 42, Issue 10, pp. 874 - 879
Ovarian cancer accounts for more deaths than all other gynecological cancers combined. To identify common low-penetrance ovarian cancer susceptibility genes,...
POLY(ADP-RIBOSE) POLYMERASE | CELLS | MULTIPLE LOCI | GENE | VARIANTS | GENETICS & HEREDITY | Chromosomes, Human, Pair 8 - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Ovary - pathology | Humans | Proto-Oncogene Proteins c-myb - genetics | Genotype | Phosphoproteins - genetics | DNA-Binding Proteins - genetics | Case-Control Studies | Homeodomain Proteins - genetics | Ovarian Neoplasms - genetics | Chromosomes, Human, Pair 2 - genetics | Polymorphism, Single Nucleotide - genetics | Female | Biomarkers, Tumor - genetics | Genome, Human | Clinical Trials, Phase I as Topic | Clinical Trials, Phase II as Topic | Ovary - metabolism | Prevention | Evaluation | Genetic susceptibility | Genomics | Oncology, Experimental | Genetic aspects | Genomes | Research | Risk factors | Cancer | Ovarian cancer | Studies | Medical research | Hospitals | Biomedical research | Councils | Health services | Family medical history | Public health
POLY(ADP-RIBOSE) POLYMERASE | CELLS | MULTIPLE LOCI | GENE | VARIANTS | GENETICS & HEREDITY | Chromosomes, Human, Pair 8 - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Ovary - pathology | Humans | Proto-Oncogene Proteins c-myb - genetics | Genotype | Phosphoproteins - genetics | DNA-Binding Proteins - genetics | Case-Control Studies | Homeodomain Proteins - genetics | Ovarian Neoplasms - genetics | Chromosomes, Human, Pair 2 - genetics | Polymorphism, Single Nucleotide - genetics | Female | Biomarkers, Tumor - genetics | Genome, Human | Clinical Trials, Phase I as Topic | Clinical Trials, Phase II as Topic | Ovary - metabolism | Prevention | Evaluation | Genetic susceptibility | Genomics | Oncology, Experimental | Genetic aspects | Genomes | Research | Risk factors | Cancer | Ovarian cancer | Studies | Medical research | Hospitals | Biomedical research | Councils | Health services | Family medical history | Public health
Journal Article
Nature Communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, p. 1628
HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing in serous epithelial ovarian cancer, leading us to...
COMMON VARIANTS | RISK | CLEAR-CELL CARCINOMA | LOCUS | MULTIDISCIPLINARY SCIENCES | GENOME-WIDE ASSOCIATION | Ovarian Neoplasms - genetics | Promoter Regions, Genetic | DNA Methylation | Genetic Predisposition to Disease | Epigenesis, Genetic | Humans | Female | Gene Expression Profiling | Polymorphism, Single Nucleotide | Hepatocyte Nuclear Factor 1-beta - genetics
COMMON VARIANTS | RISK | CLEAR-CELL CARCINOMA | LOCUS | MULTIDISCIPLINARY SCIENCES | GENOME-WIDE ASSOCIATION | Ovarian Neoplasms - genetics | Promoter Regions, Genetic | DNA Methylation | Genetic Predisposition to Disease | Epigenesis, Genetic | Humans | Female | Gene Expression Profiling | Polymorphism, Single Nucleotide | Hepatocyte Nuclear Factor 1-beta - genetics
Journal Article
British Journal of Cancer, ISSN 0007-0920, 06/2010, Volume 103, Issue 1, pp. 120 - 126
BACKGROUND: Diabetics have been found to have a greater risk of colorectal cancer than non-diabetics. METHODS: We examined whether this relationship differed...
Multiethnic Cohort | colorectal cancer | diabetes | smoking | IGF-BINDING-PROTEINS | PLASMA C-PEPTIDE | MELLITUS | INSULIN | ONCOLOGY | FACTOR (IGF)-I | GLUCOSE | SELF-REPORT | HEALTH | TYPE-2 | GROWTH-FACTOR-I | Multivariate Analysis | Diabetes Complications - ethnology | Prospective Studies | Colorectal Neoplasms - ethnology | Humans | Middle Aged | Risk Factors | Hispanic Americans | African Americans | Hawaii | European Continental Ancestry Group | Male | Diabetes Complications - etiology | Asian Continental Ancestry Group | Colorectal Neoplasms - etiology | Female | Aged | Cohort Studies | Epidemiology
Multiethnic Cohort | colorectal cancer | diabetes | smoking | IGF-BINDING-PROTEINS | PLASMA C-PEPTIDE | MELLITUS | INSULIN | ONCOLOGY | FACTOR (IGF)-I | GLUCOSE | SELF-REPORT | HEALTH | TYPE-2 | GROWTH-FACTOR-I | Multivariate Analysis | Diabetes Complications - ethnology | Prospective Studies | Colorectal Neoplasms - ethnology | Humans | Middle Aged | Risk Factors | Hispanic Americans | African Americans | Hawaii | European Continental Ancestry Group | Male | Diabetes Complications - etiology | Asian Continental Ancestry Group | Colorectal Neoplasms - etiology | Female | Aged | Cohort Studies | Epidemiology
Journal Article
Nature Genetics, ISSN 1061-4036, 2010, Volume 42, Issue 10, pp. 880 - 884
Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer...
COMPLEX | BRCA1 | GENETICS & HEREDITY | GENOME-WIDE ASSOCIATION | Oligonucleotide Array Sequence Analysis | Adenocarcinoma, Mucinous - pathology | Humans | Middle Aged | Ovarian Neoplasms - pathology | Gene Expression Profiling | Cystadenocarcinoma, Serous - genetics | Cystadenocarcinoma, Serous - pathology | Case-Control Studies | Ovarian Neoplasms - genetics | Chromosomes, Human, Pair 19 - genetics | Endometrial Neoplasms - genetics | Female | Tumor Cells, Cultured | Ovary - metabolism | Genetic Predisposition to Disease | Genome-Wide Association Study | Ovary - pathology | Genotype | Adaptor Proteins, Signal Transducing - genetics | Polymorphism, Single Nucleotide - genetics | Endometrial Neoplasms - pathology | Adenocarcinoma, Clear Cell - pathology | Biomarkers, Tumor - genetics | Adenocarcinoma, Mucinous - genetics | Genome, Human | Adenocarcinoma, Clear Cell - genetics | Prevention | Evaluation | Genetic susceptibility | Genetic variation | Identification and classification | Risk factors | Ovarian cancer | Studies | Medical research | Hospitals | Biomedical research | Councils | Health services | Histology | Cancer
COMPLEX | BRCA1 | GENETICS & HEREDITY | GENOME-WIDE ASSOCIATION | Oligonucleotide Array Sequence Analysis | Adenocarcinoma, Mucinous - pathology | Humans | Middle Aged | Ovarian Neoplasms - pathology | Gene Expression Profiling | Cystadenocarcinoma, Serous - genetics | Cystadenocarcinoma, Serous - pathology | Case-Control Studies | Ovarian Neoplasms - genetics | Chromosomes, Human, Pair 19 - genetics | Endometrial Neoplasms - genetics | Female | Tumor Cells, Cultured | Ovary - metabolism | Genetic Predisposition to Disease | Genome-Wide Association Study | Ovary - pathology | Genotype | Adaptor Proteins, Signal Transducing - genetics | Polymorphism, Single Nucleotide - genetics | Endometrial Neoplasms - pathology | Adenocarcinoma, Clear Cell - pathology | Biomarkers, Tumor - genetics | Adenocarcinoma, Mucinous - genetics | Genome, Human | Adenocarcinoma, Clear Cell - genetics | Prevention | Evaluation | Genetic susceptibility | Genetic variation | Identification and classification | Risk factors | Ovarian cancer | Studies | Medical research | Hospitals | Biomedical research | Councils | Health services | Histology | Cancer
Journal Article
Cancer Discovery, ISSN 2159-8274, 2016, Volume 6, Issue 9, pp. 1052 - 1067
Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis, but this has not been investigated systematically by genome-wide...
DEATH RECEPTORS | CELLS | POPULATION | BIOLOGICAL PATHWAYS | RISK LOCI | PROFILES | VARIANTS | ONCOLOGY | TRAIL-INDUCED APOPTOSIS | ENRICHMENT ANALYSIS | PASSENGER COMPLEX CPC | Prostatic Neoplasms - metabolism | Genetic Predisposition to Disease | Genome-Wide Association Study | Meta-Analysis as Topic | Datasets as Topic | Signal Transduction | Humans | Male | Chromosome Mapping | Genetic Loci | Gene Regulatory Networks | Case-Control Studies | Breast Neoplasms - metabolism | Ovarian Neoplasms - genetics | Organ Specificity - genetics | Breast Neoplasms - genetics | Prostatic Neoplasms - genetics | Enhancer Elements, Genetic | Female | Polymorphism, Single Nucleotide | Quantitative Trait Loci | breast cancer | prostate cancer | pleiotropy | ovarian cancer | genome-wide association studies
DEATH RECEPTORS | CELLS | POPULATION | BIOLOGICAL PATHWAYS | RISK LOCI | PROFILES | VARIANTS | ONCOLOGY | TRAIL-INDUCED APOPTOSIS | ENRICHMENT ANALYSIS | PASSENGER COMPLEX CPC | Prostatic Neoplasms - metabolism | Genetic Predisposition to Disease | Genome-Wide Association Study | Meta-Analysis as Topic | Datasets as Topic | Signal Transduction | Humans | Male | Chromosome Mapping | Genetic Loci | Gene Regulatory Networks | Case-Control Studies | Breast Neoplasms - metabolism | Ovarian Neoplasms - genetics | Organ Specificity - genetics | Breast Neoplasms - genetics | Prostatic Neoplasms - genetics | Enhancer Elements, Genetic | Female | Polymorphism, Single Nucleotide | Quantitative Trait Loci | breast cancer | prostate cancer | pleiotropy | ovarian cancer | genome-wide association studies
Journal Article
Diabetes, ISSN 0012-1797, 01/2014, Volume 63, Issue 7, pp. 2551 - 2562
textabstractGlycated hemoglobin A1c (HbA1c) is used as a measure of glycemic control and also as a diagnostic criterion for diabetes. To discover novel loci...
GENETIC-VARIATION | COMMON VARIANTS | OXIDATIVE STRESS | CELL TRAITS | METAANALYSIS | ENDOCRINOLOGY & METABOLISM | WIDE ASSOCIATION | MUTATIONS | HAPLOTYPE | EXPRESSION | CELIAC-DISEASE | Glycated Hemoglobin A - analysis | Humans | Middle Aged | Asian Continental Ancestry Group - genetics | Far East - epidemiology | Male | Genetic Loci | Genome-Wide Association Study - statistics & numerical data | Genetic Heterogeneity | Adult | Blood Glucose - genetics | Female | Aged | Polymorphism, Single Nucleotide | Asian Continental Ancestry Group - statistics & numerical data | Cohort Studies | Genome-wide association studies | Usage | Hemoglobin | Research | Diabetes | Diagnosis | Meta-analysis | Metabolomics | Genetics | Genomes | Proteomics
GENETIC-VARIATION | COMMON VARIANTS | OXIDATIVE STRESS | CELL TRAITS | METAANALYSIS | ENDOCRINOLOGY & METABOLISM | WIDE ASSOCIATION | MUTATIONS | HAPLOTYPE | EXPRESSION | CELIAC-DISEASE | Glycated Hemoglobin A - analysis | Humans | Middle Aged | Asian Continental Ancestry Group - genetics | Far East - epidemiology | Male | Genetic Loci | Genome-Wide Association Study - statistics & numerical data | Genetic Heterogeneity | Adult | Blood Glucose - genetics | Female | Aged | Polymorphism, Single Nucleotide | Asian Continental Ancestry Group - statistics & numerical data | Cohort Studies | Genome-wide association studies | Usage | Hemoglobin | Research | Diabetes | Diagnosis | Meta-analysis | Metabolomics | Genetics | Genomes | Proteomics
Journal Article
British Journal of Cancer, ISSN 0007-0920, 09/2012, Volume 107, Issue 7, p. 1204
Journal Article
Cancer Epidemiology, Biomarkers & Prevention, ISSN 1055-9965, 2013, Volume 22, Issue 5, pp. 880 - 890
BACKGROUND: There are several well-established environmental risk factors for ovarian cancer, and recent genome-wide association studies have also identified...
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | ONCOLOGY | INFLAMMATION | SUSCEPTIBILITY | HISTOLOGIC TYPE | ASSOCIATION | ORAL-CONTRACEPTIVES | Genetic Predisposition to Disease | Genome-Wide Association Study | Humans | Middle Aged | Risk Factors | Ovarian Neoplasms - pathology | Genotype | Gene-Environment Interaction | Case-Control Studies | Ovarian Neoplasms - epidemiology | Ovarian Neoplasms - genetics | Female | Aged | Environmental Exposure - statistics & numerical data | Gene-environment interactions | epidemiology | pooled analysis | ovarian cancer | histological subtype
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | ONCOLOGY | INFLAMMATION | SUSCEPTIBILITY | HISTOLOGIC TYPE | ASSOCIATION | ORAL-CONTRACEPTIVES | Genetic Predisposition to Disease | Genome-Wide Association Study | Humans | Middle Aged | Risk Factors | Ovarian Neoplasms - pathology | Genotype | Gene-Environment Interaction | Case-Control Studies | Ovarian Neoplasms - epidemiology | Ovarian Neoplasms - genetics | Female | Aged | Environmental Exposure - statistics & numerical data | Gene-environment interactions | epidemiology | pooled analysis | ovarian cancer | histological subtype
Journal Article
International Journal of Obesity, ISSN 0307-0565, 03/2018, Volume 42, Issue 3, pp. 384 - 390
OBJECTIVE: Body mass index (BMI) is commonly used to assess obesity, which is associated with numerous diseases and negative health outcomes. BMI has been...
COMMON VARIANTS | OBESITY | NUTRITION & DIETETICS | METAANALYSIS | GENOTYPE IMPUTATION | ENDOCRINOLOGY & METABOLISM | BODY-MASS INDEX | POPULATIONS | GENETIC-LOCI | AFRICAN-AMERICANS | GENOME-WIDE ASSOCIATION | EPIDEMIOLOGY PAGE | Body Mass Index | Genome-Wide Association Study | Genomics | Humans | Polymorphism, Single Nucleotide - genetics | Continental Population Groups - genetics | Continental Population Groups - statistics & numerical data | Quantitative trait loci | Body mass index | Disease susceptibility | Genetic aspects | Health aspects | Populations | Adipose tissue | Data processing | Population studies | Genomes | Single-nucleotide polymorphism | Regression analysis | Metabolism | Minority & ethnic groups | Epidemiology | Population genetics | Loci | Ethnic factors | Chromosome 1 | Consortia | American Indians | Ethnicity | Replicating | Body mass | Body size | Race | Polygenic inheritance
COMMON VARIANTS | OBESITY | NUTRITION & DIETETICS | METAANALYSIS | GENOTYPE IMPUTATION | ENDOCRINOLOGY & METABOLISM | BODY-MASS INDEX | POPULATIONS | GENETIC-LOCI | AFRICAN-AMERICANS | GENOME-WIDE ASSOCIATION | EPIDEMIOLOGY PAGE | Body Mass Index | Genome-Wide Association Study | Genomics | Humans | Polymorphism, Single Nucleotide - genetics | Continental Population Groups - genetics | Continental Population Groups - statistics & numerical data | Quantitative trait loci | Body mass index | Disease susceptibility | Genetic aspects | Health aspects | Populations | Adipose tissue | Data processing | Population studies | Genomes | Single-nucleotide polymorphism | Regression analysis | Metabolism | Minority & ethnic groups | Epidemiology | Population genetics | Loci | Ethnic factors | Chromosome 1 | Consortia | American Indians | Ethnicity | Replicating | Body mass | Body size | Race | Polygenic inheritance
Journal Article