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chemistry, medicinal (21) 21
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Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2019, Volume 62, Issue 11, pp. 5594 - 5615
A promising design paradigm for small-molecule inhibitors of tubulin polymerization that bind to the colchicine site draws structural inspiration from the... 
CHEMISTRY, MEDICINAL | ISOCOMBRETASTATIN A-4 | COLCHICINE SITE INHIBITORS | NATURAL-PRODUCTS | ANTINEOPLASTIC AGENTS | TUMOR | CELL-GROWTH | BINDING | CANCER | DIVERSE SET | COMBRETASTATIN A4 PHOSPHATE
Journal Article
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 3203 - 3203
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 03/2016, Volume 24, Issue 5, pp. 938 - 956
Targeting tumor vasculature represents an intriguing therapeutic strategy in the treatment of cancer. In an effort to discover new vascular disrupting agents... 
Dihydronaphthalene analogs | Small-molecule synthesis | Anti-cancer agents | Inhibitors of tubulin polymerization | Combretastatin analogs | Amino acid prodrug salts | Benzosuberene analogs | Vascular disrupting agents | CHEMISTRY, MEDICINAL | SOLID TUMORS | COLORIMETRIC ASSAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESTER DERIVATIVES | ANTINEOPLASTIC AGENTS | ANTIMITOTIC AGENTS | CHEMISTRY, ORGANIC | CELL-GROWTH | TUMOR VASCULATURE | SERUM LEUCINE AMINOPEPTIDASE | BLOOD-VESSELS | A4 PHOSPHATE | Optical Imaging | Bibenzyls - therapeutic use | Humans | Amino Acids - chemistry | Coumarins - chemistry | Antineoplastic Agents - therapeutic use | Prodrugs - chemistry | Structure-Activity Relationship | Bibenzyls - chemistry | Tubulin - metabolism | Drug Design | Water - chemistry | Female | Breast - pathology | Naphthalenes - chemistry | Solubility | Breast - blood supply | Neoplasms - blood supply | Breast Neoplasms - blood supply | Antineoplastic Agents - chemistry | Mice, SCID | Breast Neoplasms - drug therapy | Amino Acids - therapeutic use | Coumarins - therapeutic use | Neoplasms - drug therapy | Animals | Breast - drug effects | Breast Neoplasms - pathology | Cell Line, Tumor | Mice | Prodrugs - therapeutic use | Neoplasms - pathology | Naphthalenes - therapeutic use | Antimitotic agents | Antineoplastic agents | Analysis | Vascular Disrupting Agents | Benzosuberene Analogues | Small-Molecule Synthesis | Inhibitors of Tubulin Polymerization | Anti-Cancer Agents | Combretastatin Analogues | Amino Acid Prodrug Salts | Dihydronaphthalene Analogues
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 03/2017, Volume 27, Issue 5, pp. 1304 - 1310
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 12/2013, Volume 21, Issue 24, pp. 8019 - 8032
Journal Article
Journal of Natural Products, ISSN 0163-3864, 09/2013, Volume 76, Issue 9, pp. 1668 - 1678
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 12/2015, Volume 23, Issue 24, pp. 7497 - 7520
Journal Article
Cancer Letters, ISSN 0304-3835, 2015, Volume 369, Issue 1, pp. 229 - 241
Journal Article
MEDCHEMCOMM, ISSN 2040-2503, 08/2019, Volume 10, Issue 8, pp. 1445 - 1456
Numerous members of the combretastatin and chalcone families of natural products function as inhibitors of tubulin polymerization through a binding interaction... 
DESIGN | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUBULIN POLYMERIZATION | ANTIMITOTIC AGENTS | BENZOSUBERENE ANALOGS | ANTINEOPLASTIC AGENTS | COMBRETASTATIN A-4 | DIHYDRONAPHTHALENE | CELL-GROWTH | INHIBITORS | DERIVATIVES
Journal Article
ISSN 2040-2503, 10/2018, Volume 9, Issue 1, pp. 1649 - 1662
The natural products colchicine and combretastatin A-4 ( CA4 ) have provided inspiration for the discovery and development of a wide array of derivatives and... 
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 12/2012, Volume 58, pp. 568 - 572
Journal Article
MedChemComm, ISSN 2040-2503, 2018, Volume 9, Issue 10, pp. 1649 - 1662
The natural products colchicine and combretastatin A-4 (CA4) have provided inspiration for the discovery and development of a wide array of derivatives and... 
Journal Article
MEDCHEMCOMM, ISSN 2040-2503, 10/2018, Volume 9, Issue 10, pp. 1649 - 1662
The natural products colchicine and combretastatin A-4 (CA4) have provided inspiration for the discovery and development of a wide array of derivatives and... 
CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | VASCULAR-DISRUPTING AGENTS | TARGETING AGENTS | ANTINEOPLASTIC AGENTS | TUBULIN POLYMERIZATION | BENZOSUBERENE ANALOGS | ANTIMITOTIC AGENTS | TUMOR | CELL-GROWTH | A4 PHOSPHATE | CANCER
Journal Article