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Nature medicine, ISSN 1546-170X, 2014, Volume 20, Issue 6, pp. 590 - 591
The development of new therapies is an arduous, time-consuming and costly task. Furthermore, the development of many compounds runs into issues related to... 
Clinical Trials as Topic - trends | Metformin - therapeutic use | Drug Repositioning - trends | Humans | Metformin - pharmacology | Drug Repositioning - methods | Drug Discovery - legislation & jurisprudence | Neoplasms - drug therapy | Molecular biology | Pharmacology | Kinetics
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2005, Volume 309, Issue 5744, pp. 2222 - 2226
Journal Article
Cell reports (Cambridge), ISSN 2211-1247, 2016, Volume 16, Issue 10, pp. 2576 - 2592
The mechanisms underlying Zika virus (ZIKV)-related microcephaly and other neurodevelopment defects remain poorly understood. Here, we describe the derivation... 
NEURAL PROGENITORS | LONG-TERM | HUMAN BRAIN | ADAPTER | CENTRAL-NERVOUS-SYSTEM | INFECTION | MICE | BINDING KINASE 1 | ORGANOIDS | INNATE IMMUNITY | CELL BIOLOGY | Neocortex - pathology | Neurons - pathology | Transcription, Genetic - drug effects | Brain - embryology | Neuroglia - ultrastructure | Neuroglia - pathology | Humans | Brain - virology | Centrosome - drug effects | Gene Expression Profiling | Microcephaly - virology | Neural Stem Cells - ultrastructure | Zika Virus Infection - virology | Neural Stem Cells - immunology | Neuroepithelial Cells - immunology | Neuroprotective Agents - pharmacology | Spinal Cord - pathology | Microcephaly - pathology | Neuroepithelial Cells - virology | Nucleosides - pharmacology | Fetus - virology | Cell Death - drug effects | Phosphorylation - drug effects | Neurons - drug effects | Protein-Serine-Threonine Kinases - metabolism | Zika Virus - pathogenicity | Proto-Oncogene Proteins - metabolism | Zika Virus - ultrastructure | Neurons - virology | Virus Replication - drug effects | Neuroepithelial Cells - ultrastructure | Immunity, Innate - drug effects | Zika Virus Infection - pathology | Neural Stem Cells - virology | Zika Virus - physiology | Zika Virus - drug effects | Mitochondria - metabolism | Mitochondria - drug effects | Receptor Protein-Tyrosine Kinases - metabolism | Neural Stem Cells - enzymology | Centrosome - metabolism | Mitosis - drug effects | Brain - pathology | Protein Kinase Inhibitors - pharmacology | Neuroglia - virology | Neuroepithelial Cells - drug effects | Neurons/pathology | Zika Virus/pathogenicity | Mitochondria/metabolism | Virus Replication/drug effects | Microcephaly/pathology | Neurons/drug effects | Protein-Serine-Threonine Kinases/metabolism | Neural Stem Cells/immunology | Neuroglia/ultrastructure | Neuroepithelial Cells/drug effects | Neuroepithelial Cells/virology | Life Sciences | Brain/pathology | Zika Virus/drug effects | Brain/embryology | Mitochondria/drug effects | Fetus/virology | Neocortex/pathology | Neuroglia/pathology | Cell Death/drug effects | Mitosis/drug effects | Transcription, Genetic/drug effects | Nucleosides/pharmacology | Neural Stem Cells/enzymology | Neural Stem Cells/ultrastructure | Neuroepithelial Cells/ultrastructure | Receptor Protein-Tyrosine Kinases/metabolism | Microcephaly/virology | Proto-Oncogene Proteins/metabolism | Neuroprotective Agents/pharmacology | Zika Virus/ultrastructure | Neuroepithelial Cells/immunology | Brain/virology | Immunity, Innate/drug effects | Spinal Cord/pathology | Zika Virus/physiology | Neuroglia/virology | Microbiology and Parasitology | Zika Virus Infection/pathology | Neurons/virology | Zika Virus Infection/virology | Neural Stem Cells/virology | Centrosome/drug effects | Protein Kinase Inhibitors/pharmacology | Centrosome/metabolism | Phosphorylation/drug effects
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2013, Volume 77, Issue 5, pp. 859 - 866
Experience rearranges anatomical connectivity in the brain, but such plasticity is suppressed in adulthood. We examined the turnover of dendritic spines and... 
CORD CONTUSION | NEOCORTEX IN-VIVO | STRUCTURAL PLASTICITY | VISUAL-CORTEX | DENDRITIC SPINE STABILITY | AXONAL REGENERATION | DEPENDENT SYNAPTIC PLASTICITY | NEUROSCIENCES | OCULAR-DOMINANCE PLASTICITY | CORTICAL CIRCUITS | TRANSGENIC MICE | Neurosciences | Proteins | Brain research | Rodents | Age
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2017, Volume 95, Issue 2, pp. 281 - 296.e6
Journal Article
Science (American Association for the Advancement of Science), ISSN 0036-8075, 8/2002, Volume 297, Issue 5584, pp. 1190 - 1193
Axonal regeneration in the adult central nervous system (CNS) is limited by two proteins in myelin, Nogo and myelin-associated glycoprotein (MAC). The receptor... 
COS cells | Axons | Growth cones | Receptors | Neurites | Neurons | Myelin | Central nervous system | Reports | Gangliosides | Binding sites | SIALOADHESIN | INHIBITION | PROTEIN | NEURITE OUTGROWTH | ANALOGS | INTERACTS | MULTIDISCIPLINARY SCIENCES | AXON REGENERATION | GANGLIOSIDES | BINDING | FAMILY | Neurites - physiology | GPI-Linked Proteins | Myelin-Associated Glycoprotein - genetics | Myelin-Associated Glycoprotein - metabolism | Type C Phospholipases - metabolism | Peptide Fragments - pharmacology | Axons - physiology | Ganglia, Spinal - cytology | Phosphatidylinositol Diacylglycerol-Lyase | Recombinant Fusion Proteins - metabolism | Transfection | Cloning, Molecular | Myelin Proteins - pharmacology | Receptors, Cell Surface - chemistry | Neurons - metabolism | Nogo Proteins | Nogo Receptor 1 | Binding Sites | Protein Structure, Tertiary | Peptide Fragments - metabolism | Gene Library | Ganglia, Spinal - embryology | Sialic Acids - metabolism | Receptors, Cell Surface - metabolism | Nerve Regeneration | Recombinant Fusion Proteins - chemistry | Chick Embryo | Myelin Proteins - chemistry | Animals | Myelin-Associated Glycoprotein - chemistry | Ligands | Mice | Myelin Proteins - metabolism | COS Cells | Ganglia, Spinal - metabolism | Receptors, Cell Surface - genetics | Proteins | Composition | Glycoproteins | Structure | Nervous system
Journal Article
Nature (London), ISSN 1476-4687, 2002, Volume 417, Issue 6888, pp. 547 - 551
Journal Article