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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2013, Volume 110, Issue 51, pp. E4939 - E4939
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2018, Volume 77, Issue Suppl 2, p. 1300
BackgroundMethotrexate (MTX) is a widely applied anti-rheumatic and anti-leukemic drug. For its intracellular retention and pharmacologic activity, MTX relies... 
Glutamic acid | Enzymatic activity | Perchloric acid | Rheumatoid arthritis | Leukemia | Erythrocytes | Substrate preferences | Peripheral blood mononuclear cells | Leukocytes (mononuclear) | Methotrexate | Patients | Blood
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 04/2013, Volume 92, Issue 4, pp. 627 - 631
Journal Article
Neurology, ISSN 0028-3878, 2014, Volume 82, Issue 16, pp. 1425 - 1433
Journal Article
Leukemia, ISSN 0887-6924, 10/2017, Volume 31, Issue 10, pp. 2020 - 2028
Neomorphic mutations in isocitrate dehydrogenase 1 (IDH1) are frequently found in several human cancer types including acute myeloid leukemia (AML) and lead to... 
FREQUENT | IMPACT | ONCOLOGY | LEUKEMOGENESIS | GROWTH | 2-HYDROXYGLUTARATE LEVELS | MUTATIONS | DIFFERENTIATION | HEMATOLOGY | SUFFICIENT | Neoplastic Stem Cells - drug effects | Humans | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Mutation, Missense | Isocitrate Dehydrogenase - antagonists & inhibitors | Molecular Targeted Therapy | Leukemia, Myeloid, Acute - enzymology | Histone Code - drug effects | Protein Processing, Post-Translational - drug effects | Leukemia, Myeloid, Acute - drug therapy | Myeloid Cells - drug effects | Antineoplastic Agents - pharmacology | Neoplasm Proteins - genetics | Myelopoiesis - drug effects | Benzimidazoles - therapeutic use | Tumor Stem Cell Assay | Aniline Compounds - pharmacology | Enzyme Inhibitors - pharmacology | Isocitrate Dehydrogenase - genetics | Enzyme Inhibitors - therapeutic use | Xenograft Model Antitumor Assays | Point Mutation | Animals | Methylation - drug effects | Cell Line, Tumor | Benzimidazoles - pharmacology | Glutarates - metabolism | Mice | Aniline Compounds - therapeutic use | Mutation | DNA Methylation - drug effects | Neoplastic Stem Cells - enzymology | Leukemia, Myeloid, Acute - genetics | Gene mutations | Health aspects | Isocitrate dehydrogenase | Animal models | Cell survival | Myeloid leukemia | Leukemia | Oral administration | Stem cell transplantation | Inhibitors | Allografts | Rodents | Stem cells | Xenografts | DNA methylation | Methylation | Differentiation | Acute myeloid leukemia | Deoxyribonucleic acid--DNA | Cancer | Original
Journal Article
Annals of Oncology, ISSN 0923-7534, 2017, Volume 28, Issue 11, pp. 2725 - 2732
Thymidylate synthase (TS) has a predictive role in pemetrexed treatment of mesothelioma; however, additional chemoresistance mechanisms are poorly understood.... 
Malignant pleural mesothelioma | PCFT | Methylation | Expression | Pemetrexed | Outcome | malignant pleural mesothelioma | pemetrexed | CARBOPLATIN | expression | SOLID TUMORS | HUMAN LEUKEMIA-CELLS | PHASE-II | MECHANISMS | THYMIDYLATE SYNTHASE EXPRESSION | CHEMOTHERAPY | LUNG-CANCER | ONCOLOGY | methylation | MUTATIONS | outcome | Original
Journal Article
Anesthesiology, ISSN 0003-3022, 10/2012
Background:  Induction of general anesthesia often induces unwanted hypotension which is commonly treated with vasoactive medication to restore an appropriate... 
Journal Article
Science, ISSN 0036-8075, 10/2010, Volume 330, Issue 6002, pp. 336 - 336
Journal Article
European Journal of Paediatric Neurology, ISSN 1090-3798, 2017, Volume 21, pp. e124 - e124
Journal Article
Journal Article