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dose-response relationship, drug (7) 7
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sirolimus - therapeutic use (6) 6
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1. Full Text Changes in lung function and chylous effusions in patients with lymphangioleiomyomatosis treated with sirolimus
by Taveira-Dasilva, Angelo M and Hathaway, Olanda and Stylianou, Mario and Moss, Joel
Annals of internal medicine, ISSN 0003-4819, 2011, Volume 154, Issue 12, pp. 797 - 805
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | General aspects | Medical sciences | Antibacterial agents | Pharmacology. Drug treatments | Antibiotics. Antiinfectious agents. Antiparasitic agents | Lung Neoplasms - drug therapy | Humans | Immunosuppressive Agents - therapeutic use | Lymphangioleiomyomatosis - physiopathology | Middle Aged | Pleural Effusion - physiopathology | Antibiotics, Antineoplastic - adverse effects | Tomography, X-Ray Computed | Lung - diagnostic imaging | Lymphangiomyoma - diagnostic imaging | Lung Neoplasms - physiopathology | Angiomyolipoma - drug therapy | Antibiotics, Antineoplastic - blood | Angiomyolipoma - physiopathology | TOR Serine-Threonine Kinases - antagonists & inhibitors | Immunosuppressive Agents - blood | Adult | Female | Sirolimus - adverse effects | Chyle - secretion | Sirolimus - therapeutic use | Angiomyolipoma - diagnostic imaging | Lung - physiopathology | Lymphangioleiomyomatosis - drug therapy | Sirolimus - blood | Lymphangiomyoma - physiopathology | Lymphangiomyoma - drug therapy | Antibiotics, Antineoplastic - therapeutic use | Observation | Immunosuppressive Agents - adverse effects | Lung Neoplasms - diagnostic imaging | Cell Proliferation - drug effects | Lymphangioleiomyomatosis - diagnostic imaging | Respiratory Function Tests | Muscle, Smooth - pathology | Leiomyoma | Tuberous sclerosis | Physiological aspects | Research | Lungs | Drug therapy | Changes | Therapy | Womens health | Lung diseases | Medical treatment | Clinical outcomes | Index Medicus | Abridged Index Medicus
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2. Full Text Atenolol versus Losartan in Children and Young Adults with Marfan's Syndrome
by Lacro, Ronald V and Dietz, Harry C and Sleeper, Lynn A and Yetman, Anji T and Bradley, Timothy J and Colan, Steven D and Pearson, Gail D and Selamet Tierney, E. Seda and Levine, Jami C and Atz, Andrew M and Benson, D. Woodrow and Braverman, Alan C and Chen, Shan and De Backer, Julie and Gelb, Bruce D and Grossfeld, Paul D and Klein, Gloria L and Lai, Wyman W and Liou, Aimee and Loeys, Bart L and Markham, Larry W and Olson, Aaron K and Paridon, Stephen M and Pemberton, Victoria L and Pierpont, Mary Ella and Pyeritz, Reed E and Radojewski, Elizabeth and Roman, Mary J and Sharkey, Angela M and Stylianou, Mario P and Wechsler, Stephanie Burns and Young, Luciana T and Mahony, Lynn and Pediat Heart Network Investigators and Pediatric Heart Network Investigators
The New England journal of medicine, ISSN 0028-4793, 11/2014, Volume 371, Issue 22, pp. 2061 - 2071
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | General aspects | Medical sciences | Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis | Angiotensin II Type 1 Receptor Blockers - adverse effects | Angiotensin II Type 1 Receptor Blockers - therapeutic use | Humans | Aortic Valve Insufficiency | Child, Preschool | Infant | Male | Marfan Syndrome - physiopathology | Young Adult | Aorta - growth & development | Marfan Syndrome - drug therapy | Adrenergic beta-Antagonists - adverse effects | Adult | Female | Child | Adrenergic beta-Antagonists - therapeutic use | Aortic Aneurysm - prevention & control | Aorta - drug effects | Linear Models | Treatment Outcome | Disease-Free Survival | Atenolol - therapeutic use | Marfan Syndrome - mortality | Aorta - surgery | Losartan - therapeutic use | Atenolol - adverse effects | Losartan - adverse effects | Treatment outcome | Care and treatment | Losartan | Analysis | Adults | Dosage and administration | Children | Atenolol | Health aspects | Marfan syndrome | Risk factors | Marfan's syndrome | Connective tissue diseases | Cardiovascular disease | Clinical outcomes | Coronary vessels | Surgery | Regurgitation | Aorta | Death | Surface area | Cardiology | Drug therapy | Index Medicus | Abridged Index Medicus
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3. Full Text Sustained effects of sirolimus on lung function and cystic lung lesions in lymphangioleiomyomatosis
by Yao, Jianhua and Taveira-DaSilva, Angelo M and Jones, Amanda M and Julien-Williams, Patricia and Stylianou, Mario and Moss, Joel
American journal of respiratory and critical care medicine, ISSN 1073-449X, 12/2014, Volume 190, Issue 11, pp. 1273 - 1282
Sirolimus | LAM | Lung cystic destruction | Respiratory System | Life Sciences & Biomedicine | Critical Care Medicine | General & Internal Medicine | Science & Technology | Cysts - drug therapy | Lung Neoplasms - drug therapy | Forced Expiratory Volume - drug effects | Humans | Lymphangioleiomyomatosis - physiopathology | Antibiotics, Antineoplastic - adverse effects | Lung Neoplasms - pathology | Tomography, X-Ray Computed | Lung - diagnostic imaging | Lung Neoplasms - physiopathology | Lymphangioleiomyomatosis - pathology | Time Factors | Adult | Sirolimus - adverse effects | Lung - pathology | Sirolimus - therapeutic use | Lung - physiopathology | Lymphangioleiomyomatosis - drug therapy | Disease Progression | Antibiotics, Antineoplastic - administration & dosage | Sirolimus - administration & dosage | Antibiotics, Antineoplastic - therapeutic use | Lung - drug effects | Quality of Life | Lung Neoplasms - diagnostic imaging | Respiratory Function Tests | Index Medicus | Abridged Index Medicus | lung cystic destruction | Original | sirolimus
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4. Full Text Advances in and limitations of up-and-down methodology: A précis of clinical use, study design, and dose estimation in anesthesia research
by Pace, Nathan L and Stylianou, Mario P
Anesthesiology (Philadelphia), ISSN 0003-3022, 07/2007, Volume 107, Issue 1, pp. 144 - 152
Biological and medical sciences | Anesthesia | Medical sciences | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy | Data Interpretation, Statistical | Humans | Anesthetics - pharmacology | Logistic Models | Dose-Response Relationship, Drug | Pregnancy | Algorithms | Animals | Adult | Female | Anesthesiology | Anesthetics - administration & dosage | Research Design | Anesthesia, Obstetrical | Index Medicus | Abridged Index Medicus
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5. Full Text Decline in Lung Function in Patients With Lymphangioleiomyomatosis Treated With or Without Progesterone
by Taveira-DaSilva, Angelo M and Stylianou, Mario P and Hedin, Carolyn J and Hathaway, Olanda and Moss, Joel
Chest, ISSN 0012-3692, 12/2004, Volume 126, Issue 6, pp. 1867 - 1874
respiratory function | interstitial lung diseases | progesterone | Interstitial lung diseases | Respiratory function | Progesterone | Respiratory System | Life Sciences & Biomedicine | Critical Care Medicine | General & Internal Medicine | Science & Technology | Cardiology. Vascular system | Biological and medical sciences | Medical sciences | Pneumology | Follow-Up Studies | Humans | Lymphangioleiomyomatosis - physiopathology | Middle Aged | Lung - physiopathology | Lymphangioleiomyomatosis - drug therapy | Forced Expiratory Volume | Progesterone - therapeutic use | Pulmonary Diffusing Capacity | Adult | Female | Aged | Respiratory Function Tests | Cystic fibrosis | Care and treatment | Research | Risk factors | Index Medicus | Abridged Index Medicus
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6. Full Text A Randomized, Placebo-controlled, Double-blinded, Crossover Trial of Pioglitazone for Severe Asthma
by Kaler, Maryann, C.R.N.P and Barochia, Amisha V., M.B.B.S., M.H.S and Weir, Nargues A., M.D and Cuento, Rosemarie A., C.R.N.P and Stylianou, Mario, Ph.D and Roth, Mark J., M.D and Filie, Armando C., M.D and Vaughey, Ellen C., M.D and Nathan, Steven D., M.D and Levine, Stewart J., M.D
Journal of allergy and clinical immunology, ISSN 0091-6749, 2017, Volume 140, Issue 6, pp. 1716 - 1718
Allergy and Immunology | Allergy | Immunology | Life Sciences & Biomedicine | Science & Technology | Edema | Laboratories | Pioglitazone | Clinical trials | Ligands | Inflammation | Diabetes | Drug dosages | Asthma | Index Medicus | Abridged Index Medicus | Peroxisome Proliferator-activated Receptor-γ (PPAR-γ)
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7. Full Text Pregnancy in lymphangioleiomyomatosis: clinical and lung function outcomes in two national cohorts
by Taveira-DaSilva, Angelo M and Johnson, Simon R and Julien-Williams, Patricia and Johnson, Jan and Stylianou, Mario and Moss, Joel
Thorax, ISSN 0040-6376, 10/2020, Volume 75, Issue 10, pp. 904 - 907
Life Sciences & Biomedicine | Respiratory System | Science & Technology | Pregnancy Complications, Neoplastic - etiology | Humans | Lymphangioleiomyomatosis - physiopathology | Lung Neoplasms - therapy | Lung Neoplasms - physiopathology | Pregnancy Complications, Neoplastic - physiopathology | Pneumothorax - etiology | Lung Neoplasms - complications | Forced Expiratory Volume | Pregnancy | Young Adult | Vital Capacity | Lymphangioleiomyomatosis - complications | Lymphangioleiomyomatosis - therapy | Pregnancy Complications, Neoplastic - therapy | Adult | Female | Pregnancy Outcome | Cohort Studies | Pneumothorax | Medical imaging | Cysts | Womens health | Preeclampsia | Lung transplants | Patients | Cesarean section | Age | Index Medicus
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8. Rates of change in FEV1 and DLCO as potential indicators for mTOR inhibitor therapy in premenopausal lymphangioleiomyomatosis patients
by Taveira-DaSilva, Angelo M and Julien-Williams, Patricia and Jones, Amanda M and Stylianou, Mario and Moss, Joel
The European respiratory journal, ISSN 0903-1936, 04/2018, Volume 51, Issue 4, pp. 1702258 - 1702258
Life Sciences & Biomedicine | Respiratory System | Science & Technology | TOR protein | Rapamycin | Carbon monoxide | Patients
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9. Full Text Risk factors for hospital morbidity and mortality after the Norwood procedure: A report from the Pediatric Heart Network Single Ventricle Reconstruction trial
by Tabbutt, Sarah, MD, PhD and Ghanayem, Nancy, MD and Ravishankar, Chitra, MD and Sleeper, Lynn A., ScD and Cooper, David S., MD, MPH and Frank, Deborah U., MD, PhD and Lu, Minmin, MS and Pizarro, Christian, MD and Frommelt, Peter, MD and Goldberg, Caren S., MD and Graham, Eric M., MD and Krawczeski, Catherine Dent, MD and Lai, Wyman W., MD and Lewis, Alan, MD and Kirsh, Joel A., MD and Mahony, Lynn, MD and Ohye, Richard G., MD and Simsic, Janet, MD and Lodge, Andrew J., MD and Spurrier, Ellen, MD and Stylianou, Mario, PhD and Laussen, Peter, MD and Pediatric Heart Network Investigators and Pediatric Heart Network
The Journal of thoracic and cardiovascular surgery, ISSN 0022-5223, 2012, Volume 144, Issue 4, pp. 882 - 895
Cardiothoracic Surgery | Cardiac & Cardiovascular Systems | Respiratory System | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Surgery | Science & Technology | Cardiology. Vascular system | Heart | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy | Biological and medical sciences | Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava | Medical sciences | Pneumology | Hypoplastic Left Heart Syndrome - mortality | Multivariate Analysis | Postoperative Complications - etiology | Prospective Studies | Infant Mortality | Norwood Procedures - adverse effects | Heart Defects, Congenital - surgery | Humans | Hypoplastic Left Heart Syndrome - surgery | Ventricular Function | Postoperative Complications - mortality | North America | Time Factors | Infant, Newborn | Length of Stay | Hospital Mortality | Risk Assessment | Risk Factors | Kaplan-Meier Estimate | Proportional Hazards Models | Postoperative Complications - therapy | Treatment Outcome | Hypoplastic Left Heart Syndrome - physiopathology | Blalock-Taussig Procedure - adverse effects | Disease-Free Survival | Heart Ventricles - abnormalities | Blalock-Taussig Procedure - mortality | Heart Ventricles - physiopathology | Norwood Procedures - mortality | Heart Ventricles - surgery | Heart Defects, Congenital - mortality | Heart Defects, Congenital - physiopathology | Hemodynamics | Infants (Newborn) | Pediatrics | Medical colleges | Genetic disorders | Patient outcomes | Children's hospitals | Mortality | Congenital heart disease | Morbidity | Risk factors | Index Medicus | Abridged Index Medicus
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10. Full Text Effect of Statins Alone Versus Statins Plus Ezetimibe on Carotid Atherosclerosis in Type 2 Diabetes. The SANDS (Stop Atherosclerosis in Native Diabetics Study) Trial
by Fleg, Jerome L and Mete, Mihriye and Howard, Barbara V and Umans, Jason G and Roman, Mary J and Ratner, Robert E and Silverman, Angela and Galloway, James M and Henderson, Jeffrey A and Weir, Matthew R and Wilson, Charlton and Stylianou, Mario and Howard, Wm. James
Journal of the American College of Cardiology, ISSN 0735-1097, 2008, Volume 52, Issue 25, pp. 2198 - 2205
atherosclerosis | carotid artery intima-media thickness | ezetimibe | Prospective Studies | Tunica Media - drug effects | Humans | Middle Aged | Ezetimibe | Male | Carotid Artery Diseases - pathology | Cholesterol, LDL - blood | Female | Diabetes Complications - pathology | Drug Therapy, Combination | Diabetes Mellitus, Type 2 - complications | Carotid Artery Diseases - drug therapy | Severity of Illness Index | Cholesterol, LDL - drug effects | Diabetes Complications - drug therapy | Linear Models | Biomarkers - blood | Disease Progression | Tunica Intima - drug effects | Anticholesteremic Agents - therapeutic use | Azetidines - therapeutic use | Carotid Artery, Common - drug effects | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Carotid Artery, Common - pathology | Diabetes Mellitus, Type 2 - pathology | Confidence intervals | Ultrasonic imaging | Atherosclerosis | Lipids | Blood pressure | Triglycerides | Diabetes | Low density lipoprotein | Cholesterol | Statins | Native North Americans | Veins & arteries | Index Medicus | Abridged Index Medicus | CIMT
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11. Full Text Contemporary Outcomes After the Fontan Procedure. A Pediatric Heart Network Multicenter Study
by Anderson, Page A.W and Sleeper, Lynn A and Mahony, Lynn and Colan, Steven D and Atz, Andrew M and Breitbart, Roger E and Gersony, Welton M and Gallagher, Dianne and Geva, Tal and Margossian, Renee and McCrindle, Brian W and Paridon, Stephen and Schwartz, Marcy and Stylianou, Mario and Williams, Richard V and Clark III, Bernard J and Pediat Heart Network Investigat and Pediatric Heart Network Investigators
Journal of the American College of Cardiology, ISSN 0735-1097, 07/2008, Volume 52, Issue 2, pp. 85 - 98
diastolic function | echocardiography | brain natriuretic peptide | exercise | cardiac magnetic resonance | Fontan | pediatric | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Ventricular Function - physiology | Age Factors | Cross-Sectional Studies | Heart Defects, Congenital - surgery | Heart - physiology | Humans | Heart Defects, Congenital - pathology | Child, Preschool | Male | Treatment Outcome | Fontan Procedure | Adolescent | Sex Factors | Female | Exercise - physiology | Heart Defects, Congenital - physiopathology | Health Status | Child | Heart Ventricles - pathology | Natriuretic Peptide, Brain - blood | Cohort Studies | Heart Defects, Congenital - blood | Heart | Heart rate | Pediatrics | Heart attacks | Statistical methods | Cardiology | Variance analysis | Age | Index Medicus | Abridged Index Medicus
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12. Full Text Effect of Statins Alone Versus Statins Plus Ezetimibe on Carotid Atherosclerosis in Type 2 Diabetes
by Fleg, Jerome L., MD and Mete, Mihriye, PhD and Howard, Barbara V., PhD and Umans, Jason G., MD, PhD and Roman, Mary J., MD and Ratner, Robert E., MD and Silverman, Angela, MSN, CANP and Galloway, James M., MD and Henderson, Jeffrey A., MD, MPH and Weir, Matthew R., MD and Wilson, Charlton, MD and Stylianou, Mario, PhD and Howard, Wm. James, MD
Journal of the American College of Cardiology, ISSN 0735-1097, 2008, Volume 52, Issue 25, pp. 2198 - 2205
Cardiovascular | Internal Medicine | carotid artery intima-media thickness | atherosclerosis | ezetimibe | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Type 2 diabetes | Diabetics | Analysis | Low density lipoproteins | Atherosclerosis | Native Americans | Diabetes | Research | Cholesterol | Statins | Medical colleges | Research institutes
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