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Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 10/1998, Volume 18, Issue 10, pp. 1523 - 1533
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 10/2007, Volume 293, Issue 4, pp. 2210 - 2218
Targeting cannabinoid-2 (CB2) receptors with selective agonists may represent a novel therapeutic avenue in various inflammatory diseases, but the mechanisms... 
Adhesion molecules | Inflammation | RhoA | Endothelial activation | C-REACTIVE PROTEIN | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | MOLECULE EXPRESSION | ATHEROSCLEROSIS | NECROSIS-FACTOR-ALPHA | KNOCKOUT MICE | endothelial activation | CANNABINOID RECEPTORS | inflammation | adhesion molecules | NITRIC-OXIDE | THERAPEUTIC TARGETS | PERIPHERAL VASCULAR DISEASE | POTENTIAL ROLE | CB2 RECEPTOR ACTIVATION | Inflammation - chemically induced | Leukocyte Rolling - drug effects | Tumor Necrosis Factor-alpha - metabolism | Receptor, Cannabinoid, CB2 - agonists | Humans | Male | Monocytes - metabolism | NF-kappa B - metabolism | rhoA GTP-Binding Protein - metabolism | Aorta - metabolism | RNA, Messenger - metabolism | Receptor, Cannabinoid, CB2 - genetics | Coronary Vessels - metabolism | Lipopolysaccharides | Dose-Response Relationship, Drug | Inflammation - metabolism | Anti-Inflammatory Agents - therapeutic use | Chemokine CCL2 - metabolism | Disease Models, Animal | Coronary Vessels - drug effects | Anti-Inflammatory Agents - pharmacology | Endothelial Cells - metabolism | Aorta - drug effects | Mice, Inbred C57BL | Cells, Cultured | Cannabinoids - pharmacology | Monocytes - drug effects | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Cannabinoids - therapeutic use | Intercellular Adhesion Molecule-1 - metabolism | Animals | Signal Transduction - drug effects | Inflammation - prevention & control | Mice | Vascular Cell Adhesion Molecule-1 - metabolism | Endothelial Cells - drug effects
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 11463 - 11
Sphingolipids have been accorded numerous biological functions however, the effects of feeding a western diet (diet rich in cholesterol and fat) on skin... 
CELLS | ULCERATIVE DERMATITIS | HUMAN-NEUTROPHILS | PROTEIN | C57BL/6 MICE | MULTIDISCIPLINARY SCIENCES | DISEASE | ATHEROSCLEROSIS | KERATINOCYTES | LACTOSYLCERAMIDE | APOLIPOPROTEIN-E | Hair | Phenotypes | High cholesterol diet | Biodegradability | Dermis | Sphingolipids | Propanol | Cholesterol | High fat diet | Metastases | Apolipoprotein E | Arteriosclerosis | Rodents | Skin
Journal Article
Circulation, ISSN 0009-7322, 06/2014, Volume 129, Issue 23, pp. 2403 - 2413
BACKGROUND—Glycosphingolipids, integral components of the cell membrane, have been shown to serve as messengers, transducing growth factor–initiated... 
Molecular imaging | Mice | Glycosphingolipids | Knockout | Atherosclerosis | atherosclerosis | CARDIAC & CARDIOVASCULAR SYSTEMS | GLUCOSYLCERAMIDE SYNTHASE | SERUM | molecular imaging | GENE KNOCKOUT MICE | mice, knockout | INSULIN SENSITIVITY | ADHESION | METABOLISM | glycosphingolipids | ENDOTHELIAL-CELLS | PERIPHERAL VASCULAR DISEASE | EXPRESSION | DENSITY-LIPOPROTEIN RECEPTOR | Hyperlipidemias - genetics | Calcium - metabolism | Male | Aorta - metabolism | Antigens, CD - metabolism | Dose-Response Relationship, Drug | Pulsatile Flow - drug effects | Cholesterol, Dietary - pharmacology | Diet, High-Fat | Ultrasonography | Lipoproteins, LDL - metabolism | Rabbits | Aorta - diagnostic imaging | Hyperlipidemias - metabolism | Models, Cardiovascular | Aorta - drug effects | Coronary Artery Disease - metabolism | Glycosphingolipids - biosynthesis | Hyperlipidemias - drug therapy | Enzyme Inhibitors - pharmacology | Lactosylceramides - metabolism | Morpholines - pharmacology | Coronary Artery Disease - drug therapy | Mice, Knockout | Gene Expression Regulation - drug effects | Animals | Apolipoproteins E - genetics | Vascular Stiffness - drug effects | Coronary Artery Disease - genetics | Glycosphingolipids - metabolism | Glucosylceramides - metabolism | Animal experimentation | Usage | Physiological aspects | Research | Apolipoproteins | Cholesterol
Journal Article
PROTEOMICS – Clinical Applications, ISSN 1862-8346, 09/2018, Volume 12, Issue 5, pp. 1870042 - n/a
Aberrant protein glycosylation is associated with the occurrence of cardiac hypertrophy. Heart arterial blood contains a biomarker (brain naturetic protein:... 
Heart failure | Heart | Heart enlargement | Proteins | Brain | Polysaccharides | Biomarkers | Glycosylation | Biosynthesis | Cardiovascular diseases | Heart diseases | Coronary artery disease | Glycan | Hypertrophy
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 09/2015, Volume 465, Issue 1, pp. 159 - 164
ApoE−/− mice fed a high fat and high cholesterol (HFHC) diet (20% fat and 1.25% cholesterol) from 12 weeks of age to 36 weeks revealed an age-dependent... 
Cardiac hypertrophy | Lactosylceramide | Glycosphingolipids | Atherosclerotic heart disease | OXIDATIVE STRESS | STRETCH | BIOCHEMISTRY & MOLECULAR BIOLOGY | HYPERLIPIDEMIA | ATHEROSCLEROSIS | LEFT-VENTRICULAR HYPERTROPHY | BIOPHYSICS | DISEASE | MASS | HYPERTENSION | Apolipoproteins E - deficiency | Natriuretic Peptide, Brain - metabolism | Cardiomegaly - etiology | Diet, High-Fat - adverse effects | Cardiomegaly - pathology | Male | Galactosyltransferases - genetics | Glucosyltransferases - metabolism | Atrial Natriuretic Factor - genetics | Galactosyltransferases - antagonists & inhibitors | Phosphorylation - drug effects | Heart Ventricles - pathology | Glucosyltransferases - genetics | Glucosyltransferases - antagonists & inhibitors | Gene Expression | Natriuretic Peptide, Brain - genetics | Atrial Natriuretic Factor - metabolism | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Cardiotonic Agents - pharmacology | Galactosyltransferases - metabolism | Mice, Knockout | Myocytes, Cardiac - pathology | Animals | Cardiomegaly - prevention & control | Myocytes, Cardiac - drug effects | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Apolipoproteins E - genetics | Glycosphingolipids - antagonists & inhibitors | Glycosphingolipids - metabolism | Myocytes, Cardiac - metabolism | Mitogen-Activated Protein Kinases - genetics | Heart Ventricles - metabolism | Mice | Cardiomegaly - genetics | Cholesterol - adverse effects | Heart Ventricles - drug effects | Mitogen-Activated Protein Kinases - metabolism | Prevention | Heart | Heart enlargement | Diastereomers | Analysis | Apolipoproteins | Gene expression | Gangliosides
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e63726
In a xenograft model wherein, live renal cancer cells were implanted under the kidney capsule in mice, revealed a 30-fold increase in tumor volume over a... 
SPHINGOLIPID METABOLISM | GLYCOSPHINGOLIPID BIOSYNTHESIS | CELLS | ADHESION | ACTIVATED PROTEIN-KINASE | CHOLESTEROL | GLUCOSYLCERAMIDE SYNTHASE | MULTIDISCIPLINARY SCIENCES | RECEPTOR | LACTOSYLCERAMIDE | C-FOS EXPRESSION | Kidney - pathology | Kidney Neoplasms - metabolism | Antigens, CD - metabolism | Enzyme Inhibitors - administration & dosage | Glucosyltransferases - metabolism | Kidney - metabolism | Time Factors | Galactosyltransferases - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - metabolism | Disease Models, Animal | Glucosyltransferases - antagonists & inhibitors | Peptide Fragments - metabolism | Kidney - drug effects | Administration, Oral | Morpholines - administration & dosage | Enzyme Inhibitors - pharmacology | Tumor Suppressor Protein p53 - metabolism | Lactosylceramides - metabolism | Morpholines - pharmacology | Treatment Outcome | Galactosyltransferases - metabolism | Blotting, Western | Disease Progression | Animals | Signal Transduction - drug effects | Tumor Burden - drug effects | Kidney Neoplasms - pathology | Mice | Mice, Inbred BALB C | Kidney Neoplasms - drug therapy | Glucosylceramides - metabolism | Gangliosides | Models | Cancer | TOR protein | Cell proliferation | Pediatrics | Syngeneic grafts | AKT protein | Biosynthesis | Kinases | Ceramide glucosyltransferase | Angiogenesis | Cell growth | Synthesis | Allografts | Rodents | Surgery | Xenografts | Inhibition | Cardiology | Vascular endothelial growth factor | Medical research | AKT1 protein | Kidneys | Rapamycin | Propanol | Gene expression | Inhibitors | Kidney cancer | Kidney diseases | Tumors
Journal Article
Journal Article