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1. Full Text Oxaliplatin, fluorouracil, and leucovorin with or without cetuximab in patients with resected stage III colon cancer (PETACC-8): an open-label, randomised phase 3 trial
by Taieb, Julien, Prof and Tabernero, Josep, Prof and Mini, Enrico, Prof and Subtil, Fabien, PhD and Folprecht, Gunnar, MD and Van Laethem, Jean-Luc, Prof and Thaler, Josef, Prof and Bridgewater, John, MD and Petersen, Lone Nørgård, Prof and Blons, Hélène, PhD and Collette, Laurence, PhD and Van Cutsem, Eric, Prof and Rougier, Philippe, Prof and Salazar, Ramon, Prof and Bedenne, Laurent, Prof and Emile, Jean-François, Prof and Laurent-Puig, Pierre, Prof and Lepage, Come, Prof and PETACC-8 Study Investigators
Lancet Oncology, The, ISSN 1470-2045, 2014, Volume 15, Issue 8, pp. 862 - 873
Summary Background Since the 1990s, fluorouracil-based adjuvant chemotherapy has significantly reduced the risk of tumour recurrence in patients with stage III... 
Hematology, Oncology and Palliative Medicine | SURVIVAL | 1ST-LINE TREATMENT | THERAPY | ONCOLOGY | BEVACIZUMAB | ADJUVANT TREATMENT | NSABP C-07 | KRAS | COMBINATION | METASTATIC COLORECTAL-CANCER | CHEMOTHERAPY | ras Proteins - genetics | Colonic Neoplasms - genetics | Proto-Oncogene Proteins p21(ras) | Adenocarcinoma - pathology | Colonic Neoplasms - drug therapy | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Diarrhea - chemically induced | Colonic Neoplasms - surgery | Fluorouracil - therapeutic use | Antibodies, Monoclonal, Humanized - administration & dosage | Leucovorin - adverse effects | Fluorouracil - adverse effects | Infusions, Intravenous - adverse effects | Adult | Female | Leucovorin - therapeutic use | Adenocarcinoma - genetics | Chemotherapy, Adjuvant | Cetuximab | Antibodies, Monoclonal, Humanized - adverse effects | Drug Eruptions - etiology | Exons - genetics | Proto-Oncogene Proteins - genetics | Adenocarcinoma - drug therapy | Mucositis - chemically induced | Disease-Free Survival | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Colonic Neoplasms - pathology | Intention to Treat Analysis | Aged | Neoplasm Staging | Organoplatinum Compounds - therapeutic use | Organoplatinum Compounds - adverse effects | Adenocarcinoma - surgery | Prevention | Care and treatment | Chemotherapy | Colon cancer | Hospitals | Leucovorin | Product development | Cancer | Life Sciences
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2. Full Text Comments on the article of C.-Y. Lai, L. Tian, and E.F. Schisterman on the “Exact confidence interval estimation for the Youden index and its corresponding optimal cut-point”
by Subtil, Fabien
Computational Statistics and Data Analysis, ISSN 0167-9473, 2011, Volume 55, Issue 12, pp. 3379 - 3380
► Reliable credible intervals are important for optimal cut-point. ► Bayesian inference is an alternative to generalized confidence intervals. ► Bayesian... 
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3. Full Text Comments on the article of C.-Y. Lai, L. Tian, and E.F. Schisterman on the "exact confidence interval estimation for the Youden index and its corresponding optimal cut-point
by Subtil, Fabien
Computational Statistics and Data Analysis, ISSN 0167-9473, 12/2011, Volume 55, Issue 12, pp. 3379 - 3380
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4. Full Text Unequal intra‐group variance in trajectory classification
by Klich, Amna and Ecochard, René and Subtil, Fabien
Statistics in Medicine, ISSN 0277-6715, 12/2018, Volume 37, Issue 28, pp. 4155 - 4166
Classifying patients into groups according to longitudinal series of measurements (ie, trajectory classification) has become frequent in clinical research.... 
ECM algorithm | intra‐group variance | classification | longitudinal measure | trajectories | heterogeneity | intra-group variance | MEDICINE, RESEARCH & EXPERIMENTAL | MIXTURE | MAXIMUM-LIKELIHOOD | MEDICAL INFORMATICS | BINARY DATA | MULTIVARIATE | STATISTICS & PROBABILITY | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | MODELS | EM ALGORITHM | MATHEMATICAL & COMPUTATIONAL BIOLOGY | OUTCOMES | Algorithms
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5. Full Text French Intensive Care Society, International congress – Réanimation 2016
by Jaillette, Emmanuelle and Girault, Christophe and Brunin, Guillaume and Zerimech, Farid and Chiche, Arnaud and Broucqsault-Dedrie, Céline and Fayolle, Cyril and Minacori, Franck and Alves, Isabelle and Barrailler, Stephanie and Robriquet, Laurent and Delaporte, Emmanuel and Thellier, Damien and Delcourte, Claire and Duhamel, Alain and Nseir, Saad and Valette, Xavier and Desmeulles, Isabelle and Savary, Benoit and Masson, Romain and Seguin, Amélie and Daubin, Cédric and Sauneuf, Bertrand and Verrier, Pierre and Pottier, Véronique and Orabona, Marie and Samba, Désiré and Viquesnel, Gérald and Lermuzeaux, Mathilde and Hazera, Pascal and Hanouz, Jean-Luc and Parienti, Jean-Jacques and Du Cheyron, Damien and Demoule, Alexandre and Clavel, Marc and Rolland-Debord, Camille and Perbet, Sébastien and Terzi, Nicolas and Kouatchet, Achille and Wallet, Florent and Roze, Hadrien and Vargas, Frédéric and Guérin, Claude and Dellamonica, Jean and Jaber, Samir and Similowski, Thomas and Quenot, Jean-Pierre and Binquet, Christine and Vinsonneau, Christophe and Barbar, Saber-Davide and Vinault, Sandrine and Deckert, Valérie and Lemaire, Stephanie and Hssain, Ali Ait and Bruyère, Rémi and Souweine, Bertrand and Lagrost, Laurent and Adrie, Christophe and Jung, Boris and Daurat, Aurelien and De Jong, Audrey and Chanques, Gérald and Mahul, Martin and Monnin, Marion and Molinari, Nicolas and Lheureux, Olivier and Trepo, Eric and Hites, Maya and Cotton, Frederic and Wolff, Fleur and Surin, Rudy and Créteur, Jacques and Vincent, Jean-Louis and Gustot, Thierry and Jacobs, Frederique and Taccone, Fabio Silvio and Neuville, Mathilde and Timsit, Jean-François and El-Helali, Najoua and Le Monnier, Alban and Magalhaes, Eric and Radjou, Aguila and Smonig, Roland and Soubirou, Jean-François and Voiriot, Guillaume and Sonneville, Romain and Bouadma, Lila and Mourvillier, Bruno and Gélisse, Elodie and Brasseur, Alexandre and Roisin, Sandrine and De Backer, Daniel and Van Ruychevelt, Valerie and Carlier, Eric and Piagnerelli, Michael and Vanhaeverbeek, Michel and Danguy, Christine and Biston, Patrick and Au, Siu-Ming and Begot, Emmanuelle and ... and Qualité et Sécurité des Soins - CBPR-CFAR and Brain Liver Pitié-Salpêtrière Study Group (BLIPS), Paris, France and Working Group on Mechanical Ventilation and Outcomerea Study Group and COCOONs Study Group and Groupe ALIVE and For the GrrrOH: Groupe de recherche en réanimation respiratoire en Onco-Hématologie (Group for Research in Respiratory Intensive Care Onco-Hematology and EPURE Study Group and For the OUTCOMEREA Study Group and For the BIBLIOFLASH Study Group and Groupe de Recherche en Réanimation Respiratoire et Onco-Hematologique (GRRROH) and RETROMARS Study Group and BoReal study group and ABDOMIX Group and Groupe de travail sur la ventilation and Groupe de Recherche en Reanimation Respiratoire du patient d’Onc-hématologie and Groupe RMM and Université Paris 6 —Pierre et Marie Curie and Institut National pour la Santé et la Recherche Médicale, UMRS1158, Paris and Groupe de Recherche en Réanimation Respiratoire en Onco-Hématologie and ABLE French Investigators and ENCEPHALITICA Study Group and Septiflux trial Group and CRICS Network and OutcomeRéa and Committee of young intensivists of the French Society for Intensive Care Medicine (FICS) and NutriSIP and CNER DESC réanimation grand ouest and Phase Angle Project Investigators
Annals of Intensive Care, ISSN 2110-5820, 6/2016, Volume 6, Issue S1, pp. 1 - 236
PHYSICIANS ABSTRACTSO1 Impact of tracheal cuff shape on microaspiration of gastric contents in intubated critically ill patients: a multicenter randomized... 
Intensive / Critical Care Medicine | Emergency Medicine | Anesthesiology | Medicine & Public Health
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6. Full Text An enhancement of ROC curves made them clinically relevant for diagnostic-test comparison and optimal-threshold determination
by Subtil, Fabien and Rabilloud, Muriel
Journal of Clinical Epidemiology, ISSN 0895-4356, 2015, Volume 68, Issue 7, pp. 752 - 759
Abstract Objectives The receiver operating characteristic curves (ROC curves) are often used to compare continuous diagnostic tests or determine the optimal... 
Internal Medicine | Optimal threshold | Diagnostic test | Test selection | Utility | ROC curve | Decision analysis | YOUDEN INDEX | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | PREFERENCES | HEALTH CARE SCIENCES & SERVICES | Toxoplasmosis, Congenital - blood | Prevalence | Immunoglobulin G - blood | Monitoring, Physiologic - statistics & numerical data | Area Under Curve | Humans | Decision Support Techniques | Hypertrophy, Left Ventricular - diagnosis | False Negative Reactions | Reference Values | Models, Statistical | Differential Threshold | Hypertrophy, Left Ventricular - complications | Hypertension - complications | ROC Curve | Diagnostic Tests, Routine - statistics & numerical data | Child | Early Diagnosis | Research Design | Toxoplasmosis, Congenital - diagnosis | Medical tests | Analysis | Studies | Confidence intervals | Medical research | Accuracy | Disease | Decision making | Rodents | Expected utility | Methods | Life Sciences
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7. Full Text The precision–recall curve overcame the optimism of the receiver operating characteristic curve in rare diseases
by Ozenne, Brice and Subtil, Fabien and Maucort-Boulch, Delphine
Journal of Clinical Epidemiology, ISSN 0895-4356, 2015, Volume 68, Issue 8, pp. 855 - 859
Abstract Objectives Compare the area under the receiver operating characteristic curve (AUC) vs. the area under the precision–recall curve (AUPRC) in... 
Internal Medicine | Rare events | Receiver operating curve | Area under the curve | Performance assessment | Binary biomarker | Precision-Recall curve | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | HEALTH CARE SCIENCES & SERVICES | Predictive Value of Tests | Prevalence | Area Under Curve | Humans | Sensitivity and Specificity | Biomarkers | Rare Diseases - epidemiology | ROC Curve | Confidence intervals | Medical imaging | Disease | Expected values
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8. Full Text Short-Term effects of the prone positioning maneuver on lung and chest wall mechanics in patients with acute respiratory distress syndrome
by Riad, Zakaria and Mezidi, Mehdi and Subtil, Fabien and Louis, Bruno and Guérin, Claude
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 05/2018, Volume 197, Issue 10, pp. 1355 - 1358
According to Pelosi and colleagues (2), an increase in Ecw triggers the redistribution of ventilation and improves oxygenation in the prone position. [...]we... 
RESPIRATORY SYSTEM | CRITICAL CARE MEDICINE | Respiratory therapy | Ventilators | Intensive care | Respiratory distress syndrome | Mechanics | Patients | Respiratory system
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9. Full Text Geriatric Factors Predict Chemotherapy Feasibility: Ancillary Results of FFCD 2001-02 Phase III Study in First-Line Chemotherapy for Metastatic Colorectal Cancer in Elderly Patients
by Thomas Aparicio and Jean-Louis Jouve and Laurent Teillet and Dany Gargot and Fabien Subtil and Valérie Le Brun-Ly and Jacques Cretin and Christophe Locher and Olivier Bouché and Gilles Breysacher and Jacky Charneau and Jean-François Seitz and Mohamed Gasmi and Laetitia Stefani and Mohamed Ramdani and Thierry Lecomte and Emmanuel Mitry
Journal of Clinical Oncology, ISSN 0732-183X, 04/2013, Volume 31, Issue 11, pp. 1464 - 1470
Purpose Elderly patients form a heterogeneous population. Evaluation of geriatric factors may help evaluate a patient's health status to better adapt... 
SURVIVAL | OLDER PATIENTS | DECISION-MAKING | ONCOLOGY | OXALIPLATIN | TOXICITY | QUALITY-OF-LIFE | FLUOROURACIL | SURVEY-13 | AGE | Multivariate Analysis | Prospective Studies | Geriatric Assessment - statistics & numerical data | Cognition Disorders - chemically induced | Humans | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Activities of Daily Living | Dose-Response Relationship, Drug | Neoplasm Metastasis | Fluorouracil - administration & dosage | Fluorouracil - adverse effects | Colorectal Neoplasms - drug therapy | Aged, 80 and over | Camptothecin - administration & dosage | Female | Camptothecin - analogs & derivatives | Camptothecin - adverse effects | Drug Administration Schedule | Logistic Models | Treatment Outcome | Health Services for the Aged - statistics & numerical data | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Colorectal Neoplasms - pathology | Index Medicus | Life Sciences
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10. Full Text kmlShape: An efficient method to cluster longitudinal data (Time-Series) according to their shapes
by Genolini, Christophe and Ecochard, René and Benghezal, Mamoun and Driss, Tarak and Andrieu, Sandrine and Subtil, Fabien
PLoS ONE, ISSN 1932-6203, 06/2016, Volume 11, Issue 6, p. e0150738
Background Longitudinal data are data in which each variable is measured repeatedly over time. One possibility for the analysis of such data is to cluster... 
MENSTRUAL-CYCLE | CURVE REGISTRATION | ALIGNMENT | EM ALGORITHM | MULTIDISCIPLINARY SCIENCES | TRAJECTORIES | OVULATION | CLASSIFICATION | K-MEANS ALGORITHM | MODEL | FUNCTIONAL DATA | Data Interpretation, Statistical | Algorithms | Humans | Cluster Analysis | Cluster analysis | Usage | Longitudinal method | Analysis | Menstruation | Neurodegenerative diseases | Menstrual cycle | Time series | Data processing | Trajectories | Clustering | Time lag | Partitioning | Classification | Luteinizing hormone | Alzheimer's disease | Methods | Biomechanics | Life Sciences | Bioengineering | Human health and pathology | Imaging | Mechanics | Physics | Tissues and Organs
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11. Full Text Comments on the article of C.-Y. Lai, L. Tian, and EF Schisterman on the "Exact confidence interval estimation for the Youden index and its corresponding optimal cut-point"
by Subtil, F
COMPUTATIONAL STATISTICS & DATA ANALYSIS, ISSN 0167-9473, 12/2011, Volume 55, Issue 12, pp. 3379 - 3380
a* Reliable credible intervals are important for optimal cut-point. a* Bayesian inference is an alternative to generalized confidence intervals. a* Bayesian... 
TESTS | STATISTICS & PROBABILITY | OPTIMAL THRESHOLD | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS
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12. Full Text Prevalence of iron deficiency in patients aged 75 years or older with heart failure
by Mini, Paul and Marc, Bonnefoy and Fabien, Subtil and Chuzeville, Michel
Journal of Geriatric Cardiology, ISSN 1671-5411, 2018, Volume 15, Issue 11, pp. 682 - 686
Background The latest studies presented at the American Heart Association (AHA) meeting on heart failure and the update of the European Cardiology Society's... 
Heart failure | Iron deficiency | Very elderly patient | CARDIAC & CARDIOVASCULAR SYSTEMS | THERAPY | EJECTION FRACTION | FERRIC CARBOXYMALTOSE | GERIATRICS & GERONTOLOGY
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13. Full Text A Bayesian method to estimate the optimal threshold of a marker used to select patients' treatment
by Blangero, Yoann and Rabilloud, Muriel and Ecochard, René and Subtil, Fabien
Statistical Methods in Medical Research, ISSN 0962-2802, 2018, pp. 96228021882139 - 962280218821394
The use of a quantitative treatment selection marker to choose between two treatment options requires the estimate of an optimal threshold above which one of... 
expected utility | treatment selection | Biomarker | threshold | predictive marker | Bayesian | Statistics
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