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Nature Communications, ISSN 2041-1723, 05/2017, Volume 8, Issue 1, p. 15183
The germline mutation rate has been extensively studied and has been found to vary greatly between species, but much less is known about the somatic mutation... 
PLURIPOTENT STEM-CELLS | POINT MUTATIONS | NUMBER | DNA-SEQUENCE | CLONAL HEMATOPOIESIS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MOUSE | CANCER | GENOME | AGE
Journal Article
F1000Research, ISSN 2046-1402, 2017, Volume 6, p. 2153
Adeno-associated virus (AAV) has shown promising therapeutic efficacy with a good safety profile in a wide range of animal models and human clinical trials.... 
Aging | CRISPR/Cas9 complex | Adeno-associated virus | Genome editing | CRISPR | Animal models | Genetic disorders | Disease | Toxicity | Clinical trials | Nervous system | Genomes | Ribonucleic acid--RNA | Vectors (Biology) | Proteins | Medicine | Animals | Brain research | Mutagenesis | Immunogenicity | Efficiency | Packaging | Serotypes | Photoreceptors | Nuclease | Gene therapy | Deoxyribonucleic acid--DNA
Journal Article
Alzheimer's & Dementia, ISSN 1552-5260, 07/2018, Volume 14, Issue 7, pp. P1400 - P1401
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 07/2018, Volume 14, Issue 7, pp. P1400 - P1401
Journal Article
Frontiers in Genetics, ISSN 1664-8021, 2015, Volume 5, p. 472
Journal Article
Annual Review of Physiology, ISSN 0066-4278, 01/2013, Volume 75, p. 645
  Genome instability has long been implicated as the main causal factor in aging. Somatic cells are continuously exposed to various sources of DNA damage, from... 
Intervention | Tissue | Ultraviolet radiation | DNA damage | Aging | Genomes | Mutation
Journal Article
Aging Cell, ISSN 1474-9718, 08/2015, Volume 14, Issue 4, pp. 497 - 510
Summary The workshop entitled ‘Interventions to Slow Aging in Humans: Are We Ready?’ was held in Erice, Italy, on October 8–13, 2013, to bring together leading... 
anti‐aging | longevity regulation | aging | dietary restriction | lifespan studies | longevity gene | centenarians | Dietary restriction | Anti-aging | Centenarians | Longevity gene | Aging | Lifespan studies | Longevity regulation | SECRETORY PHENOTYPE | STEM-CELL FUNCTION | EXTENDS LIFE-SPAN | NORDIHYDROGUAIARETIC ACID | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | METHIONINE RESTRICTION | anti-aging | DIETARY-PROTEIN RESTRICTION | TELOMERE DYSFUNCTION | CALORIC RESTRICTION | RESVERATROL SUPPLEMENTATION | MOLECULAR-MECHANISMS | AMP-Activated Protein Kinases - metabolism | Ribosomal Protein S6 Kinases - metabolism | TOR Serine-Threonine Kinases - metabolism | Longevity - drug effects | Humans | Aging - drug effects | Insulin-Like Growth Factor I - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | TOR Serine-Threonine Kinases - genetics | Aging - genetics | Sirtuins - genetics | Signal Transduction | Growth Hormone - metabolism | Gene Expression Regulation | Caloric Restriction - methods | Longevity - genetics | Biological Factors - therapeutic use | Growth Hormone - genetics | Animals | Prescription Drugs - therapeutic use | Diet | Growth Hormone - antagonists & inhibitors | Mice | Enzyme Activation | Ribosomal Protein S6 Kinases - antagonists & inhibitors | Ribosomal Protein S6 Kinases - genetics | Sirtuins - metabolism | AMP-Activated Protein Kinases - genetics | Insulin-Like Growth Factor I - antagonists & inhibitors | Insulin-Like Growth Factor I - metabolism | Drugs | Reviews
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