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Cancer Science, ISSN 1347-9032, 09/2017, Volume 108, Issue 9, pp. 1843 - 1849
Spliced variant isoforms of CD 44 ( CD 44v) are a marker of cancer stem cells in solid tumors. They stabilize the xCT subunit of the transporter system xc(–)... 
Cancer stem cell | salazosulfapyridine | non‐small‐cell lung cancer | 44v | oxidative stress | CD44v | non-small-cell lung cancer | METASTASIS | CARCINOMA CELLS | CLEAVAGE | CHEMOTHERAPY | VARIANT EXONS 8-10 | TRIAL | ONCOLOGY | SULFASALAZINE | EXOSOMES | EXPRESSION | CD44 | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - drug therapy | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Lung Neoplasms - pathology | Male | Treatment Outcome | Hyaluronan Receptors - blood | Antineoplastic Combined Chemotherapy Protocols - toxicity | Cisplatin - administration & dosage | Biomarkers, Tumor - blood | Sulfasalazine - administration & dosage | Maximum Tolerated Dose | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Pemetrexed - administration & dosage | Adult | Carcinoma, Non-Small-Cell Lung - blood | Female | Aged | Lung Neoplasms - blood | Carcinoma, Non-Small-Cell Lung - drug therapy | Neoplasm Staging | Antimitotic agents | Antioxidants | Medical research | Chemotherapy | Stem cells | Clinical trials | Medicine, Experimental | Sulfasalazine | Lung cancer, Non-small cell | Antineoplastic agents | Cancer | Cell proliferation | Anorexia | Toxicity | Lung cancer | Kinases | Cancer therapies | CD44 antigen | Drug dosages | Genotypes | Glutathione | Neutropenia | Alanine | Research & development--R&D | Patients | Cisplatin | Hypotension | Pneumonitis | Cell death | Medical prognosis | Isoforms | Alanine transaminase | Solid tumors | Apoptosis | Tumors | Index Medicus | Original
Journal Article
Gastric Cancer, ISSN 1436-3291, 11/2017, Volume 20, Issue 6, pp. 1004 - 1009
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1561 - 16
Journal Article
Cancer Science, ISSN 1347-9032, 12/2018, Volume 109, Issue 12, pp. 3874 - 3882
Autocrine and paracrine factors, including glutamate and epidermal growth factor ( EGF ), are potent inducers of brain tumor cell invasion, a pathological... 
xCT | glioma | epidermal growth factor receptor | GluN2B | glutamate | MIGRATION | CELLS | TYROSINE PHOSPHORYLATION | NMDA RECEPTORS | EGFR | INVASION | ONCOLOGY | BIOLOGY | DEFICIENT | EXPRESSION | MODULATION | Neoplasm Transplantation | Phosphorylation | Humans | Receptors, N-Methyl-D-Aspartate - metabolism | Sulfasalazine - pharmacology | Brain Neoplasms - metabolism | Glioma - metabolism | Amino Acid Transport System y+ - metabolism | Receptors, N-Methyl-D-Aspartate - chemistry | Dizocilpine Maleate - administration & dosage | Protein Domains | Cell Survival - drug effects | ErbB Receptors - metabolism | Brain Neoplasms - drug therapy | Disease Progression | Drug Synergism | Sulfasalazine - administration & dosage | Cell Movement - drug effects | Animals | Signal Transduction - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Glutamic Acid - metabolism | Mice | Epidermal Growth Factor - pharmacology | Dizocilpine Maleate - pharmacology | Glioma - drug therapy | Methyl aspartate | Epidermal growth factor | Gliomas | Brain tumors | Development and progression | Aspartate | Glutamate | Immunoglobulins | Cell survival | Epidermal growth factor receptors | Paracrine signalling | N-Methyl-D-aspartic acid receptors | Glutamic acid receptors | Kinases | Cell adhesion & migration | Glioma cells | Conflicts of interest | Sulfasalazine | Autocrine signalling | Cell migration | Tumors | Original
Journal Article
Cancer science, ISSN 1347-9032, 08/2019
Targeting the function of membrane transporters in cancer stemlike cells is a potential new therapeutic approach. Cystine-glutamate antiporter xCT expressed in... 
Journal Article
Oncotarget, ISSN 1949-2553, 09/2018, Volume 9, Issue 73, pp. 33832 - 33843
The cystine-glutamate antiporter subunit xCT suppresses iron-dependent oxidative cell death (ferroptosis) and is therefore a promising target for cancer... 
Drug repurposing | Ferroptosis, aldehyde dehydrogenase (ALDH) | XCT
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 04/2016, Volume 473, Issue 1, pp. 125 - 132
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2014, Volume 32, Issue 15_suppl, pp. e19129 - e19129
Journal Article
Oncotarget, ISSN 1949-2553, 05/2018, Volume 9, Issue 35, pp. 24000 - 24013
Anti-anaplastic lymphoma kinase (ALK)-targeted therapy dramatically improves therapeutic responses in patients with ALK-rearranged lung adenocarcinoma (Ad-LC).... 
Epithelial-mesenchymal transition | Anaplastic lymphoma kinase rearrangement | Circulating tumor cells | TelomeScan | Squamous cell lung cancer
Journal Article
Cancer Treatment and Research Communications, ISSN 2468-2942, 2016, Volume 9, pp. 106 - 110
Chemotherapy is a standard treatment for patients with advanced non-small cell lung cancer (NSCLC); however, it occasionally causes adverse events. Serious... 
Chemotherapy | Interstitial pneumonia | Non-small cell lung cancer | Risk factor | Serious adverse events
Journal Article
09/2019
The present invention is directed to provide antitumor agent including water-soluble sulfasalazine as an active ingredient. Antitumor agents were obtained... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
11/2018
The present invention is directed to provide antitumor agent including water-soluble sulfasalazine as an active ingredient. Antitumor agents were obtained... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
10/2018
The present invention is directed to provide antitumor agent including water-soluble sulfasalazine as an active ingredient. Antitumor agents were obtained... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
07/2017
[Problem] The purpose of the present invention is to provide an antitumor agent that contains a water-soluble sulfasalazine as an active ingredient. [Solution]... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
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