Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (235) 235
Publication (29) 29
Paper (6) 6
Book / eBook (4) 4
Book Review (2) 2
Book Chapter (1) 1
Conference Proceeding (1) 1
Patent (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (82) 82
humans (73) 73
female (42) 42
male (38) 38
animals (32) 32
analysis (27) 27
proteins (24) 24
middle aged (23) 23
neurosciences (21) 21
adult (19) 19
biophysics (18) 18
oncology (18) 18
medical and health sciences (17) 17
medicin och hälsovetenskap (17) 17
studies (17) 17
research (16) 16
aged (15) 15
multidisciplinary sciences (15) 15
risk factors (14) 14
article (13) 13
physics (13) 13
cancer (12) 12
genetic aspects (12) 12
kinetics (12) 12
medicine (12) 12
time factors (12) 12
journal article (11) 11
lipids (11) 11
research article (11) 11
activation (10) 10
chemotherapy (10) 10
denmark (10) 10
membranes (10) 10
natural sciences (10) 10
naturvetenskap (10) 10
basic medicine (9) 9
clinical medicine (9) 9
diffusion (9) 9
environmental sciences (9) 9
fluorescence (9) 9
medical genetics (9) 9
medicine & public health (9) 9
medicinsk genetik (9) 9
medicinska och farmaceutiska grundvetenskaper (9) 9
physiological aspects (9) 9
biomarkers (8) 8
cardiac & cardiovascular systems (8) 8
cell biology (8) 8
genes (8) 8
hematology (8) 8
identification (8) 8
klinisk medicin (8) 8
magnetic resonance imaging (8) 8
neurology (8) 8
original (8) 8
usage (8) 8
biochemistry & molecular biology (7) 7
biological sciences (7) 7
clinical neurology (7) 7
colorectal cancer (7) 7
deoxyribonucleic acid--dna (7) 7
genetic variation (7) 7
genetics (7) 7
genetics & heredity (7) 7
genome-wide association (7) 7
metaanalysis (7) 7
models, molecular (7) 7
mortality (7) 7
motivational interviewing (7) 7
patients (7) 7
phenotype (7) 7
physiology (7) 7
science (7) 7
treatment outcome (7) 7
tumors (7) 7
aged, 80 and over (6) 6
behavior (6) 6
biochemistry (6) 6
body mass index (6) 6
breast cancer (6) 6
cancer therapies (6) 6
capillaries - physiopathology (6) 6
care and treatment (6) 6
cerebral-blood-flow (6) 6
cerebrovascular circulation (6) 6
chemistry, physical (6) 6
clinical trials (6) 6
colorectal neoplasms - genetics (6) 6
ecology (6) 6
endocrinology & metabolism (6) 6
enzymes (6) 6
epidemiology (6) 6
genetic research (6) 6
in situ hybridization, fluorescence (6) 6
irinotecan (6) 6
laboratories (6) 6
liposomes (6) 6
medical research (6) 6
metastasis (6) 6
methods (6) 6
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (241) 241
Danish (2) 2
Arabic (1) 1
French (1) 1
German (1) 1
Portuguese (1) 1
Spanish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Direct observation of Thermomyces lanuginosus lipase diffusional states by Single Particle Tracking and their remodeling by mutations and inhibition
by Bohr, SSR and Lund, PM and Kallenbach, AS and Pinholt, H and Thomsen, J and Iversen, L and Svendsen, A and Christensen, SM and Hatzakis, NS
SCIENTIFIC REPORTS, ISSN 2045-2322, 11/2019, Volume 9, Issue 1, pp. 1 - 11
Lipases are interfacially activated enzymes that catalyze the hydrolysis of ester bonds and constitute prime candidates for industrial and biotechnological... 
TRANSITION | ACTIVATION | PHOSPHOLIPID-VESICLES | MOTION | SPECTROSCOPY | MOLECULE | KINETICS | ORIENTATION | MULTIDISCIPLINARY SCIENCES | CURVATURE | MICROSCOPY | Enzymes | Mutation | Lipase | Localization | Diffusion | Structure-function relationships
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Geometrical Membrane Curvature as an Allosteric Regulator of Membrane Protein Structure and Function
by Asger Tonnesen and Sune M Christensen and Vadym Tkach and Dimitrios Stamou
Biophysical Journal, ISSN 0006-3495, 01/2014, Volume 106, Issue 1, p. 201
  Transmembrane proteins are embedded in cellular membranes of varied lipid composition and geometrical curvature. Here, we studied for the first time the... 
Proteins | Membranes | Lipids | Permeability
Journal Article
Details down arrow
3. Full Text Direct observation of proton pumping by a eukaryotic P-type ATPase
by Veshaguri, Salome and Christensen, Sune M and Kemmer, Gerdi C and Ghale, Garima and Møller, Mads P and Lohr, Christina and Christensen, Andreas L and Justesen, Bo H and Jørgensen, Ida L and Schiller, Jürgen and Hatzakis, Nikos S and Grabe, Michael and Günther Pomorski, Thomas and Stamou, Dimitrios
Science, ISSN 0036-8075, 03/2016, Volume 351, Issue 6280, pp. 1469 - 1473
In eukaryotes, P-type adenosine triphosphatases (ATPases) generate the plasma membrane potential and drive secondary transport systems; however, despite their... 
ACTIVATION | DOMAIN | SINGLE | TRANSPORTER | ENZYME | MEMBRANE H+-ATPASE | MULTIDISCIPLINARY SCIENCES | SYSTEMS | CHANNELS | MICROARRAYS | TRANSLATION | Membrane Potentials - drug effects | Protein Structure, Tertiary | Protons | Allosteric Regulation | Molecular Imaging | Membrane Potentials - physiology | Proton-Translocating ATPases - chemistry | Arabidopsis Proteins - metabolism | Proton-Translocating ATPases - metabolism | Arabidopsis Proteins - chemistry | Ion Transport | Proton-Translocating ATPases - antagonists & inhibitors | Arabidopsis Proteins - antagonists & inhibitors | Valinomycin - pharmacology | Hydrogen-Ion Concentration | Arabidopsis thaliana | Eukaryotes | Genetic aspects | Observations | Adenosine triphosphatase | Enzymes | Biochemistry
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS
by William Y C Huang and Qingrong Yan and Wan-Chen Lin and Jean K Chung and Scott D Hansen and Sune M Christensen and Hsiung-Lin Tu and John Kuriyan and Jay T Groves
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 07/2016, Volume 113, Issue 29, p. 8218
  The assembly of cell surface receptors with downstream signaling molecules is a commonly occurring theme in multiple signaling systems. However, little is... 
Molecules | Reaction kinetics | T cell receptors | Stochastic models
Journal Article
Details down arrow
5. Full Text H-Ras forms dimers on membrane surfaces via a protein—protein interface
by Wan-Chen Lin and Lars Iversen and Hsiung-Lin Tu and Christopher Rhodes and Sune M. Christensen and Jeffrey S. Iwig and Scott D. Hansen and William Y. C. Huang and Jay T. Groves
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2014, Volume 111, Issue 8, pp. 2996 - 3001
The lipid-anchored small GTPase Ras is an important signaling node in mammalian cells. A number of observations suggest that Ras is laterally organized within... 
Proteins | Fluorescence | Lipids | Dimers | Cell membranes | Nucleotides | Dimerization | Density | Rotation | P branes | Ras signaling | Ras assay | ACTIVATION | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | GTP-BINDING PROTEINS | PLASMA-MEMBRANE | BOUND PROTEINS | GREEN FLUORESCENT PROTEIN | FUNCTIONAL-ANALYSIS | DYNAMICS | DIFFUSION | LIVING CELLS | Amino Acid Sequence | Magnetic Resonance Spectroscopy | Humans | Models, Molecular | Molecular Sequence Data | ras Proteins - metabolism | Protein Interaction Domains and Motifs - genetics | ras Proteins - chemistry | Protein Conformation | Cell Membrane - metabolism | Fluorescence Polarization | Microscopy, Fluorescence | Physiological aspects | Protein research | Research | Protein-protein interactions | Membrane proteins | Biological Sciences
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. H-Ras forms dimers on membrane surfaces via a protein-protein interface
by Wan-Chen Lin and Lars Iversen and Hsiung-Lin Tu and Christopher Rhodes and Sune M Christensen and Jeffrey S Iwig and Scott D Hansen and William Y C Huang and Jay T Groves
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2014, Volume 111, Issue 8, p. 2996
  The lipid-anchored small GTPase Ras is an important signaling node in mammalian cells. A number of observations suggest that Ras is laterally organized... 
Proteins | Membranes | Cellular biology | Anisotropy | Fluorescence | Lipids | Mutation
Journal Article
Details down arrow
7. Intermembrane Docking Reactions Are Regulated by Membrane Curvature
by Andreas H Kunding and Michael W Mortensen and Sune M Christensen and Vikram K Bhatia and Ivan Makarov and Ralf Metzler and Dimitrios Stamou
Biophysical Journal, ISSN 0006-3495, 12/2011, Volume 101, Issue 11, p. 2693
  The polymorphism of eukaryotic cellular membranes is a tightly regulated and well-conserved phenotype. Recent data have revealed important regulatory roles... 
Proteins | Genotype & phenotype | Eukaryotes | Membranes | Polymorphism
Journal Article
Details down arrow
8. Full Text A Fluorescence-Based Technique to Construct Size Distributions from Single-Object Measurements: Application to the Extrusion of Lipid Vesicles
by Kunding, Andreas H and Mortensen, Michael W and Christensen, Sune M and Stamou, Dimitrios
Biophysical Journal, ISSN 0006-3495, 2008, Volume 95, Issue 3, pp. 1176 - 1188
We report a novel approach to quantitatively determine complete size distributions of surface-bound objects using fluorescence microscopy. We measure the... 
FREEZE-FRACTURE | UNILAMELLAR VESICLES | BIOPHYSICS | MEMBRANE CURVATURE | LIGHT-SCATTERING | BILAYERS | FRACTURE ELECTRON-MICROSCOPY | LIPOSOMES | RECONSTITUTION | SPATIALLY MODULATED ILLUMINATION | BIOLOGICAL-MEMBRANES | Particle Size | Molecular Probe Techniques | Microscopy, Fluorescence - methods | Image Interpretation, Computer-Assisted - methods | Molecular Conformation | Unilamellar Liposomes - chemistry | Membrane Lipids - chemistry | Measurement | Fluorescence | Methods | Lipids | Biochemistry | Biophysics | Microscopy | Particle size distribution | Size distribution | Vesicles | Light scattering | Extrusion | Illumination | Membranes
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Single Vesicle Assaying of SNARE-Synaptotagmin-Driven Fusion Reveals Fast and Slow Modes of Both Docking and Fusion and Intrasample Heterogeneity
by Sune M Christensen and Michael W Mortensen and Dimitrios G Stamou
Biophysical Journal, ISSN 0006-3495, 02/2011, Volume 100, Issue 4, p. 957
  Lipid mixing between vesicles functionalized with SNAREs and the cytosolic C2AB domain of synaptotagmin-1 recapitulates the basic Ca2+ dependence of neuronal... 
Proteins | Signal transduction | Calcium | Lipids | Kinetics | Maximum likelihood method | Diffusion
Journal Article
Details down arrow
10. Full Text Stochastic geometry sensing and polarization in a lipid kinase-phosphatase competitive reaction
by Hansen, SD and Huang, WYC and Lee, YK and Bieling, P and Christensen, SM and Groves, JT
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 07/2019, Volume 116, Issue 30, pp. 15013 - 15022
Phosphorylation reactions, driven by competing kinases and phosphatases, are central elements of cellular signal transduction. We reconstituted a native... 
bistability | ACTIVATION | MEMBRANE | MULTIDISCIPLINARY SCIENCES | OCRL | HIGH-AFFINITY BINDING | kinase | PHOSPHATIDYLINOSITOL 4-PHOSPHATE | SIGNALING SYSTEM | LIGATION-INDEPENDENT CLONING | NUCLEOTIDE EXCHANGE FACTOR | stochastic | polarization | phosphatase | DIFFUSION | FEEDBACK | Phosphates | Cellular signal transduction | Phosphatases | Phosphotransferases | Polarization | Membranes | Phosphorylation | Confinement | Composition | Copy number | Variations | Lipids | Membrane composition | Kinases | Phosphatase | Signalling systems | Bistability | Signal transduction | Lipid kinase | Transduction | Stochasticity | Diffusion | Biological Sciences | PNAS Plus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
11. Full Text Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics
by Iversen, Lars and Tu, Hsiung-Lin and Lin, Wan-Chen and Christensen, Sune M and Abel, Steven M and Iwig, Jeff and Wu, Hung-Jen and Gureasko, Jodi and Rhodes, Christopher and Petit, Rebecca S and Hansen, Scott D and Thill, Peter and Yu, Cheng-Han and Stamou, Dimitrios and Chakraborty, Arup K and Kuriyan, John and Groves, Jay T
Science, ISSN 0036-8075, 2014, Volume 345, Issue 6192, pp. 50 - 54
Activation of the small guanosine triphosphatase H-Ras by the exchange factor Son of Sevenless (SOS) is an important hub for signal transduction. Multiple... 
SIGNAL-TRANSDUCTION | SEVENLESS | AUTOINHIBITION | ENZYME CATALYSIS | HISTONE DOMAIN | SINGLE-MOLECULE | MULTIDISCIPLINARY SCIENCES | TIME | PROTEINS | PLASMA-MEMBRANE | CELL | Proteins | Physiological aspects | Genetic research | Cellular signal transduction | Genetic aspects | Research | Molecular biology | Genetic regulation | Membranes | Biochemistry | Cellular biology | Enzyme kinetics | Enzymes | Control | Government regulations | Dynamics | Catalytic activity | Dynamical systems
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
12. Full Text Nanoscale high-content analysis using compositional heterogeneities of single proteoliposomes
by Mathiasen, Signe and Christensen, Sune M and Fung, Juan José and Rasmussen, Søren G. F and Fay, Jonathan F and Jorgensen, Sune K and Veshaguri, Salome and Farrens, David L and Kiskowski, Maria and Kobilka, Brian and Stamou, Dimitrios
Nature Methods, ISSN 1548-7091, 08/2014, Volume 11, Issue 9, pp. 931 - 934
Proteoliposome reconstitution is a standard method to stabilize purified transmembrane proteins in membranes for structural and functional assays. Here we... 
IN-VITRO | BIOCHEMICAL RESEARCH METHODS | RESONANCE ENERGY-TRANSFER | RECEPTOR | MEMBRANE-PROTEINS | G-PROTEIN | LIPOSOMES | Spectrometry, Fluorescence - methods | Algorithms | Receptors, G-Protein-Coupled - analysis | Microscopy, Fluorescence - methods | Nanotechnology - methods | Image Interpretation, Computer-Assisted - methods | Receptors, G-Protein-Coupled - chemistry | Proteolipids - chemistry | Research | Liposomes | Structure | Membrane proteins | Proteins | Membranes | Scientific method | Biophysics | Nanotechnology
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
13. Full Text Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS
by William Y. C. Huang and Qingrong Yan and Wan-Chen Lin and Jean K. Chung and Scott D. Hansen and Sune M. Christensen and Hsiung-Lin Tu and John Kuriyan and Jay T. Groves and Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2016, Volume 113, Issue 29, pp. 8218 - 8223
The assembly of cell surface receptors with downstream signaling molecules is a commonly occurring theme in multiple signaling systems. However, little is... 
Kinetic proofreading | Protein assembly | Signal transduction | Membrane dwell time | Single molecule | SPECIFICITY | signal transduction | SINGLE-MOLECULE | PHOSPHORYLATION | kinetic proofreading | MULTIDISCIPLINARY SCIENCES | protein assembly | PLASMA-MEMBRANE | membrane dwell time | single molecule | RECEPTOR TYROSINE KINASES | GRB2 | PROTEINS | SIGNALING COMPLEXES | T-CELLS | LINKER | ras Proteins | Receptors, Antigen, T-Cell - metabolism | Signal Transduction | Membranes, Artificial | Membrane Proteins - metabolism | Kinetics | Adaptor Proteins, Signal Transducing - metabolism | GRB2 Adaptor Protein - metabolism | Son of Sevenless Proteins - metabolism | Phosphotyrosine - metabolism | Tyrosine | Physiological aspects | Cellular signal transduction | Observations | Protein-protein interactions | BASIC BIOLOGICAL SCIENCES | 60 APPLIED LIFE SCIENCES | Biological Sciences
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
14. Full Text Mixing subattolitre volumes in a quantitative and highly parallel manner with soft matter nanofluidics
by Christensen, Sune M and Bolinger, Pierre-Yves and Hatzakis, Nikos S and Mortensen, Michael W and Stamou, Dimitrios
Nature Nanotechnology, ISSN 1748-3387, 2012, Volume 7, Issue 1, pp. 51 - 55
Handling and mixing ultrasmall volumes of reactants in parallel can increase the throughput(1,2) and complexity(3) of screening assays while simultaneously... 
MEMBRANE-FUSION | VESICLE FUSION | SPECTROSCOPY | LIPID VESICLES | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY | SYSTEMS | NANOSCIENCE & NANOTECHNOLOGY | MICROFLUIDICS | DROPLETS
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
15. Full Text One-way membrane trafficking of SOS in receptor-triggered Ras activation
by Christensen, Sune M and Tu, Hsiung-Lin and Jun, Jesse E and Alvarez, Steven and Triplet, Meredith G and Iwig, Jeffrey S and Yadav, Kamlesh K and Bar-Sagi, Dafna and Roose, Jeroen P and Groves, Jay T
Nature Structural and Molecular Biology, ISSN 1545-9993, 09/2016, Volume 23, Issue 9, pp. 838 - 846
SOS is a key activator of the small GTPase Ras. In cells, SOS-Ras signaling is thought to be initiated predominantly by membrane recruitment of SOS via the... 
SEVENLESS | HISTONE DOMAIN | EGF-RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | CELL BIOLOGY | SIGNAL-TRANSDUCTION | BIOPHYSICS | T-CELL-ACTIVATION | NUCLEOTIDE EXCHANGE FACTOR | GRB2 | ADAPTER PROTEIN | LYMPHOCYTES | Jurkat Cells | Allosteric Regulation | Humans | ras Proteins - metabolism | SOS1 Protein - physiology | MAP Kinase Signaling System | Protein Transport | Endocytosis | Animals | Proto-Oncogene Proteins c-bcr - physiology | ras Proteins - chemistry | Chickens | Protein Binding | Protein Domains | Cell Membrane - metabolism | Enzyme Activation | Kinetics | Lipid Bilayers - chemistry | SOS1 Protein - chemistry | Cellular proteins | Cell receptors | Cellular signal transduction | Genetic aspects | Cell membranes | Properties | Health aspects | Lipids | Biophysics | Cellular biology | Enzyme kinetics
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
16. Full Text Interferometric Detection of Single Gold Nanoparticles Calibrated against TEM Size Distributions
by Zhang, Lixue and Christensen, Sune M and Bendix, Poul Martin and Bhatia, Vikram Kjøller and Loft, Steffen and Stamou, Dimitrios
Small, ISSN 1613-6810, 08/2015, Volume 11, Issue 29, pp. 3550 - 3555
Single nanoparticle analysis: An interferometric optical approach calibrates sizes of gold nanoparticles (AuNPs) from the interference intensities by... 
membranes | size determination | interferometric optics | gold nanoparticles | lipid bilayers | diffusion coefficients | OPTICAL-DETECTION | PHYSICS, CONDENSED MATTER | PHYSICS, APPLIED | SUPPORTED BILAYER | MATERIALS SCIENCE, MULTIDISCIPLINARY | NANOMATERIALS | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | LIPID-MEMBRANES | CHEMISTRY, MULTIDISCIPLINARY | DEPENDENCE | SCATTERING MICROSCOPY | PARTICLE TRACKING | DYNAMICS | MEMBRANE SURFACES | DIFFUSION | Gold - chemistry | Materials Testing - standards | Particle Size | Gold - analysis | Reproducibility of Results | Microscopy, Electron, Transmission - standards | Sensitivity and Specificity | Calibration - standards | Interferometry - standards | Lipid Bilayers - chemistry | Metal Nanoparticles - analysis | Nanoparticles | Multiplexing | Gold | Transmission electron microscopy | Lipids | Calibration | Diffusion | Interferometry
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
17. Full Text Highly Accurate Quantification of the Oligomerization of the β2 Adrenergic Receptor using FRET
by Mathiasen, Signe and Tønnesen, Asger and Christensen, Sune M and Jose Fung, Juan and Kobilka, Brian and Stamou, Dimitrios
Biophysical Journal, ISSN 0006-3495, 01/2012, Volume 102, Issue 3, pp. 232a - 233a
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights