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Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 2045 - 2045
Abstract Tumor antigen directed T-cells, using chimeric antigen receptors (CAR), have shown remarkable clinical responses in B-cell malignancies, particularly... 
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2012, Volume 7, Issue 9, p. e46364
Chronic inflammation is a major contributing factor in the pathogenesis of many age-associated diseases. One central protein that regulates inflammation is... 
LIFE-SPAN | ACETYLATION | PHOSPHORYLATION | NEGATIVE REGULATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | DNA-DAMAGE | DEPENDENT GENE-EXPRESSION | CELL-SURVIVAL | CYTOKINE RELEASE | SMALL-MOLECULE ACTIVATORS | Inflammation - chemically induced | Sirtuin 1 - metabolism | Transcription Factor RelA - antagonists & inhibitors | Humans | Transcriptional Activation - drug effects | Male | Benzimidazoles - chemistry | Sirtuin 1 - genetics | Transcription Factor RelA - genetics | Inflammation - metabolism | Inflammation - drug therapy | Tumor Necrosis Factor-alpha - immunology | Acetylation | Interleukin-12 - biosynthesis | Cell Line | Anti-Inflammatory Agents - pharmacology | Inflammation - immunology | Animals | Anti-Inflammatory Agents - chemistry | Signal Transduction - drug effects | Transcription Factor RelA - metabolism | Small Molecule Libraries | Interleukin-12 - immunology | Lipopolysaccharides - pharmacology | Benzimidazoles - pharmacology | Thiazoles - chemistry | Mice | Mice, Inbred BALB C | Protein Processing, Post-Translational | Thiazoles - pharmacology | Tumor Necrosis Factor-alpha - biosynthesis | Phosphorylation | Pathogenesis | Arthritis | Kinases | Lipopolysaccharides | Proteins | Reduction | Rodents | Transcription activation | Post-translation | Aging | Chronic obstructive pulmonary disease | Synaptotagmin | Age | Chronic illnesses | NF-κB protein | Antiinflammatory agents | Cytokines | Secretion | Interleukin 12 | Pharmacology | Inflammation | Tumor necrosis factor-α | Metabolism | Gene expression | Chemical compounds | SIRT1 protein | NAD | Signaling | Deacetylation | New classes | Kidney diseases
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 1036 - 1036
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 232 - 232
Tumorigenesis, tumor progression and metastasis require metabolic rewiring to support the need for rapid biomass accumulation, reduction of oxidative stress... 
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2017, Volume 114, Issue 43, pp. 11404 - 11409
The enzyme serine hydroxymethyltransferse (SHMT) converts serine into glycine and a tetrahydrofolate-bound one-carbon unit. Folate one-carbon units support... 
DLBCL | SHMT | Cancer metabolism | Glycine | Folate | SERINE HYDROXYMETHYLTRANSFERASE | SPECIFICITY | MULTIDISCIPLINARY SCIENCES | PROLIFERATION | DEHYDROGENASE | cancer metabolism | folate | glycine | PATHWAY | SUBSTRATE | SYNTHETASE | PHGDH | ONE-CARBON METABOLISM | Physiological aspects | Lymphomas | Methyltransferases | Health aspects | Biological Sciences
Journal Article
Cell Metabolism, ISSN 1550-4131, 04/2019, Volume 29, Issue 4
Serine is a substrate for nucleotide, NADPH, and glutathione (GSH) synthesis. Previous studies in cancer cells and lymphocytes have shown that serine-dependent... 
Medical colleges | RNA | Serine | Oncology, Experimental | Research | Glycine | Macrophages | Homeopathy | Materia medica and therapeutics | Analysis | Therapeutics | Physiological aspects | Mitogens | Cancer
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2017, Volume 114, Issue 43, p. 11404
The enzyme serine hydroxymethyltransferse (SHMT) converts serine into glycine and a tetrahydrofolate-bound one-carbon unit. Folate one-carbon units support... 
Metabolomics | Biotechnology | Toxicity | Serine | Cytotoxicity | Thymidine | Imports | Glycine | Folic acid | Defects | Mitochondria | Colon cancer | Enzymatic activity | Vitamin B | Xenografts | Colon | Inhibition | Tetrahydrofolic acid | Metabolism | Carbon | Lymphoma | Inhibitors | Lymphocytes B | Cell lines | Lymphomas | Cancer | B-cell lymphoma
Journal Article
Cell Metabolism, ISSN 1550-4131, 02/2017, Volume 25, Issue 2, p. 482
(Cell Metabolism 25, 345–357; February 7, 2017) As a result of an author oversight in the originally published version of this article, the Supplemental... 
Journal Article
Cell Metabolism, ISSN 1550-4131, 04/2019, Volume 29, Issue 4, pp. 1003 - 1011.e4
Serine is a substrate for nucleotide, NADPH, and glutathione (GSH) synthesis. Previous studies in cancer cells and lymphocytes have shown that serine-dependent... 
inflammation | immunometabolism | glutathione | macrophage | LPS response | serine metabolism | IL-1beta | sepsis | one-carbon metabolism | GLYCINE | GENE-1 | SUCCINATE-DEHYDROGENASE | ACID | MITOCHONDRIA | ENDOCRINOLOGY & METABOLISM | ITACONATE | CELL | ONE-CARBON METABOLISM | IL-10 | CELL BIOLOGY
Journal Article
ISSN 1550-4131, 2017
During immune challenge, T lymphocytes engage pathways of anabolic metabolism to meet the demands of clonal expansion and development of effector functions.... 
Journal Article
Vascular Pharmacology, ISSN 1537-1891, 09/2006, Volume 45, Issue 3, pp. 154 - 162
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2009, Volume 52, Issue 17, pp. 5449 - 5461
Cortisol and the glucocorticoid receptor signaling pathway have been implicated in the development of diabetes and obesity. The reduction of cortisone to... 
METABOLIC SYNDROME | POTENT | CHEMISTRY, MEDICINAL | MECHANISM | HYPERGLYCEMIC MICE | SELECTIVE INHIBITORS | BETA-KETO SULFONES | 11-BETA-HSD1 INHIBITORS | VISCERAL OBESITY | DISCOVERY | TRIAZOLES
Journal Article
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