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Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 10/2018, Volume 28, Issue 19, p. 3141
The voltage gated sodium channel Na.sub.v1.7 plays an essential role in the transmission of pain signals. Strong human genetic validation has motivated... 
Care and treatment | Pain | Analysis | Chronic pain
Journal Article
Nature, ISSN 0028-0836, 07/2012, Volume 487, Issue 7408, pp. 505 - 509
Mutationally activated kinases define a clinically validated class of targets for cancer drug therapy(1). However, the efficacy of kinase inhibitors in... 
CELL LUNG-CANCER | SURVIVAL | HETEROGENEITY | ACTIVATION | RECEPTOR TYROSINE KINASES | THERAPY | MET AMPLIFICATION | MULTIDISCIPLINARY SCIENCES | ACQUIRED-RESISTANCE | SENSITIVITY | TUMOR-CELLS | Receptor, ErbB-2 - genetics | Humans | Receptor, ErbB-2 - metabolism | Melanoma - enzymology | Phosphatidylinositol 3-Kinases - metabolism | Hepatocyte Growth Factor - pharmacology | Breast Neoplasms - metabolism | Melanoma - genetics | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cell Survival - drug effects | Melanoma - pathology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Breast Neoplasms - drug therapy | Hepatocyte Growth Factor - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Breast Neoplasms - genetics | Signal Transduction - drug effects | Breast Neoplasms - pathology | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Line, Tumor | Ligands | Protein Kinase Inhibitors - pharmacology | Quinazolines - pharmacology | Drug Resistance, Neoplasm - drug effects | Mitogen-Activated Protein Kinases - metabolism | Antimitotic agents | Physiological aspects | Antineoplastic agents | Growth factors | Health aspects | Phosphotransferases | Substance abuse treatment | Epidermal growth factor | Rodents | Biomarkers | Breast cancer | Insulin-like growth factors | Kinases | Drug resistance | Tumors | Index Medicus
Journal Article
Science, ISSN 0036-8075, 12/2015, Volume 350, Issue 6267, pp. aac5464 - aac5464
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 12/2011, Volume 10, Issue 12, pp. 2426 - 2436
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2011, Volume 54, Issue 21, pp. 7579 - 7587
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2019, Volume 62, Issue 8, pp. 4091 - 4109
Using structure- and ligand-based design principles, a novel series of piperidyl chromane arylsulfonamide Nav1.7 inhibitors was discovered. Early optimization... 
Journal Article
Biophysical Journal, ISSN 0006-3495, 02/2016, Volume 110, Issue 3, pp. 33a - 34a
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2009, Volume 19, Issue 19, pp. 5576 - 5581
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2018, Volume 61, Issue 11, pp. 4810 - 4831
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 2019, Volume 62, Issue 8, pp. 4091 - 4109
Using structure- and ligand-based design principles, a novel series of piperidyl chromane arylsulfonamide Na 1.7 inhibitors was discovered. Early optimization... 
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 2010, Volume 53, Issue 3, pp. 1086 - 1097
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 03/2016, Volume 7, Issue 3, pp. 277 - 282
We report on a novel series of aryl sulfonamides that act as nanomolar potent, isoform-selective inhibitors of the human sodium channel hNaV1.7. The... 
pain | Na | Sodium channel | aryl sulfonamide | 1.5 | formalin model | 1.7 | cold allodynia
Journal Article