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analysis (3) 3
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research (3) 3
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aerobic glycolysis (2) 2
blood lactate (2) 2
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follow-up studies (2) 2
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hypertonic (2) 2
hypothermia, induced (2) 2
hypothermia, induced - adverse effects (2) 2
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1. Full Text Cerebral Extracellular Lactate Increase is Predominantly Nonischemic in Patients with Severe Traumatic Brain Injury
by Sala, Nathalie and Suys, Tamarah and Zerlauth, Jean-Baptiste and Bouzat, Pierre and Messerer, Mahmoud and Bloch, Jocelyne and Levivier, Marc and Magistretti, Pierre J and Meuli, Reto and Oddo, Mauro
Journal of Cerebral Blood Flow & Metabolism, ISSN 0271-678X, 11/2013, Volume 33, Issue 11, pp. 1815 - 1822
Growing evidence suggests that endogenous lactate is an important substrate for neurons. This study aimed to examine cerebral lactate metabolism and its... 
traumatic brain injury | cerebral blood flow | cerebral microdialysis | lactate | cerebral metabolism | PERFUSION-CT | SEVERE HEAD TRAUMA | SYNAPTIC FUNCTION | NUCLEAR-MAGNETIC-RESONANCE | NEUROSCIENCES | POSITRON-EMISSION-TOMOGRAPHY | BLOOD LACTATE | GLUCOSE | ENDOCRINOLOGY & METABOLISM | SUBARACHNOID HEMORRHAGE | COMBINED MICRODIALYSIS | ENERGY-METABOLISM | HEMATOLOGY | Prospective Studies | Cerebrovascular Circulation - physiology | Humans | Lactic Acid - metabolism | Male | Brain Injuries - metabolism | Brain Injuries - physiopathology | Intracranial Pressure - physiology | Oxygen Consumption - physiology | Cerebral Cortex - metabolism | Brain Injuries - diagnosis | Hypoxia, Brain - metabolism | Glycolysis - physiology | Extracellular Space - metabolism | Neurophysiological Monitoring | Microdialysis | Glasgow Coma Scale | Adult | Female | Cohort Studies | Original
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2. Full Text Effect of moderate hyperventilation and induced hypertension on cerebral tissue oxygenation after cardiac arrest and therapeutic hypothermia
by Bouzat, Pierre and Suys, Tamarah and Sala, Nathalie and Oddo, Mauro
Resuscitation, ISSN 0300-9572, 2013, Volume 84, Issue 11, pp. 1540 - 1545
Abstract Aim Improving cerebral perfusion is an essential component of post-resuscitation care after cardiac arrest (CA), however precise recommendations in... 
Emergency | Near infrared spectroscopy | PaCO2 | Cerebral autoregulation | Blood pressure | Cardiac arrest | Hypothermia | PaCO | CEREBROVASCULAR REACTIVITY | MILD HYPOTHERMIA | REPERFUSION | BLOOD-FLOW | CARDIOPULMONARY-RESUSCITATION | AUTOREGULATION | CLINICAL-RELEVANCE | EMERGENCY MEDICINE | NEAR-INFRARED SPECTROSCOPY | SUBARACHNOID HEMORRHAGE | BRAIN | CRITICAL CARE MEDICINE | Prospective Studies | Humans | Middle Aged | Male | Survival Rate | Treatment Outcome | Cerebrovascular Circulation | Heart Arrest - physiopathology | Intracranial Pressure - physiology | Pilot Projects | Spectroscopy, Near-Infrared | Aged, 80 and over | Hypothermia, Induced | Female | Aged | Hyperventilation | Heart Arrest - therapy | Hypertension | Health aspects
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3. Full Text Serum procalcitonin as a marker of post-cardiac arrest syndrome and long-term neurological recovery, but not of early-onset infections, in comatose post-anoxic patients treated with therapeutic hypothermia
by Engel, Harald and Ben Hamouda, Nawfel and Portmann, Katharina and Delodder, Frederik and Suys, Tamarah and Feihl, François and Eggimann, Philippe and Rossetti, Andrea O and Oddo, Mauro
Resuscitation, ISSN 0300-9572, 2013, Volume 84, Issue 6, pp. 776 - 781
Abstract Objective To examine the relationship of early serum procalcitonin (PCT) levels with the severity of post-cardiac arrest syndrome (PCAS), long-term... 
Emergency | Prognosis | Procalcitonin | Mortality | Outcome | Cardiac arrest | Post-resuscitation disease | Post-cardiac arrest syndrome | Infections | Hypothermia | MULTICENTER | INTENSIVE-CARE UNITS | RANDOMIZED CONTROLLED-TRIAL | SEPSIS | PNEUMONIA | DOBUTAMINE | SUCCESSFUL CARDIOPULMONARY-RESUSCITATION | ADMISSION | EMERGENCY MEDICINE | NEURON-SPECIFIC ENOLASE | MYOCARDIAL DYSFUNCTION | CRITICAL CARE MEDICINE | Prospective Studies | Protein Precursors - blood | Humans | Middle Aged | Male | Hypoxia - therapy | Coma - complications | Hypothermia, Induced - methods | Infection - diagnosis | Adult | Female | Calcitonin Gene-Related Peptide | Severity of Illness Index | Hypothermia, Induced - adverse effects | Calcitonin - blood | Intensive Care Units | Risk Factors | Treatment Outcome | Hypoxia - complications | Biomarkers - blood | Switzerland | Hypoxia - blood | Heart Arrest - blood | Aged | Heart Arrest - therapy | Coma | Neurosciences | Care and treatment | Universities and colleges | Health aspects
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4. Full Text Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain
by Bouzat, Pierre and Sala, Nathalie and Suys, Tamarah and Zerlauth, Jean-Baptiste and Marques-Vidal, Pedro and Feihl, François and Bloch, Jocelyne and Messerer, Mahmoud and Levivier, Marc and Meuli, Reto and Magistretti, Pierre J and Oddo, Mauro
Intensive Care Medicine, ISSN 0342-4642, 3/2014, Volume 40, Issue 3, pp. 412 - 421
Experimental evidence suggests that lactate is neuroprotective after acute brain injury; however, data in humans are lacking. We examined whether exogenous... 
Pediatrics | Pain Medicine | Emergency Medicine | Pneumology/Respiratory System | Traumatic brain injury | Medicine & Public Health | Lactate | Cerebral microdialysis | Brain metabolism | Intensive / Critical Care Medicine | Hypertonic | Anesthesiology | FDG-PET | HEAD-INJURY | INTRACRANIAL HYPERTENSIVE EPISODES | SODIUM LACTATE | GLUCOSE-METABOLISM | GLUTAMATE | INCREASE | AEROBIC GLYCOLYSIS | COMBINED MICRODIALYSIS | ENERGY-METABOLISM | CRITICAL CARE MEDICINE | Neuroprotection | Microdialysis - methods | Prospective Studies | Brain Injuries, Traumatic - drug therapy | Humans | Lactic Acid - metabolism | Middle Aged | Male | Respiration, Artificial | Brain - drug effects | Brain - metabolism | Frontal Lobe - diagnostic imaging | Brain Injuries, Traumatic - metabolism | Time Factors | Sodium Lactate - pharmacology | Sodium Lactate - administration & dosage | Glucose - metabolism | Pyruvic Acid - metabolism | Adult | Female | Infusions, Intravenous | Energy Metabolism - drug effects | Cerebral palsy | Complications and side effects | Brain | Development and progression | Research | Risk factors | Injuries
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5. Full Text Normobaric Hyperoxia is Associated with Increased Cerebral Excitotoxicity After Severe Traumatic Brain Injury
by Quintard, Hervé and Patet, Camille and Suys, Tamarah and Marques-Vidal, Pedro and Oddo, Mauro
Neurocritical Care, ISSN 1541-6933, 08/2014, Volume 22, Issue 2, pp. 243 - 250
Normobaric oxygen therapy is frequently applied in neurocritical care, however, whether supplemental FiO(2) has beneficial cerebral effects is still... 
Brain | Oxygen | Traumatic brain injury | Cerebral microdialysis | Excitotoxicity | Hyperoxia | Glutamate | MORTALITY | OXYGEN-TOXICITY | CLINICAL NEUROLOGY | THERAPY | METABOLISM | SEVERE HEAD-INJURY | IMPROVEMENT | ARTERIAL HYPEROXIA | INTRACRANIAL-PRESSURE | RESUSCITATION | CRITICAL CARE MEDICINE | Humans | Middle Aged | Male | Brain Injuries - therapy | Hyperoxia - chemically induced | Brain - metabolism | Microdialysis | Oxygen Inhalation Therapy - adverse effects | Hyperoxia - complications | Adult | Female | Brain Chemistry | Glutamic Acid - metabolism | Hemoglobin | Brain damage | Analysis | Injuries
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6. Full Text Automated Quantitative Pupillometry for the Prognostication of Coma After Cardiac Arrest
by Suys, Tamarah and Bouzat, Pierre and Marques-Vidal, Pedro and Sala, Nathalie and Payen, Jean-François and Rossetti, Andrea O and Oddo, Mauro
Neurocritical Care, ISSN 1541-6933, 10/2014, Volume 21, Issue 2, pp. 300 - 308
Sedation and therapeutic hypothermia (TH) delay neurological responses and might reduce the accuracy of clinical examination to predict outcome after cardiac... 
Coma | Prognosis | EEG | Cardiac arrest | Pupillometry | Intensive / Critical Care Medicine | Internal Medicine | Pupillary light reactivity | Neurology | Medicine & Public Health | Pupillary response | Evoked potentials | Outcome | Therapeutic hypothermia | LIGHT REFLEX | MILD THERAPEUTIC HYPOTHERMIA | CARDIOPULMONARY-RESUSCITATION | CLINICAL NEUROLOGY | PROSPECTIVE COHORT | RECOVERY | PREDICTORS | POSTANOXIC PATIENTS | SURVIVORS | CRITICAL CARE MEDICINE | Predictive Value of Tests | Prospective Studies | Humans | Middle Aged | Coma - therapy | Male | Hypnotics and Sedatives - therapeutic use | Coma - diagnosis | Reflex, Pupillary - physiology | Infrared Rays | Aged, 80 and over | Adult | Female | Aged | Heart Arrest - complications | Coma - etiology | Neurosciences | Analysis | Hypothermia
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7. Full Text Accuracy of Brain Multimodal Monitoring to Detect Cerebral Hypoperfusion After Traumatic Brain Injury
by Bouzat, Pierre and Marques-Vidal, Pedro and Zerlauth, Jean-Baptiste and Sala, Nathalie and Suys, Tamarah and Schoettker, Patrick and Bloch, Jocelyne and Daniel, Roy T and Levivier, Marc and Meuli, Reto and Oddo, Mauro
Critical Care Medicine, ISSN 0090-3493, 11/2014, Volume 43, Issue 2, pp. 445 - 452
Objective: To examine the accuracy of brain multimodal monitoring consisting of intracranial pressure, brain tissue Po-2, and cerebral microdialysis in... 
Brain multimodal monitoring | Microdialysis | Traumatic brain injury | Brain oxygen | Cerebral blood flow | Neuromonitoring | Intracranial pressure | TOMOGRAPHY | SEVERE HEAD TRAUMA | TISSUE OXYGEN-TENSION | traumatic brain injury | BLOOD-FLOW | brain oxygen | DELIVERY | brain multimodal monitoring | neuromonitoring | intracranial pressure | microdialysis | LACTATE | cerebral blood flow | PERFUSION-PRESSURE | INTRACRANIAL-PRESSURE | CRITICAL CARE MEDICINE | Intensive Care Units | Prospective Studies | Blood Chemical Analysis | Cerebrovascular Circulation - physiology | Brain - physiopathology | Humans | Middle Aged | Hospitals, University | Male | Tomography, X-Ray Computed | Brain Injuries - physiopathology | Intracranial Pressure - physiology | Brain Injuries - diagnostic imaging | Adult | Brain Injuries - blood | Female | ROC Curve
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8. Full Text Neuroenergetic response to prolonged cerebral glucose depletion after severe brain injury and the role of lactate
by Patet, Camille and Quintard, Hervé and Suys, Tamarah and Bloch, Jocelyne and Daniel, Roy T and Pellerin, Luc and Magistretti, Pierre J and Oddo, Mauro
Journal of Neurotrauma, ISSN 0897-7151, 10/2015, Volume 32, Issue 20, pp. 1560 - 1566
Lactate may represent a supplemental fuel for the brain. We examined cerebral lactate metabolism during prolonged brain glucose depletion (GD) in acute brain... 
brain injury | glucose | cerebral microdialysis | lactate | cerebral metabolism | HEAD-INJURY | TIGHT GLYCEMIC CONTROL | NEUROSCIENCES | CLINICAL NEUROLOGY | DELIVERY | OXYGEN | BLOOD-FLOW CHANGES | C-13-LABELED MICRODIALYSIS | TRANSPORT | METABOLISM | INCREASE | CRITICAL CARE MEDICINE | Humans | Lactic Acid - metabolism | Middle Aged | Male | Brain Injuries - metabolism | Brain - metabolism | Young Adult | Microdialysis | Glucose - metabolism | Adult | Brain Injuries - blood | Female | Blood Glucose - metabolism | Lactates | Brain | Care and treatment | Research | Cerebral anoxia | Injuries | Neurochemistry | Neurology | Brain damage | Glucose
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9. Full Text Clinical Evolution After a Non-reactive Hypothermic EEG Following Cardiac Arrest
by Juan, Elsa and Juan, Elsa and Novy, Jan and Novy, Jan and Suys, Tamarah and Suys, Tamarah and Oddo, Mauro and Oddo, Mauro and Rossetti, Andrea O and Rossetti, Andrea O
Neurocritical Care, ISSN 1541-6933, 6/2015, Volume 22, Issue 3, pp. 403 - 408
Lack of electroencephalography (EEG) background reactivity during therapeutic hypothermia (TH) has been associated with poor outcome in post-anoxic comatose... 
Neurology | NSE | Post-anoxic coma | Prognostication | Medicine & Public Health | Intensive / Critical Care Medicine | EEG reactivity | Internal Medicine | Anoxic-ischemic encephalopathy | Hypothermia | IMPROVE | ADULT COMATOSE SURVIVORS | INJURY | CLINICAL NEUROLOGY | THERAPEUTIC HYPOTHERMIA | PREDICTORS | RESUSCITATION | CRITICAL CARE MEDICINE | Predictive Value of Tests | Prognosis | Prospective Studies | Humans | Middle Aged | Coma - physiopathology | Coma - therapy | Male | Electroencephalography | Heart Arrest - physiopathology | Young Adult | Hypoxia-Ischemia, Brain - diagnosis | Aged, 80 and over | Hypothermia, Induced | Adult | Female | Hypoxia-Ischemia, Brain - therapy | Aged | Heart Arrest - complications | Coma - etiology | Heart Arrest - therapy | Hypoxia-Ischemia, Brain - physiopathology | Coma | Neurosciences
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10. Full Text Results of the ICTuS 2 Trial (Intravascular Cooling in the Treatment of Stroke 2)
by Lyden, Patrick and Hemmen, Thomas and Grotta, James and Rapp, Karen and Ernstrom, Karin and Rzesiewicz, Teresa and Parker, Stephanie and Concha, Mauricio and Hussain, Syed and Agarwal, Sachin and Meyer, Brett and Jurf, Julie and Altafullah, Irfan and Raman, Rema and Hess, Mary Jane and Mullin, Anthony and Jane Hess, Mary and Muranevici, Gabriela and Piantadosi, Bonnie and Jimenez-Maggiora, Gustavo and So, Jia-Shing and Jain, Sonia and Diringer, Michael and Derdeyn, Colin and Stern, Barney and Hamilton, Scott and Dietrich, Dalton and Becker, Kyra and Yenari, Midori and Dirnagl, Ulrich and Wijman, Christine and Chamorro, Ángel and Janis, Scott and Moy, Claudia and Lin, Felice and Song, Shlee and Schlick, Konrad and Khanolkar, Pooja and Edwards, Nancy J and Roldan, Ana and Wilson, Jeanette and Little, Amy and Lewis, Pam and Neil, William and Bruce, Nhu and Guzik, Amy and Sohdi, Ajeet and Herial, Nabeel and Ovbiagele, Bruce and Meyer, Dawn and Modir, Royya and Chavez, Ronelyn and Velazquez, Angela and Mayer, Stephan and Claassen, Jan and Falo, Cristina and Tafreshi, Gilda and Kelly, Nancy and Shell, Erin and Dugan, Guy and Kim, Elizabeth and Tanner, Amy and Michel, Patrik and Eskandari, Ashraf and Oddo, Mauro and Suys, Tamarah and Remillard, Suzette and Cordier, Maria and Brown, Robert and Jasak, Sara and McCullough, Louise and Brautigam, Robert and Alexandrov, Andrei and Sisson, April and Albright, Karen and Broessner, Gregor and Schmutzhard, Erich and Escioglou, Elissanet and Jones, William and Poisson, Sharon and Simpson, Jennifer and Shah, Qaisar and Jonczak, Karin and Bussinger, Patricia and Lewandowski, Christopher and Berry, Shannen and Lundell, AnneMarie and Miller, Joseph B and Cruz-Flores, Salvador and Holzer, Eve and Torretta, Susan and Brown, David and Heim, Laura and Smith, Carlos and Kelley, Chip and Greer, David and Marcolini, Evadne G and Gilmore, Emily J and Rutledge, Neil and McBee, Del and ... and Collaborators
Stroke, ISSN 0039-2499, 12/2016, Volume 47, Issue 12, pp. 2888 - 2895
BACKGROUND AND PURPOSE—Therapeutic hypothermia is a potent neuroprotectant approved for cerebral protection after neonatal hypoxia-ischemia and cardiac arrest.... 
therapeutics | pneumonia | hypothermia | intention to treat analysis | neuroprotection | stroke | ischemic stroke | C-REACTIVE PROTEIN | STATEMENT | METAANALYSIS | THROMBECTOMY | VOLUME | HOSPITAL CARDIAC-ARREST | CARE | CLINICAL NEUROLOGY | THERAPEUTIC HYPOTHERMIA | ACUTE ISCHEMIC-STROKE | PERIPHERAL VASCULAR DISEASE | COMATOSE SURVIVORS | Single-Blind Method | Hypothermia, Induced - adverse effects | Follow-Up Studies | Outcome Assessment (Health Care) | Humans | Middle Aged | Male | Hypothermia, Induced - instrumentation | Hypothermia, Induced - methods | Hypothermia, Induced - standards | Aged, 80 and over | Female | Aged | Stroke - therapy
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11. Full Text Improvement of Neuroenergetics by Hypertonic Lactate Therapy in Patients with Traumatic Brain Injury Is Dependent on Baseline Cerebral Lactate/Pyruvate Ratio
by Quintard, Hervé and Patet, Camille and Zerlauth, Jean-Baptiste and Suys, Tamarah and Bouzat, Pierre and Pellerin, Luc and Meuli, Reto and Magistretti, Pierre J and Oddo, Mauro
Journal of Neurotrauma, ISSN 0897-7151, 04/2016, Volume 33, Issue 7, pp. 681 - 687
Energy dysfunction is associated with worse prognosis after traumatic brain injury (TBI). Recent data suggest that hypertonic sodium lactate infusion (HL)... 
Original Articles | traumatic brain injury | cerebral blood flow | cerebral microdialysis | lactate | hypertonic | INTRACRANIAL HYPERTENSIVE EPISODES | NEUROPROTECTIVE ROLE | NUCLEAR-MAGNETIC-RESONANCE | PERFUSION CT | NEUROSCIENCES | CLINICAL NEUROLOGY | SODIUM LACTATE | MICRODIALYSIS | POSITRON-EMISSION-TOMOGRAPHY | BLOOD LACTATE | GLUCOSE | ENERGY-METABOLISM | CRITICAL CARE MEDICINE | Prospective Studies | Brain Injuries, Traumatic - drug therapy | Humans | Lactic Acid - metabolism | Middle Aged | Male | Tomography, X-Ray Computed | Young Adult | Sodium Lactate - therapeutic use | Brain Injuries, Traumatic - metabolism | Microdialysis | Pyruvic Acid - metabolism | Adult | Female | Infusions, Intravenous | Blood Glucose - metabolism | Energy Metabolism - physiology | Imaging, Three-Dimensional | Energy Metabolism - drug effects | Lactates | Brain | Energy metabolism | Care and treatment | Bioenergetics | Research | Health aspects | Injuries | Neurology | Traumatic brain injury | Energy | Metabolism | Original
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12. Full Text Prediction of awakening from hypothermic postanoxic coma based on auditory discrimination
by Tzovara, Athina and Rossetti, Andrea O and Juan, Elsa and Suys, Tamarah and Viceic, Dragana and Rusca, Marco and Oddo, Mauro and Lucia, Marzia De
Annals of Neurology, ISSN 0364-5134, 05/2016, Volume 79, Issue 5, pp. 748 - 757
Objective Most of the available clinical tests for prognosis of postanoxic coma are informative of poor outcome. Previous work has shown that an improvement in... 
CARDIAC-ARREST | COMPLEX SOUND SEQUENCES | THERAPEUTIC HYPOTHERMIA | EEG | NEURAL DETECTION | TARGETED TEMPERATURE MANAGEMENT | SURVIVORS | NEUROSCIENCES | MISMATCH NEGATIVITY | CARDIOPULMONARY-RESUSCITATION | PROGNOSTICATION | CLINICAL NEUROLOGY | Confidence intervals | Discrimination
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13. Full Text Cerebral Lactate Metabolism After Traumatic Brain Injury
by Patet, Camille and Suys, Tamarah and Carteron, Laurent and Oddo, Mauro
Current neurology and neuroscience reports, 04/2016, Volume 16, Issue 4, p. 31
Cerebral energy dysfunction has emerged as an important determinant of prognosis following traumatic brain injury (TBI). A number of studies using cerebral... 
Neuroprotection | Animals | Humans | Lactic Acid - metabolism | Glucose - metabolism | Cerebrovascular Circulation | Brain Injuries - metabolism | Hypoxia - metabolism
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14. Full Text Cerebral Lactate Metabolism After Traumatic Brain Injury
by Patet, Camille and Suys, Tamarah and Carteron, Laurent and Oddo, Mauro
Current Neurology and Neuroscience Reports, ISSN 1528-4042, 4/2016, Volume 16, Issue 4, pp. 1 - 7
Cerebral energy dysfunction has emerged as an important determinant of prognosis following traumatic brain injury (TBI). A number of studies using cerebral... 
Neurology | Neurosciences | Cerebral metabolism | Traumatic brain injury | Medicine & Public Health | Lactate | Energetic dysfunction | Glucose | INTRACRANIAL HYPERTENSIVE EPISODES | PENTOSE-PHOSPHATE PATHWAY | NUCLEAR-MAGNETIC-RESONANCE | BLOOD-FLOW | NEUROSCIENCES | CLINICAL NEUROLOGY | SODIUM LACTATE | POSITRON-EMISSION-TOMOGRAPHY | GLUCOSE-METABOLISM | AEROBIC GLYCOLYSIS | COMBINED MICRODIALYSIS | COGNITIVE DEFICITS | Lactates | Glucose metabolism | Brain | Analysis | Physiological aspects | Glutamate | Dextrose | Injuries
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