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Biochemical Society Transactions, ISSN 0300-5127, 11/2018, Volume 46, Issue 6, pp. 1707 - 1712
Leucine-rich repeat kinase 2 (LRRK2) is mutated in familial Parkinson's disease, and pathogenic mutations activate the kinase activity. A tour de force screen... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN | KINASE
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2019, Volume 294, Issue 5, pp. 1706 - 1709
Low-density lipoprotein particles are taken up by cells and delivered to the lysosome where their cholesterol esters are cleaved off by acid lipase. The... 
cholesterol transport | NPC intracellular cholesterol transporter | Patched | Hedgehog | NPC1 | NPC2 | cholesterol-binding protein | transporter | cholesterol | Niemann-Pick C disease | sterol metabolism | lysosomes | low-density lipoprotein (LDL) | lysosome | DOMAIN | C2 PROTEIN | DEFICIENT | REQUIRES | PICK C1 PROTEIN | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | STEROL-BINDING | RESIDUES | REVEALS | INSIGHTS
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2010, Volume 107, Issue 46, pp. 19614 - 19618
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 10/2013, Volume 203, Issue 2, p. 233
  Cyclin E regulates the cell cycle transition from G1 to S phase and is degraded before entry into G2 phase. Here we show that RhoBTB3, a Golgi-associated,... 
Eukaryotes | Cell cycle | Adenosine triphosphatase
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2005, Volume 280, Issue 16, pp. 15485 - 15488
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2015, Volume 112, Issue 48, p. 14876
  Lysosomes are lined with a glycocalyx that protects the limiting membrane from the action of degradative enzymes. We tested the hypothesis that Niemann-Pick... 
Proteins | Rodents | Glycosylation | Low density lipoprotein | Cells | Cholesterol
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 02/2010, Volume 188, Issue 4, p. 451
  In this issue, Duran et al. (2010. J. Cell Biol. doi: 10.1083/jcb.200911154) and Manjithaya et al. (2010. J. Cell Biol. doi: 10.1083/jcb.200911149) use yeast... 
Proteins | Enzymes | Yeast | Genetics | Binding sites
Journal Article
Nature Cell Biology, ISSN 1465-7392, 01/2010, Volume 12, Issue 1, pp. 3 - 4
Exosomes are endosome-derived membrane vesicles that are key for intercellular communication in the immune system and elsewhere. Rab27A and Rab27B GTPases and... 
TRANSPORT | RAB27B | GTPASES | GRANULES | MEMBRANE | CELL BIOLOGY | rab GTP-Binding Proteins - metabolism | Cell Communication | rab27 GTP-Binding Proteins | Exosomes - physiology | Humans | Endosomes
Journal Article
Nature Cell Biology, ISSN 1465-7392, 05/2013, Volume 15, Issue 5, pp. 446 - 448
Sorting nexin proteins (SNXs) and the cargo-selective retromer complex play key roles in receptor recycling from endosomes to the cell surface. A global... 
RETROMER | MEMBRANE | CELL BIOLOGY | Glucose - metabolism | Sorting Nexins - analysis | Proteomics - methods | Humans | Cell receptors | Cell physiology | Research | Observations | Cellular control mechanisms | Testing
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2016, Volume 113, Issue 36, pp. 10079 - 10084
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2010, Volume 107, Issue 46, p. 19614
  The Golgi complex is a central processing compartment in the secretory pathway of eukaryotic cells. This essential compartment processes more than 30% of the... 
Proteins | Eukaryotes | Genes | Models | Molecular biology
Journal Article
Cell, ISSN 0092-8674, 12/2013, Volume 155, Issue 6, pp. X1203 - 1206
The 2013 Nobel Prize in Physiology or Medicine has been awarded to James Rothman, Randy Schekman, and Thomas Südhof "for their discoveries of machinery... 
Journal Article
The EMBO Journal, ISSN 0261-4189, 01/2018, Volume 37, Issue 1, pp. 1 - 18
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2011, Volume 108, Issue 47, p. 18932
Niemann-Pick type C1 (NPC1) protein is needed for cellular utilization of low-density lipoprotein-derived cholesterol that has been delivered to lysosomes. The... 
Proteins | Mutation | Low density lipoprotein | Binding sites | Cholesterol
Journal Article
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