Arthritis Research and Therapy, ISSN 1478-6354, 10/2017, Volume 19, Issue 1, pp. 231 - 8
Background: Interleukin-6 (IL-6) transduces signals via phosphorylation of STAT3 (pSTAT3). Tocilizumab (TCZ) is an IL-6 receptor blocker, which, when...
CD4+T cell | Tocilizumab | Rheumatoid arthritis | Interleukin-6 | Phosphorylated STAT3 | ACT-RAY | CRITERIA | TRIAL | MONOTHERAPY | CLASSIFICATION | RHEUMATOLOGY | Flow Cytometry - methods | Antibodies, Monoclonal, Humanized - therapeutic use | Humans | Middle Aged | Male | Biological Assay - methods | CD4-Positive T-Lymphocytes - immunology | Signal Transduction - drug effects | Arthritis, Rheumatoid - drug therapy | STAT3 Transcription Factor - drug effects | Adult | Female | Aged | Arthritis, Rheumatoid - immunology | Interleukin-6 - metabolism | CD4-Positive T-Lymphocytes - drug effects | STAT3 Transcription Factor - metabolism | Antirheumatic Agents - therapeutic use | Patient outcomes | Physiological aspects | Genetic aspects | Cellular signal transduction | Research | Drug therapy | Signal transduction | Flow cytometry | Immunoglobulins | Phosphorylation | Cytokines | Laboratories | Pathogenesis | Rheumatology | Rheumatism | Health risk assessment | CD4+ T cell
CD4+T cell | Tocilizumab | Rheumatoid arthritis | Interleukin-6 | Phosphorylated STAT3 | ACT-RAY | CRITERIA | TRIAL | MONOTHERAPY | CLASSIFICATION | RHEUMATOLOGY | Flow Cytometry - methods | Antibodies, Monoclonal, Humanized - therapeutic use | Humans | Middle Aged | Male | Biological Assay - methods | CD4-Positive T-Lymphocytes - immunology | Signal Transduction - drug effects | Arthritis, Rheumatoid - drug therapy | STAT3 Transcription Factor - drug effects | Adult | Female | Aged | Arthritis, Rheumatoid - immunology | Interleukin-6 - metabolism | CD4-Positive T-Lymphocytes - drug effects | STAT3 Transcription Factor - metabolism | Antirheumatic Agents - therapeutic use | Patient outcomes | Physiological aspects | Genetic aspects | Cellular signal transduction | Research | Drug therapy | Signal transduction | Flow cytometry | Immunoglobulins | Phosphorylation | Cytokines | Laboratories | Pathogenesis | Rheumatology | Rheumatism | Health risk assessment | CD4+ T cell
Journal Article
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Multi-dimensional analysis identified rheumatoid arthritis-driving pathway in human T cell
ANNALS OF THE RHEUMATIC DISEASES, ISSN 0003-4967, 10/2019, Volume 78, Issue 10, pp. 1346 - 1356
Objectives Rheumatoid arthritis (RA) is an autoimmune disease accompanied by lymphocyte infiltration into joint synovium. While T cells are considered to be...
RAPAMYCIN | METABOLISM | DIFFERENTIATION | RHEUMATOLOGY | SIGNATURE | MTOR | TH17 CELLS
RAPAMYCIN | METABOLISM | DIFFERENTIATION | RHEUMATOLOGY | SIGNATURE | MTOR | TH17 CELLS
Journal Article
Arthritis Research and Therapy, ISSN 1478-6354, 10/2019, Volume 21, Issue 1, pp. 14 - 8
BackgroundUltrasonography (US) can directly demonstrate joint inflammation, including grayscale (GS) signs of synovial hypertrophy and power Doppler (PD)...
Rheumatoid arthritis/DG | Diagnostic imaging | Inflammation | Cytokines | Ultrasonography | VISUALIZATION | CRITERIA | TISSUE | SONOGRAPHY | CLASSIFICATION | RHEUMATOLOGY | POWER DOPPLER ULTRASONOGRAPHY | ULTRASOUND | Rheumatoid arthritis | KNEE-JOINT | VASCULARITY | Care and treatment | Usage | Diagnosis | Ultrasound imaging | Studies | Knee | Ultrasonic imaging | Blood & organ donations | Rheumatology | Classification | Rheumatism | Joint surgery | Vascular endothelial growth factor
Rheumatoid arthritis/DG | Diagnostic imaging | Inflammation | Cytokines | Ultrasonography | VISUALIZATION | CRITERIA | TISSUE | SONOGRAPHY | CLASSIFICATION | RHEUMATOLOGY | POWER DOPPLER ULTRASONOGRAPHY | ULTRASOUND | Rheumatoid arthritis | KNEE-JOINT | VASCULARITY | Care and treatment | Usage | Diagnosis | Ultrasound imaging | Studies | Knee | Ultrasonic imaging | Blood & organ donations | Rheumatology | Classification | Rheumatism | Joint surgery | Vascular endothelial growth factor
Journal Article
PLOS ONE, ISSN 1932-6203, 07/2019, Volume 14, Issue 7, p. e0220570
Background Pembrolizumab is currently approved as a first-line therapy for advanced non-small cell lung cancer (NSCLC) patients with a programed death ligand-1...
NIVOLUMAB | PD-1 | MULTIDISCIPLINARY SCIENCES | Treatment outcome | Cancer patients | Analysis | Genetic aspects | Diagnosis | Lung cancer, Non-small cell | Drug therapy | Health aspects | Therapy | Lung cancer | Melanoma | Non-small cell lung carcinoma | Risk reduction | Oncology | Metastasis | Cancer therapies | Patients | Clinical outcomes | Medicine | Confidence intervals | Pembrolizumab | Chemotherapy | Hospitals | Immunotherapy | PD-L1 protein | Response rates | Biomarkers | Ligands | Hormone replacement therapy | Mutation | Risk management | Apoptosis
NIVOLUMAB | PD-1 | MULTIDISCIPLINARY SCIENCES | Treatment outcome | Cancer patients | Analysis | Genetic aspects | Diagnosis | Lung cancer, Non-small cell | Drug therapy | Health aspects | Therapy | Lung cancer | Melanoma | Non-small cell lung carcinoma | Risk reduction | Oncology | Metastasis | Cancer therapies | Patients | Clinical outcomes | Medicine | Confidence intervals | Pembrolizumab | Chemotherapy | Hospitals | Immunotherapy | PD-L1 protein | Response rates | Biomarkers | Ligands | Hormone replacement therapy | Mutation | Risk management | Apoptosis
Journal Article
Journal of Instrumentation, ISSN 1748-0221, 2016, Volume 11, Issue 4, pp. 1 - 127
The identification of jets containing b hadrons is important for the physics programme of the ATLAS experiment at the Large Hadron Collider. Several algorithms...
Large detector systems for particle and astroparticle physics | Large detector-systems performance | Pattern recognition, cluster finding, calibration and fitting methods | Performance of High Energy Physics Detectors | QUARK-PAIR PRODUCTION | PARTON DISTRIBUTIONS | INSTRUMENTS & INSTRUMENTATION | HADRON COLLIDERS | MATRIX-ELEMENTS | CROSS-SECTION | COLLISIONS | Reconstruction | Hadrons | Algorithms | Large Hadron Collider | Efficiency | Jets | Calibration | Marking | Physics - High Energy Physics - Experiment | Physics | High Energy Physics - Experiment | PHYSICS OF ELEMENTARY PARTICLES AND FIELDS | Fysik | Subatomär fysik | Physical Sciences | Subatomic Physics | Naturvetenskap | Natural Sciences
Large detector systems for particle and astroparticle physics | Large detector-systems performance | Pattern recognition, cluster finding, calibration and fitting methods | Performance of High Energy Physics Detectors | QUARK-PAIR PRODUCTION | PARTON DISTRIBUTIONS | INSTRUMENTS & INSTRUMENTATION | HADRON COLLIDERS | MATRIX-ELEMENTS | CROSS-SECTION | COLLISIONS | Reconstruction | Hadrons | Algorithms | Large Hadron Collider | Efficiency | Jets | Calibration | Marking | Physics - High Energy Physics - Experiment | Physics | High Energy Physics - Experiment | PHYSICS OF ELEMENTARY PARTICLES AND FIELDS | Fysik | Subatomär fysik | Physical Sciences | Subatomic Physics | Naturvetenskap | Natural Sciences
Journal Article
Amino Acids, ISSN 0939-4451, 12/2018, Volume 50, Issue 12, pp. 1679 - 1684
The increased protein requirement of endurance athletes may be related to the need to replace exercise-induced oxidative losses, especially of the...
Life Sciences | Biochemistry, general | Analytical Chemistry | Life Sciences, general | Protein synthesis | Non-essential amino acids | Biochemical Engineering | Proteomics | Neurobiology | Amino acid requirement | Endurance training | Post-exercise recovery | REQUIREMENTS | OXIDATION TECHNIQUE | LEUCINE METABOLISM | GLUTAMINE | YOUNG MEN | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMANS | MUSCLE | CURRENT RECOMMENDATIONS | RECOVERY | PHENYLALANINE | Nutritional Requirements | Endurance Training | Protein Biosynthesis | Phenylalanine - metabolism | Humans | Male | Physical Endurance | Amino Acids, Essential - metabolism | Athletes | Food, Fortified | Young Adult | Dietary Proteins - metabolism | Running | Adult | Amino Acids, Essential - administration & dosage | Phenylalanine - administration & dosage | Dietary Supplements | Protein biosynthesis | Exercise | Phenylalanine | Branched chain amino acids | Dietary supplements | Chain branching | Amino acids | Durability | Recovery | Proteins | Food intake | Endurance | Oxidation | Carbon 13
Life Sciences | Biochemistry, general | Analytical Chemistry | Life Sciences, general | Protein synthesis | Non-essential amino acids | Biochemical Engineering | Proteomics | Neurobiology | Amino acid requirement | Endurance training | Post-exercise recovery | REQUIREMENTS | OXIDATION TECHNIQUE | LEUCINE METABOLISM | GLUTAMINE | YOUNG MEN | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMANS | MUSCLE | CURRENT RECOMMENDATIONS | RECOVERY | PHENYLALANINE | Nutritional Requirements | Endurance Training | Protein Biosynthesis | Phenylalanine - metabolism | Humans | Male | Physical Endurance | Amino Acids, Essential - metabolism | Athletes | Food, Fortified | Young Adult | Dietary Proteins - metabolism | Running | Adult | Amino Acids, Essential - administration & dosage | Phenylalanine - administration & dosage | Dietary Supplements | Protein biosynthesis | Exercise | Phenylalanine | Branched chain amino acids | Dietary supplements | Chain branching | Amino acids | Durability | Recovery | Proteins | Food intake | Endurance | Oxidation | Carbon 13
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2755 - 12
Sustained clinical remission (CR) without drug treatment has not been achieved in patients with rheumatoid arthritis (RA). This implies a substantial...
CELLS | OBESITY | SCORE | BIOMARKER | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | VALIDATION | RATIO | INDEX | INFLIXIMAB | DISEASE-ACTIVITY | Cell Count | Humans | Transcriptome | Blood Proteins - immunology | Monocytes - immunology | Methotrexate - therapeutic use | Infliximab - therapeutic use | Case-Control Studies | Lymphocytes - immunology | Arthritis, Rheumatoid - drug therapy | Blood Proteins - genetics | Monocytes - pathology | Proteomics - methods | Antirheumatic Agents - therapeutic use | Neutrophils - pathology | Severity of Illness Index | Antibodies, Monoclonal, Humanized - therapeutic use | Neutrophils - drug effects | Gene Expression Regulation | Neutrophils - immunology | Treatment Outcome | Remission Induction | Arthritis, Rheumatoid - pathology | Biomarkers, Pharmacological - blood | Monocytes - drug effects | Arthritis, Rheumatoid - genetics | Lymphocytes - pathology | Lymphocytes - drug effects | Arthritis, Rheumatoid - immunology | Leukocytes (neutrophilic) | Arthritis | Gene expression | Patients | Molecular chains | Monocytes | Lymphocytes | Rheumatoid arthritis | Phenotyping | Peripheral blood | Remission | Signatures | Monitoring
CELLS | OBESITY | SCORE | BIOMARKER | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | VALIDATION | RATIO | INDEX | INFLIXIMAB | DISEASE-ACTIVITY | Cell Count | Humans | Transcriptome | Blood Proteins - immunology | Monocytes - immunology | Methotrexate - therapeutic use | Infliximab - therapeutic use | Case-Control Studies | Lymphocytes - immunology | Arthritis, Rheumatoid - drug therapy | Blood Proteins - genetics | Monocytes - pathology | Proteomics - methods | Antirheumatic Agents - therapeutic use | Neutrophils - pathology | Severity of Illness Index | Antibodies, Monoclonal, Humanized - therapeutic use | Neutrophils - drug effects | Gene Expression Regulation | Neutrophils - immunology | Treatment Outcome | Remission Induction | Arthritis, Rheumatoid - pathology | Biomarkers, Pharmacological - blood | Monocytes - drug effects | Arthritis, Rheumatoid - genetics | Lymphocytes - pathology | Lymphocytes - drug effects | Arthritis, Rheumatoid - immunology | Leukocytes (neutrophilic) | Arthritis | Gene expression | Patients | Molecular chains | Monocytes | Lymphocytes | Rheumatoid arthritis | Phenotyping | Peripheral blood | Remission | Signatures | Monitoring
Journal Article
Journal of the Neurological Sciences, ISSN 0022-510X, 12/2018, Volume 395, pp. 88 - 90
Sporadic Creutzfeldt-Jakob disease (sCJD) is the most common form of human prion disease; it is characterized as a transmissible spongiform encephalopathy....
Crossed cerebellar diaschisis | MRI | SPECT | Creutzfeldt-Jakob disease | NEUROSCIENCES | CLINICAL NEUROLOGY | Medical research | Enzymes | Medical colleges | Encephalitis | CT imaging | Epilepsy | Electroencephalography | Analysis | Prions | Medicine, Experimental | SPECT imaging | Enzyme-linked immunosorbent assay
Crossed cerebellar diaschisis | MRI | SPECT | Creutzfeldt-Jakob disease | NEUROSCIENCES | CLINICAL NEUROLOGY | Medical research | Enzymes | Medical colleges | Encephalitis | CT imaging | Epilepsy | Electroencephalography | Analysis | Prions | Medicine, Experimental | SPECT imaging | Enzyme-linked immunosorbent assay
Journal Article
Arthritis Research and Therapy, ISSN 1478-6354, 05/2016, Volume 18, Issue 1, p. 106
Background: In this study, we sought to identify definitive biomarkers associated with disease activity in primary Sjogren's syndrome (pSS). Methods: Serum...
Biomarker | Disease activity | Serum protein | Sjögren's syndrome | Proteomics | B-LYMPHOCYTE STIMULATOR | CELLS | Sjogren's syndrome | SYSTEMIC-LUPUS-ERYTHEMATOSUS | RHEUMATOLOGY | SALIVARY-GLANDS | CXCL13 | MASS-SPECTROMETRY | PLATELET SEROTONIN LEVEL | TNF-ALPHA | CLASSIFICATION CRITERIA | UP-REGULATION | Enzyme-Linked Immunosorbent Assay | Humans | Middle Aged | Sjogren's Syndrome - blood | Adult | Female | Male | Aged | Biomarkers - blood | Proteomics - methods | High-Throughput Screening Assays - methods
Biomarker | Disease activity | Serum protein | Sjögren's syndrome | Proteomics | B-LYMPHOCYTE STIMULATOR | CELLS | Sjogren's syndrome | SYSTEMIC-LUPUS-ERYTHEMATOSUS | RHEUMATOLOGY | SALIVARY-GLANDS | CXCL13 | MASS-SPECTROMETRY | PLATELET SEROTONIN LEVEL | TNF-ALPHA | CLASSIFICATION CRITERIA | UP-REGULATION | Enzyme-Linked Immunosorbent Assay | Humans | Middle Aged | Sjogren's Syndrome - blood | Adult | Female | Male | Aged | Biomarkers - blood | Proteomics - methods | High-Throughput Screening Assays - methods
Journal Article
Japanese Journal of Ophthalmology, ISSN 0021-5155, 5/2019, Volume 63, Issue 3, pp. 243 - 254
To evaluate the efficacy of indocyanine-green angiography (ICGA)-guided navigated focal laser photocoagulation for diabetic macular edema (DME).Prospective,...
indocyanine green angiography | navigated laser | Medicine & Public Health | microaneurysm | Ophthalmology | focal laser photocoagulation | diabetic macular edema | PROMPT | OPHTHALMOLOGY | RETINAL VEIN OCCLUSION | RANIBIZUMAB | ENDOTHELIAL GROWTH-FACTOR | DEFERRED LASER | Edema | Medical imaging | Angiography | Diabetes mellitus | Fovea | Retina | Visual acuity | Acuity | Eye | Lasers | Fluorescein | Eye (anatomy) | Diabetes
indocyanine green angiography | navigated laser | Medicine & Public Health | microaneurysm | Ophthalmology | focal laser photocoagulation | diabetic macular edema | PROMPT | OPHTHALMOLOGY | RETINAL VEIN OCCLUSION | RANIBIZUMAB | ENDOTHELIAL GROWTH-FACTOR | DEFERRED LASER | Edema | Medical imaging | Angiography | Diabetes mellitus | Fovea | Retina | Visual acuity | Acuity | Eye | Lasers | Fluorescein | Eye (anatomy) | Diabetes
Journal Article
Diabetes, ISSN 0012-1797, 05/2016, Volume 65, Issue 5, pp. 1410 - 1423
Beige adipocytes emerge postnatally within the white adipose tissue in response to certain environmental cues, such as chronic cold exposure. Because of its...
THERMOGENESIS | WHITE FAT | ACTIVATED PROTEIN-KINASE | ENDOCRINOLOGY & METABOLISM | HYPOTHALAMIC AMPK | PPAR-GAMMA | BROWN ADIPOSE-TISSUE | CAPSICUM-ANNUUM | CH-19 SWEET | ENERGY-METABOLISM | TRANSCRIPTIONAL COMPLEX | Adipocytes, Beige - drug effects | Transcription Factors - chemistry | Capsaicin - therapeutic use | Adipogenesis - drug effects | Capsaicin - chemistry | Male | Hydrogenation | Anti-Obesity Agents - therapeutic use | Adrenergic beta-2 Receptor Agonists - pharmacology | Receptors, Adrenergic, beta-2 - chemistry | DNA-Binding Proteins - metabolism | Capsaicin - agonists | Adipocytes, Beige - pathology | Adrenergic beta-2 Receptor Agonists - therapeutic use | Anti-Obesity Agents - antagonists & inhibitors | Adrenergic beta-2 Receptor Antagonists - pharmacology | Anti-Obesity Agents - agonists | Cold Temperature | Obesity - chemically induced | Receptors, Adrenergic, beta-2 - genetics | Mice, Inbred C57BL | Cells, Cultured | Acclimatization | Adrenergic beta-2 Receptor Antagonists - toxicity | Capsaicin - analogs & derivatives | Mice, Transgenic | Adipocytes, Beige - cytology | Random Allocation | Transcription Factors - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Receptors, Adrenergic, beta-2 - metabolism | Obesity - metabolism | Obesity - pathology | Gene Expression Regulation - drug effects | Transcription Factors - metabolism | Animals | Signal Transduction - drug effects | Oxygen Consumption - drug effects | Obesity - prevention & control | Protein Stability - drug effects | Capsaicin - antagonists & inhibitors | Dietary Supplements | Energy Metabolism - drug effects | Adipocytes, Beige - physiology | Weight reducing preparations | Obesity | Complications and side effects | Fat cells | Dosage and administration | Research | Beta adrenoceptors | Pharmacology and Therapeutics
THERMOGENESIS | WHITE FAT | ACTIVATED PROTEIN-KINASE | ENDOCRINOLOGY & METABOLISM | HYPOTHALAMIC AMPK | PPAR-GAMMA | BROWN ADIPOSE-TISSUE | CAPSICUM-ANNUUM | CH-19 SWEET | ENERGY-METABOLISM | TRANSCRIPTIONAL COMPLEX | Adipocytes, Beige - drug effects | Transcription Factors - chemistry | Capsaicin - therapeutic use | Adipogenesis - drug effects | Capsaicin - chemistry | Male | Hydrogenation | Anti-Obesity Agents - therapeutic use | Adrenergic beta-2 Receptor Agonists - pharmacology | Receptors, Adrenergic, beta-2 - chemistry | DNA-Binding Proteins - metabolism | Capsaicin - agonists | Adipocytes, Beige - pathology | Adrenergic beta-2 Receptor Agonists - therapeutic use | Anti-Obesity Agents - antagonists & inhibitors | Adrenergic beta-2 Receptor Antagonists - pharmacology | Anti-Obesity Agents - agonists | Cold Temperature | Obesity - chemically induced | Receptors, Adrenergic, beta-2 - genetics | Mice, Inbred C57BL | Cells, Cultured | Acclimatization | Adrenergic beta-2 Receptor Antagonists - toxicity | Capsaicin - analogs & derivatives | Mice, Transgenic | Adipocytes, Beige - cytology | Random Allocation | Transcription Factors - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Receptors, Adrenergic, beta-2 - metabolism | Obesity - metabolism | Obesity - pathology | Gene Expression Regulation - drug effects | Transcription Factors - metabolism | Animals | Signal Transduction - drug effects | Oxygen Consumption - drug effects | Obesity - prevention & control | Protein Stability - drug effects | Capsaicin - antagonists & inhibitors | Dietary Supplements | Energy Metabolism - drug effects | Adipocytes, Beige - physiology | Weight reducing preparations | Obesity | Complications and side effects | Fat cells | Dosage and administration | Research | Beta adrenoceptors | Pharmacology and Therapeutics
Journal Article
Cancer Science, ISSN 1347-9032, 07/2013, Volume 104, Issue 7, pp. 896 - 903
Rearrangements of the proto‐oncogene RET are newly identified potential driver mutations in lung adenocarcinoma (LAD). However, the absence of cell lines...
ALK | PROFILE | ONCOLOGY | LANDSCAPE | MUTATIONS | CANCER | PROTOONCOGENE | Lung Neoplasms - drug therapy | Proto-Oncogene Proteins c-ret - metabolism | Adenocarcinoma of Lung | Apoptosis - drug effects | Cytoskeletal Proteins - genetics | Humans | Lung Neoplasms - metabolism | Proto-Oncogene Proteins c-akt - genetics | Adenocarcinoma - metabolism | Piperidines - pharmacology | Cytoskeletal Proteins - metabolism | Adenocarcinoma - genetics | Antineoplastic Agents - pharmacology | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins c-ret - antagonists & inhibitors | Lung Neoplasms - genetics | Cell Survival - drug effects | RNA, Messenger - genetics | Transcriptome - drug effects | Down-Regulation - drug effects | Adenocarcinoma - drug therapy | Animals | MAP Kinase Signaling System - drug effects | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | Mice, Nude | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mutation | Quinazolines - pharmacology | Proto-Oncogene Proteins c-ret - genetics | Adenocarcinoma | RNA | Analysis | Genes | Genetic aspects | Genetic transcription | Nucleotide sequencing | DNA sequencing | Cancer | AKT protein
ALK | PROFILE | ONCOLOGY | LANDSCAPE | MUTATIONS | CANCER | PROTOONCOGENE | Lung Neoplasms - drug therapy | Proto-Oncogene Proteins c-ret - metabolism | Adenocarcinoma of Lung | Apoptosis - drug effects | Cytoskeletal Proteins - genetics | Humans | Lung Neoplasms - metabolism | Proto-Oncogene Proteins c-akt - genetics | Adenocarcinoma - metabolism | Piperidines - pharmacology | Cytoskeletal Proteins - metabolism | Adenocarcinoma - genetics | Antineoplastic Agents - pharmacology | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins c-ret - antagonists & inhibitors | Lung Neoplasms - genetics | Cell Survival - drug effects | RNA, Messenger - genetics | Transcriptome - drug effects | Down-Regulation - drug effects | Adenocarcinoma - drug therapy | Animals | MAP Kinase Signaling System - drug effects | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | Mice, Nude | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mutation | Quinazolines - pharmacology | Proto-Oncogene Proteins c-ret - genetics | Adenocarcinoma | RNA | Analysis | Genes | Genetic aspects | Genetic transcription | Nucleotide sequencing | DNA sequencing | Cancer | AKT protein
Journal Article
Internal Medicine, ISSN 0918-2918, 2017, Volume 56, Issue 23, pp. 3193 - 3197
Severe pulmonary arterial hypertension (PAH) rarely develops in children with an atrial septal defect (ASD), even those with a large defect. We herein report...
congenital heart disease | lung transplantation | Eisenmenger syndrome | pulmonary arterial hypertension | atrial septal defect | BMPR2 mutation | Atrial septal defect | Congenital heart disease | Pulmonary arterial hypertension | Lung transplantation | RIGHT VENTRICLE | MEDICINE, GENERAL & INTERNAL | CONGENITAL HEART-DISEASE | MUTATIONS | VASCULAR-DISEASE | Heart Septal Defects, Atrial - surgery | Severity of Illness Index | Genetic Testing | Bone Morphogenetic Protein Receptors, Type II - genetics | Heart Defects, Congenital - surgery | Humans | Hypertension, Pulmonary - physiopathology | Familial Primary Pulmonary Hypertension - genetics | Hypertension, Pulmonary - genetics | Male | Treatment Outcome | Familial Primary Pulmonary Hypertension - physiopathology | Heart Defects, Congenital - genetics | Lung Transplantation | Heart Septal Defects, Atrial - complications | Adult | Hypertension, Pulmonary - etiology | Hypertension | Young adults | Bone morphogenetic protein receptor type II | Syngeneic grafts | Heart transplantation | Transplantation | Right ventricular failure | Coronary artery disease | Genetic analysis | Electrocardiography | Children | Ventricle | Heart diseases | Case Report
congenital heart disease | lung transplantation | Eisenmenger syndrome | pulmonary arterial hypertension | atrial septal defect | BMPR2 mutation | Atrial septal defect | Congenital heart disease | Pulmonary arterial hypertension | Lung transplantation | RIGHT VENTRICLE | MEDICINE, GENERAL & INTERNAL | CONGENITAL HEART-DISEASE | MUTATIONS | VASCULAR-DISEASE | Heart Septal Defects, Atrial - surgery | Severity of Illness Index | Genetic Testing | Bone Morphogenetic Protein Receptors, Type II - genetics | Heart Defects, Congenital - surgery | Humans | Hypertension, Pulmonary - physiopathology | Familial Primary Pulmonary Hypertension - genetics | Hypertension, Pulmonary - genetics | Male | Treatment Outcome | Familial Primary Pulmonary Hypertension - physiopathology | Heart Defects, Congenital - genetics | Lung Transplantation | Heart Septal Defects, Atrial - complications | Adult | Hypertension, Pulmonary - etiology | Hypertension | Young adults | Bone morphogenetic protein receptor type II | Syngeneic grafts | Heart transplantation | Transplantation | Right ventricular failure | Coronary artery disease | Genetic analysis | Electrocardiography | Children | Ventricle | Heart diseases | Case Report
Journal Article
International Journal of Hematology, ISSN 0925-5710, 3/2017, Volume 105, Issue 3, pp. 353 - 360
Transfusion is believed to be the main cause of iron overload in Japan. A nationwide survey on post-transfusional iron overload subsequently led to the...
Iron overload | Hereditary hemochromatosis | Hemochromatosis | Post-transfusional iron overload | Medicine & Public Health | Hematology | Oncology | HOMEOSTASIS | JUVENILE HEMOCHROMATOSIS | HEPCIDIN | HEMOJUVELIN GENE | IDENTIFICATION | FAMILY | MUTATIONS | ANEMIA | HEMATOLOGY | FERROPORTIN DISEASE | Japan - epidemiology | Iron Overload - genetics | Humans | Middle Aged | Male | Iron - metabolism | Transfusion Reaction | Iron Overload - etiology | Young Adult | Metabolic Networks and Pathways - genetics | Ferritins - blood | Iron Overload - epidemiology | Liver Diseases - etiology | Adolescent | Aged, 80 and over | Adult | Female | Surveys and Questionnaires | Aged | Hemochromatosis - diagnosis | Mutation | Hemochromatosis - epidemiology | Surveys | Medical colleges | Transferrin | Gene mutations | Ferritin | Resveratrol | Public opinion | Causes and theories of causation | Diseases
Iron overload | Hereditary hemochromatosis | Hemochromatosis | Post-transfusional iron overload | Medicine & Public Health | Hematology | Oncology | HOMEOSTASIS | JUVENILE HEMOCHROMATOSIS | HEPCIDIN | HEMOJUVELIN GENE | IDENTIFICATION | FAMILY | MUTATIONS | ANEMIA | HEMATOLOGY | FERROPORTIN DISEASE | Japan - epidemiology | Iron Overload - genetics | Humans | Middle Aged | Male | Iron - metabolism | Transfusion Reaction | Iron Overload - etiology | Young Adult | Metabolic Networks and Pathways - genetics | Ferritins - blood | Iron Overload - epidemiology | Liver Diseases - etiology | Adolescent | Aged, 80 and over | Adult | Female | Surveys and Questionnaires | Aged | Hemochromatosis - diagnosis | Mutation | Hemochromatosis - epidemiology | Surveys | Medical colleges | Transferrin | Gene mutations | Ferritin | Resveratrol | Public opinion | Causes and theories of causation | Diseases
Journal Article